Wilprafen Solutab. Adult reviews, instructions for use, analogs, where to buy, price

For the treatment of infectious diseases provoked by bacterial strains sensitive to josamycin, use Vilprafen Solutab. The antibiotic has a mild anti-inflammatory effect, according to reviews of adults who have taken the medicine.

Forms of release and composition of the drug

In pharmacies, the antibacterial medication is offered in the form of large oval dispersible tablets of the classic white color for such drugs with a barely noticeable yellowish tinge.

The dosage is engraved on the back and the abbreviation IOSA on the front. The antibiotic has a pleasant sweetish taste and strawberry aroma, which makes it easier to swallow.

A dividing line is applied to the surface of the tablets. It is designed to conveniently split the drug when you need to take half the dose. The antimicrobial drug is packaged in sealed and sterile blisters made of aluminum foil and transparent medical polymer.

Each block contains 5 tablets. The secondary packaging is an oblong box made of laminated cardboard, decorated in blue and white colors. The pack contains 2 blisters with antibiotic tablets.

The active substance of the drug josamycin propionate is an antibacterial chemical compound of the macrolide series. The peculiarity of its molecular structure is the attachment of propionic acid ester atoms.

The volatile substance has a strong effect on the biochemical properties of the antibiotic and facilitates the penetration of pathogenic pathogens into the cells. Each tablet contains 1000 mg of josamycin propionate.

Auxiliary components of the medicinal composition:

• microcrystalline cellulose - biologically active plant substance that improves digestive function and enhances the excretion of Wilprafen;
• hypromellose - facilitates the dissolution of the tablet and plays a structure-forming role;
• strawberry essence - natural powder flavoring, which gives the tablets a pleasant smell and taste;
• magnesium stearate - an emulsifier that converts different chemicals into a uniform dosage form;
• aspartame - sweetener, food additive E951;
• sodium docusate - anionic surfactant that improves intestinal motility, enhances penetration and pharmacological characteristics of the antibiotic;
• colloidal silicon dioxide - a mineral substance, an effective enterosorbent.

Wilprafen Solutab reviews of adults are characterized as a drug that is well accepted by the body. This is achieved through a precisely calibrated chemical formula.

Pharmacological properties

An antibacterial drug of the macrolide category has a pronounced antimicrobial effect. With a high concentration of pathogenic microflora in the inflammatory focus, it prevents its spread.

Vilprafen Solutab has pronounced bacteriostatic properties, delaying the reproduction of pathogens. Josamycin causes irreversible structural and physiological changes in the cells of pathogenic agents.

This pharmacological mechanism leads to bacteriostasis - the loss of the ability of strains to reproduce, but does not provoke their death. In high doses, the drug destroys microorganisms, destroying their cellular structure.

Macrolide derivatives are considered to be the least toxic antimicrobial agents. The tablets slightly affect the natural enterobacteriaceae of the gastrointestinal tract, without causing digestive dysfunctions, which is very rare for potent antibiotics.

Vilprafen Solutab is a systemic (generalized) drug. Pharmacological properties, high degree and a wide range of antibacterial activity make it possible to use it to suppress pathogenic agents that colonize in various organs and parts of the body.

Pharmacodynamics and pharmacokinetics

The mechanism of the antimicrobial action of josamycin propionate is based on the ability of this aggressive chemical compound to disrupt the process of protein synthesis inside the bacterial cell. It irreversibly binds to the 50S-subunit of non-membrane organelles - ribosomes.

Microbial resistance to macrolide antibiotics is developed more difficult and less frequently than to representatives of other pharmacological groups of similar purpose.

Gram-positive and Gram-negative aerobes sensitive to Wilprafen Solutab:

• Bacillus cereus - a spore-forming pathogenic microorganism that releases large volumes of toxins, provoking gastrointestinal disorders and meningoencephalitis in newborns;
• corynebacteria - rod-shaped microorganisms, typical causative agents of opportunistic infections, purulent sepsis, osteomyelitis, endocarditis and others;
• rhodococci - nocardi-like bacteria that cause an abscess of the pulmonary organ, endophthalmitis, pansinusitis;
• bordatella - whooping cough, a typical causative agent of acute respiratory syndromes;
• branhamella - a pathogen that attacks the mucous membranes, provoking the development of bronchitis, pneumonia, endocarditis;
• compilobacterium legionella - a polymorphic and mobile microbe that affects the digestive organs;
• moraxella - a conditionally pathogenic agent, with a decrease in immune defense, causing inflammatory processes in the structure of the gastrointestinal tract, urinary tract, and respiratory tract.

Wilprafen Solutab reviews of adults are positioned as a drug that can cope with any infectious diseases provoked by microorganisms sensitive to methicillin.

When taken orally at the recommended therapeutic dosage, josamycin propionate is easy to overcomes the gastroenterological barrier, penetrating the systemic circulation and providing generalized impact.

Food does not affect the bioavailability and pharmacokinetic properties of the antibiotic. The limiting plasma concentration of the main physiologically active component of the medicinal composition is observed 1-4 hours after oral administration.

The blood saturation with the active substance of Wilprafen Solutab is fixed at the level of 0.2-0.3 mg / l. With protein fragments of the plasma fraction, no more than 15% of the taken dose enters into chemical interaction.

Josamycin propionate is evenly distributed in tissues, with the exception of the cerebral organ. The concentration in them exceeds the plasma content. The active component of the antibiotic retains its own bacteriostatic properties for a long time.

The highest saturation with josamycin is found in:

• tissues of the pulmonary apparatus;
• tonsils;
• sweat secretions;
• salivary secretion;
• lacrimal fluid.

The concentration of the main pharmacologically active component of the antibiotic drug in bronchial mucus exceeds the plasma content by 8-9 times. Josamycin is metabolized mainly in the hepatic tissues under the influence of bile enzymes.

The constituents of the chemical formula of the antimicrobial drug are excreted mostly through the bile ducts, to a lesser extent - during the deurination process. The half-life does not exceed 1-2 hours.

It is prolonged in patients with liver dysfunction, renal failure, inflammation of the urinary tract. Removal of metabolites of the main active component of a macrolide drug by deurination is fixed at a level of 10-15%.

Indications for use

Vilprafen Solutab is used to treat infectious diseases provoked by pathogenic pathogens that are not resistant to josamycin. The drug is often included in the complex therapy of inflammatory processes.

It acts on microorganisms that are practically localized in all functional systems.

Antimicrobial medication is indicated for infectious infections:

• epidermis and soft tissues;
• epithelial covering;
• genitals;
• urinary tract;
• dental cavity;
• respiratory canals;
• digestive system.

The range of infectious diseases that macrolide antibiotics can cope with is extremely wide. It is actively used in dental, urological, gynecological practices.

Vilprafen Solutab is used to treat inflammation of the ENT organs and ophthalmic diseases of an infectious nature.

Dermatologists prescribe antibacterial tablets for:

• acne;
• furunculosis;
• phlegmon;
• infection of burns and wounds.

The drug successfully copes with abscesses, lymphadenitis and postoperative infection. The antibiotic is effective for numerous urogenital infections.

These include:

• epididymitis - inflammation of the epididymis in men;
• cervicitis - an infectious disease of the cervix;

  

• prostatitis - inflammation of the prostate gland;
• urethritis - bacterial infection of the urethral canal;
• venereal lymphogranulomatosis, characterized by the proliferation of lymphoid tissue;
• gonorrhea;
• syphilis.

Josamycin inhibits strains resistant to antibiotics of the penicillin group. This allows it to be prescribed for chronic genital infections.

Otolaryngologists use a macrolide drug to treat:

• laryngitis;
• sinusitis;
• tonsillitis;
• scarlet fever and other inflammatory diseases of the upper respiratory tract.

Vilprafen Solutab demonstrates good efficiency in suppressing pathogenic microflora of the oral cavity. Reviews of adults indicate that dentists often prescribe an antibacterial drug for alveolar abscess, inflammation of the gum tissue, periodontitis.

Gastroenterologists use the drug to eliminate diseases of the digestive system associated with with Helicobacter pylori - a conditionally pathogenic microorganism sensitive to macrolide antibiotics.

Vilprafen Solutab is part of maintenance therapy for chronic gastritis, peptic ulcer disease, intestinal perforation. Ophthalmologists prescribe it for blepharitis and dacryocystitis.

Contraindications

Antimicrobial pills have a minimum number of absolute medical prohibitions on their use. Vilprafen Solutab is contraindicated in severe chronic functional disorders of the liver.

In patients with such diagnoses, difficulties arise with the elimination of metabolites of the active substance and auxiliary components of the drug. An antibacterial medication is not prescribed with established hypersensitivity to macrolide compounds and allergies to additional components of the tablet formula.

At what age can the drug be used?

Vilprafen Solutab is suitable for both adults and children. For juvenile patients, it is prescribed in emergency cases and at a reduced dosage. The age limit for use is set at the level of a year and a body weight of at least 10 kg.

Children younger are not treated with antimicrobial pills. The drug in an unformed baby's body can cause unpredictable physiological reactions and negatively affect the development of the child.

Instructions for use, dosage

Dispersible tablets are taken orally as a whole, without chewing or dissolving. Another option is preliminary dissolution in drinking liquid. It is advisable to use no more than 20 ml of water or juice for 1 tablet. Thorough stirring will create a pleasant tasting suspension.

This option is especially suitable for children and with problems with swallowing. Teenagers from 14 years old and adults are prescribed a daily dose of medication in the amount of 1-3 pcs. with equal time intervals between receptions. For children, the daily dose is calculated by weight.

The standard treatment regimen for infectious and inflammatory diseases in patients under 14 years of age provides for the use of 40-50 mg of the active ingredient for each kg of body weight. The total daily dose is distributed in equal parts for 2-3 doses. The pediatrician adjusts the multiplicity and volume of the drug individually.

A common treatment regimen for children under 14 years of age:

Body weight, kg	Daily rate, g
10-20	0.25-0.5 2 times a day
20-40	0.5-1.0 2-3 times a day
More than 40 kg	1-3 2 times a day

The duration of the course of treatment is determined by the doctor on an individual basis. In accordance with the nature of the pathological process, the age and history of the patient, the duration of antibiotic therapy is set for up to 3 weeks.

WHO recommends treating streptococcal tonsillitis with Vilprafen for at least 10 days. Common spherical acne requires the use of tablets at a dosage of 500 mg 2 times a day.

This scheme is maintained for 14-28 days, then they switch to supportive therapy, reducing the volume of the drug by half. For inflammation of the digestive organs caused by Helicobacter pylori, the drug is taken in a dosage of 1000 mg for 1-2 weeks.

Vilprafen Solutab (reviews of adults confirm this) gives especially good results as part of the complex therapy of infectious diseases of the gastrointestinal tract. In case of an atrophic state of the gastric mucosa, against the background of a deficiency of hydrochloric acid that dissolves food, confirmed by the results of a pH-measurement, tablets should be taken 1 time per day, 1000 mg.

Side effects

The antibiotic has multidirectional negative effects on the body. The digestive system can respond to antimicrobial medication with heartburn and the development of complicated pseudomembranous colitis. Hypersensitivity reactions are rare.

Of the side effects due to biological intolerance, an allergic rash without itching is noted. An increase in the transistor activity of enzymes in the plasma fraction of blood is characteristic of the liver and bile ducts while taking pills.

Overdose

When the recommended therapeutic norm is exceeded, side effects increase and partial signs of drug intoxication are found.

They are expressed in:

• nausea and vomiting;
• pain in the epigastric zone;
• dizziness;
• impaired auditory perception;
• movement coordination disorder.

In case of an overdose, symptomatic therapy is carried out, the stomach is washed and a large volume of drinking fluid is supplied to the body to accelerate metabolic processes.

special instructions

When treating with Vilprafen Solutab, it is advisable to take lactobacilli to restore the intestinal microflora. Otherwise, severe diarrhea and pseudomembranous colitis are possible. Their combination is capable of causing a life-threatening condition.

Patients with chronic dysfunctions of the renal organ during antibiotic therapy require constant monitoring of the clearance of endogenous creatinine. There may be a need to reduce the dose of the antimicrobial drug.

When using josamycin, the composition of the pathogenic microflora should be taken into account. Strains resistant to other macrolide antibiotics also demonstrate increased resistance to the effects of Wilprafen Solutab.

Drug interactions

When combined with antihistal drugs based on terfenadine and astemizole, the clearance of pharmacologically active substances slows down. Their excessive accumulation in tissues and plasma fraction of blood can cause severe cardiac arrhythmias, which is life-threatening.

Vilprafen Solutab (adult reviews note this effect), when combined with lincosamide antibiotics, loses some of its antimicrobial properties. Josamycin adversely affects theophylline elimination.

It is forbidden to take such a medicinal tandem. Cross-use with medicinal formulations containing ergot alkaloids increases vasoconstriction - narrows the lumen of the bloodstream, which leads to a sharp increase in blood pressure.

The simultaneous use of josamycin with cyclosporine causes an increase in the nephrotoxic concentration of the latter in the blood plasma. A similar effect is obtained by combining a macrolide antibiotic with Digoxin, a cardiotonic drug from the group of cardiac glycosides.

Analogs

Preparations with the same active ingredient as Vilprafen Solutab are not sold in pharmacies. Theoretically, tablets can be noticed with any macrolide antibiotic. Such a decision is solely within the competence of the attending physician. The analogue is selected taking into account the composition of the bacterial microflora and biological compatibility.

Macrolide antibiotics with an identical mechanism of antimicrobial activity:

• Erythromycin. It is used for infectious lesions of the respiratory tract, prostatitis, amoebic dysentery.
• Clarithromycin. Semisynthetic drug used to treat tonsillopharyngitis, acute sinusitis, SARS.
• Azithromycin. A powerful antibiotic with a broad spectrum of bacteriostatic action.
• Roxithromycin. It is a semi-synthetic macrolide derivative widely used in dermatological and pulmonary practice.
• Spiramycin. Antibiotic for the treatment of community-acquired pneumonia, extragenital chlamydia, articular rheumatism, and other infectious diseases.

Ordinary Wilprafen differs from Solutab only in the form of release. The first is a standard oral insoluble tablet without pleasant aroma and taste.

Terms, conditions of sale and storage

Vilprafen Solutab belongs to potent medicines and is sold in pharmacies exclusively with a prescription. The shelf life of antibacterial tablets is 4 years. It is necessary to store the medicine outside the zone of exposure to solar ultraviolet radiation at temperatures up to + 25 ° C.

Price

The Dutch macrolide antibiotic Wilprafen Solutab costs 645 rubles in the capital's drugstore chains. Reviews of adult patients claim that in the regions it can be purchased cheaper.

Video about the drug

Indications and instructions for Vilprafen tablets: