How to take Concord 5 mg and 2.5 mg tablets - instructions for use

Before taking Concor tablet, you should read the Instruction for Use.

Concor - composition of the preparation

Concor tablets are a preparation of a group of beta-blockers. The main substance in the composition of tablets is bisoprolol. Basically, it is not on metabolic processes or airway resistance.

Excipients are:

• calcium hydrogenorthophosphate in a volume of 132 mg;
• corn starch in a volume of 14.5 mg;
• silica colloid in a volume of 1.5 mg;
• microcrystalline cellulose in a volume of 10 mg;
• crospovidone in a volume of 5.5 mg;
• and magnesium stearate in a volume of 1.5 mg.

Produced by Concordor 5 mg and Concor 2.5 mg tablets.

Indications - from what help

Concor tablets are prescribed for heart diseases:

• of hypertension;
• in the diagnosis of ischemic heart disease;
• with stable angina in the patient;
• as well as with chronic heart failure.

Action by

It works by blocking beta 1-adrenergic receptors of the heart, and reduces the activity of sympathoadrenal systems. With a single use, a patient with coronary heart disease feels a decrease in heart rate. Simultaneously, it reduces the shock volume of the heart, which in turn reduces the need for myocardium in oxygen.

With prolonged administration of the drug, a decrease in the total peripheral resistance of the vessels is observed. The greatest effect can be observed after 3-4 hours from taking the drug. The peculiarity of Concor is also that in the course of 24 hours after application, its effect is preserved. In order to minimize blood pressure, appoint a course for up to two weeks.

Concor tablets when taken internally for 90 percent are absorbed by the gastrointestinal tract. Cleansing of the drug occurs through the kidneys and liver.

Contraindications

1. The drug can not be taken in the presence of acute heart failure, also with chronic insufficiency, which is in the stage of decompensation.
2. It should not be used in cases of sinoatrial blockade, severe bradycardia, at a heart rate of less than 60 beats per minute, when the patient has a lowered blood pressure( this is a systolic - less than 100 millimeters of mercury).Also with severe forms of bronchial asthma and chronic obstructive pulmonary disease.
3. You can not also drink Concor in the presence of Raynaud's disease, pheochromocytoma, metabolic acidosis, and up to 18 years.
4. It is also not recommended to use if there is sensitivity to the components in the formulation.

Instructions for Use

Tablets are taken orally once a day. It is recommended to drink with water before meals, or during meals. Do not chew the drug or wash it in powder.

Special instructions for receiving:

1. 
   Arterial hypertension and angina pectoris .The dose of the drug is prescribed individually, taking into account the heart rate and well-being of the patient. Initially, a dose of 5 mg is prescribed, if necessary, increased to 10. The maximum possible dose is 20 mg.
2. Chronic heart failure .Before discharge of the drug, the doctor usually prescribes titration. To receive tablets, the patient should not have an exacerbation of heart failure. To prevent impairment, it is recommended to take Concor 2.5 mg tablets once a day, dividing in two. Thus, for the first time the patient takes 1.25 mg, then slowly increasing to 2.5, then - to 3, 75 and then - to 5 mg and so to 10 mg per day.

The dose should be increased strictly under the supervision of a physician, in the presence of a positive reaction. The maximum possible dose of the drug is 10 mg. At the same time, constant monitoring of blood pressure and heart rate is necessary, as well as follow the symptoms of chronic heart failure. It is likely that the patient may feel worse after taking the first dose of the drug against the background of titration. In this case, the dose can be reduced. In extreme cases, consider the option of discontinuing the drug.

Often, Concor's reception is long-term, sometimes until the end of life. Strictly not recommended for children until 18 years of age. It should also be used carefully in case of type 1 diabetes, as well as with severe renal or hepatic impairment, in the diagnosis of cardiomyopathy, heart disease or heart valve. There was no reliable data on the use of Concor in the presence of these diseases.

Possible side effects of

In the instruction itself, Concord has an impressive list of side effects. Nevertheless, this drug is much better tolerated by patients than blockers of the old generation. Therefore, the presence of side effects is very unlikely.

Usually side effects are:

1. From the side of the central nervous system. Patients may note weakness, fatigue, headache and dizziness, nightmares at night or insomnia, anxiety, anxiety, depression, fatigue, minor confusion, trembling and numbness in the limbs.
2. Sense organs. Deterioration of sight, hearing, conjunctivitis, problems with tearing, and dry eyes are noted.
3. Cardiovascular system problems. Sedation bradycardia, palpitations, atrioventricular blockade, heart rhythm problems, worsening of symptoms of patients with chronic heart failure, such as: dyspnea, swelling. There are also arterial hypotension, vasospasms, which are manifested as cold feet and pain in the sternum.
4. GASTROINTESTINAL TRACT.A feeling of dryness in the mouth, nausea, vomiting, problems with the stool, taste problems are noted.
5. Respiratory system. Injected nasal sinuses, breathing problems, bronchospasm.
6. Endocrine system. Increases blood sugar in diabetics, or decreases. Weakened thyroid function.
7. Allergic rashes are possible.
8. Skin symptoms. Sweating, frequent redness, psoriasis.
9. The blood levels of platelets, leukocytes and agranulocytes change. Increase in liver enzymes and bilirubin.
10. Pregnant women may experience developmental delay, decrease blood sugar and decrease heart rate in a child.
11. Also possible joint pain, decreased libido, withdrawal symptoms.

When comparing Concor with beta-blockers of the old generation, it can be noted that the side effects are identical, but the frequency of their occurrence in Concor is several times lower. In any case, the use of this drug should be carried out with the advice of a doctor.

Compatibility with other

preparations

1. With the combination of Concor with medications for inhalation and with phenytoin, its ability to reduce heart rate and blood pressure increases.
2. If a patient has diabetes mellitus, the drug weakens the action of insulin, and can also cause symptoms of lowering blood sugar. Palpitation may increase and blood pressure may rise. On the other hand, relatively old beta-blockers, in Concor these features are weaker.
3. Concor in the patient's blood worsens the withdrawal from the body of lidocaine and xanthines. Because of what these substances for a long time can be in the body.
4. Also, the reduction in pressure with Conkor safely converts to "no" due to non-steroidal anti-inflammatory drugs, hormonal contraceptives and estrogens.

There is also a risk of increased bradycardia in patients who take Concor in conjunction with:

• cardiac glycosides;
• methyldopa;
• with reserpine and guanfacin;
• with verapamil and diltiazem;
• with amiodorone;
• with other anti-arrhythmia medications.

Arterial pressure decreases more strongly with the combination of Concor with such drugs:

• nifedipine;
• by diuretics;
• by clonidine;
• sympatolytic;
• hydralazine;
• other medicines against hypertension.

Any antidepressants, neuroleptics, alcohol and hypnotics, taken with Concor, strongly depress the central nervous system. In addition, Concor can not be used in combination with MAO inhibitors. If this is neglected, the blood pressure can be greatly reduced, so it is recommended to take a break between courses in two weeks.

Concor in chronic heart failure

The drug has proven effective in treating patients with chronic heart failure. This is confirmed by the results of many international studies, which were carried out back in the 90's. More than three thousand patients with chronic heart failure participated in these studies, which made it clear that:

• Overall mortality decreased by 34 percent.
• The risk of death decreased by 44 percent.
• The number of hospitalizations decreased by 20 percent.
• Hospitalizations with weighted symptoms decreased by 36 percent.

CONCLUSION IN CHD( coronary heart disease)

In the same 90 years, studies were conducted of the effects of bisoprolol in Concor's composition and its effect on the treatment of coronary artery disease. In the study, 330 patients with ischemic heart disease and angina pectoris were examined. They received 10 mg of the drug per day for a month, the next month the dosage was doubled. The results show that the increased dose does not have a noticeable improvement, but the drug itself effectively reduces the risk of death, acute myocardial infarction, and likelihood of hospitalization with a diagnosis of unstable angina.

Thus, Concor is a modern advanced and selected drug from the group of beta-blockers. It is proven to cope well with increased blood pressure, coronary heart disease and hypertension. In the presence of many side effects, in reality they are very rare, and the medicine is well tolerated by patients. Its use can significantly reduce the frequency of angina attacks. Also, it does not harm the smooth muscles of the body, for example, bronchi or arteries.

Advantages of

Unlike other beta-blockers, this drug has several advantages:

• It should be taken only once a day, since the action is long.
• You can take without food, and do not chew.
• Affects exactly the organs that are needed, thereby reducing the percentage of side effects, compared to other blockers.
• Does not reduce potency. Among the side effects this effect, of course, is indicated, but only in rare cases, patients noted deterioration of potency.
• It can be used for type 2 diabetes, or for people at increased risk of diabetes.
• It is easy to apply to people elderly.
• There is a significant number of analogues.
• Affordable price.

Reviews on the use of Concor confirm the effectiveness of the drug.

Analogues and the price of

preparations As Concor is a medicine based on bisoprolol, you can always ask the medicine in the pharmacy where it is present.

Analogues:

• Carvedilol.
• Amlodipine.
• Norvasc.
• Lercamen.
• Bisoprolol.
• Niperten.
• Coronale.
• Atenolol.

Average cost of Concor varies depending on the packaging and the region. The cost of the drug in St. Petersburg and Moscow:

• Concor 2.5 mg 30 tablets in a package - 160-170 r
• Concor 5 mg 30 tablets in a package - 220-230 rubles.
• Concor 5 mg 50 tablets in a package 330-350 rub.
• Concor 10 mg 30 tablets in a package 340-360 rub.
• Concor 10 mg 50 tablets in a 500-550 package.

What is better for Concor or Bisoprolol?

When buying the desired beta-blocker with bisoprolol, there is a choice between the foreign drug - Concor, and the Russian - Bisoprolol. In favor of Russia is its price - about 30-40 rubles, in the packaging is also exactly 30 tablets of 5 mg of substance, only they differ in shape and color - round, yellow. However, it is not purchased so often, probably because of the lack of advertising.

What is better Concor or Coronale?

Coronal also contains bisoprolol, it is produced by a company from Slovakia. These drugs are equally active, but the Coronal at a cost is at least 100 rubles from the drug Concor.

Thus, the main difference is only in the price and advertised drugs.

Feedback on application

Review No. 1

Well helped my mom. She suffers from high blood pressure, often because of this visits the doctor, but all had problems with the selection of the right drug. Necessary was that so that well influenced the rhythm of the heart and the blood pressure.

This drug has helped. Stabilized the heart rate and increased blood pressure. With this, no side effects. And it is quite inexpensive only 200 rubles. I recommend!

Irina, 29 years - Moscow

Reviewed № 2

Hello, my man was recently diagnosed with a very unexpected diagnosis - arrhythmia. We immediately turned to the doctor, he ordered us Concor. In the pharmacy sold tablets Concor 5 mg and 2.5 mg. We took 5, it turned out to be more practical. In the package itself 30 tablets, and very cheaply -250 rubles. We had enough for a couple of months, following the dosage, broke the tablets in half and took them once a day.

They are by the way yellow, and in the shape of a heart, and breaking comfortably. I myself have been taking beta-blockers myself for a very long time. About six months ago I bought a new one - Concor. This is the most original of the entire list of benoprolol medicines. And probably, therefore, more expensive than others. I liked it, very convenient pill.

Since I take 1.25 mg, I usually purchase a 2.5-mg Concor package. Great - I drank it and forgot it until the next day. Another very convenient and detailed instruction. For all this time there are no complaints, there are no side effects either.

Анастасия, 38 years - Спб

Review № 3

It helped. I myself am already elderly, and my heart problems have long had an arrhythmia with tachycardia. I tried a lot of drugs, but when I was assigned to Concor I finally felt the long-awaited improvement. Just every day before eating I take a pill. My dose is usually 5 to 10 mg, according to the advice and under the supervision of my doctor.

Therefore, I take a packing of tablets of 5 mg. By the way, the prices depending on the pharmacies vary, you can find for 170 rubles, and for 220. Although it is dispensed without a prescription, but it has many side effects and I do not recommend using it without a special doctor's appointment. .. Everyone's health!

Daria, 63 years old - Novosibirsk

Review No. 4

I started using it during pregnancy. My doctor sent me to a cardiologist who diagnosed a sinus tachycardia. Then he appointed Concor. After reading his instructions, I was upset, it was written that my child may develop a bradycardia. But still listened to the cardiologist, and as it turned out not in vain.

Since the first application of the change has not felt, but the next day the pulse decreased from 145 to 73. I was very pleased. I took it for about two weeks, during which time my pressure decreased, my pain in the side receded, my breath shortened. By the way, I was still very touched by the packaging and the shape of the tablets - such hearts with a break in half. And the price for a heart drug is low, only 230. And with the baby it's all right!

Evgeniya, 31 year old