Complex pyobacteriofag (pyobacteriofag combined). Reviews, instructions for use, where to buy, how to take, price

In the fight against infectious diseases, doctors refuse to use potent antibacterial drugs, replacing them with bacteriophages. One of these is the complex pyobacteriophage. According to reviews, the tool does not cause side reactions and generally fights against pathogenic microorganisms.

Forms of release and composition of the drug

This drug is available in the form of a clear medicinal solution. It is distinguished by the versatility of methods of use: the medication can be taken orally and applied externally. The complex pyobacteriophage is a liquid with shades of different saturation. A yellow or greenish color of the solution is considered the norm.

The drug is sold in bottles of different sizes - 20 ml and 100 ml. Each carton contains 8 bottles of smaller volume or 1 larger. The concentration of active ingredients in 1 ml of the drug does not depend on the volume of the bottle.

Each drop of the solution contains filtrates of phagolysates of bacteria of the following strains:

• staphylococcal;
• streptococcal;
• enteropathogenic (Escherichia coli, Proteus);
• klebsiella;
• Pseudomonas aeruginosa.

A pyobacteriophage is a complex of lysis products of a liquid bacterial culture affected by a bacteriophage. It is a kind of mixture of components of bacterial cells and a nutrient medium containing bacteriophage particles.

Phagolysates are created by suspension, purification and sterilization. Some scientists are sure that it is bacteriophages that have a huge impact on the formation of human immunity.

Preservatives, 8-hydroxyquinoline sulfate are included in the composition of Pyobacteriophage as auxiliary components.

Pharmacological properties

The word "bacteriophage" in translation from Greek means "destruction of bacteria." In modern medicine, this term assumes a family of individual viruses that can affect some representatives of the microflora. In the treatment of infectious diseases, phages are used that live in a human habitat (in water, soil, on the surfaces of objects).

The therapeutic properties of bacteriophages allow them to compete with antibacterial drugs.

Compared to antibiotics, Pyobacteriophage:

• has a purposeful effect, destroying exclusively the causative agent of the disease, and not the beneficial microflora;
• does not suppress the immune system;
• demonstrates good results in the treatment of indolent lingering diseases of bacterial etiology with high resistance.

The bacteriophages used in the manufacture of this drug are, in fact, parasites. Viruses invade the microbial cell and use its structures and reserves for their own growth, nutrition, reproduction. It is interesting that each bacteriophage possesses exclusively genetic material covered with a protein coat.

Each of the varieties of bacteriophages affects certain bacteria, therefore phagolysates of several strains are present in the Pyobacteriophage composition. Thanks to this, the drug is effective against various pathogens.

The complex pyobacteriophage, reviews of which are contradictory, can be used in combination with antibiotics and is not addictive.

Pharmacodynamics and pharmacokinetics

This drug starts the process of lysis of pathogens. The pyobacteriophage enters the microbe cell and after a while dissolves it, thereby completely destroying it.

The beginning of the destructive work of a bacteriophage is considered the moment of injecting its genetic information into the body of the bacterium, after which the amount of the "curative" virus begins to actively increase.

As soon as the membranes of bacterial cells begin to collapse, up to 200 bacteriophages are released from the membrane that has been lysis and continue the process of destroying neighboring pathogenic bacteria. Thus, the Pyobacteriophage continues to act until all infectious agents in the body are rendered harmless.

Indications for use

Pathological conditions that develop due to bacterial infection require complex therapy. If several decades ago there was only one solution to such problems - taking antibiotics, today bacteriophages are increasingly used in the treatment of infectious diseases.

It is important to understand that their use will become effective provided that the subspecies and strain of the bacterial pathogen are accurately identified.

In the annotation to Pyobacteriophage, it is noted that it can be used for the treatment and prevention of diseases of a purulent-inflammatory nature in the gastrointestinal tract, provoked by staphylococcal, streptococcal microorganisms, as well as enterococci, Klebsiella, Pseudomonas aeruginosa, Proteus and others enterobacteriaceae.

In this regard, the main indications for the use of Pyobacteriophage are:

• dysbiosis;
• food poisoning;
• gastroenterocolitis of various etiologies;
• inflammation of the gallbladder.

In addition to problems in the digestive organs, bacteriophages are intended for patients with respiratory diseases, otitis media, sinusitis. With laryngitis, pharyngitis, angina, Pyobacteriophage is used as monotherapy.

The effectiveness of this tool has been proven by numerous patient responses: the drug demonstrates good results in urinary tract infections, inflammatory and bacterial lesions of organs small pelvis. There is information about the use of Pyobacteriophage in post-traumatic complications of the conjunctiva, sclera or cornea.

The complex pyobacteriophage (user reviews of the drug cannot be considered a recommendation for use) should be prescribed only by a specialist.

This tool is used in the treatment of infectious diseases requiring surgical intervention:

• carbunculosis;
• abscess;
• furunculosis;
• phlegmon;
• felon.

If a bacterial pathogen joins the burns or wounds, you can also try to cope with progressive inflammation with the help of phagolysates, without antibiotics. For prophylactic purposes, the drug is prescribed to prevent nosocomial infection. Most often, with the help of Pyobacteriophage, wound surfaces, postoperative scars are treated.

Contraindications

There are no absolute prohibitions on the use of this bioactive medication. You can not use the drug Pyobacteriophage only in case of individual intolerance to the substances it contains.

Restrictions on the use of the drug during pregnancy and lactation can be considered relative. Before using this product, a doctor's consultation is required to determine the exact dosage and the duration of therapy, as well as the passage of a detailed examination in order to identify an infectious pathogen.

At what age can the drug be used?

The complex pyobacteriophage is not often used in childhood, but still the drug can be given as directed by the attending physician after 6 months. Children under this age are prescribed medication only in case of urgent need - for example, in the treatment of sepsis, enterocolitis.

As a rule, Pyobacteriophage is used for infants as enemas, but in the absence of regurgitation and comfortable tolerance, the drug can be given to the child by oral route.

It is interesting that the medicine is best given to children in the first year of life not in pure form, but diluted with milk. At the same time, the Pyobacteriophage will demonstrate higher results in the case of combining rectal and oral administration of the solution.

For babies born prematurely, a bacteriophage is introduced into the body through a gas outlet tube. For children, the average course of treatment is 5-15 days. With a recurrent course of pathology, a repeated course is possible. Pyobacteriophage is often prescribed for newborns and infants for prophylactic purposes in stationary conditions.

With the help of this medicinal solution, children are treated with pyoderma and omphalitis: a gauze napkin is moistened in a medicinal liquid and applied to the affected area or umbilical wound.

Instructions for use, dosage

The scheme of using the Pyobacteriophage is determined depending on the type of disease and the location of the infectious focus.

The medicinal solution can be used in 3 main ways:

• drink in pure or diluted form;
• do enemas;
• use as lotions, compresses, rinses.

If necessary, the drug is administered both rectally and orally at the same time. For example, with dysbiosis, acute intestinal infections or other diseases of the gastrointestinal tract, Pyobacteriophage can be administered orally 3 times a day 1 hour before meals, and in complicated cases - in parallel with enemas.

The dosage of the drug is determined individually by the doctor, based on the manufacturer's recommendations:

Patient age	Maximum single dose (ml)
Oral intake	Enema
0-6 months	5	10
6-12 months	10	20
from 1 to 3 years	15	30
from 3 years old to 8 years old	20	40
8 years and older	30	50

Local use

In diseases of the ENT organs, the use of turundas soaked in a solution is considered effective: they are installed in each ear or nasal passage and left for 1 hour.

Pyobacteriophage can be used for bacterial conjunctivitis for instillation. The instructions for use indicate the optimal dosage regimen: 2-3 drops 4-5 times during the day in each eye. The same treatment regimen is also suitable for keratoconjunctivitis.

For patients with purulent corneal ulcer or purulent iridocyclitis, a single dose after consultation with a doctor is increased by 2-3 times, and the frequency of use is increased up to 8 times a day.

Open wounds can be irrigated with complex Pyobacteriophage, make lotions or install tampons, determining the amount of the drug based on the size of the affected area. In case of abscesses, the solution is injected directly into the cavity of the focus, after which pus is removed from it.

The maximum volume of the drug used for 1 procedure is 200 ml. In osteomyelitis, 10-20 ml of Pyobacteriophage is poured into wounds after preliminary antiseptic treatment.

As a solution for external use, the drug is prescribed for various diseases of the oral cavity of a chronic form, including periodontitis and gingivitis.

Pyobacteriophage is used for rinsing: the procedure is carried out after brushing teeth 3-4 times a day, spending an average of 20 ml of liquid. Another way to use a bacteriophage is to introduce drug-soaked turunda into periodontal pockets.

With bacterial infections of the vagina and uterus, using the Pyobacteriophage, similar manipulations are performed. In specialized conditions, the drug can be injected into the cavity of the renal pelvis or bladder using drainage devices (nephrostomy, cystostomy).

Enemas

The introduction of the Pyobacteriophage solution into the rectum using an enema is recommended for food poisoning and acute conditions provoked by separate groups of enterobacteria.

Moreover, bacteriophages must be applied using the so-called "high" enema - this is a manipulation acting on the principle of communicating vessels, especially effective for intestinal obstruction and increased gas production in children 1 year old life.

The complex pyobacteriophage is administered after preliminary cleansing of the intestines. According to reviews, the procedure does not cause pain or discomfort. In order for the solution to get as far as possible, the tube with the tip must be inserted to a depth of at least 30-40 cm.

Instillation in the nose

In the treatment of inflammatory and purulent sinus infections, doctors are increasingly moving away from the use of antibiotics. Bacteriophages are used for burying, washing, irrigating disease foci.

For sinusitis, therapeutic applications are used: cotton swabs are soaked in a solution of Pyobacteriophage and installed in each nasal passage for 30-60 minutes. This method is suitable for the treatment of rhinitis and the prevention of complications associated with acute respiratory viral infections.

Purulent-inflammatory localized lesions are treated systemically. The patient is prescribed Pyobacteriophage inside and in parallel as a topical drug. Unlike antibiotics, this remedy can be used over a longer period. On average, the course of treatment with bacteriophages lasts 10-20 days.

Side effects

There is not enough information about confirmed cases of adverse reactions. It is known that the drug rarely causes symptoms of individual intolerance. Moreover, an allergy can be provoked by any of the components in the composition of the product. Patients who are not suitable for Pyobacteriophage may experience nausea, dizziness, and weakness.

The likelihood of side effects is higher for those users who neglect the rules or shelf life of the drug, ignore the manufacturer's recommendations in the instructions for use.

Overdose

The complex pyobacteriophage, reviews of which are studied by the majority of the patient on the eve of treatment, is not dangerous if the dosages prescribed by the doctor are exceeded. This drug does not negatively affect human health. There is no information in the annotation about the change in state with excessive consumption of the drug.

However, adhering to accurate dosage calculations will save your budget. With intensive use, the consumption of the drug increases, which means that in those cases where 1 package would be enough, you will have to purchase another one. Considering not the lowest cost of the bacteriophage, an additional purchase may disrupt existing plans.

special instructions

Of great importance in the dynamics of recovery will be the fact whether a test for the phagosensitivity of the pathogen to the drug was previously carried out.

If the pathogen is resistant to the effects of these bacteriophages, the use of the medication will not bring the expected results. Resistance to the components of the Pyobacteriophage can develop after prolonged use.

Shake the liquid bottle thoroughly before each dose. The presence of sediment, discoloration, turbidity of the solution indicate the loss of its medicinal properties and uselessness in the future. Bacteria that enter the container from the outside multiply rapidly in a favorable nutrient medium, disrupting the balance of bacteriophages.

To prevent this, opening the bottle, you must follow the basic rules:

• Before opening the bottle, you must treat your hands with an antiseptic and wash with soap and water.
• Before opening the bottle, you need to disinfect the stopper and protective cap.
• After processing, the lid should not be placed with its inner side facing surfaces.

Do not leave the bottle open for a long time. After opening, Pyobacteriophage can only be stored in the refrigerator. To mark the required amount of medication, you will need a regular syringe of any volume: the needle of the syringe should pierce the cork, and then, through the resulting hole, you need to draw the solution.

Drug interactions

Most bacteriophages can be used in combination with antibacterial drugs. The researchers were able to prove that phages effectively enhance the effect of antimicrobial agents, provided the pathogen is correctly identified.

If Pyobacteriophage is applied externally after antiseptics of chemical origin, between these drugs and the bacteriophage, it is necessary to wash the wound with the usual 0.9% saline solution. Treatment with viruses does not preclude the use of traditional antibacterial formulations.

There is a minimum of information about the effect of ethyl alcohol on the properties of the drug, since studies of this kind have simply not been carried out. However, to be sure of the results of treatment, doctors advise to stop drinking alcoholic beverages for some time.

By the way, alcohol is not compatible with most modern antibacterial substances used in the complex treatment of infections.

Analogs

The complex pyobacteriophage (reviews about the drug are often left by doctors, doctors with experience) has many analogues. Some of the bacteriophages have almost identical composition to this drug. The most popular substitutes

Pyobacteriophage can be considered funds with the following trade names:

• Polyvalent sextaphage - has the same composition, specifically dissolves pathogens, the price per pack starts from 750 rubles;
• Pyopolyphage - has an immunostimulating effect, but unlike Pyobacteriophage, it does not contain enterococcus phagolysate (the cost is about 800 rubles);
• Intesty bacteriophage - an absolute analogue of a domestic manufacturer, acting on a number of bacterial strains and not causing side effects (price - from 730 rubles).

All of these mixtures of phagolysate filtrates serve as worthy alternatives to antibiotics. Especially often, such drugs are used to treat diseases of the upper respiratory tract and ENT organs in children. Unlike antibacterial agents, Pyobacteriophage and its analogs do not violate the beneficial intestinal microflora and are harmless even if large doses are taken.

Terms, conditions of sale and storage

The shelf life of Pyobacteriophage depends on the conditions under which the drug will be stored. From the date of release, the medicine remains valid for 2 years, but only if it is kept in a dry place, protected from light and children.

Observance of the temperature regime is also important: the drug retains its medicinal properties from +2 to +10 ° C. After the expiration date, the treatment solution must be disposed of. An expired bacteriophage is not hazardous to health, but it will also not be able to provide any beneficial effect.

Price

The average cost of Pyobacteriophage in Russian pharmacies is 850-900 rubles. for a bottle of 100 ml. The price of a drug may vary slightly between different manufacturers in different regions of the country.

Unlike antibiotics, Piobacteriophage complex can be used as a prophylactic agent. According to reviews, bacteriophages are practically not inferior in efficiency in the treatment of intestinal infections in adults and children.

Video about the drug

Pyobacteriophage in the treatment of staphylococcus: