Allopurinol belongs to the group of drugs of antipodal action, which corrects the exchange of uric acid in the body.
The drug is available in the form of tablets for 100 and 300 mg in cans from light-protective glass or contour-cell packings.
The prescription drug is dispensed.
Composition number 1:
- allopurinol - 100 ml;
- sucrose - 20 mg;
- starch - 77.67 mg;
- magnesium stearate - 1 mg;
- food gelatin - 1.33 mg.
Composition number 2:
- allopurinol - 300 ml;
- lactose monohydrate - 49 mg;
- carboxymethyl starch - 20 mg;
- magnesium stearate - 4 mg;
- food gelatin - 5 mg;
- colloidal silicon dioxide - 2 mg.
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- Driving
- Drug interactions
- Side effects and overdose
- Overdose
- Average drug price
- Conditionsstorage What are the analogues of medication?
- Reviews of patients and doctors
- Advice on admission based on reviews
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Pharmacological action
Antifungal agent. The effect of the drug is directed to the violation of destructive synthesis of uric acid and its deposition in the tissues of the body and kidneys in the form of urate deposits.
Increases the excretion in the urine of xanthine and hypoxanthine.
Indications for use
- gout;
- lymphosarcoma;
- hyperuricemia;
- psoriasis;
- of uricosuria;
- urolithiasis;
- kidney failure;
- violation of purine metabolism in children.
Contraindications are also :
- dysfunction of the liver and kidney;
- exacerbation of gout;
- diabetes mellitus;
- pregnancy;
- lactation period;
- drug intolerance;
- other cases determined by physicians.
Dosage of medication
Allopurinol Egis tablets and its analogs indicate the following dosages:
For adults
Is used orally after a meal. The daily dose( 300 mg and more) should be divided into several doses of 100 mg.
Take plenty of fluids( water) at reception. In this case, to ensure that the daily volume of urine was not less than 2 liters, and its reaction - slightly alkaline or neutral.
The dosage of the drug is selected by a specialist individually, according to the severity of the ailment and the age of the patient:
- mild form of the disease - up to 200 mg;
- is an average disease - up to 500 mg;
- for severe disease - up to 900 mg;
- for elderly patients - low dosage.
At the onset of the disease, the dosage is monitored by a blood test for uric acid.
As a rule, a decrease in the percentage composition of uric acid under the action of the drug is observed in a day or two after the appointment.
For children
Children are prescribed such dosage:
- up to 10 years - from 5 to 10 mg / kg per day;
- up to 15 years - from 10 to 20 mg / kg per day.
Special recommendations
It should be noted that:
- The drug is not prescribed in cases of asymptomatic uricosuria, because dissolution of large stones of urate origin is possible with other methods of therapy.
- The administration of the drug to children is performed in exceptional cases of congenital impairment of purine acid metabolism and malignant neoplasms.
- Do not prescribe the drug for an acute attack of gout until it is completely stopped.
Special conditions
Discontinuation of the drug leads to a renewal of the violation of uric acid metabolism in the body for 4-5 days.
After two weeks there may be a complication of the disease, so the course of therapy should be continuous and long-lasting.
Drinking and taking medication
It is not recommended to drink alcohol in the course of treatment with Allopurinol.
Driving the machine
With prolonged treatment with the drug, there is a decrease in concentration and a decrease in reaction on the road, which is especially important when driving.
Interaction with
preparations The following should be considered:
- When interacting with coumarin anticoagulants, hypoglycemic agents and
arabinoside with adenine, the effect of these drugs is observed. - Allopurinol activity decreases with interaction with salicylates and uricosuric preparations.
- The use of allopurinol causes the accumulation of mercaptopurine and azathioprine in the body with simultaneous administration.
