How to safely and effectively take Arthrosilen

The drug Arthrosilene, which contains the main active ingredient Ketoprofen, widely used in inflammatory processes of the periarticular tissues, accompanied by increased soreness.

Arthrosilene is available in various forms:

• capsules for oral administration;
• injections for intramuscular and intravenous injections;
• gel for external use;
• aerosol, applied externally;
• suppository for rectal use.

As a non-steroidal anti-inflammatory drug, Arthrosilene stops chronic inflammatory processes, inhibiting the activity of enzymes that destroy tissues, inhibits the synthesis of prostaglandins, inhibits COX-1 and COX-2.

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Having a negligible negative effect on the gastrointestinal tract, the drug gives a good therapeutic result, acts as an analgesic, has an antipyretic effect.

Due to the effect of the drug, patients are able to develop the necessary volume of movements, the stiffness after a period of rest disappears, the edema of tissues decreases. When administered orally, the maximum effect is observed after 4 hours.

The action of external preparations analgesic, anti-edematous, they are used as anti-inflammatory for joints and soft tissues: muscles, tendons, ligaments.

Pharmacokinetics of the drug

Assimilation of the oral form, the drug in capsules gives the maximum effect after 4 hours, the stability of the result depends on the dose taken, the bioavailability exceeds 80%, when administered parenterally, the maximum concentration in the synovial fluid is manifested after one hour, and the therapeutic effect lasts longer, than with the use of other forms, up to 24 hours.

In rectal application, the degree of absorption of the drug and the manifestation of the therapeutic effect are also high, and when used externally, the drug is absorbed slowly, bioavailability is 5%.

By binding to plasma proteins, the active substance ketoprofen is well distributed in organs and tissues, in synovial fluid, in connective tissue. The metabolism of the drug occurs in the liver. Metabolism products are excreted by the kidneys during the day.

Indications for use

Depending on the form, Arthrosylenum is used in such cases:

1. Inside capsules and suppositories are used as analgesics in postoperative conditions, with pain due to overloads or injuries, with moderate pains indicating inflammation in the periarticular tissues. Drugs are prescribed for various types of arthritis, osteoarthritis, inflammation.
2. Solutions for injection are used to relieve acute pain syndrome and with postoperative pain, inflammation of the periarticular tissues of various origin.
3. Gels and aerosols are more often used for soft tissue injuries and injuries;with osteoarthritis of the spine, psoriatic arthritis, with non-rheumatic muscle pains.

Contraindications for the admission of

Contraindications for the administration of any form of the drug are:

• individual intolerance to the active substance, hypersensitivity to it or to other non-steroidal anti-inflammatory drugs;
• Aspirin Asthma;
• peptic ulcer and ulcerative colitis, Crohn's disease;
• diverticulitis;
• hemophilia and other disorders of blood clotting;
• chronic renal failure;
• lactation period.

Children's age is a contraindication for the use of the drug in all forms, except gel and aerosol.

During pregnancy, the drug is prescribed with caution only as an external agent in the third period of pregnancy.

Mechanism of action

The active substance of the preparation ketoprofen in the content of 99% penetrates into the blood plasma, binds to albumin and is distributed in tissues, inhibiting the synthesis of prostaglandins and inhibiting COX-1 and COX-2, inhibiting the activity of pathogenic enzymes.

How do I apply the medicine?

Depending on the form of the release, the instructions for use on Arthrosilen are different.

Forms of release

The preparation is manufactured:

1. In capsules , containing ketoprofen lysine salt 320 mg, and also auxiliary substances. In the blister pack there are 10 capsules, in the carton pack there is 1 blister.
2. solutions contain 80 g of ketoprofen lysine salt per one ml of the substance. Solutions are produced in ampoules made of dark glass, in cardboard packages of 6 pieces each, 2 ml each in an ampoule.
3. Suppositories contain 160 mg of active substance, in a cardboard box there are 10 strips of five in a pallet.
4. For external use of , a 5% ointment is produced in an aluminum tube weighing 30 and 50 g and an aerosol of 15% containing 150 mg of ketoprofen lysine salt per gram of drug in 25 ml cylinders in a carton packed with a spray nozzle.

More on dosages

Use of Arthrosilin orally during or after food for 3 or 4 months, one capsule per day.

Intravenous or intramuscular in a slow mode of administration, intravenously 500 ml for 30 minutes one ampoule no more than twice a day for 3 days.

Injections are performed in the hospital. Prepared solutions should be used immediately.

Rectal application of 1 suppository 2-3 times a day, the maximum daily dose is not more than 480 mg.

Outwardly the drug is used in an amount corresponding to the area of ​​the painful surface, but not more than 5 grams per application in the application of a gel and not more than 2 g when using aerosol, this is the size of a pea and the volume of a teaspoon, respectively, for no more than 10 days.

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In case of an overdose of

If there is a suspicion of exceeding the permissible dose of the drug, monitor respiratory and cardiac activity, if symptomatic treatment is found, carry out symptomatic therapy.

Side effects of

The side effects that can occur when taking the drug can be characterized by the following changes:

• digestive system suffers from ulcers, the patient feels abdominal pain, diarrhea;
• hematopoietic system responds by increasing the level of bilirubin and increasing the activity of hepatic enzymes, liver sizes exceed the norm;
• the nervous system reacts with general malaise, involuntary tremor, anxiety;
• may have lacrimation, vision problems;
• various types of skin allergies;
• cystitis, hematuria.failure of the menstrual cycle;
• bronchospasm, spasm of the larynx, rhinitis;
• tachycardia, swelling, hyper- and hypotension.
• allergic reactions: anaphylactoid reactions, swelling of the oral mucosa, swelling of the pharynx, periorbital edema.

Allergic reactions to suppositories may occur several hours after the administration of the drug: itching, burning, sensation of heaviness, hemorrhoids and exacerbation of it.

If the condition of the patient worsened during the reception of the drug, or if the above mentioned signs appeared, it is necessary to consult the doctor immediately.

Special instructions

For external application, skin dermatoses and eczema may also occur. With bronchial asthma, the drug is prescribed with caution, as in the elderly.

Capsules and solutions are not used for anemia, diabetes, sepsis, edema, high blood pressure, stomatitis, children under 12 years.

Capsules, dissolving for administration and suppositories are contraindicated in alcoholism.

For severe violations of the liver and kidneys, the drug is not prescribed.

Internally taken drugs during lactation are contraindicated. Also contraindicated in the third period of pregnancy .

Gels and aerosols are used in the first and second period of pregnancy with strong need under the supervision of a doctor.

Drugs of internal action are not prescribed to persons under 18 years of age. Gels and aerosols are used after reaching the patient for 12 years.

Interaction with other drugs

Barbiturates and tricyclic antidepressants increase the activity of ketoprofen.

The effect of anticoagulants is increased, the effect of diuretics is reduced, the side effects of glucocorticoids are exacerbated.

Simultaneous administration with other anticoagulants increases the risk of bleeding.

Strengthens the action of insulin, the dose needs to be calculated differently. Affects the production of platelets.

Let's study a qualified opinion of

A review of a doctor who uses Artrozilen in his practice.

Assigning the drug, we carefully study the patient's medical history.we live to see if he has diseases of the organs of hematopoiesis and others.

The drug works flawlessly and has already helped hundreds of sick people. The course of taking capsules lasts up to 4 months. Injections can not be taken for a long time.

Orthopedic clinic doctor, Khanaev VP

Patient feedback

I really benefit from this remedy and I do not experience any side effects from it, and the joint gains mobility and does not hurt.

Anna P, St. Petersburg

When I was prescribed a drug, I did not know where to go from the pain in the joint. The drug acted after three hours. There was finally relief.

Patient of the orthopedic clinic Galina

Cost of medication

Price Arthrosilen:

• capsules for oral administration, 10 pieces at a price of 370 rubles;
• solutions for intramuscular and intravenous injections, 6 units for 190 rubles;
• gel for external use, approximate price for 50 g - 320 rubles;
• aerosol, applied externally, for 350 rubles;
• suppository for rectal use, about 200 rubles.

It is necessary to store the medicine in a dark place not available for children at a temperature of no higher than 25 degrees. You can store suppositories and capsules for 5 years, and solutions and external forms of the drug - up to 3 years.

Gels and aerosols are dispensed without a prescription, capsules, solutions and suppositories only by prescription.

How can I replace a product?

To the analogs of Arthrosilen Oka and Flamax preparations can be classified.

Oka preparation is available in the following forms:

• in granules, which must be prepared for further oral administration;
• in suppositories containing 60 and 160 mg of active ingredient, intended for children and adults, respectively;
• as a topical solution.

Flamax is available in ampoules for intramuscular administration, in capsules containing 50 mg of active ingredient, in tablets with a dosage of 100 mg.

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