Tevanat is produced by the Israeli company Teva. Its active substance is alendronic acid, which suppresses the destruction of bone tissue. Inhibitor of bone resorption.
The preparation is available in the form of flat round white tablets with a bevel and the letter "T" on one side.
Contents of the article
- Pharmaceutical products of the drug
- In what diseases is the drug prescribed?
- When should I refrain from accepting funds?
- Possible adverse effects
- Treatment regimen
- Cases of overdose
- Drug interaction
- Special instructions
- Storage and dispensing conditions at the pharmacy
- Opinion of specialists and patients
- Similar medications
Pharmaceutical drugs
Alendronic acid, which is part of Tevanata, is an inhibitor of osteoclasts that destroy bonetissue, thereby inhibiting bone resorption. Increases the mineral density of the bones of the skeleton, participates in the formation of bone tissue with a normal histological structure.
When taken on an empty stomach in a dosage of 5 to 70 mg for 2 hours before breakfast, the bioavailability of the active ingredient in men is 0.6%, in women 0.64%.
If the medicine is taken 1-1.5 hours before meals, its bioavailability will decrease by 40%.When the pharmaceutical is taken after a cup of coffee or a glass of juice, the bioavailability decreases by 60%.
Once in the body, alendronic acid is not metabolized. Up to 78% of it is associated with proteins. First, the active substance is distributed in soft tissues, then quickly migrates to the bone, where it is either fixed or excreted unchanged with urine.
In this case, its level in the blood plasma decreases very quickly, and from the bone tissue is released slowly.
In what diseases is the drug prescribed?
Drug is prescribed for people suffering from postmenopausal osteoporosis, to reduce the likelihood of compression fractures of the spine and fractures of the femoral neck.
When should I refrain from accepting funds?
Contraindications to taking the drug are:
- individual intolerance;
- hypocalcemia;
- pathology, which slows the movement of food through the esophagus( including stenosis or achalasia of the cardia);
- inability of the patient to sit or stand for a minimum of half an hour;
- severe renal failure;
- severe anomalies in the exchange of macro- and microelements;
- age under 18 years;
- pregnancy;
- lactation.
The drug should be taken with caution if the patient suffers:
- with digestive tract diseases in the acute phase;
- hypovitaminosis D.
Possible undesirable effects of
The following negative reactions are possible when taking the remedy:
- From the digestive system : indigestion, gastralgia, acidic eructation, loose stools, constipation, dysphagia, bloating, gastritis, stomach ulcer, nausea, vomiting, esophagitis, stenosis or integrity of the esophagus, bleeding from the upper parts of the digestive tract.
- From the musculoskeletal system : myalgia, arthralgia, convulsions, osteonecrosis of the jaw, fatigue fracture of the proximal femur.
- From the metabolism of substances : hypocalcemia, hypophosphatemia.
- From the central nervous system : headaches, dizziness, perversion of taste sensations.
- From the viewpoint of : uveitis, episcleritis, scleritis.
- Allergy : rashes, itching, erythema, urticaria, Quincke's edema, malignant exudative erythema, Lyell's syndrome.
At the beginning of the treatment, there may be muscle pain, general weakness, fever. These symptoms eventually pass.
Scheme of treatment
The drug is taken orally once every 7 days. At least half an hour before breakfast, taking other drugs or drinks. Tablets can not be chewed, should be drunk only with ordinary drinking water, since any other drink reduces the bioavailability of the medication.
After taking the drug inside, you need to sit or stand for half an hour. Do not take the pill while in bed or at night.
In case the patient forgot to take the pill, he should drink it the next day in the morning and continue the treatment according to the scheme, which would be written out from the very beginning.
Cases of overdose
In the event of an overdose, vomiting, loose stools, heartburn, hypocalcemia, hypophosphatemia, esophagitis or the appearance of the mucosa of the digestive tract may occur.
To bind alendronic acid, it is indicated that milk or antacids containing calcium are taken. Because of the likelihood of developing esophageal irritation, do not induce vomiting.
The victim should be in an upright position.
Drug Interaction
When taken concurrently with food, drinks, or pharmaceutical preparations for ingestion in a composition that has calcium, it is possible that the adsorption of alendronic acid is impaired. Therefore, a break between them should be at least half an hour.
Non-steroidal anti-inflammatory drugs increase the undesirable effects of alendronic acid on the digestive tract.
Special instructions
Since there is a high probability of damage to the esophagus, it is worthwhile to see a doctor if there is or increased heartburn, swallowing act disorder, pain when swallowing, or chest pains.
Patients suffering from Barrett syndrome, you can take the drug, only by comparing all the pros and cons.
In patients at risk( cancer patients receiving chemotherapy, radiotherapy, undergoing treatment with corticosteroids or with poor oral hygiene), osteonecrosis may develop.
More often the process is observed after tooth resection and / or as a result of infection attachment. Therefore, during the treatment with biophosphates 
, it is necessary to exclude any dental procedures.
Patients suffering from hypocalcemia, hypovitaminosis D and hypoparathyroidism need to drink before the beginning of treatment drugs normalizing the mineral metabolism.
With prolonged therapy with the drug( from 1.5 to 10 years), it is possible to develop stress fractures that can appear even without injuring the body. Often, such fractures are symmetrical, so if the bone is damaged on one side, then it is necessary to constantly check the integrity of the other limb.
The drug has no sedative effect and does not affect the ability to drive a car
Storage conditions and leave at the pharmacy
Produced in the form of tablets placed in aluminum foil. In one blister there are 4 tablets, in the box there can be 1 or 3 blisters.
The drug is dispensed from the pharmacy strictly according to the doctor's prescription.
Store the medicine in a place protected from children and light at a maximum temperature of 30 degrees.
Opinion of specialists and patients
From the reviews of patients and doctors who practice the appointment of Tevanata.
I have been taking Tevanat once a year for 72 years already, which is very convenient. At the same time I drink Calcemin. Last time did densitometry: noticeable improvements.
Venus, Kazan
The drug has proved effective in the treatment of postmenopausal osteoporosis, the drug reduces the risk of fractures in all categories of citizens.
During treatment, you need to listen very carefully to your body, as against the background of therapy can develop a number of unwanted symptoms dangerous to life. Therefore, if there is a severe heartburn or pain syndrome when taking the medication, you should immediately contact a specialist to adjust the treatment regimen.
Natalia Alexandrovna, orthopedic physician
Similar medications
The following Tevanat analogues are currently available for sale: 
- Alendrochern;
- Alendronate;
- Ostalon;
- Ostererepair.
Replace Tevanat with its analogue only with the permission of a physician.
It must be remembered that self-medication is unacceptable, since the drug has a number of contraindications and side effects that can cause significant harm to health.
