There are many drugs that are used to stop the main symptoms of attention deficit disorder with hyperactivity - impulsivity, inattention and hyperactivity. But not all of them are effective and safe, especially when treating small children.
However, scientist-pharmacists managed to develop and release a highly selective potent inhibitor of presynaptic carriers of norepinephrine, the Stratter drug( the main active substance of Atomoxetine), which does not belong to psychostimulants, as well as to amphetamine derivatives. In scientific laboratories, clinical studies and observations were conducted, thanks to which the medical influence of the latest development was studied.
No adverse reactions and side effects were observed during clinical trials of the drug. Over 5000 patients took an active part in the drug testing process.
Stratter is used in 42 countries, according to statistics, more than 3, 2 million children, adolescents and adults diagnosed with ADHD managed to significantly improve their condition due to this medication.
Contents
- Pharmacological profile
- Mechanism of action
- Indications and contraindications for use
- Instruction for use
- Overdose and adverse reactions
- Special instructions
- Use of the drug for renal and hepatic dysfunction
- Interactions with other medicines
- Intended for pregnancy and lactation
- Practical experience
- Purchase and analogs
Pharmacological profile
The sympathomimetic drug of the central action belongs toAtomoxetine group of substances.
Produced in the following dosages:
- 10 mg;
- 18 mg;
- 25 mg;
- 45 mg;
- 60 mg.
Dosage is selected depending on the disease and condition of the person. One package contains seven or fourteen capsules in a blister and instructions for use.
After applying the medication, the active substance is immediately absorbed into the body and begins to have a curative effect.
The presence of proteins with albumin promotes the acceleration of the metabolism of the drug in the liver. At the same time, cytochrome interacts with internal organs. The main forming component is the oxidized metabolite 4-hydroxyatomethoxin.
Pharmacological activity is the circulation of substances within the plasma. However, this effect occurs at a minimally low concentration. Removal of the drug from the body is carried out with urine.
Mechanism of action
During the implementation of therapeutic therapy for ADHD, MAO inhibitors are most commonly prescribed. But, since Stratter is not compatible with them, it is recommended to sustain a pause in two weeks after the end of therapy with the help of this group of drugs. It is strictly forbidden to use the drug along with the administration of MAO inhibitors.
Experts say that Beta2 is an adrenostimulator that can cause numerous side reactions from the body. The risk of complications increases the likelihood of failures from the cardiovascular system( CCC).
There is no reaction of clinically significant inhibition or induction of cytochrome isoenzymes. With a pronounced metabolism, patients are confronted with an increased concentration of Atomoxetine in the blood. The level of the substance rises directly in the blood plasma.
A new generation drug helps block the re-uptake of norepinephrine. This action is carried out directly due to the interaction of proteins. It also promotes an increase in the concentration of noradrenaline in the synaptic cleft and the intensification of direct synaptic transmissions.
Indications and contraindications for use
Stratters are used in the treatment of attention deficit hyperactivity disorder in children aged six years and older, adolescents and adults.
There are a number of diseases in which it is not recommended to take this medication. In particular, this applies to patients with:
- with an angle-closure glaucoma;
- severe cardiovascular system;
- tachycardia;
- by arterial hypertension;
- impaired brain activity;
- treated with MAO inhibitors;
- with increased sensitivity to the drug.
It is forbidden to give a drug to children under the age of six. During pregnancy it is advisable not to prescribe this medication, as it is possible to harm the fetus.
The active ingredient enters the mother's milk, so for the period of treatment, breastfeeding should be abandoned.
Instruction for use
For children and adolescents with a body weight of up to seventy kilograms, a daily dose of atomoxetine is prescribed from 0.5 mg / kg. Increase the dose, if necessary, in a phased manner.
For example, after three days of taking the drug, you can already use a dosage of 1.2 mg / kg. If no improvement is observed, then the daily dose can be increased to the maximum allowed 1.8 mg / kg. This process should be carried out in stages over 3-4 weeks.
For children, adolescents and adults with a body weight of more than seventy kilograms, 40 mg of active ingredient per day can be used.
Overdose and Adverse Reactions
Symptoms of overdose can be determined by some criteria, it is manifested by the following reactions:
- drowsiness;
- behavior disorder;
- excitation;
- hyperactivity;
- dry mouth;
- tachycardia
Some symptoms are only mild. Therefore, a person feels extremely stable. If there is an allergic reaction to the active ingredient, there is a chance of lung damage.
As an adverse reaction, a decrease in appetite is most often observed, weight is lost. Quite often, therapeutic therapy with Stratter is characterized by the following negative reactions:
- vomiting;
- with nausea;
- by dizziness;
- drowsiness;
- irritability;
- psychological disorder;
- heartbeat;
- tachycardia;
- with abdominal pain;
- dyspepsia, itching;
- rash;
- dermatitis;
- influenza;
- fatigue;
- with a breakdown.
If patients have low cytochrome activity, then insomnia, loss of strength and other undesirable reactions occur. In such cases, loss of consciousness is possible. Basically, this happens when the level of metabolism decreases.
Special instructions
Therapeutic therapy is carried out exclusively under the supervision of a professional specialist. Doctors working in this field should be familiar with attention deficit hyperactivity disorder.
When the drug was used, there were cases of suicidal tendencies, especially among teenagers. When jaundice develops, the doctor stops the therapy with the use of atomoxetine.
During the period of therapeutic therapy, it is not recommended to consume alcoholic beverages in excessive quantities.
Application of the drug in violation of kidney and liver
In this case, the dosage of the drug is selected strictly individually, and the treatment is carried out under the strict supervision of the attending physician.
Interaction with other drugs
The use of adrenergic receptors, along with the use of drugs containing atomoksetin, can cause a malfunction in the cardiovascular system.
Therefore, a similar combination of drugs is not recommended.
Intended for pregnancy and lactation
Stratter is not prescribed during the period of gestation and breastfeeding. Since an active ingredient can harm the fetus or the baby.
Practical experience of using
The opinion of doctors and the feedback of parents whose children have been or are being treated with Stratter.
My child has serious health problems. I had to repeatedly take him abroad for the implementation of professional medical therapy.
The child's body no longer accepted a huge number of drugs that were prescribed to him by foreign doctors. My wife and I decided to see a local doctor.
The child was prescribed treatment with Atomoxetine. Despite the development of side effects, the child's well-being improved. We did not even expect a turn of events in this way.
Eugene, 45 years old
My body is really very susceptible to various drugs and reacts negatively to them. In this regard, it is difficult for me to choose a certain remedy. And then there's the disappointing diagnosis - ADHD.Assigned to me Stratter, very afraid to start to drink medicine. ..
But, despite the large list of contraindications and limitations, the doctor was able to control the process of therapeutic therapy and significantly improve my state of health.
Marina, 22
I always conduct a thorough diagnosis and clinical examination of the patient before prescribing this drug. However, I want to say with certainty that in most cases, the remedy has helped in improving the health cardinally.
I have repeatedly communicated with my patients after the medical therapy passed and they felt fine. At the same time, I do not recommend taking the medication alone to avoid unnecessary problems.
If you follow the recommendations of experts, then there will be no unnecessary problems. Any medicine requires compliance with dosages and a certain course of admission. Therefore, it is necessary to take responsibility for the implementation of therapeutic therapy with responsibility.
Neurologist, experience of 26 years
Purchase and analogs
Strattera is available in the form of tablets, the price of the medicine in pharmacies from 1463 to 1600 rubles. Store the drug recommended at a maximum temperature of 15-25 C.
The drug has no analogues of Russian production. The Concert of Italian manufacture has a similar effect.
