Migraine is a neurological disease characterized by attacks of severe headache localized usually in one half of the head, although sometimes painful sensations spread to both halves.
Pathology is more common in women younger than 45 years. Attacks of a headache can last from several hours to several days.
Treatment of migraine complex. Along with other medicines, non-steroidal anti-inflammatory drugs are included in the treatment of the disease. One such drug is Nurofen.
Description of the drug
The active pharmaceutical substance of the drug is ibuprofen, which stops pain and inflammation, and has antipyretic effect.
The active substance blocks the production of prostaglandins, the main mediators of pain. In addition, ibuprofen increases the threshold of pain sensitivity, as a result, the pain senses weaken.
Also, the active principle of the drug suppresses the migration of leukocytes from the systemic blood stream to the damaged tissues, which leads to the elimination of the neurogenic inflammatory process, which plays a large role in the onset of migraine attacks.
Release Nurofen in several dosage forms:
- gel for external use;
- rectal suppositories;
- coated tablets and capsules for oral administration;
- syrup for children.
To eliminate migraine attacks, the drug is prescribed in tablets and capsules.
When taken orally, the effect occurs after a maximum of 25 minutes and lasts up to 5 hours. The active substance is excreted from the body mainly with urine, and only a small part through the intestine.
Accurate impact in the headache
To date, several types of drugs for oral administration are being produced. 
All of them differ in the form of release( capsule or tablet), amount of active substance, composition. Unchanged for all remains only entering into their composition ibuprofen. According to the instructions for the use of any of the types of Nurofen for internal use is prescribed for migraine and headache.
The main differences between different types of Nurofen among themselves is as follows:
- Conventional is an enteric coated tablet. The active substance in them is 200 mg. They are used to eliminate migraine attacks of mild and moderate degree. They can not remove the attack completely, but only weaken the pain syndrome.
- Express is manufactured in the form of special capsules, from which the active substance is released more quickly, and consequently the therapeutic effect comes sooner, but in time it lasts as much as with conventional tablets. They also can not completely stop a migraine attack, but only slightly relieve the patient's health.
- Express Forte is also available in the form of capsules, but the dosage of the active substance is 400 mg, which allows for a faster therapeutic effect. It is also taken for migraines of mild to moderate severity.
- Plus is available in tablets that contain codeine in addition to ibuprofen. Codeine has an additional analgesic effect. After absorption in the digestive tract, it flows into the brain with a blood stream, where it binds to opioid receptors and turns into morphine, blocks the production of substance P, as a result, the threshold of pain sensitivity decreases. In migraine attacks, Nurofen Plus not only eliminates the headache, but also removes the attendant symptoms,
such as nausea, phono and photophobia. However, he can eliminate migraine attacks of mild to moderate severity. - Nurofen The multi-symptom for headache and migraine is a combined preparation that also contains paracetamol in addition to ibuprofen. Paracetamol increases the analgesic and antipyretic effect of ibuprofen. Improvement of the patient's well-being is observed already 10 minutes after taking the medication. The therapeutic effect of the drug on average lasts up to 8 hours. This medicine was invented quite recently in 2015 and to this day various studies are under way, and its effectiveness has not yet been fully explored.
- Express Lady is manufactured in the form of tablets containing 0.4 g of ibuprofen, so the effect comes faster and it better eliminates the headache.
Dosage and admission scheme
If the doctor has not prescribed otherwise, the scheme for taking different forms of Nurofen is as follows:
- The tablets are allowed to be taken from 6 years if the child weighs a minimum of 20 kg. For patients from 6 to 12 years, a single dose of 0.2 grams, daily - 0.8 grams. The interval between taking the medication should last at least 6 hours. Patients over 12 years of age with a body weight of over 45 kg and adults are prescribed medication in a dosage of 200 mg to 4 times a day. With severe pain, 400 mg of ibuprofen can be taken immediately, but in this case the maximum multiplicity of intake should be 3 tablets in 24 hours. The highest daily dose should not exceed 1.2 grams.
- Forte is prescribed to patients over 12 years of age for 1 tablet( 400 mg) 3 times a day. It is inadmissible to increase the daily dosage of
medication. - Express is allowed to accept for citizens over 12 years of 1 capsule( 200 mg) 3-4 times a day. It is permissible to take 2 capsules of the drug at a time. In a day you can take no more than 6 capsules. The highest daily dosage for patients under 17 years is 1 g.
- Express forte is prescribed to persons who have reached 12 years of 1 capsule( 400 mg) up to 3 times a day.
- Multi-symptom for migraine attacks, adults are allowed to take 1 tablet up to 3 times a day. Children over 12 years of age and weight over 40 kg are allowed to stop a migraine attack taking no more than 2 tablets per day.
- Plus refers to drugs of strict accountability and it is allowed to take it as directed by a doctor. Patients who are already 12 years old are usually prescribed 1 tablet 3 to 4 times a day. A break between the next dose should be at least 4 hours. When severe pain is allowed at a time to take 2 tablets, and a day not more than 6 pieces. Children under 18 years old are allowed to drink a maximum of 5 tablets a day.
- Express Lady appoint patients with 12 years of 1 tablet 3 times a day.
The dosages of the drugs used to eliminate the usual headache and stop the migraine attacks are no different. But with migraine pains, the second capsule or pill should be taken earlier than the attack will begin to gain strength.
As an analgesic, all oral forms of medication can not be taken for more than 3 days without the permission of a specialist.
What ordinary people think about this drug.
I accept Nurofen as a multisymptom from migraine. If you have time to take the drug at the beginning of the attack, then the headaches are not so strong, and overall health is much better, there is no nausea, photo and phonophobia.
It's a pity that it is not possible to take the drug for a long time, as it breaks the liver.
Svetlana
Earlier Nurofen helped, and now the effect is zero, probably the body is used to.
Maria
Unfortunately, the drug does not eliminate the cause of the disease, but only slightly improves the overall well-being of the patient and then only if the attack is not strong and at the very beginning.
