The drug Don( Dona) is created for the treatment of osteoarthrosis of various pathogenesis.
The official name and the main active substance of the drug - glucosamine sulfate, which is a natural substance that is constantly present in the body and is responsible for metabolic processes in the cartilaginous tissues, provides the growth of connective tissue in the joints and tendons of the joints.
The use of the drug activates natural processes by increasing the glucosamine content in the body, stimulates the restoration of cartilaginous tissues, replenishment of the joint fluid.
When used for prophylaxis, Don warns of early destruction of cartilage.
The content of the article
- The effect of the drug on the body
- Indications for use
- When should medication not be used
- Forms of release
- Mechanism of action
- How to use
- Possible side effects
- Information from expert
- Say ordinary people
- What are the pros and cons of the medicine
- CostWhat can I replace a medicine with?
The effect of the drug on the body
In addition, the drug has an anti-inflammatory, analgesic effect, promotes the deposition of calcium in bone tissues.
The drug restores cartilaginous tissue;inhibits the processes of protein breakdown and accelerates their synthesis, that is, promotes the growth of muscle tissue;stimulates regeneration processes, inhibits the degeneration of cartilaginous tissue;relieves painful symptoms;Suppress the development of inflammatory processes.
Replacing the lack of natural glucosamine, Dona increases the permeability of the joint capsule walls, helps restore the enzymatic processes. Sulfate esters present in the preparation contribute to the maintenance of tissue elasticity, water retention.
The absorption of the drug occurs in the small intestine, from where the drug quickly and easily penetrates into the tissues, including the articular cartilage. Within 70 h half of the drug is excreted from the body.
Indications for use
Don is intended for prevention and treatment of the following diseases:
- primary deforming arthrosis, which causes destruction and thinning of the articular cartilaginous tissue;
- joint osteoarthritis( secondary), which causes joint pain and deformity;
- osteochondrosis of all parts of the spine;
- unco-vertebral arthrosis, affecting intervertebral discs, facet joints of the spine;
- brachyopathy periarthrosis and periarthritis of the shoulder joint, characterized by inflammation of the periarticular tissues in the large joints;
- chondromalation of patella( changes in cartilage).
When should medication not be used
Precautions should be taken to treat the drug in the presence of certain diseases, conditions, allergic reactions:
- in case of phenylketonuria, which is a hereditary disease that develops as a result of protein metabolism disturbance and causes serious changes in the CNS, it is inadmissible to use powderedform of the preparation;
- is inadmissible use of the drug in the pathology of kidneys and liver of severe severity;
- in the presence of a history of epilepsy, seizures of uncertain etiology excluded intramuscular injection of the drug;
- intramuscular application of the drug for acute and chronic heart failure and cardiac blockade, arterial hypotension;
- allergic reactions to sea shellfish, as well as adverse reactions to taking aspartame, lidocaine, are a contraindication to the use;
- in the presence of diabetes, it is necessary to control the level of glycemia in the body;
- is inadmissible for use in the presence of individual intolerance to the main and auxiliary components of the drug;
- does not prescribe the drug to women during pregnancy and feeding, as well as children under 12 years old, because clinical studies of safety on this group of people have not been conducted.
No adverse effects were observed with alcohol consumption on the background of the course of treatment.
Forms of release
Dona is available in tablets, powder, in injections: 
- Powder is packaged in separate bags containing the required dose of the drug.
- Capsules are sold in packs of 80 capsules.
- Injection is supplied as a set - 6 ampoules for injections and ampoules with a solvent. To improve the therapeutic effect, the course of injections can be combined with taking capsules.
Cases of drug overdose are not known. If the medicines are taken carelessly in doses exceeding those recommended by the doctor, gastric lavage should be performed, symptomatic therapy.
