Likferr in ampoules. Price, instructions for use, where to buy, manufacturer, reviews

Iron deficiency anemia is a serious medical condition for the treatment of which the drug is used Likferr. Before using it, you should familiarize yourself with the peculiarities of using ampoules, possible side effects, contraindications and cost.

Forms of release and composition of the drug

The medicine comes in the form of a solution that can range in color from brownish red to brown. Its active ingredient is ferric iron, which is in the medication in the form of a sucrose complex (hydroxide). Additional components of the solution are water and sodium in the form of hydroxide.

The drug is available in 5 ml glass ampoules. The drug goes on sale in carton packs, which contain 5 ampoules.

Pharmacological properties

The medication is involved in metabolic processes in the body.

After entering the body, the active substance goes through several stages of transformation:

1. It breaks down into 2 components - sucrose and iron. This allows the body to absorb iron faster.
2. Distribution between tissues - the bulk of iron goes to the liver, spleen, and bone marrow.
3. Iron is consumed in the production of iron-containing enzymes (eg, hemoglobin, myoglobin) or stored in the form of ferritin (a protein in which Fe is stored in the tissues of the body - mainly in liver).

As a result, there is a rapid increase in hemoglobin levels compared to drugs that contain ferrous iron. Additionally, the risk of developing drug poisoning as a result of incorrect dosage is reduced. This phenomenon often occurs during drug treatment, where the active ingredient is ferrous iron.

It was found that the introduction of 100 mg of ferric iron increases the level of hemoglobin by 2-3%, during pregnancy this figure is 2%. Normalization of hemoglobin provides an improvement in human well-being, since it is this the component is responsible for saturating the internal organs and tissues of the body with oxygen and excretion carbon dioxide.

Pharmacodynamics and pharmacokinetics

After administration of the drug, its maximum concentration in the blood is reached after 10 minutes. The iron contained in the medication has a low level of distribution in body fluids. The withdrawal period of the drug is 12 hours. In the first 4 hours. after ingestion, less than 5% of the drug is excreted by the kidneys.

Indications for use

Likfer in ampoules, the price of which is explained by the wide range of its use, is indicated for use when:

• Iron deficiency in the body (anemia, large blood loss as a result of bleeding) when you need to quickly make up for the lack of iron.
• Inability to take medications inside (intolerance, bouts of vomiting).
• Impaired absorption of iron from food and oral preparations.
• In case of an urgent need to saturate the body with iron (mainly before surgery).
• Diseases of the gastrointestinal tract, in which you can not take iron-containing drugs inside.
• Ineffectiveness of medicinal or vitamin preparations intended to replenish iron stores.

Contraindications

Likfer in ampoules, the price of which is due to its high efficiency, is used only as directed by a doctor. Self-medication can cause deterioration in well-being.

Also, the medication is contraindicated for use when:

• anemia, which is not associated with a lack of iron in the body;
• violation of the process of excretion and absorption of iron;
• hemochromatosis, hemosiderosis (excessive accumulation of iron oxide pigment hemosiderin in body tissues);
• intolerance to the components of the drug;
• pregnancy (1st trimester);

Reception of Likferr should be carried out carefully for people with diabetes mellitus, acute liver diseases and infections, bronchial asthma, eczema, lack of vitamin B9 (folic acid).

At what age can the drug be used?

The drug is not used to treat people who have not reached the age of 18. If the use of the medicine is still necessary for children, it is recommended to inject no more than 0.15 ml of the medicine per 1 kg of body weight. It is administered by 1-3 p. per week, based on the level of hemoglobin.

Instructions for use, dosage

The drug is administered slowly by intravenous injection in several ways:

• drip (use of droppers);
• jet (with a syringe directly into the bloodstream through a vein);
• into the dialysis system.

The medication is not used for intramuscular injection!

Drip injection is the most optimal option, since the slow flow of the medication minimizes the risk of lowering blood pressure and getting the solution past the vein.

Before the procedure, the medicine is diluted with saline (0.9%) in a ratio of 1:20.

The rate of introduction of the resulting solution depends on its amount. For example, 100 mg of iron contained in a prepared dropper is administered for a minimum of 15 minutes. The maximum dose (7 mg of iron per kg of body weight) must be administered over a period of at least 3.5 hours.

Before starting treatment with Likferrom, the patient needs to make a test injection - 1 ml of the drug is administered to adults and children weighing more than 14 kg. For children with less weight, the test dose is 0.75 mg of iron per 1 kg. The procedure is carried out within 15 minutes. If after this time the patient does not feel worse, the remaining amount of the solution is injected.

The use of the inkjet method has its own characteristics:

• Likferr is introduced undiluted.
• The medication is administered slowly - 1 ml of the drug for 1 min.
• For 1 injection, it is allowed to inject no more than 10 ml of medication.
• After the procedure, the patient needs to keep his arm outstretched.

Jet injection also provides for a test dose - 1 ml of solution. It must be pricked within 1-2 minutes. The introduction of an iron-containing drug into the venous zone of the dialysis system is carried out by analogy with an intravenous injection.

The dosage of the drug is calculated individually for each patient, taking into account the level of hemoglobin in the blood and body weight. At the same time, the daily dose should not exceed 10 ml of the medication (for adults). If the dosage required for treatment exceeds the recommended daily values, the drug should be administered fractionally.

The frequency of drug administration is determined by the attending physician. Standard therapy involves the introduction of medication every other day. For example, for adult patients and people over 65 years old, Likferr is recommended to enter 1-3 p. per week (5-10 ml).

Side effects

Likfer in ampoules, the price of which is also due to its easy tolerance by the body, rarely causes side effects.

In some cases, the patient may experience headaches, dizziness, heart palpitations, a violation of taste (for example, there is a metal taste in the mouth), abdominal pain, skin rashes, increased sweating, indigestion, general weakness.

Less common health disorders such as:

• loss of consciousness;
• lowering blood pressure;
• swelling of the face, larynx, joints;
• increased body temperature;
• nausea and vomiting;
• muscle, joint pain;
• pallor of the skin;
• the formation of hematomas;
• temporary sweating of hearing or its deterioration;
• cessation of breathing.

One of the most dangerous side effects is anaphylactic shock. Therefore, before using the drug, it is necessary to check it for patient tolerance. If these symptoms persist or worsen, you should inform your doctor about this. He will adjust the dosage or select another medication.

Overdose

In case of an overdose of a drug, the patient may show signs of hemosiderosis - an excessive accumulation of iron pigment in tissues and internal organs. Another symptom of taking a medication in excess of the norm is a sharp decrease in blood pressure, which manifests itself within half an hour after administration.

It may be accompanied by pallor of the skin, impaired blood supply to internal organs, general weakness, coldness of the hands and feet.

With the development of these symptoms, it is necessary to stop using the medication and seek medical help. The patient will be prescribed symptomatic treatment, and, if necessary, taking special agents that bind iron.

special instructions

When treating with Likferrom, it is recommended:

• make sure that the drug is injected slowly - this will help to avoid the development of side effects;
• constantly monitor hemodynamics and hemoglobin levels;
• avoid getting the drug into the space near the vein, as this can cause brown skin staining and tissue death. If this happens, it is recommended to smear products containing heparin on the affected area;
• the medicine contains sucrose, which is important to consider when used by patients with diabetes mellitus;
• when developing during the treatment of bacterial infections, the drug must be canceled, since iron stimulates the growth and development of microorganisms;
• if after 2 weeks of treatment with the medication there is no improvement in the indicators, the attending physician should reconsider the diagnosis;
• it is permissible to use the drug in the 2nd and 3rd trimesters of pregnancy, only as directed by the attending gynecologist;
• the drug has the ability to enter breast milk in small quantities, therefore, during lactation, it is used with caution and in agreement with the pediatrician;
• the medicine is recommended to be administered in a hospital under the supervision of a medical staff during the procedure and within half an hour after it;
• when the drug is administered, it is necessary that it be possible to carry out anti-shock therapy. For these purposes, epinephrine solution, antihistamines can be used;
• how safe it is to drive vehicles and vehicles during treatment with Likferrom has not been established, so this should be done with caution.

Drug interactions

During treatment with Likferrom, it is prohibited to take other iron-containing drugs that are taken orally - this leads to a decrease in the absorption of Fe from the digestive tract. There is also a risk of iron overdose.

The medication may only be mixed with saline solution - dilution with other drugs may cause turbidity, precipitation of substances or other changes in the medication.

It was found that the simultaneous administration of drugs intended for the treatment of cardiovascular diseases increases the effectiveness of Likferr. Better absorption and absorption of iron is facilitated by the use of vitamin C.

Analogs

Likferr can be replaced with drugs similar in action, which are also available in the form of a solution for injection - in ampoules or in vials. These drugs have a different price, but are just as effective. Their names and descriptions are presented in the table below.

Name	Indications	Application features
Venofer (in ampoules)	If you need to quickly compensate for iron deficiency; with intolerance to oral drugs, as well as with their ineffectiveness. The medicine is also used in the inflammatory process of the intestine, when drugs for internal administration are contraindicated.	The dosage is calculated individually for each patient, taking into account the existing iron deficiency in the body. The medicine is used only for intravenous administration. The drug is prohibited for use when carrying a child (1st trimester), with increased sensitivity to its components and an excess of iron in the body.
Ferrum Lek (in ampoules)	The drug contains ferric iron. The medication is used when it is impossible to treat an iron deficiency state with drugs for internal administration or when they are ineffective.	The drug is injected intramuscularly (in the upper part of the gluteus muscle). For adult patients, a 50-60 mm needle should be used. If a person is overweight, then a longer needle is taken - 80-100 mm. When injecting children, a 32 mm needle is used. To prevent the medicine from spreading, it is recommended to pull the subcutaneous tissue down by 2 cm. Injections are recommended every other day. The dosage is set individually by the attending physician, based on iron deficiency, hemoglobin levels and the patient's body weight. Before starting treatment, a person is injected with a test dose - ¼ or half an ampoule, which is 25 and 50 mg of iron, respectively. If within 15 minutes. There was no deterioration in health, you can enter the remainder of the solution. The permissible daily dosage is 2 ampoules of the drug (200 mg Fe).
Cosmofer	It is prescribed for severe anemia, which is caused by a lack of iron in the body, as well as in the case when you need to quickly replenish the iron deficiency.	The drug is universal - it can be administered both intramuscularly and intravenously. The recommended dosage is up to 200 mg of iron or 4 ml of the drug. It is used by 2-3 p. in Week. If it is necessary to quickly replenish iron stores, it is possible to administer the drug in a volume of up to 20 mg per kg of body weight (administered intravenously). For intramuscular administration, the drug is used undiluted. Its daily dosage is 4 ml.

Terms, conditions of sale and storage

The medicine is dispensed only with a doctor's prescription. It should be stored in a dry place out of sunlight, at a temperature no higher than +25 ⁰WITH. If a sediment is found in the ampoule or it is damaged, it is prohibited to use it. The medicine should be used immediately after opening the ampoule. The medication cannot be frozen and used after the expiration date, which is 3 g. from the date of manufacture.

Price

Likfer in ampoules (the price is presented from the official websites of online pharmacies) can be bought in pharmacy chains in settlements or ordered via the Internet. The medication is sold in packs containing 5 ampoules. Its cost in online pharmacies starts from 1400 rubles.

Likferr in ampoules is effective in replenishing iron deficiency. Despite its high cost, it is fast acting, easily tolerated by the body and rarely causes side effects when used correctly.

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