Rofecoxib and preparations on its basis: the instruction, features, responses

Rofecoxib is a substance that helps with various joint and OA diseases.

The use of drugs based on rofecoxib( Viox, Rofika, Denebol) provides a rapid recovery of active joint function.

Preparations of rofecoxib can be manufactured in different forms of release, the following are found in pharmacies:

1. In the form of solution for injection injections .Each ampoule contains 25 mg of the active ingredient. One package contains 5 ampoules.
2. In the form of tablets .The tablets are placed in blisters, each containing 10 tablets. One tablet can contain 25 and 50 mg of the active ingredient.
3. In the form of gel .The gel is placed in a tube of aluminum base with a volume of 30 grams.
4. In the form of rectal suppositories .

Components of tablets are the most common form of release:

• active substance - rofecoxib;
• microcrystalline cellulose;
• lactose( dermatose DCL);
• sodium lauryl sulfate;
• admixture;
• magnesium stearate;
• iron oxide is yellow.

Pharmacological profile

The drug has anti-inflammatory, analgesic, antipyretic and anti-aggregation effect. It is a highly selective inhibitor of cyclooxygenase 2( COX-2).Slows the action of anti-inflammatory prostaglandins.

Structural formula of rofecoxib

In therapeutic dosages does not affect the activity of COX-1.

After oral administration, it is rapidly absorbed in the gastrointestinal tract. The level of bioavailability is more than 90%.Binding to proteins occurs approximately 90%.The maximum concentration is reached after about 2 hours.

Undergoes biotransformation within the liver, with the formation of about 6 inactive metabolites. It is mainly excreted through the kidneys.

About 72% is excreted as inactive metabolites and 1% in unchanged form. Through the intestine, about 14% is removed in an unchanged form. The average duration of plasma clearance is about 120 ml per minute.

At what indications should I take

Preparation? Rofecoxib and its analogs should be prescribed for the following diseases:

• during therapy of rheumatoid arthritis;
• with periarthritis in chronic form;
• for bursitis;
• if there are symptoms of tendinitis;
• during injuries of ligaments, tendons and muscle fibers.

Also, rofecoxib is used to eliminate pain in the following disorders:

• in osteochondrosis;
• intercostal neuralgia;
• pain with neuritis;
• lumbago;
• tooth pain;
• with radicular syndrome;
• with myalgia.

Contraindications and restrictions

Substance Rofecoxib and preparations based on it are not recommended for use in the presence of the following conditions:

if allergic reactions to non-steroidal anti-inflammatory drugs, salicylates, and other components of rofecoxib are occurring;

• should not be used by children under 12;
• in the presence of various oncological pathologies;
• during bronchial asthma;
• if there is a previous myocardial infarction;
• with atherosclerosis in progressive form;
• during and immediately after a stroke;
• with arterial hypertension.

How to use - schemes and dosages

If a rofecoxib preparation is used in the form of a solution( for example, Denebol), then the injection is given intramuscularly. It is injected deep into the gluteal tissue. Then one day later one injection is made. It is forbidden to use intravenously.

Initiation of therapy is best with 50 mg. Once a positive effect is observed, the dosage can be reduced to 25 mg. It is not recommended to begin treatment without a doctor's recommendation.

During therapy of osteoarthritis, the daily dosage of the drug should be 12.5 mg, the maximum dose should not exceed 25 mg. The drug for injection administration is recommended to be prescribed for an introductory course of treatment, after which the patient can be transferred to treatment with a gel and tablets.

The drug in the form of tablets can be used every other day, after the initial treatment. The intake of tablets does not depend on eating. To facilitate reception, the capsule should be washed down with a sufficient amount of water.

The preparation in the form of a gel is applied by an external method. The gel is applied to the affected areas. It should be rubbed with massaging movements until completely absorbed. Apply the gel 4 times a day. During use, it is not advisable that the product should fall on the mucous membranes of the eyes, and also on open wounds.

Each form of the drug should be prescribed by a physician. Dosage may depend on several conditions - on the general condition of the patient, on his age, on the nature of the disease, on the availability of possible contraindications.

Can I use during pregnancy

The use of drugs based on rofecoxib is prohibited during pregnancy in the third trimester.

In the 1st and 2nd trimester, application is possible only in cases where the possible benefit of the medicine for the mother will be higher than the possible harm for the unborn child.

In any case, the drug is prescribed during this period only strictly according to the indications and under the constant supervision of the attending physician.
During the breastfeeding period, use of the drug, rofecoxib and its analogs is prohibited.

Side effects of

The following unpleasant symptoms may appear during use of the preparations of rofecoxib:

• disorders of the central nervous system - the appearance of confusion, the appearance of hallucinations, there may be a slowing of thinking processes, sleep disorder, drowsiness, dizziness;
• disorders of cardiac and vascular activity - the appearance of hypertension, heart failure, disorders in the coronary and cerebral blood flow;
• disruption of the digestive system - diarrhea, nausea, heartburn, painful feelings in the upper abdomen, vomiting, stool disorder, constipation, indigestion, ulcers on the mucous layer of the oral cavity may appear;
• from the urinary system - problems with kidney function, kidney failure;
• allergic reactions - occurrence of hives, rash, redness, irritation, itching, swelling.

Special instructions

During the application of the drug Rofecoxib it is important to consider the important nuances:

• with the same action and the same composition are the drugs Rapten gel, Diklo-F, Remisid and Dolgit, all these medications are not recommended at the same time in case of having heart problems;
• during medical therapy, you should not drive a car, it is also not necessary to perform work requiring high attention;
• is contraindicated at the time of treatment to consume alcoholic beverages;
• can not be used in pregnancy in the third trimester, because during this period there is a high likelihood of the child developing a Batalov duct;
• must necessarily take into account the fact that many antibiotics can reduce the level of concentration of Rheefexib in the blood.

Overview of the doctor

Voice of the people

Reviews of patients who took drugs based on rofecoxib.

Purchase of the drug and its analogues

The price of rofecoxib preparations in the form of tablets or ampoules with a dosage of 25 mg is about 250-350 rubles, for a package with a dosage of 50 mg, the average price is 550-650 rubles. The gel costs about 190 rubles.

Shelf life of the tablets is about 3 years, for the solution, candles, gel - 2 years. The drug should be stored at a temperature of up to 25 degrees Celsius. It is released from pharmacies only by prescription.

Analogues of rofecoxib in composition or in terms of effects on the body:

• Denebol;
• Orothix;
• Celebrex;
• Revmoxib;
• Diclofenac;
• Remisid;
• Ketonal;
• Naproxen;
• Ibuprofen;
• Traumeel;
• Voltaren.