Features of the application of Naizilat: instructions, reviews

The appearance of pain in the back and in the joints may be the main symptom of the emergence of a serious illness of the ODA.If, at the time, you do not pay attention to discomfort and discomfort in the joints, then in the end it can cause complications that can lead to difficulties in movement and sometimes disability.

Nasilat is one of the modern drugs for eliminating the pain syndrome and inflammatory process in diseases of the spine and joints that belongs to the NSAID group.

Form release and constituent components

Nizilate is available in the form of tablets,orye are in the form of capsules. Above there is a film shell with a white or almost white structure. Have a characteristic odor. Tablets are placed in blisters of 10 pieces, which are contained in boxes of cardboard 2 pieces each.

What components are available in the composition:

• the main active element is amtolmethine guacyl;
• lactose monohydrate;
• hypromellose;
• colloidal silicon dioxide;
• sodium carboxymethyl starch;
• magnesium stearate.

Components contained in the film shell:

• hypromellose;
• titanium dioxide;
• macrogol 400.

Pharmacological profile

Neisylate refers to anti-inflammatory non-steroidal drugs. The drug relieves pain, relieves inflammation, fever. And also has a desensitizing, gastroprotective effect.

The active substance reduces the process of gluing together platelets, causes blocking of cyclooxygenase of the first and second type, causes a change in the metabolism of arachidonic acid, reduces the synthesis of prostaglandins, inhibits the exudative and proliferative phase of inflammation.

Causes blockage of bradykinin with tissue receptors, reduces pain in the focus of inflammation. Has an effect on thalamic pain, reduces the content of amines with a biogenic type, which possess allogeneic qualities.

In addition, the active ingredient of the preparation prevents the intensity of pain sensations, reduces the morning stiffness and increases the amplitude of movements in the joints 4 days after the start of therapeutic therapy.

Pharmacokinetic properties of

The absorption process after application of the drug is quite fast and occurs in full. There is accumulation of the drug in the walls of the digestive organs.

The high concentration of the active ingredient in the digestive system lasts about two hours. During the metabolism is subjected to hydrolysis by esterases of blood and in this process there are several metabolites - MED5, guaiacol and tolmetin.

As a result, all the decay products become active metabolite - tolmetine. This component in the course of its activity has a pharmacological effect in the tissues.

The level of binding to plasma proteins reaches 99%.The total elimination period is about 10 hours. After 24 hours, the excretion in the urine is 80% and 20% is released along with the bile.

Scope of Application

Nisylate should be used in the following conditions:

• during developing osteoarthritis;
• for rheumatoid arthritis;
• for Bechterew's disease( ankylosing spondylitis);
• for pain relief in bursitis;
• during articular syndrome during gout;
• for vertebrogenic pain syndromes;
• in the event of tendovaginitis;
• during the treatment of arthralgia;
• for trigeminal neuralgia;
• for intercostal neuralgia;
• during the pain syndrome of a different nature;
• for the treatment of headaches and dental pain;
• with painful periods in women;
• if pain is present during burns and traumatic injuries.

Contraindications and limitations

The drug should not be used if the following indications and conditions are available:

• should not be used if there is an allergy to tolmetine, amtolmethine;
• during bronchial asthma, allergies to Aspirin, and also if there is a recurrent polyposis;
• during peptic ulcer disease of the stomach and duodenum;
• presence of gastrointestinal bleeding with active course;
• if cerebrovascular bleeding occurs;
• if there are problems with blood coagulability;
• abnormalities in the intestines, which are accompanied by inflammation - ulcerative colitis, Crohn's disease( if these disorders occur in acute form);
• during heart failure with decompression type;
• for severe kidney and liver damage;
• for arterial hypertension;
• should not be used during the postoperative coronary artery bypass surgery;
• if there is intolerance to components such as lactose, as well as in the presence of a deficiency of lactase, glucose-galactose malabsorption;
• in the period of bearing of the child;
• during breastfeeding;
• should not be used by teenagers and children under 18 years of age.

Medication should be used with caution during the following conditions:

• if there is hyperbilirubinemia;
• if there is ischemic heart disease;
• for heart failure in chronic form;
• for pathologies of cerebrovascular type;
• if there is diabetes mellitus;
• if there are lesions of peripheral arteries;
• in the presence of renal failure of chronic course;
• patients in old age.

Application features: Schemes and dosages

At a time, one tablet with a dosage of 600 mg is recommended. In a day you need to take 2 tablets, each of which is washed down with a sufficient amount of liquid.

If the condition improves or the pain is not strongly pronounced, the dosage can be reduced to 1 tablet per day. In this case, the maximum daily dosage in any case should not be above 1800 mg.

In order for the medicine to retain its gastroprotective effect it is best applied on an empty stomach.

Pregnancy and lactation period

Because the constituent components of the drug may have a negative effect on the child, the medicine should not be used during pregnancy.

Ingredients are excreted together with breast milk, so the medication is not taken during breastfeeding.

Cases of overdose and induced complications of

When receiving increased dosages of the medication, unpleasant conditions may appear:

• occurrence of nausea;
• abdominal pain;
• vomiting;
• may cause metabolic acidosis.

If these symptoms appear, it is recommended to wash the stomach, also the patient must take activated charcoal. After this, you need to conduct symptomatic therapy.

During the application of Naisilat, the following side effects may occur:

• digestive disorders - nausea, dyspepsia, upsetting, vomiting, may cause a peptic ulcer;
• infectious lesions in the urinary tract are sometimes observed;
• problems with visual functions;
• occurrence of tinnitus;
• disorder in the respiratory system - the appearance of bronchospasm, rhinitis, shortness of breath, laryngeal edema;
• disorders in the nervous system - dizziness, drowsiness, the appearance of depressive conditions;
• may show a rise in blood pressure;
• disorders in the hematopoiesis system - a condition of anemia, thrombocytopenia, leukopenia;
• reactions on the skin - the appearance of rashes, purpura, the emergence of dermatitis, urticaria;
• may have various anaphylactic reactions.

Special instructions for

During the use of the medicine, the following important points should be noted:

• when using the drug, it is necessary to monitor the condition of peripheral blood, as well as the general condition of the liver and kidneys;
• treatment should be discontinued 2 days prior to taking corticosteroids;
• when using a medicine it is recommended to refrain from performing potentially dangerous activities that require increased concentration of attention.

Practical experience with

The use of Naisilate is really effective in joint diseases, which is confirmed by numerous reviews of patients and doctors.

Purchase of the drug and its analogues

In Russia, the price of one package of the preparation Naisilat №20 averages from 360 to 400 rubles, the following analog preparations are also available for purchase:

• Nimid forte;
• Naklofen;
• Orthophene;
• Panoxen;
• Argett Rapid;
• Dexketoprofen.