Mechanism of action
As already mentioned, the drug replenishes the body's deficiency of natural glucosamine. Due to the use, the production of hyaluronic acid and proteoglycans in the joint fluid is stimulated, the permeability of the joint capsule is increased, the enzymatic processes normalize, the processes of destruction of the articular cartilage are slowed down.
At the same time there is a restoration of the function of calcium deposition in bone tissue and fixation of sulfur, pain in the joints is gone.
Symptom reduction occurs after a couple of weeks. Recovery is observed a couple of months after the completion of treatment. The destructive processes in the joint are suspended, the structure of the cartilaginous tissue begins to recover.
How to use
Each package of the drug Don contains an instruction manual from which it follows that:
- Powder forms of take 4-12 weeks with a break of 2 months. It is necessary to take 1 sachet per day, pre-
dissolving in a glass of water. - The tablets are taken 20 minutes before meals. Capsules are taken three times a day, 1-2 capsules together with food, depending on the weight of the body and the degree of the disease. The course is one and a half to two months.
- For intramuscular treatment of Ampule A and Ampoule B are mixed in a syringe. Enter 3 ml of the prepared solution 3 times a week for 4-6 weeks.
Possible side effects of
Occasionally, there are cases of side effects of the drug:
- from the digestive tract: nausea, vomiting, constipation, flatulence, diarrhea;
- from the side of the central nervous system: euphoria, drowsiness, headache, disorientation, dizziness;
- from the cardiovascular system: cardiac conduction disorders;
- allergic reactions;
- tremor;
- numbness of the tongue, oral mucosa.
Information from the expert
Improvement in patients is observed after two weeks of continuous use of the drug.
The greatest effect is achieved with a course of treatment from 1 month , which lasts up to 2 months.
This explains the break in the course of treatment. At the same time, the success of the drug depends on the degree of the disease, the approach to treatment, the observance of restrictions during the treatment period, and the characteristics of the organism.
Normal people say
Most of the patients receive positive feedback about the effectiveness of the drug Don. The drug quickly relieves pain in the joints, it is effective in combination with physiotherapy procedures.
The disease has been tormenting for a number of years. The last two years I have been taking a course of treatment in the form of injections. The pains in the joints disappeared, they became freer than the movement.
Natalia
After two courses of the drug Don, the condition markedly improved
Olga
I very much hoped that immediately after using the drug, relief would come. The miracle did not happen. After the first course, she really began to feel better, but then the pain returned. I had to repeat the treatment. I drink 2 courses with breaks, 2 times a year. It's getting better, but I'll continue.
Marina
The drug should be taken on courses, several times a year, otherwise the effect will be unstable.
Sergey
The most effective are the injections, firstly the complete and immediate absorption and delivery of the substance to the tissues; secondly, the injection can be inserted at any time and only once every three days, thirdly the powder form is not very convenient, the tablets -excessive injury to the stomach.
Inga
What are the pros and cons of the drug
The drug gives high results of treatment, especially at the initial stage of arthrosis, almost completely restoring healthy functions of the cartilage tissue of the joint.
Due to the presence of natural glycosamine in the body, contraindications to use are minimal.
There are both positive and negative side effects of the drug.
The cost of the medicine
The price of the drug Don in various forms of varies from 1200 to 1400 rubles .
Shelf life is two years, subject to the conditions specified in the instructions. Keep the drug in a place inaccessible to children. The drug is dispensed at the pharmacy under the prescription of the doctor in charge.
How can I replace a medicine?
The following analogues of the drug exist according to the active substance:
- Glucosamine sulfate;
- Aminoarthrin;
- Sustilac;
- Glucosamine;
- Glucosamine hydrochloride;
- Chondroxide Maximum;
- Elbona;
- Pharmaskin TGC;
- Unium.
Replacement should be selected only by a doctor, due to the lack of a complete analogue of the drug Don.
Glucosamine, as an active substance, is found in such preparations as: Elbona, Elastenga, in the form of injections it is possible to advise such preparations as: Rumalon, Alflutop.