Side effects and overdose
- bradycardia and hypertension;
- disorders of the gastrointestinal tract in the form of diarrhea, nausea and vomiting;
- dysfunction of the liver;
- dysfunction of the central nervous system and peripheral nervous system of varying severity;
- violation of visual functions of varying degrees;
- disorders of the hematopoietic system;
- violation of the urinary system;
- endocrine disruption;
- allergic reactions of different localization;
- furunculosis;
- hair discoloration;
- hyperlipidemia.
Side effects may appear to a minor extent, but may show severe symptoms of the disease.
In some cases, the side effect of the drug is single.
Overdose
In case of an overdose:
- nausea;
- vomiting;
- dizziness;
- diarrhea.
The average price of the drug
- Allopurinol-Aegis( 90 - 123 rubles );
- Allopurinol( Organic) 50 pcs.- 65 rubles ;
- Allopurinol( Borshchagov) 50 pcs.- 71 rubles .
Storage conditions
The drug is stored in a light protected location at an acceptable temperature of + 30 degrees. Shelf life - no more than three years.
What analogues of medication exist?
- Purinol;
- Allpol;
- Alopron;
- Sanipipurol;
- Allopurinol-Aegis( Hungary).
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Reviews of patients and doctors
My father took Allopurinol for a long time. Tired side effects: anemia, increased blood sugar, pressure, exacerbated cataracts.
I had to have surgery before my eyes. Elderly people should not use this drug, yet my immunity does not cope with the stresses.
Alla, 42 years old
My elder brother had painful bouts of gout, could not sleep. When he began to drink Allopurinol, the pain gradually decreased.
It is said that allopurinol gout will not cure to the end. But at least the pain diminished. Many thanks. I'm happy for my brother.
Said, 36 years old
I take Allopurinol for prophylaxis, a little bit( a quarter of a tablet two days later for the third).
This helps to remove salts from the body. I feel dizzy after the pills, I can not help it. But the pain disappeared, and I can sleep without sleeping pills. So it turns out.
Lydia, 52 years old
I've been drinking for two weeks now. The rash on the body went, the itching is terrible. I do not know what to do. The pain has decreased, and the allergy has tortured. I choose the lesser of evils.
Amina, 48 years old
I did not get the drug. The pressure jumps, the vision has fallen, the allergy in the form of a rash, the arms and legs grow numb, the weakness is constant, the kidneys become ill.
In general, there were more side effects. Maybe it's just me. I decided to share my impressions. The medicine stopped drinking.
Nikolay, 53 years
I accept Allopurinol 5 years for 100 mg. I forgot what gout is.
I sleep peacefully, do my favorite thing, I live without trouble. Every year I take tests for uric acid. The medicine helped me a lot.
Alexander, 58 years old
Erectile function was broken. This is a catastrophe. What to do? I did not think that everything was so serious.
Сергей, 36 years old
I must listen to doctors. Has stopped to drink Allopurinolum, and again began to suffer from pains. For prevention, it is possible to conduct courses of taking allopurinol for 2-3 visits per year. And everything will be all right.
Boris, 49 years old
Advice on admission based on reviews of
That's what patients advise in their responses to Allopurinol.
I recommend everyone just to follow a diet. What I did: ruled out all the milk( except butter and cottage cheese), beans, tomatoes in any form, peanuts and beer.
For tea added sesame oil, juniper, walnut and cedar nuts, lemon. I eat a lot of celery and leeks.
I will be happy if my experience helps someone. Be healthy.
Vadim, 46 years old
I've been drinking allopurinol for two years. I feel great.
Plus to this I keep a diet and go in for sports. I think that it's not much use to just sit on some tablets. It is necessary to exclude products that cause gout. I advise everyone to do this.
Igor, 43 years old
You just need to stop drinking alcohol. Or or. Either you want to be healthy, or you will suffer. I sat on a diet, which the doctor advised.
Do not overuse, do not smoke, I'm dieting. Now I feel normal. Allopurinol I take half a day.
Became a little add physical load. If you want to live - you will observe both the diet and pills to drink, and you will refuse vodka and beer. And I want to live.
Андрей, 55 years
