1 General Information

De-Nol tablets in their composition contain:

• bismuth titrate dicitrate( 1 tablet 304.6 mg);
• povidone K30 - 17.7 mg;
• magnesium stearate - 2 mg;
• potassium polyacrylate - 23.6 mg;
• macrogol 6000 - 6 mg;
• corn starch - 70.6 mg( all components, except for the first component, are auxiliary).

The envelope consists of: macrogol 6000 - 1.1 mg - and hypromellose - 3.2 mg.

De-Nol product has the following form of release: 7 or 14 blisters, each with 8 tablets. The latter have a round shape, slightly convex. The shell is white in color with a cream shade. The smell is almost not felt. On one side of the tablets there is an inscription( gbr 152), and on the other there is an image( square with indistinct edges, corners rounded).

Store this medication at a place not accessible to children, at a temperature not exceeding 25 ° C, but not less than 15 ° C.Do not allow direct sunlight to hit the medicine. Since the release of De-Nol is suitable for use for 4 years. At the end of this time, it is not recommended to use it, as this will lead to poisoning at best.

Packed blisters in a cardboard box. In the pharmacy you can buy the drug without a prescription, however, it is recommended to take De-Nol only for the purpose of a specialist. He received good reviews and recommendations from both professionals and patients.

2 Pharmacological action

De-Nol has antiulcer, anti-inflammatory, antibacterial, astringent and gastroprotective effect on the digestive system. It can affect the ulcer from different parts of the pathogenesis.

The bismuth contained in the medicine contains citrate and oxychloride. These components, getting into an acidic environment, do not undergo dissolution in the stomach, and they create chelating formations with the protein substrate. The latter make it possible to form a film in the area of ​​ulcers and erosions on the walls of the stomach and duodenum, which has a protective effect.

The application of De-Nol allows to improve the work of cytoprotective mechanisms, and also increases the possibility of the mucous membrane of the gastrointestinal tract to withstand the negative effect of hydrochloric acid, pepsin, enzymes. Preventing the ability of the acidic environment to adversely affect the mucosa, the drug makes it possible to quickly heal emerging lesions. The antibacterial effect of the drug is based on a decrease in the enzymatic activity of the pathogenic microorganism. As a result, complete destruction of bacteria is achieved.

During treatment, the agent under consideration can change the cell membrane, which gradually makes the harmful bacterium less strong, as a result, it can not effect adhesion. The bismuth sub-citrate is easily soluble, therefore, deeply penetrating the layers of the shell, it affects harmful microorganisms. This makes it possible to get rid of the disease and reduces the risk of relapse.

The gastroprotective effect of De-Nol is due to the increase in the level of mucin, along with which the amount of bicarbonate ions increases. These processes contribute to the formation of a barrier that performs a protective function. Simultaneously, in the antrum, microcirculation is stimulated, which leads to better metabolism and quick recovery of the affected mucosa.

The considered preparation is relatively effective in relation to the secretion of hydrochloric acid, as it makes it possible to reduce its level, which affects the reduction of juice in the stomach. De-Nol is not absorbed into the digestive system, but is excreted from the body together with feces. If ingested, the plasma is excreted by the kidneys.

3 When are the drugs taken?

Indications for use may be as follows:

• stomach ulcer;
• duodenal ulcer;
• gastritis;
• gastroduodenitis;
• irritable bowel syndrome;
• functional indigestion.

It is recommended to take De-Nol with peptic ulcer diseases of the stomach and duodenum, including acute and chronic forms, if the disease in question is peptic. The ulcer is characterized by the defeat of the mucous membrane of the organs, it occurs under the influence of various pathogenic bacteria, hydrochloric acid, etc. In turn, the use of De-Nol allows bactericidal effect on the affected areas.

Also suitable for acute or chronic gastritis and gastroduodenitis. The first disease is characterized by inflammatory processes on the gastric mucosa, and the second is accompanied by inflammation of the duodenal membrane.

To apply De-Nol is effective enough for functional dyspepsia, which manifests itself with periodic abdominal pain, but the lesion of the digestive tract is not diagnosed. Recommended for use if the patient has irritable bowel syndrome only if the disease occurs with such symptoms: fever, nausea, vomiting, loose stools.

In addition to the above diseases, indications for use may include varying degrees of damage to the walls of the stomach and intestines as a result of taking non-steroidal anti-inflammatory drugs.

4 Admission Regimen

In addition to indications for use, it is important to learn how to properly treat the drug in question. Take De-Nol needed inside, while immediately drink the product( and not chew) a small amount of liquid to get a faster and more favorable result( better with ordinary still water, but not recommended milk, juice).

In each case, the dosage is prescribed by the attending physician depending on the stage of the disease development. Instruction for the use of the drug provides a course of treatment for 4 weeks. According to the recommendations of the specialist, the treatment is extended to 8 weeks. At the end of this period, it is recommended to abandon other medicines containing bismuth( for 2 months).During the course of treatment, it is not possible to take other medicines containing bismuth, since intoxication of the organism is possible.

If De-Nol is taken in more than indicated in the instructions, an overdose is possible. It leads to poisoning and disruption of normal functioning of the kidneys. The termination of reception promotes normalization of functioning of the specified bodies. At the first signs of poisoning, it is recommended to wash the stomach and take a special medicine, for example, activated charcoal.

5 Strictly prohibited

There are various contraindications regarding the application of De-Nol. First of all, they apply to patients who have kidney disease( kidney failure).You do not need to resort to this drug if you are using another medication containing bismuth in parallel. It is best to take the pill after eating.

It is not recommended to take De-Nol for children under 4 years. Before using the drug, you need to make sure that the patient does not have allergies to components that are part of the De-Nol.

There are also contraindications to the use of the drug in question by pregnant and lactating women. If the pregnant woman will take this medicine, then the appearance of gene mutations, the development of various vices and anomalies in the fetus. In a nursing woman, the product penetrates into the milk, which can cause various disturbances in the functioning of the baby's body. If you absolutely need to take De Nol, you need to stop breastfeeding.

Side effects of a different nature may occur due to individual intolerance or failure to comply with the conditions for the correct use of the medication. With the use of De-Nol, GI disorders can occur, which are manifested by symptoms such as nausea, vomiting, fever, constipation, or loose stools. However, they do not represent any danger to the patient's health and do not last long.

Allergy may be accompanied by the appearance on the skin of the rash. With prolonged use of the drug in question in large quantities, the bismuth contained therein negatively affects the activity of the central nervous system. At the first appearance of violations in the work of the body, it is necessary to stop using the drug De-Nol, which will allow the patient to return to normal.

De-Nol is a medicinal product that is recognized as highly effective in controlling ulcers of the stomach and duodenum. It is well tolerated by patients and in most cases does not cause side effects. The most favorable effect can be obtained by applying it within the framework of complex treatment of the disease.