Candesartan 8-16-32 mg. Price, instructions for use, reviews

Candesartan is a drug used to lower the value of blood pressure. The drug is produced by pharmaceutical companies in Russia and Switzerland in the form of tablets with an active element concentration of 18, 16 or 32 mg. Depending on the dosage, the severity of the therapeutic effect of the drug and the price change.

Composition and form of release

Candesartan is a classic round flat tablet with a dividing line and a white color. The product is packaged in cellular plates in the amount of 7, 10 or 14 tablets, or in jars of white plastic in the amount of 30 tablets.

The carton along with the instructions may contain:

• 2, 4 or 8 blisters containing 7 tablets each;
• 3 or 6 plates each containing 10 tablets;
• 1, 2 or 4 blisters containing 14 tablets.

Depending on the prescribed course, you can choose Candesartan tablets with the right number of tablets.

Candesartan tablets include:

List of components	Component Description
Main substance
Candesartan cilexetil	The component weakens the action of the hormone, which provokes an increase in blood pressure. However, it does not have a negative effect on other hormones that regulate the duration of the cardiovascular system.
Minor substances
Lactose monohydrate	The element improves the absorption of vitamins and minerals that normalize cardiac activity, restores the balance of microflora in the intestines, strengthens the immune system, and activates the brain.
Starch premethylated	The component has an enveloping and anti-inflammatory effect, protecting the mucous membranes of the digestive tract from irritation of the components used.
Croscarmellose sodium	The substance facilitates the dissolution of tablets in the digestive tract, facilitating the rapid release of the active element.
Microcrystalline cellulose	The component is used as a stabilizer and filler, allowing the tablets to maintain their desired shape.
Povidone	The component binds and removes harmful substances and toxins from the body.
Silicon dioxide	The substance is a filler, and also removes harmful substances from tissues and the body.
Sodium stearyl fumarate	The component activates the adaptation of body cells to oxygen deficiency during hypoxia.

The main substance in the tablet can be in the amount of 8, 16 or 32 mg.

Terms of sale, storage, prices

Candesartan 8, 16 or 32 mg (the price of the product is not high) belongs to the group of prescription drugs. At home, tablets should be stored in packaging, in a dark place and at a temperature not exceeding 28 degrees Celsius. The shelf life of Candesartan, subject to storage conditions, is 3 years.

In addition, it is necessary to take into account that the drug should be away from children, since accidental intake of it in large doses can cause fatal harm to the body.

The price of Candesartan varies according to the number of tablets in the package, the region of sale and the concentration of the active element:

Dosage of the main component	Number of tablets in a package	Minimum price	Maximum price
16 mg	10 pieces.	202 RUB	236 r
14 pcs.	218 r	286 r
28 pcs.	246 r	294 r
32 mg	30 pcs.	306 r	379 r

At the moment, tablets with a dosage of 8 mg are not available for sale, so the price range for them is not provided.

Pharmacological properties

Candesartan belongs to a group of medicines used to lower high blood pressure.

Pharmacodynamics and pharmacokinetics

Candesartan 8, 16 or 32 mg (the price of which can be checked with the doctor) exhibits the following therapeutic activity:

• prevents vasoconstriction (vasoconstriction provokes an increase in pressure);
• reduces the release of the hormone, which is responsible for the retention of salts in the body (salts retain water, as a result, an increase in pressure occurs);
• does not allow the development of tumor formations in the tissues of the heart;
• regulates water-salt balance;
• reduces vascular tone, while the heart rate does not change;
• does not allow the cells of the heart muscle and blood vessels to degenerate into malignant;
• improves relaxation of the heart muscle at rest;
• prevents the development of exacerbation of renal failure.

A decrease in the pressure indicator is noted approximately after 2 hours. The main substance is excreted from the body for 1-1.5 days (with feces and urine), after being metabolized in the liver. At the same time, the stabilization of the pressure indicator is noted approximately after 1-1.5 months of taking the medication.

The main element binds to blood proteins, therefore it penetrates into all organs and tissues. And also it should be borne in mind that in patients with kidney pathologies, the time for withdrawal of the drug from the body increases by 2 times, in this regard, the dosage of the drug must be reduced by 2 times. The age and sex of the patient does not affect the effectiveness of the medication.

Indications for use

Candesartan can be prescribed by a doctor if the patient has the following pathologies:

• diabetic nephropathy. The disease is manifested by a pronounced violation of the state of the vessels and tubules of the kidneys, as a result of a violation of carbohydrate and lipid metabolism in the kidneys;
• systematic increase in blood pressure above 140 mm Hg. Art. (arterial hypertension);
• thickening of the heart muscle in the left ventricle.

  

Candesartan is also prescribed to normalize heart function in chronic heart failure.

Contraindications

Candesartan (regardless of the amount of mg of the active ingredient), when compared with other antihypertensive drugs, has not only a low price, but also with a smaller list of contraindications:

• narrowing of the lumen of the renal arteries;
• severe renal failure;
• carrying a child (all trimesters), as well as planning conception;
• severe liver dysfunction;
• lactation. For the period of using the tablets, breastfeeding should be stopped;
• increased concentration of potassium in the blood;
• increased production of hormones by the adrenal glands;
• pronounced narrowing of the heart valve openings;
• severe cerebrovascular accident;
• the patient's age is less than 18 years, since the safety of using the medication by children has not been confirmed. But if necessary, the doctor can prescribe pills from the age of 6, subject to treatment under the strict supervision of a doctor;
• insufficient blood volume in the body;
• the presence of allergies or hypersensitivity to the composition of the tablets.

Candesartan is used with extreme caution if the patient has an artificial kidney or is on a blood purification machine.

Method of administration and dosage

Candesartan tablets should be used in the prescribed dosage 1 time over 24 hours. At the same time, the use of the medication is not associated with food intake, and the dose taken should be washed down with warm liquid (water is recommended) in an amount of 150-200 ml. It is forbidden to bite the product and even more so to chew. If it is necessary to divide the tablet, it is allowed to break it at a separation risk.

Rules for taking Candesartan tablets:

Patient health features	Dose per day	Notes (edit)
Arterial hypertension	The starting dosage is 8 mg. If there is no effect, the doctor can increase (approximately in 2 weeks) the dose by 2 times (16 mg). If, after 1 month of taking Candesartan at a dose of 16 mg, the pressure indicator does not return to normal, then the dose can be increased to 32 mg.	If taking the drug did not give a result when taking a dosage of 32 mg, then the doctor should finalize the course of therapy. Additional antihypertensive drugs may be prescribed.
Patients over 65	The initial dose of the medication, if the patient has chronic pathologies (especially in the acute stage), is adjusted by the doctor.	In the absence of chronic diseases in the patient, the course of therapy is carried out with a standard dosage.
Mild to moderate liver failure	The starting dose is 4 mg. At the same time, depending on the reaction of the body, the doctor can adjust the dosage, both up and down.	During the course of treatment, it is necessary to monitor the condition and function of the liver.
Renal failure	The starting dose is 2 mg. A further increase in the dose is carried out by the doctor, taking into account the general well-being of the patient.	The course of therapy is carried out with regular monitoring of the blood composition.
Insufficient circulating blood volume	The starting dose is 4 mg. Further, depending on the patient's condition, the doctor can adjust the treatment. The daily dose can be changed in any direction.	Candesartan is used in combination with drugs to increase blood volume in the body.
Sick of the negroid race	The body of the Negroid race is less sensitive to the active substance, so the doctor must prescribe a medication in an increased dosage.	The course of using Candesartan is used in combination with other antihypertensive drugs.
Children from 6 to 18 years old.	The starting dose is 4 mg. Further, a patient weighing less than 50 kg is allowed to increase the dosage to 16 mg, and patients weighing more than 50 kg, a gradual increase in the dose to 32 mg is allowed (that is, first 8, then 16 and finally 32 mg). It is necessary to strictly monitor the general condition of the child.	It is forbidden to use a dosage of more than 32 mg, since the medication can cause the development of serious disorders in the functioning of the kidneys or liver. Treatment should be carried out under the strict supervision of a physician.
Heart failure	The starting dosage is 4 mg. Further, every 14 days, it is necessary to increase the dose by 2 times until the value reaches 32 mg. Do not increase the dose earlier than 2 weeks later.	During the course of the course, it is necessary to monitor the work of the kidneys and liver, additional antihypertensive drugs may be prescribed.

Only a doctor can adjust the dose, as well as when and after what period of time an increase in dosage is permissible. Self-change in the course of therapy can lead to the development of serious side effects.

Side effects

Candesartan 8, 16 or 32 mg (the price of the drug can be found out from the doctor) sometimes calls for the development of side effects, the severity of which varies depending on the dosage of the active substance:

• the development of infection in the respiratory system;
• violation of the composition of the blood;
• an increase in the amount of sodium or potassium in the blood;
• dizziness or severe headache;
• dry cough, runny nose;
• nausea or abdominal pain;
• frequent and loose stools;
• inflammation of the liver or other violations of the organ in the work;
• back pain, muscles, joints;
• flushed face;
• an excessive decrease in the blood pressure indicator;
• exacerbation of renal failure.

The development of severe allergies is not excluded.

Overdose

When pills are taken in large quantities, the symptoms of poisoning appear as follows:

• severe weakness;
• dizziness, loss of balance is possible;
• a strong decrease in the pressure indicator;
• severe breathing disorder;
• rapid swelling of the extremities (fingers and toes "swell before our eyes";
• severe abdominal pain, vomiting;
• severe impairment, or refusal to work, of the kidneys or liver.

If you find symptoms of poisoning, you should immediately call an ambulance. During the waiting period of doctors, the victim is washed with a stomach. In the hospital, all vital organs are checked for the degree of damage and the appropriate therapy is selected.

The drug binds to blood proteins, therefore, hardware purification of the blood from the medication will not give a result.

special instructions

Candesartan tablets should be used with special instructions:

• in case of skipping the use of the pill, it is not required to use a double dose in the next dose. Continue to take the medication at the prescribed rate;
• you can not stop using the tablets immediately after the pressure indicator has stabilized. It is required to extend the intake of the medication for another 2-3 weeks (the exact period of prolongation of the use of Candesartan is determined by the doctor);
• with kidney pathologies, as well as with a long course (or when prescribing a drug in a large dose), it is necessary to regularly monitor the amount of salts in the blood;
• patients with heart failure, as well as patients over 75 years old, should monitor kidney function;
• if the patient is connected to an artificial kidney, then constant monitoring of the pressure indicator and blood composition is required;
• with narrowing of the renal arteries, it is required to monitor the indicators of urea and creatinine in the blood;
• in chronic heart failure, the pressure indicator should be regularly monitored;
• Candesartan can cause dizziness and severe weakness, in this regard, drive vehicles and perform hazardous work with extreme caution.

If a patient has a kidney transplant, then an individual course of therapy is selected, which is carried out under the strict supervision of a doctor.

Drug interactions

Candesartan 8.16 or 32 mg (the price of the medication is considered at the beginning of the publication) must be used with extreme caution with the following medicines:

• antihypertensive medications containing a similar active substance can cause (when used simultaneously with Candesartan) an increase in side effects;
• drugs used for anesthesia can cause a sharp drop in blood pressure, in therefore, the use of Candesartan should be discontinued approximately 2 weeks before the prescribed operations;
• potassium and sodium containing medicines provoke a sharp increase in these substances in the blood;
• diuretics increase the effectiveness of Candesartan tablets and increase the concentration of salts in the body;
• with diabetes or kidney pathologies (in moderate or severe form), the use of Candesartan with other antihypertensive drugs is prohibited;
• non-steroidal anti-inflammatory drugs and acetylsalicylic acid reduce the effectiveness of the tablets.

Medications containing lithium increase the toxic effects of Candesartan on the body.

Analogs

If necessary, you can replace Candesartan with the following drugs:

List of analogues, terms of sale and price	Active element and action of the medication	Analog features
Kozaar. Sale by prescription. The estimated cost for 28 tablets is 200 rubles.	The main component (losartan) is contained in the preparation in the amount of 50 and 100 mg, and has antihypertensive action, while the medication does not affect the activity of the nervous system and does not provoke surges in sugar blood.	The tablets are not taken until the patient reaches 18 years of age. The main characteristics of the substitute are close to Candesartan. The course of treatment is also set individually, according to the general well-being of the patient.
Lorista. Dispensed by prescription. The approximate price for 30 tablets is 250 rubles.	The main component (losartan) is in the analogue at a concentration of 50 and 100 mg. The drug lowers the blood pressure and reduces the stress on the heart.	An analogue is allowed to be taken after 18 years. The tool has a smaller list of contraindications and side effects. The dosage rules for the medication are established by the doctor.
Lozap. Sold by prescription only. The approximate cost for 30 tablets is 350 rubles.	The active element (losartan) is in a dosage of 12.5; 50 and 100 mg. The drug lowers the pressure indicator. The effectiveness of the tablets is independent of gender, race and age.	Lozap should not be administered to children under 18 years of age. It should also be borne in mind that the medication has a large list of contraindications and side effects. The course of therapy is set individually.
Telmisartan. You can buy with a prescription. The approximate price for 30 tablets is 350 rubles.	The main component (telmisartan) is contained in a concentration of 40 and 80 mg. The analogue reduces the pressure indicator without changing the heart rate, and also does not accumulate in the body and does not cause addiction.	Tablets are prohibited for taking under 18 years of age. At the same time, the medication has a small list of prohibitions, but a large list of contraindications. The rules for taking an analogue are selected by the doctor according to the general well-being of the patient and according to the body's response to treatment.
Irbesartan. Sold by prescription. The approximate cost for 30 tablets is 600 rubles.	The main element (irbesartan) is contained in the amount of 75, 150 and 300 mg. The tool reduces the pressure indicator, while it does not affect the concentration of sugar and uric acid in the body. It also relieves kidney failure.	The analogue is not used until the age of 18. The medication has a significantly smaller list of contraindications and side effects. The dosage rules, as well as the frequency and duration of admission, are set individually.

It is strictly forbidden to replace Candesartan yourself. The selection of a substitute is carried out taking into account the general well-being of the patient, the reason for the replacement. In addition, the specialist must determine a single dosage, frequency of administration and duration of the course.

Candesartan stands out among antihypertensive drugs in that the decrease in the pressure indicator is achieved gradually, and the achieved effect persists for a long time. At the same time, the higher the dosage (tablets can contain 8, 16 and 32 mg of the active substance), the faster and longer the therapeutic effect is achieved, and the price also changes.

Author: Kotlyachkova Svetlana

Video about the drug Candesartan

Candesartan. Does it reduce blood pressure: