Celecoxib in the therapy of articular diseases: instruction, reviews

Celecoxib( Celecoxib) is a popular remedy for various disorders of the musculoskeletal system and joint diseases.

This medicine reduces the inflammatory process in the joints, removes pain and prevents further spread of the pain syndrome.

The medicine is available in the form of gelatin capsules. The content of the active ingredient can be different - 100 and 200 mg. Inside the capsules there is white powder or white granules. The color of the structure is from light white to dairy. Capsules are placed in blisters, which in turn are placed in a package of cardboard base.

Ingredients:

• the main element is celecoxib;
• lactose monohydrate;
• Mg stearate;
• Na lauryl sulfate;
• Povidone;
• Croscarmellose Na.

Pharmacologicalproperties

Medication Celecoxib has anti-inflammatory, antipyretic and analgesicGet inside. Most often this medicine is used to get rid of pain in diseases of the musculoskeletal system, and also has a beneficial effect on the motor functions of the joints.

Medication Celecoxib belongs to the non-steroidal anti-inflammatory drugs( NSAIDs) of the new generation. The active component of the drug has an overwhelming effect on the enzyme COX-2.

This enzyme is responsible for the development of inflammation and the appearance of pain. But the acting component does not affect the synthesis of the enzyme COX-1.As a result, when receiving the drug, a minimal amount of side effects occurs, which are associated with the gastrointestinal tract, the circulatory system, and the urinary organs.

The absorption of the drug is rapid, while it is evenly distributed throughout the tissues. The maximum concentration level of the active ingredient in the blood is reached after 3 hours, the equilibrium concentration is reached on day 5.Splitting occurs with the help of the liver. The main excretion is carried out through the intestine along with the calves by about 57% and through the kidneys along with the urine of about 27%.

At what indications is assigned

The drug Celecoxib is recommended to be taken at the following indications:

• during the therapy of rheumatoid arthritis;
• with ankylosing spondylitis;
• for osteoarthritis;
• during psoriatic arthritis.

When the remedy is not recommended

Do not use the medication with the following indications:

• if there is an increased sensitivity to the constituents;
• is not recommended to use celecoxib concomitantly with drugs that are part of the same group;
• during bronchial and "aspirin" asthma;
• if there is peptic ulcer in acute form, which is accompanied by bleeding GIT;
• during colitis;
• in the presence of heart failure in chronic form;
• for aortocoronary bypass;
• if there are peripheral arterial diseases;
• during cerebrovascular diseases with vivid manifestation;
• for severe renal and hepatic insufficiency;
• during pregnancy;
• with breastfeeding.

Application diagram

The required dosage of the drug should be selected by the attending physician. The dose directly depends on the type of illness. Capsules should be taken orally, while they are washed down with a sufficient amount of water. During the reception of the capsule is not recommended to chew. Eating does not affect the period of application.

Usually, the drug is prescribed in short courses, while the minimum dosage level is selected. The recommended dosage is 200 mg, it must be taken daily for one or two doses. If suddenly there is a need, then at the discretion of the attending physician, the dosage can be doubled.

If the reception was missed and there is very little time left until the next, a forgotten capsule is not required to drink. Dosing is not recommended.

Intended for pregnancy and during lactation.

It is not recommended to take celecoxib tablets during pregnancy. This is due to the fact that the relevant studies on the effect of the constituent components of the drug on the unborn child have not been conducted.

For the same reason, it is not recommended to use a medicine for therapy during lactation.

Symptoms of an overdose of

During the use of the medicine, the symptoms of an overdose appear in rare cases, but still they sometimes manifest:

• drowsiness or vice versa insomnia;
• state of lethargy;
• appearance of pain in the epigastric region;
• state of nausea;
• occurrence of vomiting;
• bleeding from the stomach and intestines;
• hypertension;
• the onset of renal failure in acute form;
• reactions of anaphylactic nature;
• breathing disorder, especially its oppression;
• sometimes a coma.

If symptoms of an overdose occur, it is recommended to induce vomiting and rinse the stomach. In addition, it is necessary to take activated charcoal or osmotic laxatives, which should be used within 4 hours after taking celecoxib. Supportive and symptomatic treatment is provided in the future.

Side effects of

Celecoxib has a fairly wide range of side effects. It is worth highlighting the most common unpleasant symptoms that occur when taking this medication:

• digestive system disorders - the appearance of nausea, pain in the abdominal area, upset of the stool, namely diarrhea, a decrease in appetite;
• disorders of the nervous system - the appearance of dizziness, headache, possibly a sleep disorder, namely insomnia, a state of overexcitation;
• from the side of the immune system - the body's resistance to infectious diseases may decrease;
• skin problems - on the surface of the skin there may be a rash, redness, a sensation of itching, irritation;
• is often manifested by the influenza-like state of ;
• the occurrence of various allergic reactions of .

In rare cases, there may be irregularities in the activity of the heart, blood vessels - increased blood pressure, arrhythmia, tachycardia.from the genitourinary system may appear a decrease in resistance to infectious lesions, sometimes there are swelling, kidney failure. It is also possible the occurrence of bleeding in the stomach, intestines, the appearance of ulcerative disease, vomiting, a decrease in the level of hemoglobin. Very rarely appears a state of confusion.

Precautions for

When using celecoxib tablets, the following precautions should be observed:

• application of the drug in case of cardiac or vascular disturbances can cause deterioration of the condition, therefore, in these pathologies a reduced dosage is prescribed;
• if patients have diseases associated with fluid retention, then for them the dose is selected individually;
• should be used with extreme caution in children and adolescents under the age of 18;
• if there are disorders of kidney and liver, the dosage should be reduced;
• for peptic ulcer disease of the stomach and duodenum, the drug is prescribed only in periods of absence of exacerbations;
• in the presence of delayed metabolism, the drug is prescribed in a dosage of not more than 100 mg per day.

Practical experience of using

Review of the doctor and feedback from patients who received treatment with Celecoxib.

The price of the drug and its analogues

The packing price of celecoxib No. 30 with a dosage of 200 mg starts at 1,250 rubles and above. The price for package No. 10 with a dosage of 200 mg is from 600 rubles, for package No. 10 with a dosage of 100 mg is 440 rubles.

Analogues of celecoxib are available:

• Celebrex;
• of Dilax;
• Arkoxy;
• Dynastat;
• Renseleks;
• Revmoxib;
• Ketanov;
• ;
• Nurofen.