Venlafaxine is a remedy for depressive disorders, anxious neuroses and generalized anxiety disorder.
The use of the drug is also practiced in the treatment of diabetic polyneuropathy, as well as migraines, which is in principle uncharacteristic for antidepressants.
Contents
- Formulation and Composition
- Pharmacological Profile
- At which indications are prescribed medication
- Contraindications and limitations - conditions and diseases
- How to take - safety and efficacy
- Reception during pregnancy and lactation
- Symptoms of overdose
- Adverse events
- Discharge syndrome
- Special instructions
- Overview of the doctor
- Patients have their own opinion
- Purchase of the drug and its analogues
Form release and composition
The drug is presentedIt contains tablets that have a flat-cylindrical shape and have a facet and a risk. The structure of the tablets is white or white-yellow. Tablets are placed in the cell contour packs of 1 piece. These packages are placed in a cardboard box of 1, 2, 3, 4, 5 pieces. Produced with a dosage of 34.5 mg and 75 mg.
Ingredients:
- the main component of is venlafaxine in a dosage of 37.5 mg and 75 mg;
- auxiliary components - microcrystalline cellulose, starch, silicon dioxide, talc, magnesium stearate.
Pharmacological profile
Venlafaxine has an antidepressant effect. This drug belongs to the group of antidepressants, it is a mixture of two stereoisomers with mirror reflections. But the chemical composition of the drug, it can not be attributed to the group of antidepressant drugs.
Structural formula of venlafaxine
Active components of the drug, as well as its metabolite, O-desmethyl belong to selective serotonin reuptake inhibitors( SSRIs) and dopamine reuptake inhibitors.
In addition, the main constituent elements of the drug can enhance the activity of neurotransmitters in the central nervous system. However, they have no affinity for opioid and benzodiazepine, m- and n-cholinergic receptors, histamine receptors. Do not have an overwhelming impact on the activities of MAO.
During internal application it is quickly absorbed. After a single intake, maximum absorption occurs after 2.4 hours, and absorption of the metabolite after 4.3 hours. Eating does not affect the absorption of the medicine. At the first pass is metabolized in the liver. During repeated use, equilibrium absorption is achieved within 3 days.
Venlafaxine and its metabolite approximately 27% and 30% bind to blood proteins. The duration of their half-life is 5 and 11 hours. Excretion occurs mainly by the kidneys.
At which indication is prescribed the medicine
The drug Venlafaxine is prescribed for the following disorders: 
- in the prophylactic therapy of relapses during recurrent depressive disorder;
- during the treatment of depression, which are accompanied by an alarming condition.
- for panic attacks and anxious neuroses;
- for the treatment of diabetic polyneuropathy;
- in a combination of prescriptions for migraine therapy.
Contraindications and limitations - conditions and diseases
Medication should not be taken under the following conditions:
- if there is an increased sensitivity to the constituent components of the drug;
- should not be taken concurrently with MAO inhibitors;
- if there are severe liver disorders;
- in renal failure;
- during pregnancy;
- when breastfeeding;
- for children and teenagers under 18 years.
Also it is necessary to take with care the medicine at following conditions:
- if the myocardial infarction was recently transferred;
- for unstable angina;
- during hypertension;
- if there is a history of convulsive manifestations;
- with increased intraocular pressure;
- if there is a predisposition to bleeding from the skin and mucous membranes;
- during glaucoma of the closed type;
- with suicidal tendencies;
- in the presence of hyponatremia.
How to take - safety and efficacy of
Tablets should be taken orally. During the reception they do not need to be broken, pounded and chewed. They are swallowed completely, while they should be washed down with a small amount of water.
You need to start taking the medicine with a dosage of 37.5 mg twice a day. After a week, the dosage can be increased by 75 mg per day.
During depression, you need to take 225 mg per day for 3 doses, during severe depression you need to take 125 mg three times a day.
The withdrawal of the drug is done slowly for 14 days and not more than 75 mg per week. During renal and hepatic insufficiency, the daily dosage should be reduced by 50%.
Admission during pregnancy and lactation
The instruction states that venlafaxine is not recommended for pregnant women, due to the fact that there is no evidence of the effect of the constituent components of the drug on the future child's organism.
In cases where the remedy was prescribed to pregnant women and when the expected benefit for the mother exceeded the risk for the newborn, the child was born with impairments - external respiratory depression, apnea, cyanosis, convulsive manifestations, constant crying, irritability, sleep disturbances.
When breastfeeding the drug is not recommended to take, because the constituent components of the medication fall into the composition of breast milk.
Symptoms of an overdose of
An overdose can most often result from the simultaneous administration of a drug along with alcoholic beverages and psychotropic drugs.
During an overdose, the following symptoms may appear:
- is a state of heightened drowsiness, sometimes turning into a coma;
- diarrhea;
- manifestations of dizziness;
- tremor;
- may decrease or increase blood pressure;
- manifestation of seizures;
- symptoms of ventricular tachycardia;
- appearance of changes in the ECG.
Adverse events
Among the side effects may be the following violations:
- state of weakness, increased fatigue, the occurrence of dizziness;
- may decrease appetite;
- occurrence of vomiting, constipation, increased dryness of the oral cavity;
- may increase cholesterol levels, weight loss;
- state of hypertension, tachycardia;
- manifestation of unusual dreams, insomnia, excitability, paresthesia, muscle spasms, increased muscle tone, tremor, serotonin syndrome;
- sometimes there may be a violation of ejaculation, anorgasmia, dysuric disorders, menorrhagia;
- problems with accommodation, dilated pupil;
- occurrence of a rash on the skin, erythema multiforme;
- can cause hemorrhages in the mucous membranes and skin.
Syndrome for withdrawal
If the withdrawal of the drug is abrupt, the following symptoms may occur:
- increased fatigue;
- state of increased drowsiness;
- occurrence of dizziness;
- nausea;
- state of anorexia;
- increased dryness in the oral cavity;
- state of insomnia;
- increased anxiety;
- increased irritability;
- the state of hypomania.
To avoid the development of all these symptoms, the dosage of venlafaxine should be reduced gradually.
Special instructions
When taking venlafaxine, it is worth paying attention to the following conditions:
- the effect of the drug is slow, therefore the first few weeks of treatment should be under the control of the attending physician;
- patients who before the start of treatment had suicidal tendencies and attempts to commit suicide should always be under the supervision of a doctor;
- for the treatment of patients who have a history of aggression, the drug should be taken with extreme caution;
- patients who have affective disorders, bipolar disorder that develops when taking antidepressants, should refuse to take the medication;
- taking this medication in patients with diabetes mellitus can lead to a change in blood glucose levels;
- during treatment it is necessary to refuse the use of alcoholic drinks;
- in order to avoid the appearance of unpleasant side effects, the withdrawal of the medicine should be gradual;
- at the time of therapy should be particularly careful when performing work that requires concentration of attention, as well as when driving a car.
A doctor's review of venlafaxine and feedback from patients who receive it can clarify many points regarding the administration of this medication.
Overview of the doctor
Venlafaxine is an antidepressant that helps to eliminate depressive disorders and concomitant mental disorders of the CNS.
I often prescribe to take this medication to my patients in the disorder of the nervous system, anxiety, panic fears, during severe depressive conditions.
At first, the effect of taking the drug is not observed, this is due to its slow action. After 1 year of admission, the condition is completely normalized, the nervous system is restored. However, in the first few weeks of treatment may appear side effects, but they quickly pass.
Doctor psychiatrist
Patients have their own opinion
Years ago, I had a lot of problems in my life that led me into a long depressive state. First of all, this is my son's illness, but, thank God, everything has returned to normal.
I was also betrayed by a loved one, and this was already an extreme measure. At that time, I just did not want to live, it lasted almost 1.5 years, and that's a lot. It appears in these cases it is necessary to go to the doctor, I did not know until my sister told me.
After the appointment, the doctor said that you need to drink the preparation of venlafaxine for 6 months. After a full course of treatment, everything was normalized, even side effects did not arise.
Vera, 32 years old
I started to notice 2 years ago that I have frequent attacks of depression, anxiety, panic fear. With each day, these conditions only intensified more and more. As a result, I began to sleep badly, there were severe headaches, irritability.
Immediately I went to see a therapist. He prescribed me to take Venlafaxine. I took it about 6 months, all the unpleasant symptoms passed, the condition returned to normal. However, during the first treatment there were many side effects.
Sofia, 29 years
Purchase of the drug and its analogues
The cost of packing No. 30 with a dosage of 75 mg is from 470 to 520 rubles. The price for the packaging of venlafaxine No. 30 with a dosage of 37.5 is between 190 and 360 rubles, and analogues of the drug are also available for purchase:
- Alventa;
- Velaxin;
- Venlaxor;
- Velafax;
- Venzuert;
- Daplex;
- VENLIFT OD;
- Newvelong;
- Ephevelone.
