Instructions for use for an antidepressant Paxil: reviews, analogues

Mental disorders, stress, depressive and anxiety conditions must be eliminated at the very first stage of their occurrence. You can get rid of them with the help of antidepressants.

These drugs include Paxil, which has a sedative effect and quickly restores the central nervous system, but this drug has numerous contraindications and side effects, so it should be used with extreme caution.

Form release and composition

This drug is produced in the form of tablets with biconvex form, which are placed in blisters of 10 pieces, and those in turn,in a pack of cardboard base. One bundle can contain one, three or nine blisters.

The composition includes:

• active element - paroxetine hydrochloride hemihydrate in an amount of 22.8 milligrams;
• additional components - calcium dihydrogen phosphate dihydrate, sodium carboxymethyl starch type A, magnesium;
• the composition of the stearic coat - Opadry white YS - 1R - 7003( macrogol 400, titanium dioxide, hypromellose, polysorbate 80).

Pharmacological properties of

Paxil belongs to the group of antidepressants. The mechanism of action of this drug is to inhibit the reuptake of the mediator serotonin by neurons of the brain.

The main constituent has a slight affinity with muscarinic cholinergic receptors, for this reason the agent has minor anticholinergic effects.

Due to the fact that Paxil has a cholinolytic effect, the main component causes a rapid reduction of anxiety, eliminates insomnia, has a weak initial activation result. In rare cases, it can cause diarrhea and vomiting.

But in connection with this, this drug has a cholinolytic effect, often during its administration there is a decrease in libido, constipation appears, and body weight increases.

Paxil has a negligible effect on the seizure of norepinephrine, dopamine. In addition, it has antidepressant, timoleptic, anxiolytic effect, also has a sedative effect.

Pharmacokinetics and pharmacodynamics

After application of the drug, the active substance is absorbed and metabolized immediately during the first passage through the liver. Therefore, a small dose of proxetine enters the bloodstream than that absorbed in the digestive tract.

Increasing the dosage of the active component occurs due to not strong saturation of the metabolic pathway and a decrease in plasma paroxetine clearance. As a result, uneven concentration increases. It follows that the pharmacokinetic data are unstable and the kinetics is nonlinear.

But the non-linearity of this remedy is poorly expressed, it is mainly manifested in patients who take low dosages. Equilibrium reaction in the structure of blood plasma during the application of this drug occurs only after 7-14 days of use.

The active substance Paxil is mainly distributed in tissues. According to the pharmacokinetic data, about 1% of the main element can remain in the blood. In concentrations of the therapeutic type, almost 95% of paroxetine in the blood plasma can be bound to proteins.

The elimination half-life is between 16 and 24 hours. About 64% goes along with the urine in the form of metabolites, about 2% unchanged, the rest together with the feces in the form of metabolites and 1% unchanged.

When to apply, and when to refuse

According to the instructions Paxil must be used at the following indications:

• depressive states with varying degrees of severity, as well as their relapses;
• for various panic disorders;
• to eliminate obsessive-compulsive disorders;
• for phobias of social type;
• for stress disorders of a post-traumatic nature;
• for alarm violations of the generalized type.

Paxil should not be taken under the following conditions and indications:

• for adolescents and children under 18 years of age;
• for women during pregnancy;
• during breastfeeding;
• if there is an individual intolerance of the constituent components;
• allergic reactions to the drug;
• if patients take medications such as Nialamide, Selegiline and Thioridazine.

How to take the drug

Tablets are taken orally, at the time of ingestion they are swallowed in their entirety. At reception it is impossible to break tablets, to grind in the form of a powder or to chew. To facilitate swallowing, drink with a small amount of water. One tablet a day is taken. Take it in the morning during breakfast.

For depressive conditions, you need to take 20 mg per day. If you suddenly need, then the dosage level can be increased by 10 mg, but the highest dose should not be above 50 mg. Changes in dosage should be made no later than 14-21 days after the start of application.

Dosage during an obsessive-compulsive disorder should be 40 mg in 24 hours. The initial dose level is 20 mg per day, then every 7 days it is added to 10 mg. The highest dose at 24 hours should not be above 60 mg.

For panic disorders for adults, the dose at 24 hours should be 40 mg. At the beginning of the dose, the dosage should be 10 mg per day and slowly increased by 10 mg every 7 days. The highest dosage level should not be above 60 mg in 24 hours.

With social phobias, generalized anxiety disorders, post-traumatic stress disorders, it is recommended to take 20 mg of the drug per day. Begin reception with 10 mg per day and gradually every 7 days the dose is increased by 10 mg. The maximum dose per day should not be more than 50 mg.

Taking the drug in pregnancy and during lactation.

The use of the drug during pregnancy is contraindicated, especially at a late

.There were cases when mothers who took Paksil drug at the last term, children were born with such disorders as apnea, convulsions, cyanosis, increased excitability, unstable temperature, pressure.

Taking medication during breastfeeding is not recommended because components make up the milk.

Adverse events and overdose

During the use of Paxil tablets, the following side effects may occur:

• may experience problems with or lack of appetite;
• appearance of bruising on the surface of the skin and mucous membranes;
• occurrence of increased cholesterol levels in the blood;
• can sometimes cause hallucinations;
• state of lethargy, sluggishness;
• manifestation of headaches, dizziness;
• disorders of somnological nature - insomnia, a state of drowsiness, the occurrence of nightmares;
• may experience a state of emotional arousal;
• manifestation of involuntary muscle contractions;
• can sometimes cause heart palpitations;
• appearance of pupil dilated, blurred vision;
• disorders of dyspeptic type - diarrhea, constipation, nausea, hypo-salivation;
• appearance of hyperhidrosis;
• occurrence of yawning;
• sometimes there may be a decrease in libido;
• appearance of a rash on the skin surface;
• weight gain.

The withdrawal syndrome of Paxil is manifested by the following unpleasant symptoms:

• dizziness;
• paresthesia;
• sleep disorders;
• occurrence of hyperhidrosis;
• appearance of nausea;
• appearance of anxiety status.

When taking an increased dose, the following symptoms of overdose may appear:

• vomiting;
• occurrence of dilated pupils;
• occurrence of fever;
• alarm status;
• change in blood pressure - increase or decrease;
• occurrence of involuntary muscle contractions;
• appearance of agitation;
• the state of tachycardia.

If this symptom occurs, gastric lavage is performed, the patient is given activated charcoal 20-30 mg every 4-6 hours during the day. After that, supportive therapy is conducted.

From the practice of applying

A review of the doctor and testimonials of patients who experienced the effect of Paxil on themselves.

Price of the issue

The price of packing the medicine Paxil No. 10 is about 650-700 rubles, packing No. 30 costs about 1700-1800 rubles, and analogues are also available for purchasing:

• Adept;
• Plizil;
• Paroxetine;
• Aktaparoxetine;
• Apo-paroxetine;
• Sirestill;
• Rexetin;
• Plizil N.