Antipsychotic agent Etaperazin - instructions for use and reviews of doctors

Etaperazine is a drug from the pharmacological group of neuroleptics, refers to antipsychotics .

The active ingredient of the drug is perphenazine, which, when ingested, depresses or completely blocks certain receptors in the cerebellum and in the nerve of the gastrointestinal tract.

Comparing Etoperazine with other drugs of a similar effect, it should be noted that it is more active, but at the same time to a lesser extent inhibits the work of the central nervous system.

In addition, this drug is less toxic than some of its analogues.

Pharmacokinetics of drug

At the moment, the pharmacokinetics have not been studied enough. However, it has been established that the active substance Etaperazine actively binds to plasma proteins.

From the body the drug is excreted mainly with bile and urine.

Indications for use

It should be noted that Etaperazine has been successfully applied in several fields of medical practice.

Of course, the main industry is psychiatry. Etperazine is indicated for treatment:

• schizophrenia;
• manic and obtrusive states;
• psychosis;
• depressive states;
• delusional and hallucinatory states;
• neuroses, including states of fear, stress;
• emotional disorders.

In addition, the drug is used in obstetrical practice as an antiemetic.

Dermatologists prescribe Etoperazine for to neutralize skin itching .

Etaperazine is used as a sedative in therapy and surgery. In addition, after surgery on the organs of the gastrointestinal tract, chemotherapy and X-ray therapy, this drug can be used to treat vomiting.

In some cases, etaperazine is used to remove hiccoughs.

Contraindications for the Use of Etoperazine

The Instruction for Use indicates that Etaperazine, like most antipsychotics, has a fairly impressive list of contraindications. Among them:

• endocarditis( inflammatory processes in the internal cavity of the heart);
• certain diseases of the heart and blood vessels( heart failure, arterial hypotension);
• brain diseases, both head and spinal, especially progressive;
• disorders in the central nervous system;
• coma.
• brain injury;
• pregnancy and lactation;
• children under 12 years.

In addition to categorical contraindications, there are cases when the drug can be used, but only under the supervision of a doctor and with a special caution:

• gastrointestinal ulcer;
• disorders in kidney and liver function, including hepatic and renal failure;
• Parkinson's disease;
• violations of hematopoiesis;
• the patient has alcohol dependence;
• breast cancer;
• epilepsy;
• respiratory system diseases;
• should also use the drug with caution in elderly patients.

Treatment of migraines at home with modern folk remedies - recipes and techniques.

How to distinguish the signs of nervous exhaustion from the symptoms of other diseases of the nervous system. Methods of treatment of neuroses and neurasthenia.

How the preparation works

As already mentioned, Etaperazine has an antipsychotic effect. This effect of the drug on the body is achieved by blocking certain categories of receptors of mesocortical and mesolimbic systems by perphenazine.

Antiemetic properties of the drug are due to the fact that the active component acts on the vagus nerve of the gastrointestinal tract.

As regards the sedative properties of Etoperazine, this effect is due to the action of the active substance on the receptors of the brainstem.

Method of application of Etaperazine and dosage of

It is recommended to use tablets after eating with plenty of water.

In psychiatry, the treatment with etazperazine begins with a dose of 4-10 mg 1-2 times a day .If the patient has already taken this medication or if the disease progresses rapidly, the initial dosage can be increased to 40 mg per day.

In the future, the amount of medication taken can be increased to 80 mg per day, divided into 2-3 doses.

For patients whose disease is chronic, a course of treatment of up to 4 months is prescribed, during which the daily dose of Etaperazine is 100-150 mg.

In surgery, therapy and obstetrical practice, when the drug is used as an antiemetic, it is usually prescribed no more than 8 mg of the drug 4 times a day.

Overdose of medication

Disorders of the order of taking the drug and the use of the wrong amount of Etoperazine, which is determined by the doctor, can lead to an overdose.

Acid neuroleptic reactions may become indicative of an overdose of .Disturbing symptoms are also increased temperature, impaired consciousness, confusion of thoughts, and in especially severe cases - coma.

If a patient has any of these signs, stop taking the medication and consult a doctor to determine further treatment.

As a rule, intravenous injections of diazepam, nootropic drugs, vitamins( B and C) are prescribed. Later, depending on the patient's condition, treatment is selected symptomatically.

Side Effects of Eperazine

Like the bulk of antipsychotics, Etaperazine has a negative effect on various systems of the body:

1. On the central nervous system , the drug acts as follows: causes dizziness, drowsiness, lethargy, slowed reactions, apathy, reluctance to engage in any business. There may be weakness in the muscles, spasms, tremors, difficulty in speech function, swallowing, impaired vision. In addition, in some cases, the administration of Etaperazine may cause anxiety, paranoid conditions, strange or nightmarish dreams, and increase excitability.
2. Influence on the cardiovascular system: blood pressure jumps, tachycardia, arrhythmia, anemia, changes in heart rate, violation of hematopoiesis.
3. Effects on the digestive system: nausea, vomiting, dyspeptic disorders, weight gain due to increased appetite, dry mouth, abnormal liver function, cholestatic hepatitis, intestinal atony.
4. Urinary system: frequent urge or, on the contrary, urinary retention, polyuria, impaired renal function, in rare cases, urinary incontinence.
5. The drug can also cause allergic reactions to in the form of rashes, redness of the skin, dermatitis, fever, swelling.
6. In addition to , the side effect of taking Etaperazine may appear in the pallor of the skin, increased intraocular pressure, difficulty breathing, menstrual irregularities and breast enlargement in women, decreased libido and ejaculation in men, and increased or decreased blood sugar levels.

Special instructions for use and precautions

The Instruction for Use indicates that during the treatment with Etazerazine, doctors recommend monitoring the functioning of the liver and kidneys, as well as the state of the blood.

If the first abnormalities occur, contact your healthcare professional, because it may be necessary to adjust the course of treatment or cancel the drug.

If the treatment lasts more than 4 weeks, the patient should pay attention to whether he has symptoms of infectious diseases, because this may become a sign of agranulocytosis, a disease in which the amount of granulocytes in the peripheral blood decreases.

Especially cautious patients should be , who previously received treatment with etaperazine or other drugs with a similar active component, because they increase the risk of side effects.

Doctors recommend to abandon the work associated with the driving of vehicles, controlling mechanisms or requiring considerable concentration and mental activity, as well as working in a high temperature environment.

Before using etaperazine as an antiemetic, it is worth finding out the causes of vomiting, because the effect of the drug can mask a more serious disease( intestinal obstruction, brain tumor) and thereby aggravate the patient's condition.

The drug is dispensed by prescription.

Interaction with other

drugs Before prescribing Etaperazine, it should be clarified which medications the patient is taking at the moment and which ones will be recommended if necessary. Etperazine does not always have a positive effect on health when combined with other medicines.

For example, with caution should use this product simultaneously with atropine and similar preparations.

If the patient is taking anticonvulsants, then their dosage should be increased, because etaperazin can provoke convulsions.

Simultaneous use with drugs that depress the central nervous system can enhance this effect and cause respiratory disturbances.

Absorption of the drug is impaired when used simultaneously with antacids, lithium salts.

When combining Etaperazine with ephedrine, it is possible to reduce the vasoconstrictor effect of the latter.

Storage conditions and storage times

In order for the product to retain its properties, it is necessary to adhere to certain storage conditions.

It is recommended to place the product with a dark, dry, and most importantly, inaccessible place for children. Storage temperature should not exceed 25 degrees.

Shelf life is 3 years .

Form release and cost

The drug is available in tablet formulations. Each tablet is coated with a yellow coating. At the moment, there are tablets containing 4, 6 and 10 mg of the active substance.

The cost of the drug depends on the volume of the active substance in the composition and on the number of tablets in the package. On average, the price for Etaperazine is 215-300 rubles.

Reviews of doctors and patients about Epaerazin

Reviews of doctors and patients about the drug Etaperazine are quite contradictory.

What patients say

Basically, patients note the positive dynamics of in their condition after taking the drug.

Etaperazin acts more gently, in comparison with analogues, but it is effective in the treatment of psychoses caused by schizophrenia, persecution mania and accompanying diseases of depression, panic attacks and anxiety.

However, some people noted the appearance of severe headaches, apathy, indifference to everything that is happening, increased aggression. Teenagers are especially vulnerable to such conditions. Men notice a significant decrease in libido.

Doctors say

Doctors note that Etaperazine - is one of the most optimal preparations in its category by the ratio of effectiveness, side effects and cost.

However, as a rule, correctors are assigned to minimize unpleasant action of the medium. Do not do this yourself, without consulting a doctor, because such self-medication can significantly worsen the general condition of the patient.

And, of course, take Etoperazine only in the dosage prescribed by the doctor, and if you find any side symptoms immediately go to a specialist.

Advantages and disadvantages of

:

• low toxicity in comparison with analogues;
• soft action;
• high efficacy in the treatment of manic conditions, panic attacks, anxiety;
• beneficial effect on patients suffering from schizophrenia;
• rather low price.

Disadvantages of Etoperazine:

• sensation of drowsiness, lethargy, apathy;
• possible outbreaks of aggression, irritability, especially in adolescents;
• has a negative effect on the potency of men;
• significant number of side effects and contraindications.

Analogues of medicament

The drug Etaperazine has practically no analogues. In some cases, it is replaced by aminazine.

Aminazine

Refers to the same pharmacological group as etaperazine. Provides a calming effect of , stops attacks of hallucinations, delusions, reduces anxiety, fear, irritability, and is also used as an antiemetic.

It is used in the same cases as etaperazine, as well as with increasing muscle tone.

Available in the form of a solution for injection or tablets.

Is a more obsolete drug in comparison with etaperazinom and much worse tolerated by patients .However, its price is lower( 50-150 rubles), besides the advantage is the possibility of use for those patients who can not take tablets.

A similar action has Trifthazine and Exsazine, which are also available in the form of tablets and injection solutions.

Patients noted a fairly sparing effect of these drugs, but the practice of application showed that they are not always effective for treating delusions, obsessive ideas, and the risk of overdosing is quite high.

Video: The principle of action of neuroleptics

The doctor-neurologist tells the principle of the action of neuroleptics and describes the conditions in which neuroleptics( antipsychotics) are prescribed.