Antiallergic (antihistamines) drugs that do not cause drowsiness, are inexpensive, addictive. List, price

Antiallergic drugs new generation are responsible for suppressing histamine. Most of them do not cause drowsiness. Medicines are classified according to their composition and chemical structure.

Classification of antihistamines, their generation

There is no generally accepted classification characterizing antiallergic drugs. According to the characteristics of the chemical structure, antihistamines are divided into several groups.

Derivatives:

• piperazine;
• piperizine;
• phenothiazine;
• alphacarboline;
• quinuclidine;
• alkylamine;
• ethanolamine;
• ethylenediamine.

In clinical practice, the classification of antiallergic drugs by generation is used.

Group I includes:

• cyproheptadine;
• quifenadine;
• promethazine;
• mebhydrolin;
• chloropyramine;
• clemastine;
• doxylamine;
• diphenhydramine.

Generation II drugs:

• bamipin;
• cetirizine;
• loratadine;
• azelastine;
• terfenadine;
• dimethindene;
• acrivastine.

III generation of antihistamines:

• levocetirizine;
• desloratodine;
• fexofenadine.

Medicines belonging to the 1st generation have a pronounced sedative effect.

Why do antiallergic drugs make you feel sleepy?

Antiallergic medications that do not cause drowsiness are available at your local pharmacy. Their list is regularly updated. Drowsiness is a side effect of most 1st generation antihistamines. Medicines in this category are called sedatives.

Their mechanism of action is based on interaction not only with histamine receptors, but also with many others. Drowsiness when taking antiallergic medications occurs due to repeated administration of the drug during the day.

The therapeutic effect of them comes quickly, but has a short-term effect. With a short intake of 1st generation antihistamines, the patient develops addiction. Previous medications cease to work, and the patient is forced to change the drug every 25-30 days and try some new remedy.

Medicines with a pronounced sedative effect are not recommended for people whose work activity is associated with driving a vehicle.

What drugs do not cause drowsiness and addiction

Antiallergic drugs that do not cause drowsiness are classified as III (new) generation antihistamines. These are more advanced agents that stimulate the process of blocking H1 receptors.

Medicines in this category are responsible for relieving the characteristic symptoms of allergies. H1 receptors are located in the brain, smooth muscle tissue and blood.

Histamine is responsible for the regulation of digestive processes. Under his control is the level of saturation of the human body with food. Also, the organic compound is responsible for thermoregulation and ensuring proper rest of the brain during sleep. Antihistamines that do not cause drowsiness stop the release of histamine into cells.

Top Best New Generation Allergy Medicines That Do Not Make You Drowsy

Antiallergic drugs that do not cause drowsiness are safe for the human body, do not provoke addiction and quickly relieve the characteristic symptoms. People prone to hyperreactions should remember that drugs in this category are not able to cure the disease: with their help, you can only improve your well-being.

Cetrin

Antiallergic drug of the new generation Tsetrin does not cause drowsiness and addiction even with prolonged use. The composition contains active (main) and additional components. The active ingredients are cetirizine in the form of hydrochloride (concentration no more than 10 mg).

Auxiliary elements include:

• vegetable starch;
• milk sugar;
• polyvinylpyrrolidone;
• magnesium salts of stearic acid.

Release form:

• round, convex on both sides enteric-coated tablets (white or yellowish-white);
• transparent, sweet suspension with a fruity aroma (the dosage form does not contain foreign particles).

Cetirizine is responsible for the selective blocking of histamine receptors. With regular use, it has an antipruritic and antiexudative effect. There are no antiserotonin and anticholinergic effects.

Indications for use prescribed in the instructions:

• dermatitis;
• neurodermatitis of the allergic type;
• hives;
• angioedema;
• allergic rhinitis;
• hay fever.

The medicinal product has a number of relative and absolute restrictions on its use.

Category I includes:

• dysfunction of the kidneys and liver;
• elderly age;
• childhood.

An absolute contraindication is considered intolerance to the components present in the composition of the drug. Side effects are rare, most often when medical prescriptions are not followed.

These include:

• dizziness;
• headache;
• dyspeptic disorders.

The tablets must be taken once a day. The daily rate is 10 mg. therapeutic dose of syrup for adults - no more than 20 ml per day.

Histalong

The active ingredient in the composition of the drug is astemizole. The substance provides blocking of peripheral receptors and relieves the characteristic symptoms of allergies. With regular use, there is a decrease in capillary permeability and a weakening of bronchospasm.

The antiserotonin effect is weak. The anticholinergic and sedative effect is not observed. The therapeutic effect lasts for 48 - 72 hours. The maximum concentration of astemizole is observed after 2 to 3 hours. after the first application.

Indications for use:

• Quincke's edema;
• rash on the skin of an allergic type;
• runny nose (including seasonal);
• bronchial asthma.

Contraindications include:

• liver failure;
• childhood;
• period of childbearing and breastfeeding;
• calcium deficiency;
• simultaneous reception with other antiallergic drugs.

Release form - tablets. They must be taken on an empty stomach, after 2 - 3 hours. after eating. The daily rate for adults and adolescents is no more than 1 tablet per day. The course of application should not exceed 7 days.

Claritin

Claritin is a III generation antiallergic drug, which contains loratadine.

Additional elements include:

• vegetable starch;
• magnesium salts of stearic acid;
• milk sugar.

Release form - suspension and syrup. The drug has antiallergic, antihistamine and antipruritic effect, selectively blocking peripheral receptors. The patient feels relief in 25-30 minutes. after the first dose of the drug.

The active ingredient is not able to overcome the blood-brain barrier, it has no effect on the nervous system. Claritin is not characterized by sedation.

The drug is prescribed for the following pathologies:

• rashes on the skin, provoked by allergies;
• hives;
• conjunctivitis or allergic rhinitis.

The drug has a minimum of contraindications.

These include:

• hypersensitivity;
• breastfeeding period;
• childhood.

  

Side effects appear as:

• short-term alopecia;
• dry mouth;
• rapid fatigue.

Children from 2 years of age are most often prescribed syrup. The dosage is determined individually, taking into account the weight of the child. The second formulation can be taken by adolescents and adults. The daily norm is 10 mg, which is equivalent to 1 tablet. The course of application is 4-7 days.

Suprastin

Suprastin is marketed in the form of tablets and an injection solution. The main component is chloropyramine (analogue of tripelenamine). The action of the antiallergic drug is aimed at preventing the development of hyperreactions and arresting the release of histamine into cells.

The instructions contain the following indications:

• anaphylactic shock;
• angioedema;
• conjunctivitis, allergic rhinitis;
• serum sickness;
• hay fever;
• hives.

With hyperthermia, Suprastin can be taken simultaneously with No-Shpa. The drug is included in the complex therapy for otitis media and sinusitis.

Contraindications:

• intolerance to the ethylenediamine component;
• violation of the outflow of urine;
• prostatitis;
• myocardial infarction;
• tachycardia, arrhythmia;
• simultaneous reception with MAO inhibitors;
• angle-closure glaucoma;
• ulcerative lesions of the stomach and duodenum;
• asthma.

With an incorrectly selected dosing regimen, the risk of side effects is quite high.

These include:

• tremor;
• ataxia;
• drowsiness;
• fatigue;
• headache;
• tachycardia;
• spikes in blood pressure.

Suprastin is not prescribed for children. The daily rate for adults is 2 tablets per day. The course of application is up to 5 days. The solution for injection is administered intramuscularly in emergency cases with the development of angioedema.

Tavegil

The active ingredient in Tavegil is klimastin in the form of a hydrogen fumarate. The drug is marketed in the form of tablets or solution for injection. Additional components vary depending on the form of release.

The drug is characterized by a pronounced antipruritic and anti-edema effect. The main component slows down the formation of edema, reducing capillary permeability.

Carcinogenic, mutagenic, torratogenic effects were not identified during the studies. A drug. Does not reduce fertility when taken in reasonable doses. Tavegil is prescribed for various allergic reactions.

It can be taken by people suffering from:

• contact dermatitis;
• dermatosis;
• rhinitis;
• hay fever;
• hives;
• hemorrhagic vasculitis.

It is not recommended to take medications during the period of gestation and breastfeeding. The drug is contraindicated in hypersensitive people.

Other contraindications:

• pathology of the heart and blood vessels;
• prostatitis;
• arterial hypertension;
• obstruction of the bladder and cervix;
• bronchial asthma.

If the therapeutic norm is exceeded by 2-3 times, the patient may experience insomnia and prolonged migraine. Side effects most often disappear on their own after 2-3 days of regular use.

The tablets are taken twice a day. The daily allowance should not exceed 6 mg. Intramuscular and intravenous administration is carried out up to 2 times a day. The drug has no age restrictions.

Ketotifen

Ketitofen is an anti-allergic drug of the third generation, which contains the active substance of the same name in the form of fumarate. The medication has several forms of release, including tablets, syrup and eye drops. It has a pronounced antihistamine effect, slowing down the release of organic compounds and inhibiting the phosphodiesterase enzyme.

The drug is prescribed for rhinitis, allergic conjunctivitis and bronchial asthma.

Contraindications are:

• the period of gestation and breastfeeding;
• intolerance to the main component.

The tablets are taken twice a day. The course of treatment should not exceed 7 days. Therapeutic norm of syrup for children is 0.25 ml / kg. Eye drops are prescribed for allergic conjunctivitis (1 drop twice a day).

Allegra

The drug has no sedative effect even with prolonged use. The composition contains fexofenadine (180 or 120 mg). Release form - tablets for adults and children. The second drug contains 30 mg of fexofenadine.

Indications for use:

• chronic idiopathic urticaria;
• seasonal type rhinitis.

Contraindications:

• individual intolerance;
• children's age (up to 6 years old);
• the period of breastfeeding and carrying a child.

The drug has a number of relative restrictions on its use.

These include:

• pathology of blood vessels and heart;
• elderly age;
• renal and / or hepatic impairment.

The tablets are taken 1-2 hours before meals. The daily rate for adults and children is 120 mg / 30 mg (adult / child).

Erius

Erius is an antihistamine that does not cause addiction and drowsiness. It is marketed in syrup and tablet form. The drug is characterized by a pronounced antiallergic effect, which is achieved due to the ability of the main component to inhibit hyperreactions of inflammation caused by an allergen.

The tablets contain the following components:

• starch;
• wax;
• cellulose;
• desloratadine;
• macrogol.

Syrup composition:

• desloratadine;
• flavoring;
• sorbitol;
• purified water;
• citric acid.

The drug is prescribed to reduce itching and rash. It is effective for rhinitis, hay fever, rhinorrhea and urticaria.

Contraindications are:

• children's age (up to 12 years old);
• inherited pathologies;
• intolerance to fructose and glucose;
• renal failure.

The syrup is prescribed for children from 6 months. The daily rate is not more than 2.5 ml. Children over 6 years old are given 5 ml, adolescents - 10 ml. Adults can take 1 tablet per day. The course of treatment is 5-7 days.

The cost of drugs

The approximate cost of the above medicines is shown in the table:

Name	Price
Cetrin	From 180 rub.
Histalong	From 220 rub.
Claritin	20 160 rub.
Suprastin	From 180 rub.
Tavegil	From 250 rubles.
Ketitofen	From 170 rub.
Allegra	From 360 rub.
Erius	From 200 rubles.

It is impossible to select a drug on your own based on its cost. Self-medication, without establishing an accurate diagnosis, can provoke the development of complications.

Antiallergic drugs must be taken according to the instructions. Drugs that do not cause drowsiness do not affect the speed of reactions in any way, so the patient can drive a car during the treatment period. In a pharmacy, this category of prescription drugs is not required.

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New generation antihistamines: