Vikasol (Vikasol) tablets. Price, instructions for use, where to buy, reviews

Vicasol is an effective drug that comes in tablets with a simple chemical composition. This drug is a synthetic formula of vitamin K, and also belongs to the pharmacological group of hemostatic drugs.

Vikasol is indicated for use in adults and children of all ages in the presence of direct therapeutic indications. The average price of this drug in retail pharmacy chains ranges from 15 to 20 rubles. for 1 package.

Forms of release and composition of the drug

Vikasol - it is an antihemorrhagic drug, the main form of release of which are round tablets, coated with a protective film. Packing of this medication is carried out in contour cell blisters made of plastic and foil. Each cassette contains 10 - 20 tablets, depending on the dosage of the drug.

The main packaging of Vikasol is a cardboard box, inside which detailed instructions for the use of the tablet preparation are enclosed. Also, this medication is available in the form of a clear liquid solution without a pronounced chemical odor, which is intended for intravenous administration by installing a dropper.

The pharmacological composition of the drug Vikasol is characterized by the presence of the main and auxiliary substances. The active component of the antihemorrhagic agent is a synthetic compound of the chemical etiology of menadione sodium bisulfite with a dosage of 15 mg in each tablet.

The following substances perform an auxiliary function:

• lactose monohydrate - a natural natural preservative, which is actually "milk sugar";
• potato starch - is part of the protective shell of the tablets, and after entering the gastrointestinal cavity, it completely dissolves, releasing the active component of the drug;
• medical talc - anti-caking agent, which makes the structure of the drug more dense, prevents its premature disintegration to the state of a powder;
• sodium metabisulfite - a substance that is used in the production of Vikasol tablets as a safe antioxidant, bleach and preservative;
• calcium stearate - an auxiliary component that acts as a thickener and stabilizer of the structure of the drug Vikasol.

The composition of the drug Vikasol is completely safe for the body of adults and children. The chemicals of this medication do not cause pathological changes in functional activity. internal organs, do not have a negative effect on the work of the central and peripheral nervous systems.

The main manufacturers of the tablet form of Vikasol in Russia are the pharmaceutical companies Biosintez, Pharmstandard-Leksredstva, and Irbitsky Khimpharm Plant.

Pharmacological properties

Vicasol tablets (the price of this drug is affordable for most consumers) - it is an antihemorrhagic agent that has the following pharmacological properties:

• has a pronounced hemostatic effect (in patients with signs of vitamin K deficiency, increased tissue bleeding is observed);
• promotes more active synthesis of biologically active substances in the form of proconvergin and prothrombin, which are directly involved in the thrombotic function of the blood;
• positively affects the hepatic synthesis of plasma components of hemostasis, which are formed under the influence of K-vitamin-dependent substances;
• accelerates the physiological process of blood clotting, which is very important for patients with low platelet counts;
• acts as a source of a synthetic analogue of vitamin K, with the help of which an acute deficiency of this substance can be replenished in the shortest possible time.

Pharmacological properties of the drug Vikasol provide a positive therapeutic effect only if the patient really needs an additional amount of vitamin K, and also does not have an individual tendency to thrombosis great vessels.

Otherwise, the risk of side effects and negative complications associated with the hemostatic functions of the blood increases.

Pharmacodynamics and pharmacokinetics

Vikasol in tablets (the price of this drug is much lower than that of multivitamin complexes containing a synthetic analogue of vitamin K) - a medicinal product, the pharmacodynamics of which is characterized by the biochemical activity of its main component in the form of sodium menadione bisulfate.

By its properties, this substance is a water-soluble synthetic analogue of vitamin K. After menadione sodium bisulfate enters the gastrointestinal tract, it is rapidly absorbed into the bloodstream with further transportation to the liver tissue.

Being a part of this organ, synthetic vitamin K takes part in the synthesis of plasma enzymes that take part in the implementation of the blood coagulation function.

Menadione sodium bisulfate promotes the active production of proconvergin and prothrombin, which are converted to thrombin. This component, under the influence of a biologically active substance, fibrinogen is transformed into fibrin, which forms the basis of a thrombus.

Menadione sodium bisulfate is directly involved in the process of stopping bleeding and strengthening the walls of blood vessels. If the rules for dosing with the drug, provided for by the instructions for its use, are observed, there is no violation of the cellular composition of the blood towards an increase in the level of platelets.

The onset of a stable therapeutic effect is observed after 8-24 hours from the beginning of the systemic course of treatment.

The pharmacokinetics of Vikasol is characterized by the rapid dissolution of the tabletted structure of the drug with further absorption of its constituent components. Menadione sodium bisulfate binds well to blood plasma proteins, but this process is completely reversible.

The accumulation of the constituent component of the drug occurs in the tissues of the myocardium of the heart, spleen and liver. In the human body, menadione sodium bisulfate is broken down to the vitamin K2 compound. The process of chemical transformation occurs in the myocardium, liver tissues, and skeletal muscles of the musculoskeletal system.

Much weaker metabolic transformations of the active substance occur in the kidneys. The main products of the half-life of the synthetic analogue of vitamin K are chemicals in the form of monosulfate, diglucuronide and phosphate. The excretion of these metabolites is carried out by the kidneys in the urine.

The remaining 30% of the breakdown products of menadione sodium bisulfate are utilized through the intestines along with feces. The average duration of the half-life of the active substance of the drug Vikasol is 6-8 hours from the moment of taking the therapeutic dosage.

During this time, there is a continuous realization of the antihemorrhagic properties of the synthetic analogue of vitamin K.

Indications for use

Vikasol in tablets (the price of this medication is affordable for all segments of the population) - a drug which prevents the appearance of signs of increased bleeding of all human tissues organism.

This medicinal product is indicated for use in children, adult men and women, elderly people who suffer from the following diseases:

• acute or chronic hemorrhagic syndrome caused by hypoprothrombinemia;
• hypovitaminosis of vitamin K, provoked by the abuse of diets, poor and monotonous diet;
• obstructive jaundice;
• chronic diarrhea against the background of dysbiosis and functional disorders in the intestines, excluding the full assimilation of nutrients;
• hepatitis of a viral or intoxicating nature of origin;
• cirrhosis of the liver, regardless of the intensity of decay and death of hepatocytes;
• hemorrhagic disease in newborns (this drug can be prescribed to a woman who is in the last stages of pregnancy, and the intake of the constituent components of the medication is carried out through placenta);
• acute bleeding resulting from severe injury with damage to large areas of the body, or penetration into the abdominal cavity;
• oncological damage to liver tissue;
• frequent nosebleeds of unknown etiology;
• dysfunction of the organs of the female reproductive system, which are accompanied by the periodic occurrence of uterine bleeding.

The antihemorrhagic agent Vikasol is indicated for admission to women in the third trimester of pregnancy. In this case, the course intake of a synthetic analogue of vitamin K allows you to prevent the occurrence of bleeding in children in the first days after their birth.

The therapeutic effect of the drug is realized at the stage of intrauterine development of the baby, which is explained by the ability of menadione sodium bisulfate to overcome the placental barrier. Vicasol tablets are prescribed to patients who have undergone surgery, and are currently at the stage of rehabilitation and healing of surgical sutures.

This drug can be used as a specific antagonist in case of bleeding caused by prolonged therapy with indirect anticoagulants.

Contraindications

Vikasol in tablets (the price of this drug does not exceed 25 rubles. for 1 pack) - antihemorrhagic agent, which is categorically contraindicated for use in the following cases:

• thromboembolism of the great vessels (the risk of venous and arterial thrombosis increases with further development of severe complications);
• a change in the cellular composition of the blood towards an increase in the level of platelets;
• individual intolerance of the constituent components of the drug Vikasol, which manifests itself in the form various kinds of allergic reactions (itching of the skin, urticaria, edema of the mucous membranes and epithelial fabrics);
• hemolytic disease in infants;
• deficiency of isomaltase or sucrose, as well as fructose intolerance;
• the inability of the body to absorb the lactose contained in the Vicasol tablets;
• the period of feeding a newborn baby with breast milk.

For women in the I and II trimester of pregnancy, Vikasol is prescribed only in the extreme the case when the potential benefit from taking this medication is much higher than the risk of developing complications.

This antihemorrhagic agent is used with extreme caution in relation to patients suffering from renal and hepatic insufficiency, diabetes mellitus.

Patients with obstructive jaundice should be given preference to use the injection solution of Vikasol with drip intravenous administration. Throughout the course of treatment, it is necessary to control the level of platelets in the blood. In the event of a sharp increase in their concentration, further use of Vikasol is contraindicated.

At what age can the drug be used?

The drug Vikasol in the form of tablets is approved for use in children of newborn age, but with strict adherence to the prescribed dosage regimen.

In relation to patients of this category, constant monitoring by the attending pediatrician should be carried out. This is especially true of the cellular composition of the blood and the risk of blood clots. The appointment of therapeutic doses is carried out only by a specialized specialist based on the results of a preliminary examination of the child.

Instructions for use, dosage

Patients in the adult age category who are being treated with Vikasol tablets should take 15-30 mg of this drug once a day. The maximum daily dose of the medication cannot exceed 60 mg (4 tablets). A child under the age of 12 months. indicated for taking 2-5 mg of Vicasol per day. Children under 2 children should receive a dosage of no more than 6 mg of the medication per day.

Patients aged 3 to 4 years are being treated with this drug at a dosage of 8 mg per day. A child of the age group from 5 to 9 years old should take 10 mg of Vicasol per day. Children who are from 10 to 14 years old are shown treatment with the use of 15 mg of the drug per day.

The indicated dosage is divided into 2-3 doses. The duration of the therapeutic course is determined individually by the attending physician, and it also depends on the type of disease.

Side effects

The tablet preparation Vikasol can cause the development of the following side effects, which appear in the first 1-2 hours after taking a therapeutic dose of this medication:

• hives;
• edema of epithelial tissues and mucous membranes;
• itching of the skin;
• physical weakness;
• dizziness;
• an increase in the level of platelets in the blood with the risk of blood clots in the main vessels;
• lowering blood pressure;
• dysfunction of taste buds;
• tachycardia;
• kernicterus;
• erythematous rash;
• bronchial spasm;
• hemolytic anemia.

Patients who suffer from individual lactose intolerance may experience unpleasant symptoms in the form of nausea, spasmodic pains inside the abdominal cavity, diarrhea, and vomiting. In case of side effects, it is necessary to stop further taking the drug, and also consult your doctor.

Overdose

An overdose of the antihemorrhagic agent Vikasol is manifested by the following pathological conditions of the body:

• hypervitaminosis of vitamin K;
• hemolytic anemia;
• severe hyperprothrombinemia;
• blood vessel thrombosis;
• hyperbilirubinemia, which indicates impaired liver function;
• cramps of the lower extremities, which most often occur in children of the younger age group;
• allergic reactions in the form of skin redness, rash, itching, swelling of tissues and mucous membranes.

Patients with signs of an overdose with Vikasol tablets should receive symptomatic therapy, depending on the severity of their general condition.

If necessary, gastric lavage is performed, a course intake of sorbent preparations, direct anticoagulants, unfractionated heparin is prescribed. Platelet counts and blood clotting function should be under special control.

special instructions

During treatment with Vikasol, it is necessary to monitor the speed of psychomotor reactions and concentration attention, since this drug can cause dizziness, a decrease in blood pressure, weakness. This should be taken into account by vehicle drivers and people performing work with increased danger.

Vicasol tablets do not show a positive therapeutic effect in relation to patients suffering from hemophilia, Werlhof and Willebrand disease.

Drug interactions

The tablet preparation Vikasol weakens the pharmacological properties of indirect anticoagulants. This is especially true for drugs that are derivatives of indandione and coumarin compounds. The active substance of Vikasol does not affect the therapeutic activity of direct anticoagulants (including heparin).

Concomitant use of this drug with quinine-based antibacterial agents, sulfonamide, quinidine, and salicylate, requires an increase in the dosage of the synthetic analogue vitamin K. The appointment of Vikasol tablets with the joint administration of medications that can provoke hemolysis increases the risk of side effects.

Analogs

The table below lists the main analogues of Vikasol tablets, and also indicates their average cost in retail pharmacy chains.

Name of a medicine with similar properties	Medicinal product price
Tranexam	Tranexam is a drug in the form of tablets, coated with a protective coating, which is produced by the Russian company Stada. The average cost of a medicine is 226 rubles. for 10 tablets of 250 mg.
Gordox	Gordox is a medication from the pharmaceutical concern Gedeon Richter, which is produced in the form of a liquid solution for intravenous administration. The price of the drug is 4,770 rubles.
Cyclohemal	Cyclohemal is a drug with antihemorrhagic properties, the cost of which is 160 rubles. for a pack of 10 tablets covered with a protective film.
Solgar	Solgar is a drug that contains a concentrated analogue of vitamin K2 of a synthetic origin. The medication is produced in the United States, and its average price is 1995 rubles. for a bottle of 50 capsules of 100 μg of active substance.
Konakion	Konakion is an effective preparation that contains synthetic vitamin K1. The price of the medication is 450 rubles.

Acceptance of the above drugs with antihemorrhagic properties is possible only after a preliminary examination by a general practitioner, as well as by the appointment of this specialist.

Terms, conditions of sale and storage

Vicasol tablets are available with a prescription. The storage of this medication should be carried out away from direct sunlight and children of all age groups in an ambient temperature not higher than +8 degrees. The shelf life of the drug is 2 years.

Price

The cost of Vikasol tablets varies from 15 to 20 rubles. Vikasol is a drug with antihemorrhagic properties, the active ingredient of which is a synthetic analogue of vitamin K.

This drug is produced in the form of tablets covered with a protective film and a liquid solution that is administered intravenously using a dropper. Vikasol is prescribed for patients with severe vitamin K deficiency, a tendency to bleeding and low platelet counts.

The advantage of this drug is that it can be used for infants who need antihemorrhagic therapy. The duration of treatment is determined on an individual basis, and the price of the medication is affordable for all segments of the population.

Video about the drug

Indications and instructions for Vikasol tablets: