Sulfadimezin. Indications for use, instructions, price, reviews

Sulfadimezin is antibacterial medication, which is highly effective in the treatment of patients of different ages with disorders of the internal organs.

The indications for the use of the drug are extensive, but the patient needs to undergo a preliminary examination to determine the cause of the inflammatory process and the degree of its severity. This will allow you to select the optimal dosage and individual duration of treatment.

Release form and composition of the drug

The medication is sold in the form of tablets for oral administration. They are medium in size, round, yellowish, white or nearly white in color. The tablets are packaged in paper plates of 10 pieces; there are also foil plates, which are considered more durable. They contain 10 tablets.

Plates made of paper or plastic do not fit into large cardboard boxes, so they are sold without them. A description is attached to the plates, which details all the nuances of use and possible complications in case of violation of the recommendations. The drug contains the sulfadimezin component, which has the main therapeutic effect.

The composition of the drug contains auxiliary ingredients:

• Talc.
• Starch.
• Polysorbate.
• Stearic acid.

The components have no medicinal properties. The amount of the main ingredient in 1 tablet is 500 mg.

Pharmacological properties

Sulfadimezin, the indications for the use of which are described in detail in the instructions, has antibacterial properties, which makes it possible to use it in the case of acute manifestations of inflammatory pathologies of internal organs.

A drug:

• helps to eliminate tissue edema;
• quickly inhibits the development of pathogens;
• prevents reproduction and aggravation of the symptoms of the underlying disease.

An additional property is the ability to destroy many gram-positive and gram-negative microorganisms that provoke inflammatory pathologies of the digestive tract, respiratory and urinary system.

Pharmacodynamics and pharmacokinetics

After penetrating the digestive tract, the drug spreads rather quickly through the systemic circulation and concentrates mainly in the affected area. The active ingredient suppresses the vital activity of microbes, has bacteriostatic properties, which allows you to stop the multiplication of pathogens.

As a result of taking the medication, there is a rapid elimination of the symptoms of the disease and an improvement in the general condition of the patient.

The activity of the main substance is noted in relation to:

• shigella;
• colibacillus;
• Klebsiella.

The drug destroys the causative agents of pneumonia, some diseases of the genitourinary system, and soft tissues, which makes it universal for many patients.

The medicine has other properties:

• Eliminates tissue edema by cleansing tissues from pathogenic bacteria.
• Against the background of the use of the drug, the body temperature decreases, general disorders that arise against the background of the inflammatory process are eliminated.
• Helps prevent the rapid progression of pathology against the background of the spread of bacteria to healthy tissues and penetration into other organs.
• It shortens the recovery period, in combination with other medicines, it rather quickly improves the patient's well-being.
• Disrupts metabolic processes in pathogenic cells, which leads to their gradual death.

The drug is quite well absorbed in the digestive tract, namely in the small intestine. The bioavailability of the drug is high, and the binding to plasma proteins reaches 86%, which ensures the effectiveness and rapid onset of the therapeutic effect.

Within 1-3 hours, the maximum concentration of the active ingredient is reached in the blood. The tool belongs to short-acting sulfa drugs, therefore, the processing of the active substance is carried out in the liver rather quickly. Within 1 day, there is a complete processing and removal of the decay products of the active substance from the body.

The evacuation of metabolites occurs with the help of the kidneys. With damage to the digestive system, as well as urinary excretion, there is a deterioration in the process of processing and excretion of the ingredients of the product. Despite this, the therapeutic effect is weakened slightly. In elderly patients, there is a change in pharmacokinetic characteristics.

Indications for use

Sulfadimezin is used for various disorders of the internal organs.

The main indications for its use:

• Trachoma of various stages and shapes.
• Gonorrhea in patients of different ages.
• Respiratory system pathologies of inflammatory origin. The medication is quite effective in the fight against pneumonia, acute bronchitis and some other pathologies.
• Acute and chronic diseases of the genitourinary system of inflammatory origin.
• Diseases of the upper respiratory tract in severe form. The drug is effective for tonsillitis and laryngitis, angina of various forms and pharyngitis. With mixed inflammatory processes, the medicine also helps to eliminate the symptoms.
• Shigellosis at different stages of development.
• Otitis media in acute and chronic form.
• Sinusitis. When using the drug, patients are simultaneously prescribed other drugs that accelerate the onset of the therapeutic effect.
• Erysipelas of various forms, pyoderma. In this case, the pathology affects soft tissues and provokes systemic disorders.
• Toxoplasmosis.

The drug can be used as part of the complex treatment of pathologies of the biliary tract of inflammatory origin.

Contraindications

The medicine is not used when identifying intolerance to the components of the composition or a tendency to such manifestations.

Other barriers to therapy include the following conditions:

• Pathologies of the red bone marrow, accompanied by a violation of the process of hematopoiesis.
• An acute form of renal or hepatic failure, in which there is a violation of the functioning of the organ and a deterioration in the general condition.
• Acute infectious diseases that provoke disruption of the functioning of the digestive tract.
• Mental disorders in acute form, accompanied by various pronounced manifestations.
• Chronic diseases of the stomach and intestines in the acute stage.
• Internal bleeding as a result of perforation of the wall of the stomach or intestines.
• The period of lactation and bearing of the child.

The drug is prescribed with caution to elderly patients, since they often have chronic diseases of the liver, kidneys and heart. As a result of treatment with an agent, complications may develop in such patients.

At what age can the drug be used?

Sulfadimezin (indications for the use of the drug suggest a thorough examination before prescribing) is allowed to be taken by patients over 3 years old as directed by a doctor.

However, the official instruction also indicates that the drug is not prescribed to patients under 18 years of age in the case of diagnosing an increased level of bilirubin in the blood against the background of liver pathologies.

Instructions for use, dosage

There is a standard therapeutic regimen that is used in most cases to treat patients. The nuances of therapy may vary depending on the individual characteristics of the organism.

The standard scheme involves taking the drug only orally in a dosage prescribed by a specialist. Usually, the tablets are taken orally for 7-10 days, depending on the severity of the manifestations.

The maximum single dose for an adult is 2 g, that is, 4 tablets:

• The daily dosage for adults should not exceed 7 g, that is, 14 tablets, but usually 12 tablets are enough to obtain a pronounced result. The daily rate is divided into 4-6 doses during the day.
• For the treatment of children over 3 years of age, the dosage is selected depending on the weight. For 1 kg of body weight, there is no more than 0.1 g of the drug, while I use this dose in 1 dose, and repeat it no more than 1 time in 4 hours. Often, the breaks between doses are equal to 8 hours, if the patient's condition does not worsen.

Experts point out that the maximum daily allowance for a child should not exceed 0.15 g per 1 kg of weight. During treatment, it is divided into 4-6 doses during the day with approximately equal time intervals. In the case of an advanced course of pathology, the permissible daily rate does not increase. Treatment for children usually lasts no more than 10 days.

Pneumonia

With pneumonia, the daily dosage of the drug for the child does not differ from the standard scheme, and the therapy lasts no more than 10 days. On the first day of treatment, adults take 2 g of the medication once, after which the single dosage is reduced to 2 tablets.

This dose is repeated 4-6 times a day, depending on the severity of the symptoms of the disease. When taking it is recommended to do approximately equal time intervals. If necessary, adult therapy can be extended, but only on strict indications.

Tonsillitis

In case of revealing tonsillitis of bacterial origin, the drug is taken according to a special scheme. The daily dosage for children is 0.075 g per 1 kg of body weight. It is divided into 2-3 doses during the day.

With such a violation, the maximum rate of the drug for an adult is 6 tablets. It is divided into 3 doses during the day, making approximately equal intervals of time. Treatment of pathology lasts up to 10 days. In most cases, 7 days is sufficient.

Sinusitis

The daily norm of the drug for children with such a violation is standard, it is divided into several doses during the day. Therapy for children lasts up to 10 days, sometimes it needs to be extended according to individual indications.

Adults take 8 to 12 tablets per day, dividing the dose by 4-6 times. During treatment, it is worth observing equal time intervals, which will allow to have a uniform effect on the body. Adult treatment lasts no more than 2 weeks.

Otitis media

With such a violation, the drug is also used according to the standard scheme. The minimum course duration is 1 week. If necessary, therapy is extended to 14 days.

The dosage in each case is adjusted as necessary.

Exacerbation of bronchitis

Sulfadimezin (indications for the use of the drug include pathologies of the respiratory system) can be prescribed to patients with an exacerbation of the chronic form of bronchitis in combination with other drugs. The treatment regimen for such a violation is standard, and the course lasts no more than 10 days.

If necessary, the dosage of the agent can be adjusted in each case individually, but in most cases the standard method is suitable.

Inflammation of the biliary and urinary tract

In case of damage to the bile and urinary ducts, the drug is prescribed for adults 1 tablet 4-6 times a day. To obtain a pronounced therapeutic effect, it is enough to use the drug for 10 days.

Children with such violations also use the remedy for 10 days in a row. A single dosage for them is 0.5 g, the intake is carried out 4-6 times a day.

Shigellosis

The detection of such a disease requires the use of the drug according to the standard scheme. In this case, a prerequisite is considered to be 2 courses with a frequency of 2 weeks.

The dose change for any reason is made on an individual basis.

Erysipelas

With erysipelas of tissues, children and adults receive the medicine in a standard dosage. The treatment is carried out according to the classical scheme. If necessary, the dose and duration of treatment is adjusted by the doctor on an individual basis.

Wound infections

Treatment of patients with wound lesions lasts 10 days. At the same time, the doses for adult patients and children are standard. A reduction in dosage is possible with an improvement in the condition, but the decision in each case is made by the doctor based on the data from the examination of the affected area.

Side effects

The drug can provoke complications, which in most cases arise as a result of violation of the doctor's recommendations.

At the same time, internal organs suffer, the work of systems is disrupted:

Damage area	Most common adverse reactions
The cardiovascular system	When using the drug in patients with chronic disorders of the cardiovascular system, tachycardia and heart rhythm disturbances are observed. After discontinuation of treatment, symptoms may disappear, but more often the use of additional medications is required to normalize the condition.
Digestive tract	The digestive organs are most often affected during treatment. The condition may worsen as a result of nausea, bowel pain, flatulence, and bloating. Vomiting, poor appetite and severe thirst, dry mouth are often observed. With prolonged persistence of symptoms, disorders of the pancreas join, which manifests itself in the form of pain, repeated vomiting and stool disorder.
Nervous system	Headache, dizziness and weakness are often observed with the use of the remedy. Patients report deterioration in concentration and memory, sleep disorders and decreased performance. Usually, such symptoms occur against the background of other disorders of the digestive, cardiovascular system.
urinary system	If there is a history of pathologies of the kidneys and other parts of the urinary system, there is a deterioration in the functioning of organs when using tablets. Some patients report increased urination and pain in the bladder area.
Leather	Allergic manifestations in patients occur frequently. They are accompanied by a deterioration in the general condition, rash and itching of the skin, swelling of the mucous membranes of the oral cavity, eyes and nasal passages. In severe cases, the condition may worsen, there is swelling of the mucous membranes of the throat, which can lead to suffocation.

Negative reactions in children are manifested in an acute form, but can disappear on their own after refusal of treatment. Adults often require medication to normalize their condition.

Overdose

Sulfadimezin (indications for use should be studied in detail by patients before starting treatment) often leads to the development of an overdose in violation of instructions and taking medication in high doses for a long time period.

In case of an overdose, the patient's condition worsens, all negative reactions are more pronounced.

Patients note:

• indomitable vomiting;
• severe headache;
• dizziness.

Sometimes the condition is accompanied by acute angioedema or urticaria. This leads to a significant deterioration in well-being and, if untreated, can provoke death.

In some patients, with an overdose, anorexia develops, the condition worsens, blood pressure indicators decrease, and severe weakness is observed. If you experience life-threatening symptoms, you should immediately stop using the medication and visit a doctor.

Often it is required to place the patient in a hospital and prescribe medications for parenteral use. This helps prevent the progression of the disorder and improve the condition.

You can not independently use medicines at home if signs of an overdose appear. It is also not recommended to ignore the symptoms.

special instructions

The use of the drug should be agreed with the doctor, since self-medication can provoke complications:

• Experts note that patients suffering from intolerance to Furosemide and its analogues may develop complications when using an antibacterial medication.
• Doctors are aware of cases of death when using the medication, but in most cases it is was associated with a history of patients with chronic genetic or other severe diseases forms.
• With caution, the medication is prescribed to patients who suffer from diabetes mellitus due to an increased risk of developing negative reactions.
• When treating patients over 65 with an antibacterial agent, special care should be taken. It is recommended not to use the maximum dosages allowed by specialists, but to reduce them, especially if there is a history of severe renal pathologies.

Drug interactions

The drug is not recommended to be used concurrently with other antibiotics from this group. Benzocaine and Procaine can weaken the effectiveness of the antibacterial medication. Sulfadimezin significantly reduces the effectiveness of antibiotics from the group of cephalosporins and penicillins.

Renal complications often develop when the drug is combined with ascorbic acid. The toxicity and danger to the patient during treatment with Chloramphenicol increases if therapy is combined with the use of an antibacterial drug. The combination of a medication with any means requires prior consultation with a doctor.

Analogs

The drug has analogues that can be used in the absence of it in pharmacies or the impossibility of prescribing.

The most common substitutes are:

• Streptocide can be used as a substitute for the defeat of various microorganisms of the patient's skin. The tool has pronounced properties due to the content of sulfonamide as the main active ingredient.
• Etazol - effective antimicrobial and antibacterial tablets that can be used to treat various inflammatory pathologies of bacterial origin. The medication has an effect due to the presence of another active ingredient, but it is considered no less effective.

A substitute is selected only by a doctor based on diagnostic data. Doing this on your own is strongly discouraged.

Terms, conditions of sale and storage

Dispensing of medicines from pharmacies is carried out after presentation of a prescription from a doctor. The maximum storage time is 5 years. During storage, it is important to limit access to moisture tablets, as well as keep them out of the reach of children. Application after the expiration date is prohibited.

Price

The cost of the medicine is approximately 70-80 rubles. for 10 tablets.

Sulfadimezin is a fairly effective antibacterial drug, which is often prescribed for damage to internal organs and systems. Indications for its use require a full examination and identification of the cause of the inflammatory process.

Video about the drug

Indications for use and mechanism of action of Sulfadimezin and its analogs: