Tiapridal( Tiapridal) belongs to the group of neuroleptics, it has antipsychotic, general sedative, hypnotic and analgesic effect on the human nervous system.
Produced in the form of tablets and a solution for injection in ampoules of 2 ml of 200 mg.1 tablet and 1 ampoule contains 100 mg of Tiaprid hydrochloride, the main active ingredient.
It is used for various mental disorders and neurological disorders.
Additional ingredients of the formulation are:
- povidone;
- cellulose;
- solution or dry substance mannitol;
- magnesium;
- of silicon dioxide.
Content
- pharmacological profile
- Indications and contraindications to
- Dosing
- Symptoms and Treatment
- overdose Adverse reactions
- Cautions
- Compatible with alcohol and other drugs
- use during pregnancy
- Reception children
- From practical application
- Buying and storing
Pharmacological
profile The antipsychotic effect of the drug is provided by blocking the dopamine receptors in the corticalm, limbic, hypothalamic brain regions.
Active components of the drug are able to depressingly affect the vomiting center and the reticular formation. Receiving Tiapridal helps reduce the dyskinetic attacks of central origin, relief of symptoms of intoxication with alcoholic substances, has an analgesic effect. The advantage of the drug is that it does not inhibit the consciousness and intellectual activity of a person.
After applying the drug substance orally in a dosage of 200 mg, its concentration in the blood plasma reaches a maximum within an hour, with intramuscular injection after half an hour.
Biological availability is approximately 80%.Is able to penetrate into the cerebral cortex and through the placental barrier during pregnancy.
The half-life is about 4 hours, the drug is excreted by renal filtration with urine. If the patient suffers from acute or chronic renal failure, filtration of the decay products slows down with prolonged circulation of the substance in the bloodstream. In the presence of pathologies of the kidneys, the dosage should be selected individually.
Indications and contraindications for prescription
The drug is used in the following cases:
- for the elimination of symptomatic signs of psychomotor overexcitation, as well as aggressive emotional background, which is often found in chronic alcoholics and the elderly;
- for chronic pain syndrome.
Children over 6 years of age Thiapridal is prescribed in the following cases: 
- of a different type of chorea;
- Tourette's syndrome;
- aggressive behavior and agitation.
The use of the drug is contraindicated in the presence of increased individual sensitivity to the active ingredients or in case of an allergic reaction.
Also medicament is not prescribed in such cases:
- the presence of a benign or malignant tumor process in the brain regions;
- adrenal malignancy or chronic insufficiency;
- pregnancy and lactation, as the penetration of chemical degradation products through the barrier of the placenta and into breast milk has been proven;
- hypertensive disease of the cardiovascular system;
- kidney failure in acute or chronic type.
How to use
Before taking Thiapridal, you should evaluate the general condition of the patient. The initial use of the drug begins with small doses, with a gradual increase in dosage.
The first dose should not exceed 100 mg during the day, if there is no positive therapeutic effect, then the dosage should be increased by 100 mg per day during the week.
The standard therapeutic dose is 200 -300 mg per day. For children over 6 years of age, the dose should not exceed 150 mg per day.
Drug in the form of a solution for intramuscular injection is used only for the treatment of adult patients in the absence of positive dynamics from oral treatment with antipsychotic.
The dosage is the same as for oral administration, but in case of acute delirium the dose may be 1000 mg throughout the day, depending on the severity of the disease.
Symptoms and treatment of an overdose of
Symptomatic signs of an overdose of Tiapridal are manifested in the form:
- of central nervous system depression;
- increased blood pressure;
- disorders of the extrapyramidal nervous system;
- increased drowsiness and rapid increase in fatigue;
- of a coma.
For relief of overdose symptoms, it is necessary:
- to abruptly discontinue the use of Tiapridal;
- to drink a medication provoking the development of a vomiting reflex;
- to conduct therapy aimed at eliminating the symptoms of intoxication with parallel monitoring of the functioning of vital organs and systems.
No specific antidote has been developed to date.
Adverse Reactions
Adverse reactions may occur with prolonged use of the drug: 
- violation of contractility of muscle fibers;
- extrapyramidal disorders;
- complete relaxation of smooth muscle and striated musculature;
- sharp decrease in blood pressure indicators right up to vascular collapse;
- increase in body mass index;
- a sharp increase in the total temperature of the unexplained etiology.
Special instructions
Due to the fact that this preparation has a wide range of pharmacological effects, it inhibits the functioning of the nervous system, which can lead to the following negative reactions:
- , disorders of skeletal muscle contractility, by suppression of the peripheral nervous system;
- depression of consciousness;
- sharp decrease in blood pressure;
- fever with unexplained etiology.
The use of thiapridal in the presence of sinus bradycardia or impaired potassium metabolism in the body can lead to serious disturbances in the cardiac conduction system.
Before starting the use of the drug, it is necessary to adjust the level of potassium in the body, it is necessary to provide adequate control of the general state of the person and electrical excitability of the heart.
With prolonged use of the medication, it is recommended to refrain from managing any types of vehicles, as well as from hazardous working conditions. This is due to the oppression of the mental and emotional state.
Compatibility with alcohol and other medicines
The use of antipsychotic drugs with alcohol substitutes is contraindicated, since they have the opposite mechanism of action. Such combination can provoke the development of alcohol intoxication up to a coma.
Tiapridal is not prescribed in combination with dopaminergic agents because their combined use can lead to the development of vascular collapse and a sharp decrease in cardiac output. A sharp discontinuation of the drug may trigger the development of withdrawal syndrome.
Caution is used with Tiapridal in conjunction with antihypertensive drugs, this combination can trigger a sharp drop in blood pressure with the development of vascular collapse. Opioid analgesics when used together with antipsychotic drugs lead to an intensifying oppressive effect on the central nervous system.
Use during pregnancy
The use of thiapridal and other antipsychotics is strictly prohibited during pregnancy and lactation.
The ban on the penetration of degradation products and chemical compounds through the barrier of the placenta with a pronounced toxic effect on the growth and development of the fetus in utero is based.
In case the use of the drug is necessary, dosing should be minimal with the maximum reduction of the course of therapeutic treatment. How does the drug affect a child during lactation to this day has not been studied yet, but it is better to feed from a bottle during the period of treatment with mixtures.
Admission of children
For children older than 6 years, the drug is prescribed for the treatment of trochees and cognitive disorders caused by neurological causes. Children younger than six years of age, the drug is contraindicated.
From the practice of using
Specialist opinion and feedback from patients who took Tiapridal.
My mother has been suffering from manic-depressive psychosis for 10 years already. Since recently, the doctor psychiatrist has appointed the use of Tiapridal in a dose of 200 mg per day for arresting attacks of aggression and hallucinations.
The reception does not cause negative consequences, it helps to cope with attacks of aggression.
Galina 45 years
Recently I have widely used in my clinical practice Tiapridal for the treatment of patients with schizophrenia, manic-depressive syndrome and various kinds of psychosis. During the use of this drug adverse reactions among patients revealed nebylo.
Elena Nikolaevna, psychiatrist, seniority robots 35 years
Taking into account the feedback from patients and doctors, it should be noted that the drug has a positive therapeutic effect with a low risk of side effects.
Purchase and storage of
The price of Tiapridal is between 700 and 1000 rubles, the only analogue is Tiaprid.
Leave at the pharmacy only on prescription from the treating doctor.
Store the product in a cool, dark and not accessible place for children.
