Injections and pills Tolperil: indications, instructions, reviews

Tolperil is a central muscle relaxant. This drug is most often used for the treatment of neurological diseases. The drug belongs to the group of amino ketones.

Tolperyl is available in the form of tablets( 30 pieces of 50 and 150 mg) and injections for injections( 5 ampoules per 1 ml).One tablet( 50 mg) contains 50 mg of tolperisone hydrochloride active ingredient.

1 ml of the injection contains 100 mg of tolperisone hydrochloride and auxiliary ingredients in the form of 2.5 mg of lidocaine hydrochloride. Tablets are released in blisters in a box.

Pharmacological profile

The active ingredient of the drug blocks mono and polysynaptic reflexes. Has a mild antispasmodic and anti-adrenergic effect. It provokes an increase in peripheral blood flow regardless of the effect on the central nervous system.

Active substance tolperisone shows a wide range of effects: lowers the high myotonic tone, lowers the rigidity of muscles, eliminates unauthorized active movements and exerts a vasodilating effect.

Also, the drug is able to stabilize cell membranes, by blocking sodium channels. Accelerates the polarization reaction of cell membranes and reduces the duration of their action potential. Admission in therapeutic doses does not help suppress contractility and myocardial conductivity.

When used internally, the drug is well absorbed in the small intestine, passes an intensive metabolism in the kidneys and liver. The maximum saturation of the drug in the blood is observed one hour after its use.

Biological availability of active components is 20%.The elimination half-life is approximately one and a half hours.99% of the constituents of the drug are excreted by the kidneys in the form of antrols.

The mechanism of this muscle relaxant is to suppress the migration of the nerve impulse. The active component of the drug, Tolperisone, prevents the appearance of poly - and monosynaptic reflexes and inhibits the conductivity of impulses along the reticulospinal pathway.

Scope and contraindications

Indications:

• Presence of extrapyramidal disorders;
• cerebral palsy;
• presence of spinal and main paresis, accompanied by miotic convulsions, limb immobility, spinal automatism and hypertension;
• presence of encephalopathy and vascular epilepsy;
• presence of diseases with symptoms of muscle convulsions, stiffness and dystonia;
• obliterating arterial diseases( Raynaud's syndrome, diabetic angiopathy, Buerger's disease, arteriosclerosis of blood vessels);
• convulsions due to a previous stroke;
• presence of myelopathy;
• treatment of food ulcers;
• the presence of multiple sclerosis;
• encephalomyelitis therapy;
• restorative therapy after traumatological and orthopedic surgical interventions;
• Little's disease.

Contraindications to the use of the medicine:

• the presence of hypersensitivity to the components of the drug;
• myasthenia gravis;
• lactation period and gestation period;
• child's age.

Lidocaine is part of the medicinal product, therefore, before the appointment of Tollper, a test should be made for susceptibility to this substance.

Instructions for use

Tolpleyl injections are given intravenously - 1 ml once a day, intramuscularly - 1 ml twice a day. It is worth noting that intravenous administration of the drug is permitted only under conditions of inpatient treatment. In the case of the appointment of several muscle relaxants, the total dose of Tolperil should be lowered.

When using tablets, the duration of the therapeutic course and the dosage regimen is determined in individual conditions.

This depends on the course of the disease, the tolerability of the medication and the effectiveness of the therapy. Children older than fourteen years and adults should take a dose in the total amount of 150-450 mg per day, with a reception rate of 3 times.

Children weighing more than 30 kilograms should take about 5 mg per 1 kg of body weight( three times a day).In the presence of diseases of the liver and kidneys, the dose of the drug is reduced by half.

Cases of overdose

The nature of the symptoms exhibited when an overdose of this medication is not established. In case of excessive use of the drug, it is necessary to cancel its further use and conduct symptomatic therapy.

It should be noted that there are no special antidotes to the drug. There were described cases when after use of 600 mg of the drug, increased irritability was observed.

Overall, drug tolerance is good, but in some cases( 2% of patients), the following side effects may occur:

• cardiovascular system - significant lowering of blood pressure;
• CNS - headache, drowsiness and muscle impotence;
• digestive system - vomiting, nausea and discomfort in the abdomen;
• allergic reactions - urticaria, erythema, dyspnea and anaphylactic shock;
• lymphoid and hematopoietic system - lymphadenopathy, anemia;
• urinary system - proteinuria, urinary incontinence;
• respiratory system - shortness of breath, nosebleed, shortness of breath;
• immune system is a manifestation of the hypersensitivity reaction;
• musculoskeletal system - pain in the extremities, myalgia and muscle weakness.

On the part of laboratory indicators there is a concentration of bilirubin in the blood, a change in the dynamics of hepatic enzymes and an increase in the concentration of creatinine in the blood.

Special instructions

Tolsteryl contains Lidocaine, which is not well tolerated by everyone. Before using the drug, a sensitivity test should be performed. With cardiac and pulmonary deficiency, the medication should be taken strictly according to the indications. A long course of therapy requires a preliminary planned medical check of the condition of internal organs and systems.

The medication is allowed to be taken in the first trimester of pregnancy, but only if the therapeutic effect for the mother will exceed the possible risk of a threat to the health of the fetus.

Exact data on the ability of the active ingredient to penetrate into breast milk, no. Therefore, if you need to take a medicine, breastfeeding should be stopped. The drug is contraindicated for use in childhood.

During the course of treatment with Tolperil, it is not recommended to operate vehicles and other mechanisms. This is due to the possibility of manifestations of adverse reactions in the form of arterial hypotension and muscle weakness. If the kidneys and liver work incorrectly, you should reduce the prescribed dose of the medicine by half. The drug does not affect the alcoholic effects on the central nervous system.

Drug Interaction

When the drug Tollypil with other similar medicines accumulates active substance in the blood plasma.

The drug ingredients enhance the effect of niflumic acid. Therefore, with the joint use of these drugs, the dose of the acid should be reduced.

Synchronous use with other muscle relaxants does not cause a calming effect. The medication can be combined with tranquilizers, hypnotics and sedatives.

There is an opinion. ..

Reviews of doctors and patients who take or take Tolperil.

Medical practice shows that Tolperil is an effective and harmless medicine. Based on the statistics, the manifestation of side effects is observed only in 2% of patients.

Purchase of the drug and analogs

The drug is available in the form of tablets and injectable solutions. On average, the price for Tollyper tablets is 200 rubles, and for solutions - 300-400 rubles.

The medication should be stored at a temperature of not more than 25 degrees. The maximum shelf life is three years. Leave in pharmacies is carried out only on the prescription prescribed by the doctor.

Tollyer analogues:

• Miaxil( solution in 1 ml ampoules);
• Mydocalm( solution in ampoules of 1 ml, tablets of 50 and 150 mg);
• Baclofen( tablets of 10 and 25 mg);
• Hidostat combi( solution in ampoules).