- Composition and form of release
- Terms of sale, storage, prices
- Pharmacological properties
- Pharmacodynamics and pharmacokinetics
- Indications for use
- Method of administration and dosage
- Side effects
- special instructions
- Drug interactions
- Video about the drug Ambrobene
Ambrobene is Germanic a drug that is used for pathologies of the respiratory tract accompanied by impaired sputum discharge. The drug, due to the variety of release forms (tablets, capsules, solution for injection, as well as syrup and solution for oral and inhalation use), is easy to use for adults and children.
Composition and form of release
Ambrobene syrup is a colorless, slightly viscous and transparent liquid with a pleasant raspberry aroma. The product tastes sweet, but slightly bitter. The syrup is in a brown glass bottle equipped with a dispensing stopper and a protective cap. Together with a bottle containing 100 ml of syrup, instructions and a measuring cup are placed in a cardboard box.
The components of Ambrobene syrup are:
|List of components||Component characteristics|
|Ambroxol||The component facilitates and activates the removal of phlegm from the lungs, stimulates the activity of the cilia in the bronchi and the functioning of the bronchial glands.|
|Liquid sorbitol 70%||The element is a sweetener (does not cause an increase in blood glucose levels), maintains the desired texture in the syrup, and also has a choleretic and pronounced laxative effect.|
|Propylene glycol||The substance is used as a solvent and preservative.|
|Saccharin||The component is a sweetener that does not provoke an increase in blood sugar levels.|
|Distilled water||The element combines the components used and allows you to give the syrup the desired texture and concentration.|
|Raspberry flavor||The substance gives the syrup a pleasant aroma.|
The main substance in 5 ml of syrup contains 15 mg.
For comparison, other forms of the drug contain the active element in the following amounts:
- 750 mg per 750 ml solution for inhalation and oral administration;
- 15 mg per 2 ml solution for injection;
- 75 mg per capsule;
- 30 mg per tablet.
For adults, Ambrobene in the form of a syrup is the most convenient to use and dispense.
Terms of sale, storage, prices
Ambrobene (syrup for adults) is available in the pharmacy as well as in online pharmacies for free sale.
At home, the medication must be stored in cardboard packaging, as it protects the product from the action of sunlight, and also observe the temperature range from 2 to 30 degrees. It is required to place the drug in a place that is removed for children's access.
The shelf life of the syrup before opening the bottle is 5 years (from the moment of release) and 1 year (from the moment of opening). It is impossible to freeze or overheat Ambrobene syrup, since very low or very high temperatures have a destructive effect on the main element.
The price for a bottle of syrup in Russia can vary from 100 to 135 rubles.
Ambrobene (typical for all forms of release), according to its therapeutic properties, belongs to the group of mucolytic drugs (they facilitate and improve the discharge of sputum with a dry cough).
Pharmacodynamics and pharmacokinetics
Ambrobene syrup (its active substance) has the following effect on the tissues of the pulmonary system (in children and adults):
- reduces the viscosity of sputum in the bronchi;
- activates and improves the removal of sputum from the pulmonary system;
- enhances the mobility of cilia in the bronchi, as a result of which sputum is more actively excreted from the lungs;
- does not allow the alveoli to stick together, pathology often manifests itself in premature babies;
- normalizes the composition of mucus in the bronchi;
- prevents the degeneration of benign tumors in the lungs into a malignant form;
- stimulates the development of the lungs in the fetus during pregnancy;
- enhances the activity of enzymes in the lungs;
- prevents the transition of bronchitis to the chronic stage.
The action of Ambroxol syrup is noted within 30 minutes and can last up to 12 hours. When using the drug, it must be borne in mind that the main component penetrates the fetus, into cerebrospinal fluid and breast milk, since approximately 90% of the main element binds to proteins blood. The drug is excreted from the body mainly (90%) with urine (about 10% with feces) within 22 hours after administration.
The use of the syrup does not cause an increase in blood sugar, therefore the drug is allowed to be prescribed to patients with diabetes mellitus (but under the supervision of a doctor).
Indications for use
Doctors prescribe Ambrobene syrup to adults in case of violation of sputum removal from the lungs with the following pathologies:
- bronchitis. The disease develops as a result of the development of inflammation in the mucous membranes of the bronchi. At the same time, the remedy is effective in the course of the disease, both in acute and in chronic form;
- bronchial asthma. Pathology is chronic in nature and is manifested by a violation of the breathing process as a result of the appearance of spasms in the lungs;
- pneumonia. The disease is triggered by inflammation of the lung tissue. The disease is predominantly infectious, so the syrup is used in complex treatment;
- bronchiectasis. The pathology is characterized by a pronounced violation of the condition and work of the lungs, while a purulent-inflammatory process can develop in the lung tissues.
Ambrobene syrup prevents pathological adhesion of alveoli in adults (pathology can be caused by inhalation of dust, metal microparticles).
Ambrobene syrup is not prescribed for adults with the following prohibitions:
- high susceptibility to syrup elements;
- carrying a child in the first 12 weeks, since the safety of the medication for the fetus has not been proven;
- pathological immobilization of the cilia. The cause of the disease is a genetic disorder;
- exacerbation of ulcers in the stomach or duodenum;
- disruption of kidney function in acute form;
- pathologically increased production of sputum in the bronchi;
- identification of liver failure in an advanced form;
- the presence of epilepsy or a tendency to develop seizures;
- up to 2 years old, children can only take syrup in a stationary and under the regular supervision of a doctor;
- during lactation, it is necessary (for the period of therapy) to transfer the baby to a mixture.
When carrying a child in the 2nd and 3rd trimesters, the syrup can only be used as directed by the attending specialist. Also, Ambrobene should be used at an individual dosage and with a longer interval between doses in patients with mild or moderate renal or hepatic insufficiency.
Method of administration and dosage
Ambrobene (syrup for adults is used only after consultation with the attending physician) is taken according to the dosage. The frequency and duration of taking the medicine depend on the presence of chronic diseases in the patient and his general condition. When taking the course, you need to consume an increased amount of liquid in order to enhance the mucolytic effect.
Dosing rules for Ambrobene syrup, depending on the type and severity of pathology in adults and children over 12 years old:
|Type of disease||Dosing rules||Course and notes|
|Chronical bronchitis||Take 30 mg (10 ml of syrup) 2-3 times for 24 hours.||Take the syrup for 5-7 days. It is possible to prolong the intake of the medication only as directed by the doctor.|
|Acute bronchitis||Take 60 mg (20 ml of syrup) in the morning and evening. It is advisable to use the product from 6 to 8 in the morning and in the evening. On the fourth day, the dose is reduced to 30 mg. Take the syrup also, in the morning and in the evening, without changing the time of admission.||The duration of therapy is at least 1 week. The more accurate course is determined by the attending specialist. Additionally, antipyretic and anti-inflammatory drugs are prescribed. The type of additional medications and their dosage are selected by the doctor.|
|Bronchial asthma||Use 30 mg every 8 hours. On the third day, the frequency of taking the medication is reduced to 2 times a day (every 12 hours).||The duration of taking the syrup is 1 week. It should be borne in mind that in addition to Ambrobene, you need to take anti-asthma drugs.|
|Pneumonia||Take 30 mg 2-3 times every 24 hours. In severe pneumonia, the dosage may be 60 mg every 12 hours.||The exact course of therapy, as well as the dosage and frequency of syrup intake, are set individually for each patient.|
|Bronchiectasis||Take 60 mg every 12 hours. The recommended time for taking syrup is from 6 to 7 in the morning and from 6 to 7 in the evening. On the fourth day, the dosage should be reduced by 2 times.||Ambrobene should be taken for 7 days. You also need to take into account that a combination therapy is needed, which is selected by the doctor individually.|
|Bonding the alveoli||Use 30 mg every 12 hours. The time of taking the medication is selected individually.||The course of treatment is 1 week. In addition, inhalations may be required (prescribed by a doctor).|
The dosage and rate indicated in the table are indicative. Before taking the remedy, the attending specialist makes adjustments to the therapy. Also, the doctor discusses that the syrup should be consumed at the same time with food.
Ambrobene (syrup for adults contains an active substance that enters the bloodstream), when used, can lead to the development of the following negative reaction:
- headache. May develop 30 minutes after taking the syrup;
- weakness and fatigue;
- the development of fever;
- the appearance of abdominal pain;
- nausea, with large doses, vomiting is possible immediately after swallowing the syrup;
- liquefaction of the stool, since the drug has a laxative effect;
- dry throat and mouth;
- change or distortion of taste perception;
- profuse nasal discharge;
- the appearance of an infectious rash;
- swelling of the limbs;
- respiratory failure due to the accumulation of phlegm in the bronchi;
- violation of the outflow of urine.
If the patient has not been excluded from the allergy to the composition, then urticaria, severe cough, choking and other allergy symptoms may appear.
Syrup poisoning is possible (data are indicated for an adult patient), if during the day the patient takes more than 25 mg of the drug dose per 1 kg of body weight. For example, for a patient weighing 50 kg, overdose symptoms will appear when 1250 mg of the main component or 400 ml of syrup (4 bottles) are consumed within 24 hours.
List of symptoms for poisoning with Ambrobene syrup:
- the development of diarrhea. In the feces, the presence of blood is possible due to a violation of the mucous membranes in the duodenum;
- pronounced nervous overexcitement;
- increased production of saliva or severe dry throat and mouth;
- profuse vomiting, while blood may be present in the vomit due to damage to the gastric mucosa;
- dehydration due to diarrhea and vomiting;
- lowering pressure;
- severe abdominal pain;
- loss of taste;
- respiratory failure or suffocation due to accumulation of sputum in the bronchi or as a result of the development of allergies;
- increased body temperature accompanied by fever;
- yellowness of proteins and skin due to liver dysfunction;
- severe aggression, anxiety and hyperexcitability;
- unbearable headache;
- lack of urine;
- swelling of the limbs, face and other signs of deterioration in kidney function.
If no more than ½ hour has passed after the poisoning, then the victim needs to induce vomiting. Further (and also, when more than 30 minutes have passed after the overdose), the patient must take sorbents. After the manipulations, symptomatic therapy is used (drugs for dehydration and to eliminate diarrhea are mandatory).
Ambrobene syrup for adults should be taken after becoming familiar with the features of its use:
- Ambrobene syrup can cause the development of dermatological pathologies in a severe form and of an infectious nature. Therefore, with a predisposition to this disease, it is advisable to use the medication under the strict supervision of a physician;
- long-term use of Ambroxol is dangerous due to a violation of the condition of the mucous membranes of the mouth, digestive tract and in the lungs. In this case, the syrup should be stopped immediately;
- despite the use of sugar substitutes in the composition, the syrup contains 0.18 bread units. This value should be taken into account when prescribing a drug for patients with diabetes mellitus;
- Ambrobene can cause liquefaction of the stool (with prolonged treatment or with the use of the drug in large doses), since it has a laxative effect;
- in case of impaired kidney and liver function, in mild and moderate severity, the patient is treated with an individual dosage and with a longer interval between doses of the drug;
- if the use of the syrup caused vomiting in the first 20 minutes, then the medication must be taken again. In the case when more than 20 minutes have passed after taking Ambrobene, the drug should be used according to the schedule of administration, otherwise the likelihood of side effects will increase;
- the agent is considered highly allergenic, therefore, when first used, the agent should be used in the morning and monitor the body's reaction for 6-8 hours.
- if you skip taking a syrup, you must take the medication immediately. Further, the therapy should be carried out by counting from the new time;
- Drive a car and perform hazardous work with care.
Syrup (and other forms of release) Ambrobene is used only for dry cough (when the withdrawal of sputum is difficult). When using the drug with a wet cough, an exacerbation of the disease and a pronounced respiratory failure are noted.
Ambrobene syrup is allowed to be used in combination therapy, but only after consulting a doctor, as it is required to take into account, that the medication does not combine well with the following drugs:
- drugs to eliminate cough can cause sputum to accumulate in the lungs, as a result, the patient has a pronounced breathing disorder;
- Ambrobene provokes an increase in the concentration of antibacterial drugs in the bronchi. As a result, the likelihood of developing side effects from antibiotics increases;
- sorbents should be used about 2 hours before taking the syrup or 2 hours after using it. Otherwise, the effect of Ambrobene is greatly reduced or completely reduced to zero.
If the patient is taking medications before Ambrobene is prescribed, then this should be immediately reported to the doctor.
The list of analogues of Ambrobene syrup is quite large.
But it is allowed to replace the medication only in conjunction with the attending specialist:
- Acetylcysteine. Granules with a dosage of 100, 200 and 600 mg of acetylcysteine. Sold without a prescription. The average price is 150 rubles;
- Haliksol. The tablets include 30 mg of ambroxol hydrochloride. They are released freely. The average cost is 120 rubles;
- Bromhexine. Syrup and tablets containing 4 and 8 mg of bromhexine. Available without a prescription. The average price is 150 rubles;
- Carbocisteine. Syrup containing 2 and 5% carbocysteine. Sold freely. The average cost is 300 rubles;
- Abrol. Tablets and syrup containing hydrochloride in different concentrations in ambroxol. Sale is free. Average price 200 rubles.
The doctor can replace Ambrobene in cases where the patient has contraindications, a negative reaction has arisen, or the syrup is not available for sale.
Ambrobene syrup has been shown to be effective in relieving phlegm from dry coughs. Additionally, the agent rarely causes the development of side effects and has a small list of contraindications. In addition, the advantage of the drug is the absence of age restrictions, the drug can be taken from birth (up to 2 years under special supervision) and adults.
Author: Kotlyachkova Svetlana
Video about the drug Ambrobene
Ambrobene syrup instructions for use: