Arthrosan - is a non-steroidal anti-inflammatory drug .Has a pronounced antipyretic and analgesic effect.
Meloxicam is the active substance of the drug.
The effect is due to inhibition of cyclooxygenase-2( COX-2) activity, it has less effect on COX-1, which is involved in the synthesis of prostaglandins( PG).
Table of contents
- Pharmacokinetics of drug
- Indications for use
- Contraindications
- Dosage of drug
- Form release
- Overdose and additional indications
- Side effects
- Special instructions
- Interaction with alcohol
- Reception for dysfunction of kidney and liver function
- Interaction with other drugs
- Reception duringpregnancy and lactation
- How do doctors and patients respond about
- What patients say
- Opinion of doctors
- Advicethe reception
- Pros and cons of medication
- cost medications
- Shelf life
- Holiday in pharmacy
- analogues medications
Pharmacokinetics
drug bioavailability of the active ingredient Artrozana is 89%.With a simultaneous intake with food, the percentage of suction does not change. Well absorbed in the gastrointestinal tract.
The maximum concentration is achieved after 4-5 hours. The half-life is 12-14 hours.
99% of meloxicam binds to plasma proteins.
The difference between maximum and basal concentration in the body is small and is a ratio( 2.5: 1).
The conditional distribution space is 11 liters. The desired plasma concentration in the steady state is achieved after 3-5 days.
It is excreted equally with urine and feces.
Indications for use
As follows from the instruction, the drug is prescribed for degenerative joint diseases, in particular, for the removal of acute and chronic pain.
Suitable for arthritis, ankylosing spondylitis, osteoarthrosis.
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Contraindications
There is also a rather large number of contraindications:
- individual hypersensitivity to the components of the drug;
- children under 15 years;
- renal or hepatic insufficiency;
- peptic ulcer of the duodenum or stomach, transferred to erosive and ulcerative lesions of the gastrointestinal tract;
- Aspirin Asthma;
- pregnancy, lactation;
- heart failure.
Drug Dosages
Instructions for Use on Punctures and Tablets Arthrosan indicates that the drug can be administered orally, rectally, intramuscularly, depending on the form of release.
The dosage is selected individually, the minimum effective dose is:
- , the initial dose is 7.5;
- is taken once a day( 7.5 - 15 mg) with meals, without chewing;
- rectally - 1 suppository per day;
- with the simultaneous administration of tablets and injections intramuscularly the daily dosage should not exceed 15 mg;
Form
Tablets are issued in this form: 
- for 10 tablets in a blister, 1 /2/3/ 5 blisters in a package;
- for 15 tablets in a blister, 1 /2/ 3 blisters in a package.
Nyxes: ampoules of 2.5 ml 3 /5/ 10 pieces per package.
Candles: 7.5-15 mg of active substance in a candle weighing 25 /50/ 100 mg.
There are 10 suppositories in the packaging.
Ointment: 5% ointment in tubes 30/50 g.
Overdose and additional instructions
In case of an overdose, nausea, bleeding in the digestive tract, vomiting, asystole, renal and hepatic insufficiency, loss of consciousness, epigastric pain.
Hemodialysis, forced diuresis and alkalization of urine are ineffective in overdose with Arthrosan, as it has a high binding ability with blood proteins.
Side effects of
Often( 1 case per 100), the following side effects occur:
- dyspepsia, nausea, vomiting;
- skin rash, itching;
- dizziness, drowsiness;
- belching;
- anemia.
Sometimes( 1 case per 500):
- stomach and duodenal ulcer;
- gastrointestinal bleeding;
- tinnitus;
- the formation of an abscess with intramuscular entry;
- heartbeat, hanging blood pressure;
- exacerbation of bronchial asthma, cough.
Rarely( 1 case per 5000):
- photosensitivity;
- multiform erythema;
- toxic epidermal necrolysis;
- renal medullary necrosis;
- bullous reactions;
- disorientation.
Very rare( 1 case of 10,000):
- hyperbilubinemia;
- hyperemia of the face;
- leukopenia;
- esophagitis;
- conjunctivitis.
Specific guidance
Arthrosan is not recommended for smokers, patients with alcohol dependence and addiction.
The drug is administered with caution to patients with diabetes mellitus, with pathology of the peripheral arteries.
The drug reduces blood clotting.
Interaction with alcohol
Severe, unforeseen conditions are possible after taking, in particular, large doses of alcohol, which can be lethal.
Admission for dysfunction of kidney and liver function
Exacerbation of any kidney or liver disease should be considered when planning the use of the drug. And it is possible only with hemodialysis.
Interaction with other drugs
Preparations of the group SIOZ, fibrinolytics, antagonists of vitamin K, Heparin increase the risk of bleeding.
Take with caution the intrauterine contraceptive means, since Arthrosan can reduce the contraceptive effect.
Arthrosan reduces the effectiveness of antihypertensive drugs.
When taken concomitantly with diuretics and Cyclosporin, acute renal failure may develop.
The reception of Kolestyramin accelerates the excretion of meloxicam from the body.
Preparations of the NSAID group increase the risk of ulceration of the gastrointestinal tract.
Admission during pregnancy and lactation
To 
, reception for pregnant and lactating women is prohibited, meloxicam negatively affects the fetus, provokes internal bleeding in the digestive tract, disrupts the normal functioning of the kidneys.
It is not advisable to take the drug for women planning pregnancy, as they reduce women's fertility.
How doctors and patients respond about
We offer to study the review of doctors and patients who used injections or tablets Arthrosan.
What the patients say
Rheumatoid pain has resumed. I went to the doctor, he appointed Arthrosan. The pain subsided, but at first the head was very dizzy. A week later, dizziness has passed, acute attacks of pain have passed.
The doctor advised to take another two weeks and continue to act on the situation. They say, for the elderly, Arthrosan is not recommended, so I am observed during treatment with the doctor regularly.
Lyudmila, 57
Suddenly I was struck with pain in my knee. In the hospital, they prescribed Arthrosan. The price, of course, did not please me, but I had nowhere to go. After a two-week admission, the pain was gone. No side effects observed.
Igor, 41
One day I had sharp pains in my back. I lay in bed and could not even out.
MRI examination showed an intervertebral hernia. We prescribed Arthrosan, first 6 injections, one per day, and then tablets as needed. I feel much better now.
Svetlana, 35
Physicians opinion
In general, Arthrosan is popular among prescribed non-inflammatory anti-steroid agents, for the treatment of arthritis and similar diseases, in doctors.
Neurologists highly evaluate the drug in the ability to localize and suppress acute pain.
Tips for taking
Correct dosage or cancel taking medication only with a doctor's prior advice.
It is undesirable to drive a car, or work on site with the necessary increased care.
Advantages and disadvantages of the drug
Minus is the deficit in pharmacies, such form of Arthrosan as gel and candles, even with their effectiveness they occupy a very small niche among anti-inflammatory drugs.
The plus of this drug can be considered that it can be prescribed for a long time, since it does not have a strong depressing effect on the body.
Cost of medication
The price of injections( ampoules) No. 10 for 2.5 mg of substance - 392 rubles.
Price of tablets 20 pcs.15 mg, - for 205 rubles.
Conditions and shelf life
Shelf life of the tablets is 2 years, the solution for intramuscular injection is 5 years.
Avoid exposure to direct sunlight. Store in a dark and dry place, with a temperature of no higher than 25 degrees Celsius.
Keep out of the reach of children.
Leave at the pharmacy
With prescription.
Analogues of
Analogues Arthrosan analogues whose price is lower and the quality is better
Arthrosan is a pain reliever with anti-inflammatory and antipyretic effects in the treatment of osteoarthritis, pain. ..
