Parkinson's disease causes severe damage to the central nervous system. If the time is not to stop the development of this disease, the result will be irreversible consequences for the whole organism.
The drug Madopar helps to eliminate the symptoms inherent in Parkinson's disease, restore the activity of the nervous system and improve the general condition of the body.
Contents
- Form release and constituent elements
- Pharmacological properties
- Pharmacokinetic properties
- Pharmacokinetics in modified-release capsules
- Pharmacokinetics in high-speed tablets
- When the drug
- is taken Contraindications and limitations for the administration of
- The dosage and dosage regimen
- Reception during the period of bearing and feedingchest
- Symptoms of overdose
- Side effects
- Special instructions
- Application experience
- Price drugs and its analogs
Release form and the constituent elements
The drug is produced in the form of tablets and capsules. Also produced in the form of tablets and capsules of a dispersible type, which have a modifiable release. Tablets are placed in the cell blister for 10 pieces. One carton can contain 3 or 10 blisters.
Composition depends on the form of release:
- Madopar 125 .It is produced in the form of gelatin capsules having a solid structure. Capsules have a pink and blue color. One capsule contains 100 mg of levodopa and 25 mg of benserazide.
- Madopar GCC 125 .Are issued in the form of hard capsules of green-blue coloring. One capsule contains 100 mg of levodopa and 25 mg of benserazide.
- Madopar 125( tablets) .Produced in the form of dispersible( high-speed) tablets, having a white color. One tablet contains 100 mg of levodopa and 25 mg of benserazide.
- Madlpar 200 .This form is made in the form of tablets, they have a pink color. It has 200 mg of levadopa and 50 mg of benserazide.
Pharmacological properties of
Modopar has an anti-Parkinsonian effect.
The main active substance of levodopa is a precursor of dopamine. The principle of the effect of this component is based on the 
transformation into dopamine. As a result, the lack of dopamine inside the central nervous system is being filled.
The use of this drug eliminates tremors, hypokinesia, dysphagia, rigidity, drooling.
The second major component, benserazide, is an inhibitor of dopa decarboxylase. This substance causes the process of reducing the synthesis of dopamine in peripheral tissues. As a result, this causes an increase in the level of levodopa in the blood.
The pronounced therapeutic effect occurs within 6-8 days. The greatest positive effect occurs after 25-30 days.
Pharmacokinetic properties of
The process of absorption of active components is observed inside the upper part of the small intestine. The suction level can be from 66% to 74%.The level of maximum concentration can be reached after 60 minutes after the application of the capsules. The bioavailability level reaches 98%.
Pharmacokinetics in Modified Release Capsules
The release of the main components takes a long time. The level of the greatest concentration in the blood can reach 20-30%.The greatest concentration is achieved 3 hours after the application of the capsules. The bioavailability level reaches 50-70%.Bioavailability is not dependent on eating.
The half-life of active components is 1.5 hours. The process of excretion mainly occurs through the kidneys along with urine - almost 64%, also goes along with feces - 24%.
Pharmacokinetics in high-speed tablets
Pharmacokinetics properties are similar to capsules and tablets. However, the period of achieving the greatest concentration has a tendency to decrease.
When the drug
is taken The main purpose of Madopar is to reduce the symptoms and symptoms of Parkinson's syndrome and Parkinson's disease.
Madopar 125 in the form of tablets of high-speed dispersible type is shown in conditions:
- with Parkinsonism, who have dysphagia and akinesia in the morning and after lunch;
- under conditions of "depletion of the single dose effect" or "increasing the duration of the latency period until the desired effect of the drug".
Madopar 125 and 250 capsules and tablets can also be used in the following conditions:
- during fluctuations of any type of exposure Levodopa - "dose peak dyskinesia" and "end-of-dose phenomenon", for example, a state of immobility at night;
- if there is restless legs syndrome, idiopathic syndrome combined with restless leg syndrome, which is accompanied by renal failure in chronic form.
Contra-indications and limitations for taking
Madopar can not always be used, there are cases when the use of the drug is contraindicated.
It is not recommended to use the medicine in the presence of the following conditions:
- in the presence of diseases of the cardiovascular system, which take place in a decompensated form;
- if there are decompensated disorders of liver, kidney, and endocrine system functioning;
- various mental disorders, psychoses;
- should not be used if there is melanoma;
- during closed angle glaucoma;
- observed increased sensitivity to the components of the drug;
- is not recommended for people under 25 years of age;
- during pregnancy;
- when breastfeeding a child.
It is also necessary to use the medicine cautiously in the presence of the following conditions:
- in the period after myocardial infarction;
- if there is ulcerative disease of the stomach, duodenum;
- during arrhythmia;
- to patients with a history of osteomalacia.
The dosage and dosage regimen of
The dosage of Madopar medication depends on many factors - on the characteristics of the patient's body, on the symptoms of the disease.
Tablets or capsules should be taken as a whole, they are swallowed. In addition, drink with water. Take it when you need food. You can also use for half an hour before eating or 60 minutes after eating.
Capsules are usually swallowed whole, but 250 mg tablets can be ground into a powder. In this form, they can be swallowed more quickly. Tablets 125 with a high-speed effect are diluted in water in an amount of 25-50 ml. The solution is taken no more than 30 minutes after the dilution of the tablet.
Features of application:
- the beginning of treatment should begin with a dosage of 125 mg - 1 capsule twice a day;
- weekly dosage is increased by 1 capsule per day;
- if there are any side effects, it is better to stop taking the drug;
- after the appearance of side effects ceases, the drug can be resumed, in which case the dosage should be increased by one tablet per day every 14 days;
- effective dosage is from 200-800 mg of levadopa and 50-200 mg of benserazide per day, this amount is divided into several doses per day;
- course of treatment is usually lengthy.
Admission during childbearing and breastfeeding
Madopar medication is not allowed to be administered to women during the period of gestation. It is not recommended to use women of childbearing age with unreliable contraception. Taking medication can cause serious deviations in the development of the child's skeleton.
Contraindicated to use in women with breastfeeding, as the constituent elements penetrate into breast milk.
Symptoms of overdose
If you follow the instructions strictly, no overdose occurs. But if the necessary dose is exceeded, this symptomatology can be observed:
- state of insomnia;
- signs of arrhythmia;
- appearance of nausea;
- occurrence of involuntary movements;
- can sometimes be confused;
- vomiting.
If these symptoms occur, it is recommended that you stop using the medicine and take the necessary therapy.
Side effects of
After studying numerous reviews about Madopar, we found out that during its use, the following unpleasant conditions may appear:
- disorders in the activity of the central nervous system - the appearance of headaches, dizziness, short-term
disorientation, anxiety, sleep problems, possible depressive conditions, delusions, hallucinations; - problems in cardiac and vascular activity - arterial hypertension, arrhythmia;
- frustration of the digestive system - diarrhea, signs of nausea, vomiting, sometimes there may be a disorder of taste;
- hematopoietic system disorders - anemia, thrombocytopenia, leukopenia;
- appearance of bronchitis, rhinitis ;
- occurrence of rash, sensation of itching ;
- change in color of urine .
Special instructions
During the use of the medicine, you should pay attention to the following:
- Usually, the side effects associated with the disruption of the digestive system, arise first treatment therapy. To reduce their drug should be taken with water, as well as during eating. It is recommended to slowly increase the dosage.
- It is recommended to monitor blood, kidney, liver activity during the medication intake.
- If the drug is taken by people with closed-angle glaucoma, then periodically it is necessary to measure the intraocular pressure.
- It is not recommended to abruptly cancel taking the drug, the withdrawal should be gradual. With a sharp discontinuation of the drug increases the likelihood of a malignant neuroleptic syndrome, which can be life threatening.
Experience with
A review of the doctor and feedback from relatives of patients who take or have taken Madopar.
Madopar is an effective antiparkinsonian drug. Its use can quickly restore the activity of the nervous system, eliminate various disorders and normalize the mental activity of the brain.
If you take the medicine according to the instructions, then the effect is usually observed quite quickly. The main thing is that it is necessary to strictly follow all instructions when using. Previously, you must consult with your doctor, he should prescribe the dosage and the regimen.
If side effects occur, it is time to stop taking it until all the unpleasant symptoms disappear.
The doctor neurologist
The husband already years 5 is ill with disease Parkinsona. I never thought that someday in my life I would have to face this insidious disease.
At first it did not show much, but every day it got worse and worse. After the examination, the doctor appointed Madopar. His husband has been taking it for 2 years, in general, after taking it, he got better much. He can eat normally, lost shaking, there was clarity of mind. But still there are too many side effects.
Ирина, 45 years old
Mom is 75 years old and has had Parkinson's disease for 8 years already. At first we did not know what to do, treated by any means, except for this, she took various drugs.
However, the effect was very small. About two years ago, the doctor appointed Madopar.
After the reception, it became better, she passed a shaking, she began to feel better, there are no problems with movements. But there are too many side effects. And so only this medicine and we are saved, it is better not yet found.
Svetlana, 37 years old
Best of all reviews - the effect of receiving Madopar on video:
Price of medication and its analogues
The price of packing Madopar 125 with the number of tablets 100 is about 780-850 rubles, packing of tablets 250 № 100 costs about 1330-1400rubles, pharmacies are also available analogues of the medicine:
- Nakom;
- Sindop;
- Carbidopa;
- Levodopa;
- Pronoran;
- Eldepril;
- Yumeks;
- Tremonorm;
- Sinemet.
