Melbuck is a drug whose active ingredient is meloxicam.
It belongs to the representatives of non-steroidal anti-inflammatory drugs( hereinafter referred to as NSAIDs), namely to the group of oxycam.
Oksikamy - this is one of the drugs of the last generation of NSAIDs with high efficiency and minor side effects.
The content of the article
The content of the article
The pharmacokinetics of the
- Side effect
Pharmacological action
The medicine has antipyreantiallergic, anti-inflammatory, by inhibiting( slowing down) the formation of prostaglandins, which are cellular( tissue) mediators of inflammation.
Meloxicam is a selective inhibitor of cyclooxygenase isoenzymes, namely COX-2.
With selective deceleration of this enzyme, it is possible to minimize side effects on the part of the digestive system and excretory system, in comparison with the inhibition of COX-1. Meloxicam also does not affect the platelet aggregation reaction and blood coagulation.
The pharmacokinetics of
is characterized by high bioavailability - about 89% for tableted forms, and about 99% for intramuscular injection.
The highest concentration in blood plasma after taking the tablets is achieved for 5-6 hours, and after 60 minutes with the introduction of meloxicam in the form of injection solution. Eating does not have any effect on the absorption of the drug.
Stable concentration of the drug is observed on 3-5 days. The drug is conjugated to plasma proteins by 99%( mainly with albumins).
If the drug is taken for a long time( a year or more), its concentration in the plasma is not increased, in comparison with the values noted at the beginning of its administration.
When prescribing the medication
Indications: 
- degenerative-dystrophic and inflammatory diseases of the musculoskeletal system( Bechterew's disease, arthrosis, arthritis);
- rheumatoid arthritis;
- pain syndromes of different etiology( mastalgia - pain in the mammary glands, dorsalgia - muscle pain, pain after surgery, algodismenorea - painful menstruation, post-traumatic pains).
When the drug is not recommended
Contraindications:
- the presence of ulcerative changes in the gastric mucosa or duodenal intestine;
- Crohn's disease;
- bleeding in the digestive tract;
- severe stages of hepatic and renal failure( without hemodialysis);
- intolerance of the components of the drug or increased sensitivity to them;
- period of pregnancy and lactation;
- age to 12 years;
- asthma or significant allergic reactions in the history.
Forms of release
MELBEK is available as tablets and injection solutions:
- Tablets are available in 7.5 mg and 15 mg dosages( this is the amount of active ingredient).They include meloxicam, and auxiliary substances, including dehydrated lactose, magnesium stearate, povidone, microcrystalline cellulose.
- The injection solution for injections ( 3 ml ampoules) contains 15 mg meloxicam and additional substances: isotonic solution( sodium chlorine), water for injection, sodium hydroxide and solution stabilizers. The solution is intended for intramuscular administration only, it is not administered intravenously.
How to use the drug
The instructions for use recommend different doses of the Melbék preparation depending on the disease and its severity.
So, in the complex treatment of osteoarthritis, it is advisable to start therapy with a daily dose of 5 mg, the maximum allowable dose increase - up to 15 mg per day.
With the removal of pain in cases of Bechterew's disease and rheumatoid arthritis, the drug starts with 15 mg, if possible, gradually reducing the dose twice - to 7.5 mg per day.
In each individual case, the duration of the drug intake is determined individually. The general principle of therapy should be based on the minimum possible course of its administration with the smallest dosages that produce the expected therapeutic effect.
Overdose and side effects of
With an increase in the daily dose of more than 15 mg, regardless of the form of release of the drug, allergic reactions can develop up to anaphylactic shock, bleeding of the digestive system, general weakness, hypotension, dyspepsia.
Also with an overdose, the side effect of the drug from one or more body systems is often increased at the same time.
There is no selective antidote to meloxicam, but cholestyramine accelerates its elimination from the body. Treatment for an overdose is usually symptomatic, and should begin with a gastric lavage.
Side effect of
In most cases, the drug is well tolerated, but side effects can not be excluded.
Often they manifest themselves in the form of dyspepsia( nausea, vomiting, pain in the abdomen), anemia, the development of local edema.
There are rare changes in the blood count( decrease in leukocyte count and thrombocytopenia), changes in liver function tests( they are associated with a violation of enzyme transferase activity and bilirubin level), noise and stuffiness in the ears, redness of the face, increased heart rate, stomach ulcer,an allergic rash on the body, bleeding from the digestive tract.
Even more rare are such side effects as visual impairment, angioedema, loss of consciousness, toxic hepatitis, photophobia, anaphylactic shock.
Special instructions
In patients with chronic renal failure and cirrhosis of the liver, complications such as 
glomerulonephritis, interstitial kidney inflammation, nephrotic syndrome can occur.
These patients need to monitor daily diuresis and functional load on the kidneys. Melbeck is not recommended for patients who are on dialysis.
Patients with hepatic insufficiency may experience sharp increases in transaminases, and other changes in biochemical blood counts that are reversible when the drug is withdrawn.
The drug does not affect the concentration of attention and the ability to drive vehicles, but if there is dizziness and weakness at the time of treatment should abandon these activities.
Drinking alcohol during treatment is prohibited. Patients who take anticoagulants and antiplatelet drugs, the drug is prescribed with caution, as their joint administration with meloxicam increases the risk of bleeding. It is necessary to monitor the coagulogram indices.
The drug may lower the efficacy of hypertensive medications, such as vasodilators, ACE inhibitors and diuretics.
According to some information, the remedy, like other NSAIDs, can reduce the contraceptive effect of intrauterine spirals, but more detailed clinical studies have not been conducted.
The drug is not used during pregnancy and breastfeeding .If the medicine needs to be taken during lactation, then put the question of stopping the baby's natural feeding.
The drug is not administered until 12 years of age.
The extensive clinical use of the medication provides an opportunity to receive objective feedback about the reception of Melbeck, both from doctors and patients. Here are some of them.
The opinion of the doctors
Here are some feedbacks we can learn from articles about the use of the drug written by medical practitioners.
The need for NSAIDs is still high among patients with joint diseases, and the risk of developing side effects, especially those manifested by the gastrointestinal tract, remains the same.
The way out of this situation is the use of selective drugs, which have a minimal side effect in comparison with other NSAIDs.
On the example of Melbeck, we can see the maximum safety and high effectiveness of pain relief.
Alexey Viktorovich
Melbeck proved to be effective not only for degenerative-dystrophic changes, but also for inflammatory diseases.
In a number of cases with arthritis, we observed no less therapeutic effect than with the administration of drugs with diclofenac sodium. The risk of developing a stomach ulcer or other inflammation of the mucosa is much less, and in general, tolerance is much better for patients. "
According to clinical studies conducted in England, only 11.7% of patients did not complete treatment due to an insufficient reduction in pain, and only 0.8% had serious side effects, particularly on the part of the digestive system.
Consultation of orthopedic doctors
Tips for use from patients
Many patients write about the high efficiency and availability of Melbeck, here are a few examples for examples.
After suffering ARVI got complications on the joints - the pain was very strong, at night could not fall asleep because of them. At the consultation, the doctor diagnosed arthritis and prescribed a treatment regimen, which included this drug. After a course of five injections, the pain significantly subsided, so I was able to undergo physiotherapy in a polyclinic and get rid of this problem. I can say that the drug itself anesthetizes, but completely cured the disease helped me all in the complex.
Helena, 39
Me helps with pain in the neck, I often exacerbate osteochondrosis, I take 15 mg tablets, since from 7.5 mg there is no such persistent effect.
But I recommend first consulting with a doctor and determining the cause of pain and the optimal dose of the drug, perhaps you will have enough and lower dosages.
Leonid, 46
My mother is ill with rheumatoid arthritis, that's why we are familiar with Melbek first-hand. During periods of exacerbation, her condition worsens, walking becomes unbearably painful, and body temperature creeps up. The drug is administered intramuscularly, and literally in a few days everything passes.
But I do not recommend taking it without consulting a therapist for hypertension, since the friend had difficulties with her "constant" drugs from the pressure - they, against the background of taking the medication, began to noticeably worse keep a stable pressure.
Anna, 33
Pros and cons of the preparation
The pluses are:
- a good analgesic effect;
- high selectivity( selectivity), and as a consequence - a minimum of side effects;
- possibility of choosing the form of taking the drug( injections or tablets);
- availability;
- lack of a "cumulative" effect in blood plasma, even with a long duration of treatment.
Among the cons are:
- incompatibility with some drugs;
- inability to receive during pregnancy and lactation;
- preparation should be considered as one of the parts of the complex treatment of the disease, since it is not an etiotropic treatment.
Cost of funds
On average, the price of packing Melbeck tablets with a dosage of 7.5 mg No. 10 550-600 rubles., Packing with the same dosage of 7.5 mg, but the number of tablets No. 30 will cost you 950-1000 rubles.
In tablets of 15 mg No. 10 prices vary from 290 to 400 rubles, depending on the pharmacy. Solution for injection( 15 mg in 1.5 ml) in ampoules №3 on average costs 300 rubles.
Store the drug in a dark, dry place inaccessible to children at a temperature of no higher than 25 C. Shelf life of the tablets is 3 years, the solution in ampoules is 2 years. In pharmacies, this drug is sold by prescription.
Than it is possible to replace the medicine
Melbeck analogues are of domestic and foreign production.
To the Russian analogues are:
- Meloksikam;
- Arthrosan;
- Meloks;
- Amelotex;
- Movasin.
Among imported substitutes, such drugs can be mentioned:
- Movalis;
- Mexico;
- Meloksikam-teva.
All of them differ in price and form of release, but it takes a confident place in the pharmaceutical market due to the optimal price-quality ratio.
