Ketoprofen is a drug related to non-steroidal anti-inflammatory drugs.
In most cases, it is used for the treatment of joint diseases, when degenerative-dystrophic changes in the cartilaginous tissue are observed followed by an inflammatory process.
The application should only take place as directed by the doctor and under his close supervision.
Table of contents
- Pharmacological action of
- Pharmacokinetics of
- Indications for use
- When to not use
- preparation Forms of release
- Rules for taking
- Dosage selection is important!
- Overdosage of her and the consequences of
Pharmacological action of the drug
Ketoprofen is prescribed during an exacerbation of rheumatoid arthritis and osteoarthritis.
Within a short period this remedy can eliminate pain, relieve inflammation and reduce the local temperature of the joints.
Regular application of the presented medicinal product is able to bring human joints to the initial healthy state within a few days.
A person will not experience pain when moving and at rest. The morning stiffness of actions and a characteristic swelling will disappear.
Pharmacokinetics of
The drug is often used as an external application, which does not lead to rapid positive results, as the absorption of the agent is very slow. As a result, it turns out that the bioavailability of the drug does not exceed 5%.
After penetration, the agent is metabolized by conjugation involving glucuronic acid. Such behavior in the human body leads to the possibility of withdrawal of the agent in the form of matabolites through the kidneys.
The mechanism of action of this agent is associated with the suppression of COX-1 and COX-2, regulating the synthesis of prostaglandins - biologically active substances formed in the body and provoking the appearance of an inflammatory process.
Indications for use
As already described above, Ketoprofen is used in the treatment of joint diseases.
But its ability to exert an anti-inflammatory effect gives the advantage of using the remedy in the most unexpected moments. For example, with gum disease or ENT diseases, a solution of Ketoprofen for rinsing is used.
All diseases of the joints that lead to inflammatory processes are subject to detailed examination.
So, the drug is used to treat the following diseases:
The instructions for use indicate that Ketoprofen in the form of intramuscular, intravenous injection or when taking tablets is used in the diagnosis of diseases:
- rheumatoid arthritis is an inflammation of the joints, having a wide variety of backgrounds;
- osteoarthrosis - proliferation of bone tissue of joints due to degenerative-dystrophic changes in cartilaginous tissue;
- sciatica is a pain symptom due to a lesion of the sciatic nerve;
- gouty arthritis - degenerative joint changes with subsequent deformation;
- extraarticular rheumatism - inflammation of bone and muscle tissues;
- pseudogout - deposition in the joints of crystals of calcium pyrophosphate;
- post-traumatic pain - both in joints and bones;
- renal colic - obstruction of the urinary tract with a violation of the outflow of urine;
- myalgia - inflammatory process of intervertebral cartilage caused by hypothermia;
- radiculitis - inflammation or deformation of the nerve root of the spinal cord.
Locally applied in the form of applications using gel and ointment Ketoprofen in the diagnosis of the following diseases:
- tendosinovitis - inflammation of the periarticular ligaments;
- knee meniscus damage - damage to the cartilage lining in the knee joint;
- re-arthritis - inflammation of the joint capsule;
- sprain - damage due to incorrect movement or unsuccessful exercise;
- tendonitis - inflammation of the tendons;
- torticollis is a congenital disease characterized by underdevelopment of the sternocleidomastoid muscle;
- osteochondrosis - pinching of the nerve root of the spinal cord;
- Spondyloarthritis( Bechterew's disease) - chronic inflammation of the joints;
- thrombophlebitis of superficial veins - inflammation of the vein walls and presence of thrombus.
This is not the whole list of diseases in which Ketoprofen is used in various forms of its release.
When the
should not be used, ketoprofen, despite all its positive qualities, has contraindications for use.
The presence of the following diseases is distinguished here in a person who is banned from any use of the drug:
- pancreatitis, gastric ulcer and other diseases of the gastrointestinal tract;
- renal and hepatic insufficiency;
- pregnancy( in the third trimester);
- proctitis and hemorrhoids, if the use of the drug in the form of suppositories is implied;
- skin diseases;
- children under 6 years of age as external use;
- is prohibited for children under 12 years of age as an oral medication.
Forms of release
Ketoprofen is manufactured in such types:
- drops for oral administration;
- tablets with different component content;
- capsules with different component content;
- injection;
- lyophilized dry matter for the manufacture of intravenous and intramuscular injections with a varying proportion of the component;
- gel and cream with different concentrations for external use;
- aerosol for topical topical use, more commonly used as an anesthetic.
Rules for receiving
Only the attending physician can prescribe the treatment regimen, which diagnoses the disease in a person through a series of examinations.
But approximate dosages can be indicated by reading the instructions for use of the drug Ketoprofen.
The choice of dosage is important!
The dosage of the drug is always regulated by the attending physician. But every patient should remember that using the drug more than the allowable dose can lead to poisoning and other negative consequences.
Experts almost always take this into account and use suitable release forms with an acceptable fraction of the component content.
Despite the neglect of the disease, ingestion of Ketoprofen should not exceed the following maximum daily rates:
- At the initial stage of treatment, the medication can be used in maximum doses - up to 300 mg during meals. Maximum dosing of the drug is divided into 2-3 times.
- After elimination of an exacerbation the agent is used in doses not more than 150-200 mg per day. Reception is also carried out during meals.
- If the drug is used in the form of candles, then the maximum dose is equivalent to 200 mg per day.
- A gel or ointment is used twice a day, followed by a dry bandage.
Overdosing it and the consequences of
Overdose can be achieved with the slightest increase in the allowable dose of the drug given above.
Side effects of the drug include:
- nausea and vomiting;
- constipation or diarrhea;
- headaches and dizziness;
- increased blood pressure;
- drowsiness or excitability;
- appearance of rashes and other skin lesions.
If a person suffers from GI disorders and uses the drug without prescribing a doctor, he may be hospitalized with ulcer bleeding and other exacerbations of an already existing disease.
In some cases, if the drug has been used in the presence of contraindications, for example, pregnancy, liver failure or a child, but the dosage was met, there will also be signs of an overdose, with their subsequent progression.
For children, overdose can cause turbidity and loss of consciousness.
Rectal use beyond the permitted dosage may cause itching and skin rash.
From the practice of doctors
Comments of doctors who use in their medical practice Ketoprofen.
Ketoprofen is a new generation drug widely used in all fields. It perfectly relieves pain and inflammation, therefore it is often used in the postoperative period.
Doctor resuscitator Alexander Bystrykin
I always prescribe gel and cream to my patients who have back problems in the form of osteochondrosis and other inflammatory processes.
Physician nevrapotolog Irina Dolgushina
Overheard at the hospital
Reviews of interviewed patients who are treated with Ketoprofen are positive.
Used the drug in the form of gel immediately after pregnancy. Diko was sick with a back. I was helped almost immediately. In principle, I did not notice any side effects. Probably, you should not take tablets during lactation.
Anastasia, 26 years old, the city of Nizhnevartovsk
I hurt my leg at work. Knee-joint. A week went, limped. A friend advised to use Ketoprofen, I note that I used both gel and spray for severe pain. He only smeared gel for the night.
The result was visible in a week. The main thing is to follow the instructions. But it's better to see a doctor for a check-up after all.
Alexey Kotomsky, 42, Samara, Russia
Pros and Cons of
As a plus of the presented means, one can single out its rapid positive impact. Problems with the application of no one did not arise.
But they all used Ketoprofen according to the instructions for use, taking into account the permissible dosage.
Many of them before the application turned to the doctor, who explained the scheme of application depending on the diagnosis of the disease.
Cost of medicine
Price of Ketoprofen depending on the form of release:
- tablets - average cost within 170-220 rubles per package;
- substance-powder - the average cost of 70 to 90 rubles;
- solution for intramuscular injection - within 100 rubles;
- gel - 70 - 80 rubles per tube in 50 g.
Terms and Conditions of storage
Store the drug out of the reach of children at a temperature of not more than +25 degrees Celsius. Shelf life of the drug from the date of manufacture - no more than 2 years.
The drug is dispensed in a prescription pharmacy.
Possibility of replacing
Ketoprofen analogues, more affordable or available in pharmacies:
- Artrum;
- Bystrumgel;
- Vallusal;
- Ketonal;
- Fastum gel;
- Flamax;
- Fleksen and others.
