Singial - a medicine based on hyaluronic acid of an immunobiological nature. The main active substance of the drug is sodium hyaluronate, obtained in laboratories from the substance Streptococcus Zooedpidemicus.
Is a transparent colorless solution with increased viscosity. For a long time, the role of this substance was considered to be insignificant, narrowly focused and purely mechanical in nature.
But recent studies have shown the role of hyaluronic acid and extracellular matrix. Control the level of electrolytes and water in the fluid that is outside the cell, that is, maintain the water balance in the human body.
Also hyaluronate promotes active cure of infections and wounds, performs lubricant functions, lubricating the surface inside the joints, provides its mobility.
Thanks to all this, the component plays a big role for the body and is used not only to treat diseases and injuries associated with the skeleton and musculature, but also to preserve beauty and youth.
Contents of the article
- Pharmacological action
- Pharmacokinetics of the preparation
- Indications for use
- Contraindications
- How to put the injections?
- Overdose and additional indications
- Side effects of
- Public opinion about
- The cost of biting
Pharmacological action
Singial is a solution that is injected intraarticularly.
It is intended to replace the synovial fluid that accumulates during degeneration and inflammatory joint diseases.
Also the active agent stimulates the process of replacing the cartilage tissue of the joint. The drug is very effective, being a therapeutic agent, it is used to relieve and relieve pain in inflammation and various diseases of the human motor system.
It is especially advised to use it in the case when there is no positive effect from the use of physiotherapy procedures, gymnastic exercises, anti-inflammatory and analgesic drugs.
Pharmacokinetics of
As mentioned above, the main component of the preparation Singhial - sodium hyaluronate is able to restore useful 
characteristics of synovial fluid, physiological homeostasis, favorably influences the normalization of the liquid composition and stimulates the process of biosynthesis of hyaluronic acid.
This acid, after insertion into the joint cavity, is capable of retaining the original molecular weight. After filtration through the articular tissues and the flow into the bloodstream( peripheral), the molecular mass of the main component is significantly reduced.
Approximately 20.6 hours, the half-life in the joint cavity occurs and for 3 days - in the plasma component of the blood after passing into it from the cavity itself. The drug is retained in the synovial fluid for about 5 days. Within 9 days they will have time to undergo the processes of destruction, separation and renewal.
Approximately 83-84% of hyaluronic acid is metabolized in the liver, part of it is excreted in the form of water and carbon dioxide, about 17% can be used repeatedly in the body.
Indications for use
Most often, Singhial can be prescribed in the case of degenerative-inflammatory and traumatic lesions of joints.
This is a case of periarthritis and osteoarthritis of the knee and shoulder joints.
Contraindications
Hypersensitivity to the main active ingredient sodium hyaluronate or other reactive substances. Violations of the integrity of the skin, damage or skin disease in the area of administration.
An important restriction is severe liver disease.
How do I put an injection?
Singial is dispensed as a solution for administration of 10 mg / ml 2 ml in pre-filled and prepared syringes No. 3 and No. 1.
The drug should be injected 2 ml into the joint bag 1 time in 7 days. The period of application should be 3 weeks.
The injection volume and frequency are set individually by a specialist based on the indications, the course of the disease and the size of the joint.
Overdose and additional indications
The drug should be administered only after the aggravation of the inflammation process is facilitated. Immediately after the injection, local sensations of pain can be observed. About this, as a rule, the patient is warned in advance.
After the introduction of the drug, local anesthesia or relaxation is recommended. At carrying out strict aseptic conditions are provided.
A needle of a specific caliber 22 G is used. The medicine is injected directly into the joint zone, as getting into neighboring tissues can provoke pain sensations. Typically, the effect should appear during the first three injections.
If accumulation of liquid takes place during the process, its excess should be removed. In the case of people of advanced age, the injection should be carried out with extreme caution.
All physiological and functional characteristics of such groups of patients should be carefully studied and taken into account in the process. During clinical trials, it was found that many drugs, which include hyaluronic acid, are excreted from the body together with breast milk.
Therefore, it is necessary to avoid the use of the drug during the entire period of breastfeeding. If the rubber cap in front of the syringe is open, then the medicine can not be used. Syringes for such injections are single.
The drug is not allowed to enter into the vessels of , it is not intended for use in ophthalmology.
Side effects of
This preparation is well tolerated, but sometimes in the places of occurrence there can be various reactions: painful sensations 
immediately after administration, the appearance of swelling, swelling, hyperemia, increased temperature of individual parts of the body.
Administration of the drug may provoke an allergic reaction. In this case, the injection is stopped.
In some cases, there is chills, nausea and vomiting.
There may also be a shock state( of an uncertain frequency).Patient should be closely monitored.
Before using this drug, it is advisable to undergo a short course of examination to identify all diseases or body characteristics that may interfere with the course of treatment with this drug.
Opinion of the public about the
preparation Reviews of doctors and ordinary people who used injections of Singh to treat joints.
I, as a doctor, constantly receive feedback from colleagues from other traumatology about this drug. Singhal is registered as a medicinal product. Therefore, I choose and I advise you to protect yourself and your patients.
The cost of treatment is not so critical, and a large number of patients give their consent for treatment with this drug. And people who have already completed the course are satisfied with the results.
Stanislav Viktorovich
There are some serious points about the preparation of Singhial, related to the exclusivity of physico-chemical information about it.
All information about this medicine and all statements about excellent qualities are perfectly arranged by representatives of pharmaceutical companies. When producers shield their own preparation, scientists and doctors demonstrate posters with different tablets in a section.
What to say about the very results of all clinical trials: no research institutes of orthopedics and traumatology conducted any control studies. As a rule, doctors, receiving a medicine for free, prick it to certain groups of patients for a fee.
After that, they make detailed reports, in which they disclose all the positive results. Therefore, believe everything that pharmaceutical companies provide is not worth it. This is a business, a service for a service. Companies pay money, and doctors nod their heads.
Vasily, 39
The most negative is that in the preparation of Singhial, the dose of active ingredient of sodium hyaluronate is only 10 mg, while in others it is 20 mg.
About these 20 mg all the more you can find and read a lot of information about the studies. And this one about this drug there is no information. Everyone only says that about the action and that someone helped.
But this is a conversation at the level of emotions. The price is too high, and the dosage is reduced by 2 times. Then it's necessary to do so with each drug, and then still blame the doctors who do not think about the financial capabilities of the patient.
Petr Leonidovich, 56
Cost bites
Price solution Sinhiala for intra-articular injection, 10 mg / 2 ml, syringe / 3 pcs - is about 14745 rubles .
For storage use the place closed from light at a temperature not exceeding 25 degrees. Do not store in the freezer. Keep away from children. Shelf life is 3 years.
Before buying, you need to undergo a course of examination and after the conclusion of the prescribing physician to buy this drug.
