Macropen tablets 400 mg. Price, instructions for use for children, adults, analogues, reviews

Macropen - popular antibiotic from the macrolide group, which is available in a dosage of 400 mg. These tablets and other dosage forms are affordable.

Therefore, they are often used for the treatment of adults and children in identifying pathologies caused by microorganisms sensitive to this agent. To get exclusively benefit from the product, you should follow the instructions exactly.

Forms of release and composition of the drug

The medication can be found in pharmacies in different regions in the form of tablets and granules for suspension. The tablets have an average size, white, biconvex round shape. They are packaged in blisters of 8 pieces.

The tablets do not have a specific aroma or taste; there are no inclusions or other features when cut on a cut. Blisters are placed in an individual cardboard box, they are always accompanied by instructions for correct use. Each box contains 1 blister.

Ranules are packaged in dark glass vials. When water is added, the patient receives 115 ml of the product in liquid form. The bottle with granules is also placed in an individual cardboard box with instructions for correct use.

The ingredient midecamycin is present as the main active component in the composition of the product. In the composition of the tablet, its amount reaches 400 mg, in 5 ml of the prepared suspension, the dosage is 175 mg.

Available in the composition of tablets and auxiliary ingredients:

• Talc.
• Magnesium stearate.
• Microcrystalline cellulose.
• Starch.
• Povidone.

The suspension contains the main ingredient and additional ingredients in the form of flavorings, sucrose and other substances.

Pharmacological properties

Macropen (400 mg tablets, the price of which is affordable, helps fight various diseases) has pronounced antibacterial properties. It should be noted that the main substance in the composition has bacteriostatic properties, that is, it disrupts metabolic processes in bacteria.

This leads to their gradual death. However, in large doses, the agent has bactericidal properties, that is, it destroys bacteria quite quickly, preventing rapid reproduction.

The drug has anti-inflammatory properties, which is achieved by destroying microbes in the affected area, reducing tissue edema. The complex effect of the drug allows it to be used for various bacterial pathologies in children and adults.

Pharmacodynamics and pharmacokinetics

The medicine begins to act almost immediately after it enters the patient's body. The active ingredient of the product penetrates into organs and tissues, acts on microorganisms that provoke the pathological process. Almost immediately, the patient's condition is alleviated due to the violation of metabolic processes in bacteria, as well as deterioration in the absorption of nutrient components.

As the ingredient spreads throughout the body, the bacteria gradually die and the signs of the inflammatory process are eliminated.

If the drug is immediately prescribed in large dosages, there is a rapid death of microorganisms due to suppression of activity and stopping reproduction. As a result, the tissues are cleansed of bacteria, as well as toxins that are released during their life.

Additionally, the agent prevents the spread of microbes to healthy tissues, which avoids the development of complications. The active substance helps to improve the general condition by eliminating microbes and restoring the affected tissues. In addition, the local temperature in the area of ​​inflammation decreases, which leads to the elimination of pain.

When used for the treatment of pathologies of internal organs, the progression of the pathological process stops against the background of mass death of bacteria. The tool also stimulates tissue repair, even with prolonged exposure to pathogens.

After taking the drug inside, it is absorbed into the systemic circulation through the walls of the digestive tract. The main amount is absorbed through the walls of the small intestine.

The active substance is well absorbed and binds to plasma proteins, which explains the high bioavailability, reaching 90%. The maximum concentration of the component in the blood is reached within 1-2 hours after oral administration.

It is noted that such indicators persist for 6 hours. The highest concentration of the active substance is found in the lung tissue, skin, and the parotid gland, which allows the use of a medication for the treatment of pathologies localized precisely in these tissues.

Eating slightly reduces the plasma concentration of the ingredients, so the drug is taken separately from food. The active ingredient is processed in the liver, where it is broken down into metabolites. Excretion of decay products occurs with the help of the digestive tract, metabolites are evacuated with bile. A small amount of metabolic products are excreted by the kidneys.

In patients suffering from pathologies of the small intestine, gallbladder, and kidney, the elimination period is somewhat prolonged. If the disease is at an advanced stage, the effectiveness of the medication is significantly reduced. It should be noted that the rates of absorption and excretion in elderly patients are somewhat different.

Indications for use

Macropen is used for patients of all ages. 400 mg tablets are often prescribed because their affordable price allows almost every patient to take the full course.

The main indications for the use of the medication:

• Respiratory system pathologies of various forms and severity. The remedy can be used for acute and chronic tonsillitis, laryngitis and tracheitis. It is prescribed for the detection of bronchitis, pneumonia of varying degrees of neglect, as well as otitis media.
• Diseases of the urinary system at different stages. In this case, the agent can be used for damage to the urethra and other organs with ureaplasma, mycoplasma, chlamydia.
• Kidney pathology at the initial stage, when there are no pronounced functional disorders.
• Infectious pathologies of the mucous membranes, as well as the skin, connective tissue of the articular joints. For example, in rheumatoid arthritis, antibiotics from the penicillin group are usually used, but if an allergy to their composition is detected, macrolides are prescribed in order to eliminate acute manifestations.
• Digestive tract pathologies, accompanied by inflammation of the mucous membrane of the small intestine. With colitis of a specific form, the drug is used quite often, since it is highly effective.
• Acute whooping cough, diphtheria. With these diseases, the general condition of the patient is impaired, so the drug helps to quickly eliminate the most acute symptoms.

The tool can be used as part of the complex treatment of erysipelas, as well as some others diseases that are provoked by the negative effects of staphylococci, streptococci and some other dangerous microbes.

Contraindications

The tool is not used when detecting allergies to its components or a history of similar complications. It is not prescribed when diagnosing a severe form of hepatic or renal failure, which is associated with a violation of the process of processing and excretion of metabolites from the body.

Internal bleeding against the background of exacerbation of pathologies of the digestive tract is considered a reason for refusing to use the drug. With an exacerbation of gastric ulcer and duodenal ulcer, as well as an advanced form of gastritis, the medication is not used.

Contraindications include acute pancreatitis, calculous cholecystitis. In this case, the general condition of the patient is disturbed against the background of the progression of such pathologies. You should not use the medication for severe intestinal dysbiosis, accompanied by frequent loose stools. In this case, drug treatment can provoke severe complications.

For elderly patients, the drug is prescribed with caution, which is associated with an increased risk of complications as a result of impaired absorption and processing of active substances. Contraindications can also be individual, that is, for a particular patient, the doctor can determine the conditions that will become an obstacle to therapy with the agent.

At what age can the drug be used?

Macropen (400 mg tablets, the price of which may be different, can be used only with the permission of a specialist) in the form of tablets is allowed to be prescribed to patients over 3 years old.

The product in the form of granules is used to obtain an oral suspension approved for use in the treatment of children from the first weeks of life. However, in this case, the dosage is determined depending on several factors.

Instructions for use, dosage

The tool is used only for oral administration in a dosage prescribed by a specialist. Adults take 1 tablet 3 times a day. The dosage for each tablet is 400 mg. This means that the patient takes 1200 mg of the drug per day. Only in some cases, the dosage is increased to 1600 mg per day if the patient's condition is severe and there is a risk of complications.

The duration of the course of treatment differs depending on the patient's condition. In acute pathologies, use is prescribed for 7 days. Usually this time is enough to stop the manifestations. With advanced forms, therapy can be extended up to 10 days. Only in some cases, the treatment lasts 14 days.

Usually, 5-6 days are enough to eliminate the most pronounced manifestations. The suspension is pre-prepared using boiled and pre-chilled water.

It must be added directly to the bottle with granules, and then shake the container thoroughly to obtain a homogeneous mass. On each bottle, you can see the mark to which water should be added in order to obtain the most effective formulation with the correct concentration of the active ingredient.

Patients from 3 years old, whose body weight exceeds 30 kg, are prescribed 2-3 tablets per day for 3-7 days. Suspension is prescribed for children weighing less than 30 kg. The dosage is determined based on the weight of the individual patient.

Patient weight	Dosage of funds
Up to 5 kg	Such children are prescribed 3.75 mg of the suspension for 1 dose. The use should be repeated 2 times a day.
5 to 10 kg	The daily dose for such patients is 15 ml. It should be divided by 2 times, taken in equal amounts at approximately the same time intervals.
10 to 15 kg	A single dosage for patients is 10 ml. The remedy should be taken in the morning and in the evening.
15 to 20 kg	For such children, the daily dose is 30 ml. It is recommended to take 15 ml in the morning and in the evening.
20 to 29 kg	One-time suspension rate is 22.5 ml. Reception is also carried out 2 times a day.

The duration of use of the suspension in each case is determined individually, depending on the disease and the presence of the risk of complications.

Side effects

Macropen (400 mg tablets, the price of which is affordable for patients, often lead to various complications) can lead to the development of negative manifestations. At the same time, the risk of such reactions increases if the instructions are violated, but does not disappear if it is fully observed.

From the side of the nervous system, complications occur frequently. They are accompanied by headaches, weakness and sleep disturbances. In addition, patients may be worried about depression, there is a decrease in performance, both mental and physical. In the absence of therapy, the symptoms are aggravated.

The most pronounced reactions appear from the digestive tract. Patients report pain in the stomach, nausea, and lack of appetite. At the same time, there is a dry mouth, strong thirst.

With prolonged use of the drug, the development of frequent loose stools and pain in the intestinal region are noted. Patients are worried about intestinal colic, flatulence, bloating. If the patient does not receive help for several days, dehydration develops.

Among the atypical adverse reactions, bronchospasm can be distinguished, which develops more often in patients suffering from pathologies of the respiratory system. In addition, acute urticaria may develop as an allergic reaction. A large rash of various shapes appears on the skin of the body, limbs, which provokes itching.

The patient scratches the affected area, which leads to an aggravation of symptoms. With prolonged itching, the skin becomes irritated and sensitive, areas of damage appear, which are a favorable environment for the introduction of microorganisms.

If negative reactions appear, it is recommended to stop using the drug. If they disappear, no special treatment is required. However, if the manifestations worsen, you should consult a doctor in order to obtain symptomatic treatment.

Overdose

Cases of overdose with the drug have been recorded, so you should not exceed the permissible daily rate without the doctor's permission and take the medication for a long period.

In case of an overdose, there is an aggravation of all negative reactions, as well as a significant deterioration in the patient's condition. The headache intensifies, there is severe weakness against the background of a lack of appetite and a normal night's sleep. The pain in the stomach area also intensifies, accompanied by repeated vomiting during the day. In this case, the patient's condition after gastric emptying does not improve.

Additionally, in case of an overdose, it is possible to develop seizures, a critical increase in blood pressure indicators. In severe cases, the patient loses consciousness in case of an overdose, and other unpleasant manifestations appear.

To prevent such complications, you should strictly follow the doctor's recommendations, when the first signs of an overdose appear, stop taking it and contact a medical institution.

special instructions

Macropen (400 mg tablets, the price of which may differ depending on the region of distribution, are considered quite effective for various pathologies) should be taken before meals, since food intake somewhat reduces the concentration of the active component in blood.

The break between use should be at least 8 hours. That is why it is important during the course of therapy to take the pills at the same time, observing the interval between doses.

When treating children, it is important to simultaneously take probiotics, which prevent the development of dysbiosis. Despite the fact that the manufacturer indicates the effectiveness of the product and the minimum risk of development dysbiosis, most patients, after a course of treatment, note the appearance of disorders from intestines.

The finished suspension has a pleasant taste, which makes it easier to treat small children. In addition, the active ingredient from the suspension is better absorbed in the digestive tract, and the granules themselves contain a smaller amount of auxiliary aggressive ingredients.

Drug interactions

The drug should not be used with other antibiotics from the macrolide group, which will avoid complications and overdose. In addition, the drug should not be administered concurrently with carbamazepine. This is associated with an increased risk of complications from the liver and kidneys, as well as an increased toxic effect on the body.

Antibiotic use with anticoagulants may increase the risk of bleeding. The toxic effect on the kidneys is enhanced when the drug is used in combination with cyclosporins.

There are no negative reactions when taking the medication in combination with vascular, hypertensive, anti-inflammatory drugs. In each case, when using the funds, a doctor's consultation is required.

Analogs

The tool has no structural analogs that would contain the same active ingredient.

But other macrolides are available that have similar properties:

• Ecozitrin - a tablet formulation containing clarithromycin as the main active ingredient. The drug has pronounced antibacterial properties, helps to eliminate the manifestations of inflammatory pathologies of bacterial origin. The remedy is prescribed for adults and children from 12 years old, it is considered very effective. The daily dosage ranges from 500-1500 mg, depending on the severity of the condition.
• Azithromycin - another agent from the group of macrolides, which is available in the form of capsules and tablets, contains the active ingredient of the same name. In addition, the medication can be purchased in powder form for preparing an oral suspension. The remedy is used to treat adults and children, helps to destroy pathogens and promotes rapid recovery.

There are many more analogs of the tool, but these are used most often.

Terms, conditions of sale and storage

The drug is dispensed in pharmacies with a prescription from a doctor. It must be stored in a cool and dark place for 3 years. The finished suspension can be stored for 14 days in the refrigerator and 7 days at room temperature. After that, it cannot be used.

Price

The cost of the product in different pharmacies and regions ranges from 270-350 rubles.

Macropen is a popular and effective pill that is used for patients of different ages and has an affordable price. Usually the patient is prescribed a dosage of 400 mg, but in each case the daily rate may depend on the severity of the pathological condition. It is forbidden to use an antibiotic on your own without a doctor's prescription.

Video about Macropen

Pharmacist about Macropen: