An analogue of Prednisolone in ampoules for allergies. Instruction, price, reviews

Prednisolone is a hormonal drug, the active element of which is the substance of the same name - prednisolone (a synthetic analogue of the hormone hydrocortisone with an activity 4 times higher). The drug is produced in the form of an ointment, tablets, eye drops, as well as a solution in ampoules.

The medication is used to eliminate allergies, suppress the functioning of the immune system, and eliminate the process of inflammation. Also, the agent has an anti-shock effect. Prednisolone has a large list of contraindications, side effects, and is also addictive. In this regard, doctors often use its less safe analogues with an identical effect.

Domestic and imported analogues of the product

An analogue of Prednisolone in ampoules can be prescribed by a strictly attending physician. It is important not only to choose the right substitute, but also to calculate the required dosage. The drugs discussed later in the article have similar therapeutic effects, but differ in contraindications and side effects, so that the doctor can make a suitable replacement.

Diprospan

An analogue of Prednisolone in ampoules called Diprospan is a Belgian medication produced in the form of a suspension (the suspension is used to prepare a solution for injection).

The main element betamethasone (glucocorticosteroid) has an antihistamine, anti-shock, anti-inflammatory effect, and also helps to suppress the activity of the immune system and accelerates the withdrawal toxins from the body.

Diprospan, when compared with Prednisolone, is prescribed in the following cases:

When Diprospan is prescribed	What is Prednisolone used for?	General indications
a strong increase in the production of thyroid hormones; dermatological diseases in severe form; to eliminate inflammatory processes if inflammation affects most of the body or is severe.	dermatological pathologies in a severe form of an allergic and autoimmune nature; multiple sclerosis, manifested by memory impairment; lung cancer (used in combination therapy; violation of the condition and activity of the lungs (pneumonia, tuberculosis); violation of the condition and activity of the thyroid gland; autoimmune pathologies; a sharp decrease in the amount of glucose in the blood; an increase in the concentration of calcium in the blood due to oncological pathologies; to prevent organ rejection after transplantation; the presence of inflammatory pathologies in the organs of the digestive tract.	elimination of severe allergies, for example, anaphylactic shock; pathologies of articular and muscle tissues in severe form, which are accompanied by severe pain; swelling of brain tissue after surgery or as a result of radiation therapy; diseases accompanied by a violation of the state of the connective tissue; severe asthma attack; severe liver disease, including hepatic coma; inflammation of the kidney tissue; cancer of the blood or lymphatic system; state of shock. Poisoning of the body with toxins, burns, severe injuries; deficiency of the hormone hydrocortisone.

If Diprospan, according to the indications, is suitable as a substitute, then before prescribing the doctor must exclude contraindications in the patient, which also differ when compared with Prednisolone.

Bans for Diprospan	Contraindications for Prednisolone	General prohibitions
with intra-articular fracture; after joint surgery; destruction of cartilage tissue; hypertension (high blood pressure); exacerbation of psychological pathologies; age up to 3 years. At the same time, the use of an analogue from 3 to 18 years old is allowed only stationary and under the strict supervision of a physician.	an increased amount of lipids (fats and fat-like substances) in the blood; HIV or AIDS; the presence of kidney stones; childhood.	intolerance to the components of the product; carrying a child, since the drug can disrupt the formation and development of organs, especially the adrenal glands; the presence of an infection in the body, since the drug suppresses the immune system, which means that the infection will progress; pathology of the gastrointestinal tract in the stage of exacerbation; the recovery period after a heart attack; the period before and after vaccination; diabetes; lack of thyroid hormone production; with the destruction of bone tissue; severe kidney pathology; severe decrease in bone density; cirrhosis of the liver; obesity; increased intraocular pressure; lactation; can not be administered intra-articularly with a tendency to bleeding.

Diprospan is strictly forbidden to be administered intravenously and subcutaneously.

When using Diprospan and Prednisolone, the dosage and duration of the manipulations are selected by the doctor according to the general condition of the patient. It should be borne in mind that the analog can only be administered intramuscularly, intraarticularly and periarticularly, and the original must be administered intravenously, intraarticularly and intramuscularly.

Both medicines are not safe and the course of injections can cause the development of the following side effects:

Side effects from Diprospan	Negative reaction to prednisone	Common side effects
delayed sexual development; lack of menstruation in women; the appearance of severe abdominal pain during menstruation; nausea, decreased appetite; violation of acid-base balance; growth retardation in children.	disruption of the adrenal cortex; violation of the menstrual cycle; spread of tissue necrosis; rupture of the heart muscle when using the drug for myocardial infarction;  pathological vasoconstriction; general weakness; fainting.	skin rashes, swelling of the limbs, choking and other allergy symptoms; an increase in the amount of calcium in the blood; sodium and fluid retention in the body; a sharp increase in weight; increased production of hormones by the adrenal cortex; manifestation of symptoms of diabetes, provided that the disease was latent; an increase in the pressure indicator; increased blood clotting; the development of thrombosis; rapid muscle fatigue; decrease in muscle mass; decreased bone density; exacerbation of pathologies of the digestive tract (including the liver), may be accompanied by vomiting, flatulence; increased appetite; the appearance of acne and pustules on the epidermis; violation of skin pigmentation; development or exacerbation of heart failure; headaches; decreased heart rate; violation of the rhythm of the heart; the development of seizures; increased intracranial and intraocular pressure; increased sweating; violation of psychological balance; visual impairment, complete blindness may also occur; the development of disorientation in space; darkening of consciousness, nervousness, or anxiety; increased hair growth on the face, chest, legs / arms, including in women; slowing down wound healing; predisposition to infectious pathologies due to suppression of immunity.

The most important side effect of Prednisolone is the addiction of the body to the drug, therefore, with a sharp withdrawal of the drug, an increase in the symptoms of a negative reaction is noted, a lethal Exodus.

With the introduction of Diprospan or Prednisolone in large quantities, there is an increase in the severity of side effects, you need to urgently call an ambulance (subject to therapy at home conditions). Further, treatment is carried out in a hospital according to symptoms. You can buy both medicines strictly at the pharmacy and only with a prescription.

Important. Both medicines can be used in conjunction with other medicines only as directed by a doctor, since they are poorly combined with other drugs. It should also be borne in mind that before the appointment of Diprospan or Prednisolone, it is necessary to take tests and a complete examination by a doctor, to exclude the presence of contraindications in the patient.

Dexamethasone

Analogue Dexamethasone is available in the form of tablets, eye drops and solution (for injection) in ampoules.

The main element of the drug under the same name dexamethasone (glucocorticosteroid) has anti-inflammatory, antihistamine and anti-shock effect, and also helps to suppress the activity of the immune system and accelerates the elimination of toxins from the body. These characteristics are fully consistent with Prednisolone.

The indications for the use of Dexamethasone are the following pathologies:

• to eliminate the symptoms of allergies, with the course of a pathology in a severe form, for example, Quincke's edema;
• swelling of the brain tissue caused by a tumor, injury, or radiation therapy;
• shock states of various origins;
• pathology of kidney activity (not all diseases, therefore, the appropriateness of using an analogue is determined by a doctor);
• autoimmune diseases in acute form;
• respiratory diseases;
• pathological changes in the blood;
• dermatological diseases in severe form;
• exacerbation of inflammatory pathologies of the gastrointestinal tract;
• deficiency of the hormone hydrocortisone, manifests itself in violation of the adrenal glands;
• severe asthma;
• pathological inflammation of the connective tissue;
• in the complex treatment of oncological diseases.

The list of indications for the use of Dexamethasone is less than that of the original (all of the listed items are also present in Prednisolone). Contraindications to the use of an analog also have differences, which are listed in the table below.

Contraindications for Dexamethasone	When Prednisolone injections are prohibited	General prohibitions
the presence of mental pathologies; age up to a year. From one to 18 years of age, the use of the drug is allowed only in a hospital under the regular supervision of a doctor.	the patient is obese; increased concentration of lipids in the blood; stones in the kidneys; increased intraocular pressure; age up to 18 years.	increased sensitivity to the composition of drugs; the presence of pathogenic microflora (bacteria, fungus, virus) in the body; pregnancy; diabetes; violation of the condition of muscle and bone tissue; severe kidney and liver disease; severe heart pathologies; intra-articular drugs should not be administered if there is a tendency to develop bleeding; HIV or AIDS; diseases of the digestive tract in an acute form; period before or after vaccination; lactation.

The analogue has a list of prohibitions slightly less than that of Prednisolone. The advantage of Dexamethasone is also the possibility of using the drug in childhood.

Dexamethasone is used for intramuscular, intravenous and intra-articular administration. Single and daily dosages, as well as the duration of treatment, can only be established by a doctor. Spontaneously changing the course of therapy is strictly prohibited.

But even if the rules for using the solution are observed, the following side effects may appear:

• the development of mental disorders in the form of impaired attention, thinking or clouding of consciousness;
• causeless euphoria, hallucinations;
• depression;
• increased arterial, intracranial and intraocular pressure;
• visual impairment, the development of blindness is possible;
• headaches;
• the development of benign intracranial tumors;
• deterioration in sleep;
• predisposition to infectious pathologies due to a decrease in the protective functions of the immune system;
• the development of thrombosis;
• exacerbation of pathologies of the digestive tract;
• nausea, changes in appetite (increase or decrease), vomiting;
• sodium and fluid retention in the body;
• sharp weight gain / loss;
• violation of the activity of the adrenal cortex;
• manifestation of symptoms of diabetes, with the course of pathology in a latent form;
• growth retardation in children and delayed sexual development;
• violation of the menstrual cycle;
• increased body hair growth in the male pattern, that is, on the face, chest, legs;
• muscle and joint pain;
• decreased bone density;
• increased sweating;
• acne, acne;
• slow wound healing;
• the development of heart failure;
• decrease in the number of heartbeats;
• violation of the rhythm of the heart.

Symptoms of a severe allergy may also appear in the form of suffocation, anaphylactic shock. With the introduction of Dexamethasone in large quantities, there is an increase in side effects that can cause death (as well as an overdose of Prednisolone). The analogue is a prescription medication.

Important. Dexamethasone is approved for use in sports to increase endurance and increase muscle mass. But the application is possible only with the permission of a doctor and in short courses.

Metipred

An analogue of Prednisolone in ampoules called Metipred is produced in the form of a lyophilisate (for preparing a solution for injection). The main component (methylprednisolone) is a synthetic glucocorticosteroid and has anti-inflammatory, antihistamine and immunosuppressive effects. These characteristics are similar to the active substance Prednisolone.

Metypred injections are prescribed by doctors to eliminate the following pathologies:

• shock conditions of the body (for example, severe burns, severe trauma, toxic poisoning;
• acute forms of allergy in the form of anaphylactic shock;
• swelling of brain tissue (after surgery on brain tissue, head injury, presence of brain tumors;
• acute asthma attack;
• pathological disorder of the connective tissue;
• severe adrenal insufficiency;
• acute form of thyroid dysfunction;
• hepatitis or hepatic coma;
• severe memory impairment due to disruption of the activity of brain cells;
• inflammatory reactions in severe form.

The list of indications is much less when compared with Prednisolone. At the same time, the list of contraindications for injections by Methylpred does not differ much from the original.

When Metypred injections are contraindicated	Prohibitions for Prednisolone	General contraindications
There are no individual contraindications to the use of an analogue, but there is a list of restrictions when injections should be administered with extreme caution: the presence of pathologies of the gastrointestinal tract in an acute form; the presence of infection in the body (bacteria, viruses and fungus), as well as parasites. Provided that the pathology is not severe; HIV and AIDS; severe heart pathologies, as well as myocardial infarction in recent times; an increased indicator of pressure, including intraocular pressure; diabetes; increased or decreased production of thyroid hormones; increased production of hormones by the adrenal cortex; obesity in a patient; the presence of kidney or liver disease in acute form; increased concentration of lipids in the blood; the presence of diseases that are accompanied by a convulsive symptom; violation of bone density; age up to 18 years. Metipred is allowed to be used from birth, but at the same time, injections must be made in a hospital under the constant supervision of a doctor.	high blood lipids; diagnosing HIV or AIDS in a patient; the presence of kidney stones; diagnosis of pathogenic microflora in the body; exacerbation of diseases of the digestive tract; the recovery period after myocardial infarction; diabetes; deficiency of hormones produced by the thyroid gland; destruction of bone tissue; severe renal failure; decreased bone density; cirrhosis of the liver; increased intraocular pressure; obesity; a tendency to develop bleeding when the drug is administered intra-articularly; age up to 18 years.	increased susceptibility to the composition of the drug; carrying a child; a large area of ​​infection with a fungal infection; acute myocardial infarction; before and after vaccination; breast-feeding.

The main distinguishing feature of Metypred is a large list of warnings for the use of the medication. (these points are present in the original, but in the list of prohibitions for use) and a small list contraindications.

Metipred is allowed to be administered only intramuscularly and intravenously, Prednisolone is also used for intra-articular administration. The dosage and duration for both medicines is selected individually for each patient.

When choosing this substitute, it should be borne in mind that the course of treatment may be accompanied by side effects in the form of:

• the development of diabetes;
• violation of the functioning of the adrenal cortex;
• rapid weight gain;
• increased hair growth on the face, legs, chest, including in women;
• increased arterial, intracranial and intraocular pressure;
• lack of menstrual flow;
• soreness of menstruation;
• muscle weakness;
• stunting in children and delayed sexual development;
• nausea, sometimes nausea turns into vomiting;
• violation of the condition of the tissues and the work of the organs of the digestive tract;
• the development of gastrointestinal bleeding;
• the development of perforation (violation of the integrity) of the wall in the digestive tract;
• increased appetite or vice versa its absence;
• dysfunction of the liver;
• a decrease in the number of heartbeats, possibly until the heart stops completely;
• violation of the rhythm of heart contractions;
• development and worsening of heart failure;
• the development of thrombosis;
• increased blood clotting;
• spread of the focus of necrosis;
• slowing down wound healing;
• rupture of the heart muscle;
• violation of the mental state in the form of deterioration in attention, thinking or clouding of consciousness;
• euphoria, hallucinations;
• violation of orientation in space;
• depressive state;
• increased nervousness;
• insomnia;
• headache;
• convulsions;
• blurred vision or blindness;
• susceptibility to infection;
• sodium and fluid retention in the body;
• muscle pain and muscle weakness;
• violation of bone density;
• thinning of the epidermis;
• the appearance of adolescent acne;
• violation of skin pigmentation;
• the appearance of kidney stones in the presence of a predisposition to this pathology;
• severe allergic reactions, such as anaphylactic shock.

In case of an overdose with Metypred, an increase in side effects is noted. Symptom-based treatment is prescribed. You can buy Metipred only with a prescription.

Important. The solution prepared from the lyophilisate must be stored at a temperature of 15-20 degrees and used within 12 hours. Also, the drug is addictive (like the original), so it should be canceled gradually.

Prices

An analogue of Prednisolone in ampoules can cost both more and less. The price range depends on the manufacturer (domestic or foreign drug), as well as on the region of sale. The following is an overview of prices for the medicines discussed in the article.

Name of the drug	Number of ampoules in a package	Price range in rubles
Prednisolone	3 pcs.	35-50
Diprospan	1 PC.	550-610
Dexamethasone	10 pieces.	120-155
Metipred	1 bottle of 250 mg	360-410

Prednisolone, despite a large list of side effects, has gained popularity. The medication quickly relieves dangerous allergy symptoms and shock, saving lives.

But due to the fact that the drug is addictive and has a large list of contraindications, doctors often, suitable and less dangerous analogs are prescribed, which can be purchased both in ampoules and in tablets.

Author: Kotlyachkova Svetlana

Video about Prednisolone

Review of the doctor about the drug Prednisolone: