KONDRONOVA is a combined preparation manufactured by the Indian company Panacea Biotech, which belongs to the group of chondroprotectors and is intended for the treatment of degenerative-dystrophic diseases of the supporting connective tissue.
Produced in two dosage forms: capsules for oral administration and ointments for external use. The therapeutic effect of Kondronov is due to the glucosamine sulfate and chondroitin sulfate included in the preparation.
Capsules are hard gelatinous, blue, inside of them is a white granular powder. Ointment light brown, odorless.
Table of contents
- Pharmacodynamics of
- Pharmacokinetics
- Scope
- Restrictions on use
- Adverse events
- Pharmacological compatibility
- Dosage regimen
- Intended use of special categories of patients
- Special instructions and precautions
- Conditions of storage and sale
- Opinion of patients and specialists
- Similar remedies
Farmakodinamika means
Glucosamine and chondroitin sulfate participate in the synthesis ofdinitelnoy tissue and therefore can prevent the resorption of cartilage and activate tissue repair. In addition, these components relieve inflammation and have analgesic effect.
Glucosamine and chondroitin sulfate are inherently amino acids, which are the main component of cartilage of intervertebral discs and joints.
So glycosaminoglycans of the intercellular matrix of cartilage give elasticity to joint surfaces and ensure their slipping, and carbohydrate groups of collagen impart elasticity and strength of cartilaginous tissue.
Chondroitin plus glucosamine
The intake of glucosamine stimulates the synthesis of the cartilage matrix and protects it from chemical damage. In addition, it is a building material for connective tissue. The mechanism of its effect on the cartilaginous tissue has not been thoroughly studied.
There is an assumption that it protects the damaged cartilage from metabolic destruction caused by the use of non-steroidal anti-inflammatory agents and glucocorticosteroids, and also has a moderate anti-inflammatory effect. It also dilutes blood and prevents the formation of blood clots.
Chondroitin sulfate is necessary for the formation of healthy cartilage, it activates the production of hyaluronone, the biosynthesis of proteoglycans and colleague fibers of type II, and besides it protects hyaluronan from enzyme cleavage and the damaging effects of active radicals.
Chondroitin sulfate is necessary for maintaining the viscosity of synovia. He is involved in the regeneration of cartilaginous tissue and inhibits the activity of enzymes that break down cartilage.
In the treatment of osteoarthritis, the substance facilitates the course of pathology and reduces the need for anti-inflammatory and analgesic drugs.
Pharmacokinetic properties of
When ingesting glucosamine sulfate, bioavailability is 25%.It is excreted mainly by the kidneys in an unchanged form. Half-life is almost 3 days.
When administered orally, chondroitin sulfate bioavailability is 12%.The maximum concentration of the substance in the plasma is observed after 3-4 hours, in synovia after 4-5 hours.
Absorbed through the digestive tract, the substance accumulates in the synovia. It is excreted in the form of metabolites with urine. The elimination half-life lasts 5 hours.
Area of application
Kondronov capsules are prescribed for the treatment of osteoarthritis of I-III degree.
Indications for the prescription of the ointment are:
- osteoarthrosis I-III degree;
- idiopathic and secondary arthrosis;
- deforming arthritis;
- osteochondrosis of the spine;
- spondylosis;
- patella chondromalacia;
- of humeroparate periarthritis.
Restrictions on the use of
The absolute contraindication for the administration of capsules and ointments is:
- individual intolerance;
- diabetes mellitus;
- age under 18 years;
- bronchial asthma;
- pregnancy;
- bleeding disorder;
- thrombophlebitis;
- severe renal failure;
- Breastfeeding.
In addition to receiving capsules, contraindication is phenylketonuria.
Additional contraindications for the use of the ointment are:
- skin integrity disorder in the application area;
- dermatological diseases of various etiologies.
Adverse events
Kondrunov capsules can cause the following side reactions:
- stomach upset;
- constipation;
- bloating;
- pain in the epigastric region;
- dizziness;
- headaches;
- bronchospasm;
- heart palpitations;
- swelling and pain in the lower limbs;
- allergy;
- drowsiness;
- insomnia.
Allergic reaction may occur when applying the ointment.
Pharmacological compatibility
You should not take the drug Kondronova with anticoagulants and antiaggregants, because it is possible to increase their clinical effect.
With simultaneous admission, the absorption of tetracycline antibiotics increases, the effect of semisynthetic penicillins decreases.
The preparation Kondronova can be prescribed in combination with NSAIDs, analgesics and glucocorticoids.
Ointment can be administered concomitantly with other medicines. It is not allowed to rub the ointment with other medicines for external use simultaneously, since there is no data on their physico-chemical interaction.
Dosage regimen
Capsules are intended for oral use. To drink it is necessary on 2 pieces 2-3 times a day. They are taken regardless of food intake, without chewing, squeezed with enough liquid.
The duration of the course is from 1 to 2 months, the therapeutic effect persists up to 3 months. At the discretion of the doctor, a second course is possible.
Ointment is for external use only. A small amount of the drug massaging movements are applied to the painful areas until completely absorbed.
The course of treatment can last from 2 weeks to 4 months. If after 14 days of use, no improvement is noticeable, then you need to see a doctor to clarify the diagnosis.
Purpose of the drug for specific categories of patients
The drug is not recommended for women waiting for the baby, as there is no evidence base regarding the safety of the drug for the treatment of pregnant women.
When prescribing the drug during lactation it is recommended to stop breastfeeding, since there is no data as to whether the active ingredients penetrate into the mother's milk.
It is not necessary to use the drug for therapy of patients under 18 years of age, since it is not known how the active substances on the growing organism can be affected.
In the case of liver pathologies, adjustment of the dosing regimen is not required. 
Capsule preparation is not intended for patients with severe impairment in kidney function, when creatinine clearance is less than 35 mL / min. The remaining patients do not need to adjust the therapy regimen.
Patients in the older age group are prescribed medication as usual.
No cases of an overdose of Kondronova have been reported at this time. There is no specific antidote, treatment is symptomatic.
Special instructions and safety precautions
If there are undesirable effects on the part of the digestive system, the dosage of the drug should be halved, if they do not pass, stop taking the medication. Capsules should be used with caution in patients with bleeding history.
When taking capsules, it is necessary to be especially sharp when driving, as active substances affect the central nervous system and 
may cause dizziness.
Ointment should not be applied to mucous membranes and open wounds. After using the drug, tightly tighten the tube and wash your hands thoroughly with soap. We need to make sure that the medicine does not get in the eyes. If this happens, rinse them with running water.
In case of seafood intolerance, there may be a cross-allergy to Kondronov's preparation.
Alcohol-containing beverages do not affect the digestibility of the drug, and do not reduce its therapeutic effect.
Storage and sale conditions
Store the product protected from light and moisture, away from children at t no higher than 30 ° degrees. Do not freeze the medicine.
Shelf life 24 months. Ointment and capsules of Kondronov are allowed to be over-the-counter.
Opinion of patients and specialists
Kondronova is a rather popular drug among patients and doctors, which is confirmed by numerous reviews.
Tormented severe pain in the knees. The doctor appointed Kondronov's capsules, drank them 6 times a day for 2 months, and used ointment in parallel.
Passed pain in the joints, the amplitude of motion in the knees increased. In addition, I still observed a diet rich in glucosamine, ate a cold and marmalade. The doctor said that the effect of treatment should last 3 months, then the course should be repeated.
Zuhra
I was diagnosed with knee joint gonarthrosis and I was prescribed Kondronova. I had a month of pain and did not pass, but there was a rash. Capsules to accept has ceased, now I do not know how to get rid of an allergy.
Maksim
Kondronova's medication worked well in the treatment of osteoarthritis of I-III degree, when the joints have not yet been completely destroyed.
Therefore, before the appointment of the drug, it is necessary to take an X-ray to determine the degree of pathology. In parallel, you must follow a diet enriched with gelatin and give enough time to physical exertion. This can be yoga or classes using the Bubnovsky method.
Marat Almazovich, rheumatologist
Similar products
Today a wide selection of analogues of the drug is on sale. The complete structural analogue are: 
- Teraflex;
- Artra.
In addition, the pharmaceutical industry produces partial analogues of the Kondronov preparation, such as:
- Dona;
- Structum;
- Chondroitin-Acos. There are also synonyms for the pharmacological group:
- Zometa;
- Diclosan;
- Artro-Active.
It is not necessary to replace the drug with a synonym without the permission of a specialist, since all the means have their own peculiarities of application.download. ..
