Whether it is necessary to take Algeric's medication: contradictory reviews, safe analogs and a high price of the drug

Algerika- antiepileptic , an anticonvulsant drug.

The key constituent of the drug is pregabalin. This active substance has anticonvulsant properties and in turn is an analogue of gamma-aminobutyric acid, which contains an alkyl substituent.

Although molecular structures are similar in these two substances, nevertheless the activity characteristic of gamma-aminobutyric acid is not inherent in pregabalin.

Pharmacokinetics For pharmacokinetic drug

active substance - pregabalin inherent linear. Low intra-individual variability.

The pharmacokinetics of the active ingredient after taking the dose of the drug necessary for a single use coincides with the pharmacokinetics in subsequent application, and therefore it is not necessary to control its concentration.

Assimilation of

During oral administration of the drug to an empty stomach, pregabalin is well absorbed in the gastrointestinal tract. The time for which the highest concentration of the drug in the blood plasma is observed - 1 hour with a single dose.

With subsequent admission, the time that is necessary to note the highest concentration of the drug in the blood plasma does not change. The amount of medicinal substance that reaches the place of its action in the body is approximately 90%.

The process of food intake somewhat reduces the rate at which the drug is absorbed, as well as the degree of absorption of pregabalin.

That is, with the use of the drug at the same time as food, the time for which the highest concentration of the drug in the blood plasma is observed is increased by 2.5 hours, and the maximum concentration decreases on average by 25%( when compared with fasting).

Distribution in the body

The apparent specific volume of the active substance after oral administration is approximately 0.6 l / kg.

This substance does not bind to plasma proteins. For the key substance of the drug is characterized by excellent penetration through the blood-brain and hemoplacental barriers and has the property of excreted in breast milk.

Metabolism

The key substance of the Algeric preparation almost does not lend itself to biotransformation. Only a small percentage of pregabalin( not more than 1%) is transformed.

Inference from the body

The key substance of the drug is mainly excreted through the kidneys, without changing the species. Cleansing of blood plasma and kidneys from pregabalin is directly proportional to the purification of creatinine.

Indications for use

Instructions for use on the preparation Algerika indicates that there are a number of indications for the use of this medication.

Here are some of the them:

• pain resulting from pathological excitation of neurons in the PNS or CNS in adults;
• epilepsy( as an additional therapy of paroxypal seizures accompanied by convulsions);
• is a mental disorder characterized by a general sustained anxiety that is not related to any specific situations or objects;
  diffuse symmetrical pain, affecting the muscles and the skeleton as a whole.

Contraindications

The drug does not cost use:

• for children under the age of 18;
• during pregnancy and during breastfeeding;
• for hypersensitivity to individual components;
• with lactose intolerance.

Mechanism of action

The key substance has the property of binding to a subunit that is characterized as an auxiliary, potential-dependent calcium channel in the CNS, thereby replacing 3 H-gabapentin.

Instructions for use

We study the instructions for use with Algeric tablets.

How to use

Oral, regardless of the process of eating, the recommended dose is 150-600 mg / day ( several receptions).The capsule with the medicine must be swallowed whole. To wash down with the recommended amount of a liquid, that is a minimum of 200 ml.

The amount of time during which you need to take the medicine and the amount of medication taken is determined by the attending physician, individually for each person, according to the characteristics of the ailment, and also the organism of the sick person.

Forms and cost

A white powder in granules is placed in capsules( pink cover with the inscription "TEVA", body - yellow with the inscription "7621").One capsule is pregabalin, 300 mg.

There are such packages:

• 7 pieces, a package of thermoplastic materials, 2 packs of cardboard;
• 7 pcs, pack of thermoplastic materials, 8 packs of cardboard.

On average, the price of Algeric's medication ranges from 400 rubles.

Dosage regimen

The drug is administered orally at 150-600 mg per day , usually divided into 2-3 doses.

Additional recommendations:

• for patients with kidney problems, the dose is assigned individually according to the creatinine clearance;
• patients with a disorder of the functioning of the liver dose adjustment is not needed;
• patients aged 65+ may need to reduce the amount of medication taken due to age-related impairment of kidney function.

If you missed the medication, then the subsequent dose should be taken as soon as possible, but not if the time for taking the subsequent dose is approaching.

Application of the amount of the drug over the norm

The data on symptoms of an overdose are very small.

Such reactions of as:

• are possible;
• depressiveness;
• alarm;
• confusion.

Things to do: rinse the stomach, drink activated charcoal. If there is an urgent need, then you need to use hemodialysis.

Side Effects of

The product has a lot of side effects, so prescribe the drug is recommended only for acute necessary.

Circulatory system

The process of blood formation is affected by such effects:

• agranulocytosis;
• disease, in which there is a decrease in the number of platelets, is pathological in nature.

Metabolism

There are such side effects of : appetite enhancement, weight change.

From the nervous system

To the operation of the CNS can affect:

• most often there is a feeling of uncertainty in its position relative to space, drowsiness;
• also shows confusion, nervousness, memory loss, trembling of limbs, disturbed sleep and balance, etc.;
• even less common are anxiety, depression, panic attacks, problems associated with violation of the selection of words, "nightmares", violation of the speech apparatus, fussiness, possible loss of the ability to taste, loss of consciousness;
• even less often you can find such symptoms as a partial disorder of the ability to write something, a sense of smell when they are completely absent, etc.

Vision, hearing, vestibular apparatus

The normal functioning of the organs of vision is affected:

• is most often affected by visual impairment,"Bifurcation" of objects;
• not so often there is a sensation of dryness in eyes and painful sensations, excessive teardropping, "sparkles" in the eyes and others.

On the part of the hearing and vestibular organs, such disruption of operation was observed, as:

• , the loss of balance occurs frequently;
• rarely increases the sharpness of the perception of sounds.

The cardiovascular system

CCC is also susceptible to certain side effects. For example:

• increase the amount of blood that flows to some part of the human body;
• enhancing arter.pressure;
• is much less common in the frequency of heartbeat.

Respiratory system

The respiratory system undergoes such an exposure:

• dyspnea;
• sensation of dry mucous in the respiratory system;
• it is rare to find stuffiness of the respiratory system, nosebleeds, snoring, etc.

The process of the digestive system is affected by:

• bloating;
• nausea;
• sensation of dryness of the mucosa;
• , symptoms such as excessive salivation, reduced oral sensitivity may be less likely to be detected;
• symptoms such as pancreatitis and a swallowing disorder are extremely rare.

Urinary system

On the part of the excretory system: incontinence and the problems of the process of urination occur occasionally.

Musculoskeletal System

Lesion of the musculoskeletal system:

• puffiness of the joints;
• spinal pain;
• spasms in the muscles;
• pain in the limbs;
• various kinds of muscle spasms;
• occasionally - pain in the neck, etc.

Sexual system

Sexual system "suffers" no less than the rest. Typical violations of are:

• ejaculation delay;
• erectile dysfunction.

A list of side effects, compiled from customer surveys

The side effects listed below were detected using pregabalin on the practice:

1. CNS :headaches, fainting, cognitive impairment.
2. Body of vision .There was a violation of the basic functions of the organs of vision.
3. Digestive system .Infrequent swelling of the tongue, nausea, and upset stomach were rarely found.
4. Skin covers .Seldom there was a puffiness of the face, an itch.
5. Cardiovascular system .Heart failure of a chronic nature took place.
6. Disorders of the urinary system are characterized by urine retention.
7. The respiratory system can sometimes be exposed to the swelling of the respiratory system, in particular the lungs.

Specific instructions

Based on the studies, you can formulate a list of guidelines for the use of tablets and capsules Algerika :

1. Diabetes sufferers may need to adjust the amount of medication taken against the background of weight gain.
2. Before starting treatment, it is necessary to alert the patient to the appearance of seizures and withdrawal syndrome, which may appear as a result of discontinuing treatment with this substance.
3. Some patients may develop suicidal ideation. In this case, you should immediately contact a doctor.
4. Impact on the ability to drive and control settings.

Parallel application with other

preparations Having carefully studied the instructions for use, it is possible to single out such moments:

• , if the drug should be taken in parallel with the use of opioid analgesics, the appearance of intestinal obstruction should be provided, especially in elderly patients;
• on concurrent use of the drug with other antiepileptic drugs and the advisability of using only this drug is not enough information;
• in the course of treatment aimed at pain syndrome in patients with vertebral trauma increases the risk of side effects of the CNS, especially lethargy, which can result from using other medications, including antispasmodics.

Use during childbearing and breastfeeding

It should be remembered that that:

1. When using the drug, women who are able to conceive should use effective contraceptives.
2. Accurate data on the safety of drug use during the period of bearing no child, so the use of the drug during pregnancy is contraindicated.
3. Studies in the course of experiments on rats have shown that the substance leaves with breast milk in rodents. Because of this, during treatment, breastfeeding is advised to be discontinued.

specialists do not recommend taking this product to children under the age of 18 years.

Reviews of patients and doctors

Reviews of Doctors

Doctors do not recommend taking medication:

1. I prescribe this drug in exceptional cases, because strong side effects take place to be ( Vasiliev RA).
2. Algeria is addictive and it is confirmed by studies, but it is difficult to argue with the effectiveness of the drug ( Naryshkina Zh. A.).

Patient reviews

Patients also indicate a negative effect of the medication on the organism:

1. I was prescribed this medicine and at first everything was good, it helped quickly, but then all these side effects just started to drive me crazy. .. and to finish the application I needed a wholeweek, or even longer ( Roman).
2. An excellent product. .. though some "sidekicks" are worried, but in general the picture is quite good ( Semyon).
3. In principle, the drug is effective and worthwhile. .. but it depends on the person. Here is my friend could not take it for long, allergic reactions went ( Valentine).

In general, it can be seen that as the Algerian attack has nothing to do with treatment, it is rather a partially legalized drug.

What can I advise

Tips for receiving from patients:

• take better during meals, in order to reduce the effect on the GI tract;
• with plenty of water;
• does not apply when driving or controlling complex machinery.

Alcoholic properties of

There is information that the use of this drug is addictive, because patients who are dependent on any medication need to use Algerik very carefully.

Pros and cons of the preparation

The following qualities of are distinguished:

• high efficiency;
• fast effect;
• a large number of side effects;
• addictive.

Storage

Keep out of the reach of children at temperatures up to 250 °. Shelf life - 3 years.

Leave at the pharmacy

In pharmacies Algerika is sold only with a prescription!

Substitute Drugs

Below are analogues of Algerika, plus the pros and cons of acquiring and using them.

Benzonale

Has anticonvulsant properties. The composition and pharmacology is similar to phenobarbital, but unlike it:

• has a less harmful effect on the central nervous system;
• price is lower;
• reduces the incidence of seizures;
• is addictive;
• should not be given to children.

Depakin

An anticonvulsant drug , which effectively fights with various forms of epilepsy. Has a sedative property.

The mechanism of action of is not fully understood:

• helps to cope with epileptic seizures;
• can be administered to children;
• effective;
• price compared to the original drug below;
• is very toxic, especially the liver "suffers".

Sabril

An effective drug that increases the content of gamma-aminobutyric acid in the CNS:

• is an active drug;
• is a form for children;
• value is overstated.

Video: Lyrics( algeric, pregabalin): mechanism of action

The danger of taking Algerica and its analogues systematically. Why it is important to get medical advice before taking the drug.