Features of the use of Artrotek: instructions, reviews

Arthrotek - analgesic anti-inflammatory tablets used for various diseases of the joints and spine. Produced by their well-known pharmaceutical company PHARMACIA Ltd, a member of the PFIZER group of companies.

The drug is available in the form of coated tablets. Each capsule contains 2 active ingredients: diclofenac sodium and misoprostol.

There are 2 types of drugs that differ in the quantitative content of diclofenac sodium. Thus, Arthrotek contains 50 mg of it, and Arthrotek Forte 75 mg. The content of misoprostol in both preparations is 200 μg.

Auxiliary components of the tablet are:

• MCC;
• methylhydroxypropylcellulose;
• with hydrogenated castor oil;
• aerial force;
• with crospovidone;
• with corn starch;
• magnesium stearate;
• diethyl phthalate;
• povidone and cellulose acetate phthalate.

Pharmacological profile

Arthrotek belongs to the NSAID group. Its pharmacological effect is due to the active components that make up the composition:

1. Diclofenac sodium is a non-steroidal anti-inflammatory drug that has analgesic, anti-inflammatory, antirheumatic and antipyretic effects. Also, this substance inhibits the aggregation of platelets.

   Formula of Misoprostol

   When taking diclofenac, pain in joints and spine is relaxed during calmness and movement, morning stiffness and swelling of the joints are eliminated, and their functioning improves.

2. Misoprostol is a synthetic analogue of prostaglandin E1, which has antiulcer, gastroprotective, uterotonizing and activity stimulating activity. It provides improved blood supply to the gastrointestinal mucosa, reduces the formation of stomach hydrochloric acid and pepsin, and stimulates the formation of bicarbonates in the duodenum.

Both active substances are rapidly absorbed, which provides a rapid effect of the drug. Substances are excreted mainly with urine. In this case, about 50% of diclofenac is excreted with feces and bile.

Diclofenac inhibits COX-1 and COX-2.This reduces the formation of prostaglandins. Misoprostol is contained in the drug as opposed to the negative effects of diclofenac on the gastrointestinal mucosa. It enhances the activity of factors that are involved in the protection of the gastrointestinal mucosa.

Scope and contraindications

Arthrothec is effective in the following pathologies:

• ankylosing spondylitis;
• rheumatoid arthritis;
• osteoarthritis;
• rheumatism of the joints;
• joint-muscle pain, having a different etiology.

Administration of the drug is prohibited when:

• is hypersensitive to the constituent components of the drug;
• bleeding of the gastrointestinal tract;
• hematopoietic disorders;
• "aspirin" bronchial asthma;
• pregnancy;
• of lactation;
• of the patient under 18 years of age.

With caution and under the supervision of a doctor, the drug can be prescribed for anemia, porphyria, hepatic and renal insufficiency, hypertension, bronchial asthma, heart failure, erosive and ulcerative gastrointestinal diseases, heart diseases and in old age.

Application and dosage features

Use Arthrotek should be taken during meals.

In the treatment of all diseases in the treatment of which the drug is effective, the following doses are used:

• Arthrotek - 1 tablet 2 to 3 times a day;
• Forte series - 1 tablet, no more than 2 times a day.

The exact treatment regimen with the indication of doses and the frequency of reception is prescribed only by the attending physician in each case individually.

Cases of overdose and "pobochki"

To date, no toxic doses of Arthrotek have been established, however, there are described symptoms of overdose in patients' recalls:

• nausea;
• pain in epigastrium;
• vomiting;
• confusion;
• abdominal pain;
• drowsiness;
• diarrhea;
• convulsions;
• tremor;
• heartbeat;
• increase in blood pressure.

To treat these conditions, it is necessary to rinse the stomach and take the sorbent. Then symptomatic therapy is carried out.

The medicine has an impressive list of side effects. However, this does not mean that they will necessarily show up, since a fairly good tolerability of the drug is noted.

The drug can cause:

• epigastric pain;
• indigestion;
• diarrhea;
• itching;
• duodenitis;
• insomnia;
• dizziness;
• gastritis;
• esophagitis;
• hemorrhagic rash;
• headaches;
• GI bleeding;
• urticaria;
• dysmenorrhea;
• pain in the mammary glands;
• cramping abdominal pains;
• anemia;
• disorders of the menstrual cycle;
• menorrhagia;
• vaginitis;
• nephritis;
• pancreatitis;
• vision impairment;
• mood changes, etc.

Special instructions

Consider the possible development of gastric or duodenal ulcers, even if there are no symptoms on the part of the digestive system. Therefore, long-term use of the drug requires control.

It is not recommended to take the drug to women without making sure that there is no pregnancy. During treatment, you must adhere to reliable contraceptive measures.

It is forbidden to take Arthrotek concomitantly with alcohol.

Patients with impaired renal and hepatic function should be administered with caution and under the supervision of a physician.

Interaction with other

medications The following interactions with other medications should be considered when treating Artrotec:

• acetylsalicylic acid reduces the therapeutic effect of the drug, therefore simultaneous administration is not recommended;
• diclofenac, included in the drug, increases the level of Digoxin , so constant monitoring is necessary;
• drug weakens the natriuretic effect of diuretics , which requires extreme caution when taken concomitantly;
• preparation may reduce the effect of antihypertensive agents ;
• drug should be taken with caution to people receiving therapy with sugar-lowering agents and insulin ;
• with caution apply the drug concomitantly with Lithium and Methotrexate ;
• antacids reduce the absorption of diclofenac;
• diclofenac may increase the nephrotoxicity of Cyclosporin .

Pregnancy and lactation reception

It is strictly forbidden to use the drug for the therapy of pregnant women because of the ability of misoprostol to cause uterine contractions.

This can lead to premature birth, miscarriage, fetal death. In addition, misoprostol provokes the development of serious fetal malformations. Diclofenac, in turn, provokes a premature occlusion of the Botallov duct.

The use of the drug by nursing women is also prohibited. Therefore, you should give up Arthrotek therapy, or breastfeeding for the period of treatment.

Is the point of view of

The effectiveness of the arthrochet is confirmed by positive reviews from patients to whom he helped to get rid of the pain.

Doctors also quite often include Arthrotek in the complex treatment of various diseases of the musculoskeletal system. At the same time, good tolerability and high efficiency are noted.

Direct speech

What the patients advise

Advice on admission:

• should be taken only as directed by the doctor;
• before starting treatment, it is necessary to read the annotation to the medicine;Before starting treatment,
• should be convinced of the absence of pregnancy;
• ingest whole tablets;
• should not exceed the recommended dose;
• at occurrence of by-effects - to stop reception.

Pros of the medium:

• high efficiency;
• has less effect on the gastrointestinal mucosa compared with diclofenac;
• rapid manifestation of analgesic effect.

Cons:

• high cost;
• a large number of side effects.

Purchase of the drug and its analogues

Store the drug at room temperature, not exceeding 25 degrees. It is forbidden to apply the drug after the expiration date, should be released from pharmacies according to the doctor's prescription.

Arthrotek is a unique preparation and there is no completely similar medicament for the composition. But other drugs from the NSAID group will also have the same properties, especially a variety of diclofenac-based drugs:

• Voltaren;
• Diklak;
• Diclouran;
• Orthofen, etc.

Replace the drug only after consulting a doctor.