Hepatrombin G (Hepatrombin H) suppositories. Reviews, instructions for use, analogues, price

Hepatrombin G is a drug produced in the form suppositories and intended for the treatment of hemorrhoids in case of exacerbation of primary symptoms or recurrence of a chronic form of the disease. According to reviews of people faced with such an unpleasant problem, active substances help to quickly stop pain, relieve inflammation and prolong periods of remission.

Form of release and composition of the drug Gepatrombin G

Hepatrombin G - suppositories, reviews of which recommend their use in complex therapy. They are combined with external ointments, preparations for internal use, observing the rules of a healthy lifestyle. With monotherapy, the result of treatment will also be achieved, but it may take a little more time.

The torpedo shape of the suppositories allows them to be smoothly and accurately inserted into the anus even in the presence of acute symptoms in the form of pain and minor bleeding. In addition to them, the line of products for the treatment of hemorrhoids includes an ointment for external use. It allows you to target the hemorrhoidal cones and accelerate the resorption of the nodes.

Active substances in suppositories Hepatrombin:

• heparin Na - 120 IU;
• prednisolone - 1.675 mg;
• polidocanol - 30 mg.

  

Auxiliary components:

• glycerol tristearate;
• silica;
• migliol 812;
• novat V.

Additional substances allow you to form a dense structure of suppositories and deliver active ingredients directly to the inflamed area unchanged. The drug is packed in polymer blisters, 5 pieces each. 2 blisters together with instructions for medical use are placed in a cardboard box.

Pharmacological properties

Hepatrombin G - suppositories, reviews of which speak of their high efficiency.

They have therapeutic effects:

• promote the resorption of exudate;
• prevent blood clots;
• regenerate rectal tissue;
• relieve inflammatory reactions.

Thanks to the complex composition, after 1 application of the suppositories, the process of restoring the tissues of the inner walls of the rectum begins.

Pharmacodynamics and pharmacokinetics

The effect is due to the activity of the active components included in the composition.

Actingsubstance	Pharmacological activity
Heparin sodium	The substance is an acidic glycosaminoglycan with a sulfur content. Was first isolated from the liver. The molecule includes several polysaccharide chains connected by a single protein core. The main direction of therapeutic activity is the prevention of blood clotting.
Prednisolone	A synthetic glucocorticosteroid for topical use has anti-inflammatory, antiallergic, antipruritic and antiexudative effects. Reduces the activity of the main mediators of the development of these reactions.
Polidocanol	The substance causes denaturation of proteins, thereby causing hardening of damaged hemorrhoids. An additional analgesic effect provides some relief of the sick person's condition.

After absorption, heparin undergoes biological transformation in the liver (under the influence of the heparinase enzyme) and other parts of the body by tissue macrophages. The connection with plasma proteins reaches 95%. The substance in its original and transformed form is excreted by the renal blood filtration system. The half-life normally does not exceed 1.5 hours.

Prednisolone, after absorption, is converted into inactive metabolites in the liver, after which the process of their excretion by the kidneys begins. Only 1% of the administered dose remains unchanged. The biological half-life is 18-36 hours, from plasma - 115-212 minutes.

Polidocanol works locally. Products after denaturation of protein tissues are excreted naturally with feces.

Indications for use

Hepatrombin G - suppositories, reviews of which confirm that the drug helps to get rid of symptoms on average in 1 week. When combined with other effective agents, the effectiveness usually increases.

Indications for the use of candles:

• acute thrombosis of the veins of the anus;
• external and internal hemorrhoids;
• eczema, itching, cracks in the anus;
• fistulous formations.

If the severity of symptoms is significant, specialist advice is recommended.

Contraindications

Conditions in the presence of which candles should not be used include the following pathologies:

• skin lesions by viruses, bacteria, fungi;
• a tendency to develop bleeding;
• I trimester of gestation;
• reactions to vaccinations;
• swelling on the skin;
• tuberculosis;
• syphilis.

It is also not recommended to use candles with increased sensitivity to the components that make up their composition.

At what age can you use the candle preparation?

Younger childhood is a contraindication. Restrictions on the use of suppositories Hepatrombin G are completely removed from the age of 14. In other cases, the decision on the admissibility and necessity of using the drug can only be made by an observing specialist.

Instructions for use, dosage

Suppositories should be used 1 piece up to 2 times a day with approximately the same time intervals. It is recommended to introduce suppositories only after the act of defecation.

The components included in the composition can lead to stimulation of intestinal motility, as a result of which the active substances do not have time to be absorbed and have a therapeutic effect. The rounded shape allows you to do this quickly and relatively painlessly.

Instructions for correct insertion into the anus:

• nails should be cut short;
• before starting the procedure, wash your hands thoroughly with warm water and soap;
• the same actions should be performed with the external genital organs;
• wipe off the remaining moisture with gentle movements using a soft towel;
• it is advisable to slightly cool your hands before directly opening the blister;
• for a comfortable introduction, it is recommended to lie on the left side with bent knees;
• the sphincter can be overly compressed, especially against the background of painful sensations;
• you will need to relax the muscles of the anus as much as possible and then proceed with a smooth introduction;
• in the presence of internal bumps, the tip of the candle can be slightly rounded to reduce pain;
• you need to enter the candle slowly, while simultaneously monitoring the relaxed state of the anal muscle;
• at the end of the procedure, the suppository does not always reach the target zone;
• to avoid this, you can push it deeper with a smooth glass or plastic stick;
• for easier introduction, you can lubricate all elements with mineral or vegetable oil.

After the procedure is completed, you should stay in bed for at least 30 minutes. This will help to avoid muscle strain and premature leakage of the candle carrier. If you have the urge to visit the toilet room, you should deliberately restrain them. After a while, they will disappear, and the active ingredients will begin to restore activity.

Side effects

Suppositories Hepatrombin G, according to reviews, can cause negative consequences after their use.

They are mainly associated with the development of local and systemic allergic reactions:

• rashes in the anal area;
• hyperemia of the mucous membranes;
• hives.

In very rare cases, Quincke's edema may develop, which will be associated with the absorption of active substances into the systemic circulation.

Overdose

With too frequent administration or a one-time use of drugs with similar components in the composition, systemic side effects may develop, associated with exceeding the permissible amount of glucocorticoids:

• increased nervous irritability;
• interruptions in the work of the heart and blood vessels;
• depressive conditions;
• intestinal bleeding;
• steroid ulcers in the gastrointestinal tract;
• liver dystrophy;
• sleep disorders;
• pancreatitis;
• osteoporosis;
• obesity;
• alopecia;
• euphoria;
• psychosis.

The listed deviations during normal use are encountered only in very rare cases.

special instructions

With an excessive frequency of use, the likelihood of side effects increases, an increase in symptoms and a slowdown in regenerative processes in the mucous membranes of the rectum.

Drug interactions

Data on drug interactions were not provided.

Analogs

If necessary, the drug can be replaced with any other remedy designed to solve the problem of the appearance of hemorrhoids and inflammatory processes in the rectum.

Candles Posterisan forte

The drug is available in the form of rectal suppositories and is designed to quickly relieve the symptoms of hemorrhoids.

They include the following components:

• inactivated microbial cells E. coli 1000 million;
• hydrocortisone 5 mg.

Excipients include hard fat, macrogolglycerol, disodium edetate, vitamin E, acetylcysteine ​​and phenol as a preservative.

The pharmacological action is to remove the inflammatory process and increase the local immunity of cells. The composition includes special cells that, upon contact with mucous membranes, trigger a response in the form of the production of leukocyte particles by phagocytes.

The result is a quick removal of tissue swelling, inflammation and a decrease in the volume of exudate. At the same time, the tone of the vessels increases, their permeability is normalized, the tissues begin enhanced regeneration in the damaged areas.

The mode of using suppositories is standard - 2 times a day after bowel movement, if possible. To increase the effectiveness of the course of treatment, it is recommended to combine suppositories with an ointment of the same name. The duration of therapy can reach 2-3 weeks, but the first improvements occur literally after the introduction of 1 suppository.

Rectal capsules Proctosedil

The drug is produced in a special form - special capsules for administration into the rectum. Each dark glass jar contains 20 pieces.

Composition of active ingredients:

• hydrocortisone - 2.79 mg;
• framycetin - 5.00 mg;
• esculoside - 5.00 mg;
• benzocaine - 5.00 mg;
• butamben - 5.00 mg.

As auxiliary substances, the preparation contains lanolin, soft paraffin, liquid paraffin, glycerin, methyl and propylparabens, titanium dioxide, polyethylene glycol and water. Hydrocortisone quickly and effectively suppresses almost any form of inflammatory reactions, eliminates swelling, pain, redness and other manifestations.

Esculoside in its properties is close to the action of vitamin P, which is used to reduce capillary fragility in the walls of blood vessels. Framycetin is a broad-spectrum antibiotic. Use for hemorrhoids allows you to destroy the pathological microflora, which in some cases significantly aggravates the course of the disease.

Benzocaine and butamben relate to painkillers, the use of which during an exacerbation greatly facilitates the well-being of a sick person. In addition, the substances relieve excessive spasticity of the sphincter and muscles, thereby providing an easier introduction of capsules during further treatment and a decrease in pain.

Recommendations for therapeutic use:

• the optimal mode of administration is in the morning and in the evening with a 12-hour interval after bowel movement;
• the maximum dose for 1 time - 1 capsule, for 1 day - 3 capsules;
• the duration of treatment is no more than 7 days.

By the end of this period, all symptoms of inflammation and pain have disappeared in most patients.

STADA holding preparations

The Russian manufacturer Nizhpharm, in close cooperation with it, produces many effective and affordable drugs on the Russian market.

Among them, for the treatment of hemorrhoids, the following funds are allocated in the form of rectal suppositories:

• Sea buckthorn oil;
• Belladonna extract;
• Methyluracil;
• Anestezol;
• Anusole.

1. Sea buckthorn oil - a repeatedly tested remedy for the healing of any wound surfaces. After rectal administration of a suppository containing 0.5 g of the active ingredient, active stimulation of tissues for regeneration begins. The result is rapid scarring of lesions on the mucous membranes, the disappearance of pain and the neutralization of free radicals.
2. Belladonna extract in combination with the fatty components of the suppository base, it quickly relieves pain in the area of ​​damage and promotes healing of the resulting ulcerative lesions. Additionally, the drug has an antispasmodic effect on the sphincter and rectal walls.
3. Methyluracil - an active stimulator of tissue repair. The drug has an immunostimulating effect, accelerates the growth and granulation of a young layer of epithelial cells, including those varieties that are highly prone to proliferation.
4. Anestezol contains benzocaine, bismuth subgallate, levomenthol and zinc oxide. The complex composition allows you to have a multifaceted effect on hemorrhoids, quickly relieving inflammation and stimulating the healing of damaged mucous membranes.
5. Anusol, based on belladonna extract, xeroform, zinc sulfate heptahydrate and bismuth tribromophenolate, relieves spasms, pain, inflammation. Additionally, the drug has an antiseptic and astringent effect, which in combination also quickly helps to relieve exacerbation of hemorrhoids.

Diclofenac suppositories

Hemorrhoids are not a specific indication for their use. However, the powerful analgesic and anti-inflammatory effects significantly speed up recovery when other topical preparations are used together.

One of the main purposes of their use is long-term pain relief for the subsequent relief of the process. the introduction of specialized funds in the form of rectal suppositories or creams using a hard applicator.

Terms, conditions of sale and storage

The drug should be stored out of the reach of small children, out of direct sunlight. The maximum ambient temperature should not exceed 25 ° C. The optimal indicator is 15 ° C. Shelf life from the date of production - no more than 3 years. Do not use the drug if the package has been damaged.

Price in pharmacies in Moscow, St. Petersburg, regions

Hepatrombin G - suppositories, reviews of which are 90% positive. They have a relatively low price - about 200 rubles. It depends on the location of the pharmacy and the owner's pricing policy. If you need to save money, it is possible to order the drug in online services that will deliver it in a short time to a convenient pick-up point.

Hepatrombin G is a functional preparation in the form of suppositories for the treatment of hemorrhoidal pathological processes.

According to reviews, maximum efficiency and high speed of achieving a therapeutic effect can be achieved with an integrated approach to treatment. In the future, compliance with the basic rules of nutrition and a healthy lifestyle will minimize the risk of recurrence of the disease.

Video about suppositories Hepatrombin

Instructions and description of the drug Gepatrombin: