Indirect anticoagulants. List of drugs in pills new

Indirect anticoagulants are drugswhich prevent increased blood clotting and improve blood circulation.

The list of drugs includes various drugs in tablet and other forms, which may have different components in the composition, but have a similar therapeutic effect on the body. Prescribing medications should only be done by a doctor based on the examination data.

Classification

The mechanism of action of drugs from the group of indirect anticoagulants is based on the ability of active components to suppress the formation of prothrombin in the patient's liver.

This slows down the formation of blood clots and thinns the blood somewhat. There are several groups of drugs from the group of indirect anticoagulants. They differ in composition and nuances of action, despite the common mechanism for all medicines.

Variety of funds	Features of the action
Indan-1-3dione derivatives	These drugs have rather pronounced properties, they are produced in most cases in tablet form. The mechanism of action of the drug is aimed at slowing down the formation of prothrombin in the patient's liver, as well as slightly thinns the blood, which has a beneficial effect on the functioning of the heart and the entire cardiovascular systems
Coumarin derivatives	Means from this subgroup have an anticoagulant effect due to the content of neodycoumarin or warfarin. The drugs reduce the amount of vitamin K derivatives in the liver, which slows down the process of thrombus formation. An additional advantage of the funds is the ability to influence the formation of proteins involved in blood coagulation.
New generation drugs	The new generation products also have a similar mechanism of action, prevent clot formation and improve blood circulation in large and small vessels. They are available in tablet form, prescribed in long courses, since the effect does not appear immediately, but persists for a long period of time.

Depending on the specific disease, the general condition of the patient and the presence of concomitant deviations, the specialist selects the most suitable medication.

Rating of drugs from the pharmacy

Indirect anticoagulants (the list of drugs includes funds based on different components) today can be purchased at different pharmacies when the need arises. To choose the best remedy, you should first visit a doctor.

Warfarin

One of the most popular drugs from the group of indirect anticoagulants, which acts due to the presence of warfarin in the substance and is available in tablet form. The drug helps block the production of proteins and prothrombin in the liver, which reduces the likelihood of blood clots forming against the background of various diseases of internal organs.

The medicine has a long list of indications for prescribing:

• Ischemic stroke in the acute stage or the recovery period after undergoing such a disease.
• Blood pathologies that provoke increased coagulation.
• The need for prevention of recurrent myocardial infarction.
• Thromboembolic complications in patients who suffer from pathologies of the cardiovascular system.
• Myocardial infarction in the acute stage, the recovery period after suffering an attack.
• The recovery period after undergoing surgery on the internal organs.

The drugs can also be used as part of the complex therapy of certain heart pathologies. In combination with other agents, the effectiveness of the treatment is increased. The medication is dispensed in pharmacies upon presentation of a prescription from a doctor. The tool is considered one of the most affordable, and its price is 60-120 rubles. depending on the number of tablets in the package.

The application begins after consulting a doctor. The daily allowance is 2 tablets, which should be taken at about the same time every day.

The duration of therapy is determined individually, depending on the severity of the manifestations and characteristics of the course of the disease in a particular patient. Usually tablets are taken for 4-8 weeks. Correction of the dose and duration of treatment is also carried out on an individual basis.

The tool has contraindications. It is not used for intolerance to the components, acute bleeding and pathologies of the liver, kidneys in an acute form. The drug is contraindicated in the case of diagnosing arterial aneurysm, gastric ulcer and bacterial endocarditis.

If the instructions are violated, patients will certainly develop complications from the internal organs and systems. The most common negative reaction is considered to be an increased risk of bleeding against the background of a significant decrease in the amount of prothrombin in the blood.

Complications often affect the digestive tract, patients have diarrhea, indigestion, pain in the stomach. The medicine does not provoke an overdose, provided it is taken in the doses prescribed by the doctor.

However, with prolonged use in large quantities, there is an aggravation of all negative reactions and a significant deterioration in the condition. If such symptoms appear, you should immediately stop using the product and visit a doctor.

Syncumar

Indirect anticoagulants (the list of drugs includes expensive drugs) can have an effect due to the content of the substance acenocoumarol. For example, the drug Syncumar acts precisely due to this component and has pronounced anticoagulant properties.

The drug inhibits the synthesis of prothrombin, which reduces the likelihood of blood clots forming and circulatory disorders due to the overlap of blood vessels.

The tool is available in tablet form, has a high price, reaching 3800 rubles. for 90 tablets. It is prescribed in case of a history of patients with blood pathologies, thromboembolism or diseases of the cardiovascular system. The medicine is also used to prevent postoperative complications. It is dispensed in pharmacies with a prescription from a doctor.

Tablets are used in long courses of 4-6 weeks. In this case, the dosage of the drug in the first few days is 6-8 mg. 1 tablet may contain 1 or 2 mg of active substance. After several days of high-dose intake, the daily intake is reduced to 4 mg. Reception is recommended to be carried out at about the same time every day.

The tool has quite a few contraindications that should be considered before prescribing:

• Lactation and pregnancy period.
• Severe acute pathologies of the liver and kidneys.
• Intolerance to the components of the composition.
• Diarrhea of ​​various origins.
• Bleeding tendency.
• Malignant neoplasms.
• Depletion of the body against a background of prolonged illness or nutritional deficiency.
• Lack of vitamin K and C in the body.
• Chronic arterial hypertension of severe form.
• Retinopathy of diabetic origin.

The remedy is not prescribed for children and adolescents under 18 years of age. If the patient does not follow the instructions, he develops negative reactions from the internal organs and systems. They manifest as bleeding gums, headaches, and upset stools. Some talk about sleep disturbances, hair loss, and fever.

Hematomas often appear on the body, even in the absence of bruises and other injuries. The drug rarely provokes an overdose, but when used in high doses, all negative reactions are aggravated, bleeding and other complications may develop.

Fenindion

The drug is in the form of tablets for oral administration, which contains phenindione as the main active ingredient. The tool helps prevent the formation of blood clots, improves blood flow through the vessels, and prevents the development of pathologies of the heart and brain.

The use of the medication is advisable in order to prevent postoperative complications during manipulations on internal organs, diagnosing thrombosis, thrombophlebitis. In acute cerebrovascular accident and myocardial infarction, medication is also often prescribed.

The tablets are sold in different pharmacies with a prescription from a doctor, their cost is approximately 60-90 rubles. The medicine is taken by mouth throughout the day at regular intervals. The initial dose for the first 2 days is 4-6 tablets. It is divided 3 times during the day. After that, the rate can be reduced to 3 tablets per day, after a while it is 1-2 tablets per day.

Dosage adjustment is carried out by a doctor according to individual indications. The duration of the course is 2-4 weeks, depending on the patient's condition. The drug is not prescribed for a tendency to bleeding and intolerance to the components of the composition, during lactation and pregnancy.

It is also not recommended to take it in case of detection of pericarditis, malignant neoplasm. It is forbidden to take pills to patients under 18 years of age.

The medicine can provoke various complications, especially if the instructions are violated:

• Stool disorder.
• Increased body temperature.
• Skin rash and irritation of the mucous membranes.
• Headache.
• Increased bleeding.
• Suppression of the functioning of the red bone marrow.

Taking medicine in high doses often leads to the development of an overdose. It is accompanied by an exacerbation of all symptoms, bleeding and other complications. The condition requires an immediate visit to a doctor and the use of special medications.

Warfarex

Indirect anticoagulants can have a rather pronounced effect, even in severe pathological conditions. The list of drugs includes the Warfarex agent, which acts due to the content of warfarin as the main active ingredient.

The drug is available in tablet form for oral administration, helps to improve the condition of patients and prevents the progression of the disease.

It is prescribed in the case of deep vein thrombosis, the development of myocardial infarction, as well as during the recovery period after suffering an ischemic stroke.

The tool is considered to be quite effective. It accumulates in small amounts in blood and tissues, which reduces the risk of complications.

Take pills, if necessary, to carry out preventive measures in order to prevent the development of complications after undergoing surgery. The daily dosage of the drug for the patient is usually 5 mg, that is, 1 tablet.

But in some cases, the reception begins with 2.5 mg, which avoids complications against the background of exceeding the required norm. Treatment with the remedy lasts up to 4 weeks, this time is enough to get the result.

The drug can provoke complications in the form of headaches, weakness and fatigue, skin pain and increased bleeding.

That is why contraindications should be taken into account when prescribing:

• The patient's age is up to 18 years.
• Lactation and pregnancy period.
• Persistent severe hypertension.
• Acute kidney and liver damage.
• Acute intravascular coagulation of blood against the background of certain disorders. Despite its anticoagulant properties, the drug is not used in this case.
• Diabetes.
• Alcohol intoxication and chronic alcoholism.
• Thrombocytopenia.
• Hemorrhagic stroke.
• Exacerbation of gastric ulcer and duodenal ulcer.

The most common negative reaction when using the drug is considered to be bleeding and hemorrhages in the internal organs. Sometimes the drug provokes headaches, sleep disturbances and allergic reactions. At the same time, there is a deterioration in the general condition.

The medicine does not provoke an overdose when taken in the prescribed doses. However, if the instructions are violated, such reactions often occur, which leads to a significant deterioration in well-being, as well as the appearance of a threat to the patient's life.

Dispensing drugs from pharmacies is carried out on prescription from a doctor. Its cost differs in different regions and is approximately 120-130 rubles.

Marevan

Means in tablet form, which contains warfarin as the main substance. The principle of action of the drug is based on the ability of the active component to suppress the formation process coagulation factors in the liver, while it does not significantly affect the amount platelets.

Thanks to the use of the drug, it is possible to significantly reduce the risk of blood clots in the postoperative period, in case of myocardial infarction, ischemic stroke. The drug can be used in the acute and subacute period of such diseases.

It is prescribed in long courses of 3-6 weeks with a daily intake of 1 to 3 tablets, depending on the severity of manifestations. In each case, the specific dosage is determined individually.

The drug is not prescribed in case of intolerance to its components, as well as under the age of 18. The drug is contraindicated during pregnancy and lactation, diagnosing acute pathologies of the kidneys and liver of severe form.

In some cases, the drug is not used when an uncontrolled form of arterial hypertension is detected, it is not prescribed for a tendency to bleeding. The drug quite often provokes various complications, especially if the recommendations of a specialist are not followed.

The most common negative reactions are:

• Headache and dizziness.
• Bleeding, violation of the integrity of the vascular wall in the absence of any damage.
• Jaundice.
• Nausea and bouts of vomiting, upset stools.
• Allergic reactions in the form of rash, itching, peeling of the skin.
• Critical decrease in blood clotting factors.

The tablet remedy, when taken in high doses, can provoke an overdose. In most patients, it manifests itself as a significant deterioration in well-being and other disorders, often requiring immediate medical attention.

You can buy the product in pharmacies without presenting a prescription from a doctor. The cost starts from 120 rubles. and depends on the amount of medicine in the package.

Neodikumarin

Indirect anticoagulants (the list of drugs in this group includes not so many drugs) can have an effect due to the presence of ethyl biscumacetate in the composition. This component is contained in the medication Neodikumarin, which has a rather pronounced therapeutic impact, helps prevent the development of thrombosis against the background of an increase in the production of factors in the liver coagulability.

By suppressing the synthesis of components, blood thinning occurs and blood circulation is improved. The drug is available in tablet form, it is taken orally in the dosage prescribed by the doctor.

Usually, the use of 1-3 tablets per day is shown, depending on the patient's condition and blood counts in laboratory diagnostics. Treatment lasts up to 4 weeks, the duration is also determined individually.

Tablets are prescribed for thrombosis and thrombophlebitis, and other disorders accompanied by increased blood coagulability. However, in case of intolerance to the components of the composition, during the period of bearing a child and breastfeeding, the medication is not used. It is contraindicated in case of a tendency to bleeding, acute disorders of the liver, kidneys, stomach.

Many patients note that the medicine rarely provokes complications. Sometimes there is bleeding gums, weakness and fatigue, upset stools. An overdose of pills is not provoked when taken correctly. Dispensing of medication in pharmacies is carried out after presentation of a certified prescription form. The cost is approximately 150-200 rubles.

Dikumarin

Tableted medication based on dicumarol. It acts on the formation of proteins and certain clotting factors, which inhibits the formation of blood clots.

The drug is considered very effective and is prescribed for the following violations:

• Tendency to thrombosis.
• Thrombosis and thromboembolism.
• Pathology of the heart, brain.
• The rehabilitation period after undergoing surgery on organs.
• Pathology of peripheral vessels.
• Myocardial infarction and the recovery period after undergoing this disease.
• Coronary insufficiency.

The drug is taken orally, 1-2 tablets per day, preferably at the same time. The treatment lasts at least 2 weeks, but according to individual indications it can be extended up to 4-6 weeks. Do not prescribe tablets for intolerance to the components of the composition, acute bleeding, stomach pathologies in an acute form.

Nursing and pregnant women are also not prescribed medication. If the instructions are violated, the level of coagulation factors in the blood decreases in patients, which leads to bleeding. There have been no cases of overdose with the drug, but doctors do not consider this a reason for abuse of pills.

The product is dispensed in pharmacies after presentation of the prescription form. Its price starts at 130 rubles.

Acenocoumarol

Indirect anticoagulants (the list of drugs allows in each case to choose the most effective medicine) often contain the substance acenocoumarol, such as the drug of the same name, produced in a tablet form.

The tool has pronounced properties and helps prevent the development of complications against the background of blood thickening and the formation of blood clots.

It is prescribed for thrombosis, in the acute and subacute period of myocardial infarction, ischemic stroke.

Often, tablets are included in preventive courses for patients suffering from chronic diseases of blood vessels, heart, and brain.

The tablets are taken by mouth for 4-6 weeks. In each case, the duration can be adjusted depending on the patient's condition.

The daily norm of the drug for the patient is 1-3 tablets. You cannot increase or decrease it yourself.

Tablets are contraindicated in case of allergy to ingredients, patients under the age of 18, lactating and pregnant women. You should not use them during an exacerbation of gastric ulcer, with acute hepatitis.

If the instructions are violated, patients develop allergies, and bleeding of the gums, the appearance of hematomas on the body. The drug does not provoke an overdose if the instructions are followed.

The dispensing of the drug in pharmacies is carried out after the presentation of the prescription form. The price is approximately 160-190 rubles.

Nafrine

The medication is available in tablet form and is used in case of detection of pathologies accompanied by increased blood clotting. The anticoagulant effect is carried out due to the presence of warfarin in the composition as the main ingredient. Prescribe a medicine for various forms of atherosclerosis, thrombosis and other diseases.

The daily dosage is determined individually, but is usually 2 tablets. They are taken within 2 weeks, after which the doctor decides on the extension or completion of therapy.

The drug is not prescribed for hemorrhagic stroke, a tendency to bleeding and a critical decrease in prothrombin levels in the blood. It is also contraindicated for pregnant and lactating women, patients under 18 years of age.

Often, when applied, complications develop in the form of indigestion, hemorrhagic diathesis, exacerbation of chronic liver and kidney pathologies. In case of an overdose, all the symptoms are aggravated, therefore, if the condition worsens, it is necessary to refuse to take it and consult a doctor.

The medicine is dispensed today in pharmacies with a prescription from a doctor. Its price is approximately 200-250 rubles.

Warfarin Nycomed

Oral tablets, which have a therapeutic effect due to the content of warfarin in the composition. The drug acts directly on the formation of prothrombin in the liver, slows down the process somewhat, which prevents the formation of blood clots.

A medicine is prescribed for diseases of the heart, blood vessels, brain, accompanied by increased blood clotting. Reception continues for at least 2 weeks, but I can extend it up to 3-6 weeks according to individual indications. The daily dosage is 2-3 tablets, which can be taken at approximately equal intervals.

The drug is contraindicated in case of a tendency to bleeding, diabetes mellitus, in the acute period of gastric ulcer and gastritis. It is not prescribed for children and adolescents, nursing women and patients during the period of bearing a child.

Negative reactions during use do not occur so often, manifest in the form of allergic symptoms, deterioration of the general condition and an increased risk of bleeding.

Overdose is accompanied by aggravation of all reactions, the appearance of a threat to the patient's health and life. The medicine can be purchased at various pharmacies with a prescription from a specialist. The cost starts from 100 rubles.

Indirect anticoagulants are considered to be quite effective for many pathologies from the side of internal organs. The list of drugs includes many drugs that have a common mechanism of action. Despite this, the selection of the drug in each case is carried out individually.

Anticoagulant videos

Basic pharmacology of anticoagulants: