Sermion belongs to the category of alpha-blockers. Has spasmolytic effect on the vessels of the brain, relaxes their walls, which improves blood circulation and tissue supply with oxygen molecules.
The active component of the drug is nicergoline. A substance that is used to treat disorders of the vascular system of the brain, peripheral and cerebral circulatory disorders.
Contents
- Composition and Formulation of Medication
- Pharmacological Profile
- Indications and Contraindications for Use
- Method of Application and Dosage
- Specific Instructions and Patients
- Cases of Overdose and Adverse Reactions
- Interaction with Other Drugs
- Practice Guidelines for
- Practical Advice
- Value of Agent
Composition anddosage form
Sermion is produced in tablets with a different dosage of nicergoline.
5 mg active ingredient in round, convex, orange-coated tablets, in which( in mg):
- nicergoline - 5;
- hydrophosphate calcium dihydrate - 100;
- microcrystalline cellulose - 22.4;
- magnesium carbonate - 1.3;
- sodium carboxymethylcellulose - 1,3.
10 mg of the active ingredient in tablets of round, convex shape in a white shell, in which( in mg):
- nicergoline - 10;
- hydrophosphate calcium dihydrate - 94.3;
- microcrystalline cellulose - 22.4;
- of magnesium carbonate - 2;
- sodium carboxymethylcellulose - 1,3.
30 mg of active ingredient in tablets of round, biconvex form in orange shell, in which( in mg): 
- nicergoline - 30;
- hydrophosphate calcium dihydrate - 72.69;
- microcrystalline cellulose - 22.4;
- magnesium carbonate - 3.61;
- sodium carboxymethylcellulose - 1,3.
In the coating of tablets 5 and 10 mg - sucrose, gum acacia and sandaraka, talc, magnesium carbonate, titanium dioxide, rosin and carnauba wax.
The tablet shell of 30 mg consists of hypromellose, polyethylene glycol, titanium dioxide, silicone and iron oxide yellow.
The preparation is also produced in powder form for the preparation of essences for injections. In its composition, in addition to nicergoline( 4 mg), include lactose monohydrate and tartaric acid. A vial with a solvent( NaCl) is applied to the vial of lyophilized mass.
Pharmacological profile
The medication has a relaxing effect on blood vessels, expanding them by blocking adrenaline, resulting in improved blood flow to the brain and the metabolic processes in it are enhanced, and the likelihood of blood clots is reduced.
The drug has a direct effect on cerebral systems, resulting in improved mental processes.
Active component, getting into the body, is transformed, forming active metabolites. They, in turn, have a directional effect on the nervous system, stimulate the absorption of glucose by the brain, the synthesis of proteins and nucleic acids.
The medicine is quickly absorbed by the body almost completely, regardless of the dosage form and meals. The highest concentration in blood plasma is achieved after 2-3 hours. The highest concentration of metabolites is observed after 2-4 hours. Most of the medicine is excreted with urine, the rest - with excrement.
Indications and contraindications for use
Indications for use of the drug Sermion: 
- treatment and rehabilitation after acute, chronic cerebral vascular and metabolic disorders - the consequences of atherosclerosis, hypertension, blood clots and blood clots, transistor attacks, vascular dementia and vasospasm;
- therapy and rehabilitation after acute, chronic peripheral vascular and metabolic disorders - syndromes associated with them - arteriopathy of the hands or feet, Raynaud's disease;
- treatment of hypertensive crises( as an adjuvant).
The drug is contraindicated in patients who have an anamnesis:
- myocardial infarction;
- hypotension( including orthostatic);
- decreased heart rate( bradycardia);
- bleeding( haemorrhage) of various origins;
- high sensitivity to the components of the drug.
Patients who suffer from hyperuricemia or gout should be informed about this to the doctor who will adjust the dose or replace the drug with another.
Method of application and dosage of
To restore the functions of cerebral hemodynamics and to eliminate the consequences of its violation, Sperm tablets are administered at a dosage of 5-10 mg three times a day at regular intervals. The effect of taking the medication is gradual, therefore the course of treatment can not be less than 3 months.
For the treatment of vascular dementia, Sermion is prescribed with a dosage of 30 mg. Reception is carried out 1-2 times a day for 1 tablet. The course of treatment - from 6 months, if necessary, is adjusted by the attending physician.
In severe cases( treatment and rehabilitation after an ischemic stroke), the drug should be taken parenterally( bypassing the digestive tract):
- intramuscularly - 2-4 ml of reconstituted essences from 2 times per day;
- intravenously - 4-8 mg of lyophilizate dissolved in 100 ml of saline( 0.9%) or dextrose( 5-10%) 1-2 times a day( at the doctor's discretion), the drug should be administered very slowly;
- intraarterially - 4 mg of lyophilisate dissolved in the applied solvent( NaCl 0.9%) once a day, it should be borne in mind that the time of drug administration to the artery is at least 2 minutes.
After stabilization of the patient's condition, it is possible to switch to oral medication. Before taking the drug, you need to consult a doctor who will prescribe the optimal dosage and course of treatment individually, based on the symptomatology and severity of the disease.
Special instructions and patients
The effect of the drug on the fetal condition has not been studied, therefore during pregnancy Sermion is prescribed only in those cases when there is a threat to the health of the mother. During lactation, the components of the drug penetrate into breast milk, so it is advisable to stop breastfeeding during treatment.
Sermion is not assigned to children and adolescents under 18 years of age.
Driving and steering vehicles immediately after taking the drug is not recommended. In case of violations of the kidneys, the medication is prescribed in reduced doses.
For the period of treatment it is necessary to refuse from alcohol intake. Incompatibility of the drug with alcohol can lead to violations of the cardiovascular system.
Cases of overdose and adverse reactions
The use of a large dose of Sermion can lead to a temporary decrease in blood pressure and the appearance of concomitant symptoms - dizziness, weakness, darkening in the eyes. In this case, it is necessary to take a horizontal position before the state is normalized.
Prolonged intake of Sermion can cause mild side effects: 
- lowering of blood pressure( dizziness, headache);
- drowsiness or insomnia;
- digestive disorders( bloating, diarrhea, constipation);
- allergic reactions;
- increase in blood levels of uric acid.
Interaction with other drugs
Sermion can interact with drugs metabolized by the enzyme CYP2D6( beta-blockers, antidepressants, etc.).Due to this interaction, the metabolic rate of the basic drug can vary.
Simultaneous admission with acetylsalicylic acid may increase blood thinning, which may increase the time and severity of bleeding.
Sermion can also enhance the action of medications that lower blood pressure.
Practice of application of
Having studied the opinions of doctors and the opinion of those patients who took the drug Sermion, it is possible to draw certain important conclusions.
Certainly, Sermion is a good tool for improving the blood circulation of the brain. The effect of taking the medication will only appear if you take it strictly according to the indications and in the required dosage.
But to say that this "miracle drug", which can easily cure, for example, vascular dementia, of course not. For such severe cases, one medication will not be enough, complex treatment is needed.
Do not self-medicate and prescribe self-medication to improve memory, attention, etc. Only a doctor who has established a diagnosis can prescribe the treatment and its duration. Only if all the recommendations of a specialist are followed, the medicine will bring the expected effect.
Neurologist, 23 years of experience
After experiencing stress, my mother( 71 years) began to lose memory rapidly. After consulting with a specialist, Sermion was given 30 mg of 1 tablet per day. The course of admission is 3 months with a break of 5-8 weeks.
After the course of treatment, my mother noted improvement in memory, clarity of consciousness. The drug did not cause any side effects. He has been taking it for 3 years already and feels great.
Alina Nikolaevna, 47
Has addressed to the neurologist with the complaint on constant headaches. According to the results of the rheoencephalogram( examination of the brain vessels) - a violation of cerebral hemodynamics.
The doctor appoints Sermion once a day, 30 mg. The effect was not observed for a week, but then headaches began to appear less and less. In addition, sleepiness and apathy disappeared, cheerfulness and good mood appeared. The course of admission is 2 months.
Nina, 41
Practical advice
The drug should be consumed at regular intervals between meals by squeezing a little water.
Patients treated with Sermion recommend going through the prescribed course of treatment to the end, because the therapeutic effect of the remedy does not come immediately.
To the merits of the drug can be attributed to the obvious therapeutic effect, improving the well-being and lifting the tone of the body. Another plus is the impossibility of an overdose of the medicine.
The main disadvantage, according to most patients - high selling price. Many people also note the occurrence of side effects.
Cost of
The prices for Sermion vary according to the form of release, dosage and sales region:
- 5 mg No. 30 - from 415 rubles;
- 10 mg No. 50 - from 499 rubles;
- 30 mg №30 - from 854 rubles;
- lyophilizate 4 mg 4 ampoules - starting at 1727 rub.
Store the product in its original packaging in a place inaccessible to children. Storage temperature is not higher than 25 ° C.
It is released from pharmacies only if there is a prescription from the buyer.
