Nimulide Gel is an anti-inflammatory drug that does not contain steroid hormones. It reduces inflammation and reduces pain in the spine and joints.
The drug has anti-inflammatory and analgesic effects. Used only for topical application. Stored at a temperature of no higher than 25 degrees Celsius. The shelf life of the gel is no more than 2 years from the date of manufacture.
Content of the article
- Composition and form
- Pharmacology and pharmacokinetics
- Indications for use
- Contraindications to prescribing
- Instruction for use
- Overdose and side effects
- Special instructions
- Interaction with other drugs
- Pregnancy and lactation
- Practical application of
- Practical advice
- Purchase of the preparation and its analogues
Composition and form of release
The preparation contains the following components:
- ethyl alcoholth;
- hydroxypropyl cellulose;
- carbomer;
- purified water;
- triacetin;
- dimethylacetamide N;
- phosphoric acid;
- aromatic components.
Nimesulide is the active substance. It reduces the content of the prostaglandin of a short-lived species and is the main element of kinin-stimulating prostaglandin synthesis at the site of inflammation. Reduces the activity of prostanoid receptors belonging to the type of EP and manifests itself in an analgesic and anti-inflammatory effect.
Nimesulide formula
Nimulide ointment is sold in tubes of 30 grams, of which 10% is an active substance. Ointment has a superficial effect and does not penetrate deep into the tissues.
Nimulide have a translucent structure and a homogeneous consistency of yellow color.
Produced in India.
Pharmacology and pharmacokinetics
Pharmacological action of the drug is as follows:
- Anti-inflammatory effect .The drug fights inflammation due to the effect on reproduction of prostaglandins. The gel does not affect healthy tissue.
- Anesthetic and antipyretic effect of .The drug inhibits and inhibits the production of histamines and affects the neuroreceptors of the glucocorticosteroid species.
Nimulide gel prevents the destruction of cartilage due to a decrease in the body's urokinase enzyme. It is a selective inhibitor of COX-2 and belongs to the class of sulfonanilides of NSAIDs( non-steroidal anti-inflammatory drug).
The ointment concentration of the active substance is low, so after a single application of cmax it is noted only after 20 -24 hours. In the blood there are no traces of the presence of the main metabolite( 4-hydroxynimidesulide).
Nimulide gel does not affect the absorption of food, unlike tablets and suspensions. The drug binds well to proteins when it enters the body and the proportion of the substance is approximately 96%.
The disintegration of the drug occurs in the liver, with the formation of metabolites, which are excreted from the body with urine.
In people over 55, in adolescents and in people with renal insufficiency, the pharmacokinetics profile changes insignificantly.
Indications for use
Nimulide gel is prescribed for the following diseases:
- joint and bone injuries;
- pain in the back;
- fracture;
- crack;
- diseases of the joints, muscles, bones and ligaments;
- arthrosoarthritis, arthritis, arthrosis;
- bursitis;
- arthritis of psoriatic and rheumatoid forms;
- osteoporosis;
- myalgia;
- urethritis;
- cystitis;
- inflammation in the ears.
Also ointment is used for skin infections and viral lesions.
Contraindications to the prescription of the drug
The drug is prohibited in the following cases:
- with hypersensitivity to the components of the drug;
- in renal or hepatic insufficiency;
- for allergic reactions to medication;
- children under 8 years;
- for alcoholism and drug dependence.
Instruction for use
Nimulide gel is allowed to be used externally no more than 4 times in 24 hours. A small amount of medicinal product is applied to the affected area and distributed along the skin by a light massaging movement. The drug should not be rubbed.
After application, wash hands with soap to remove any ointment or gel. The number of applications can be increased by the doctor.
Overdose and side effects of
There are currently no reported cases of an overdose of Nimulide.
Doctors do not rule out the appearance of an overdose with a single application of the amount of more than 55 grams over a large area of the skin.
If you suspect an overdose, immediately consult a doctor.
During the use of Nimulide's ointment, there may be side effects, which include:
- urticaria;
- skin rash;
- itching;
- peeling and dry skin;
- change in skin color of transient type.
If the listed adverse reactions occur during the application of the remedy, immediately discontinue use of the drug and seek medical attention.
Sometimes, when handling large areas of the skin, the following adverse reactions may occur:
- heartburn;
- nausea;
- vomiting and urge;
- stool disorder( constipation, diarrhea);
- headaches;
- dizziness;
- swelling;
- anemia;
- agranulocytosis;
- increased transaminase renal activity.
In rare cases, the use of ointment can trigger an anaphylactic shock, the development of ulcers in the gastrointestinal tract and gastralgia.
Special instructions
Nimulide is not allowed to be applied to the mucous membranes and skin, affected by dermatosis. Avoid contact with eyes. Do not apply to open wounds and cuts.
Ointment should not be rubbed into the skin. Do not cover the treated area with an occlusive dressing.
Interaction with other drugs
Along with the gel with extreme caution, you need to take diuretic, hypotensive and hypoglycemic drugs.
It is necessary to avoid simultaneous intake of Nimulide and agents containing lithium, ciclosporin and methotrexate.
All such cases should be notified by your doctor.
Pregnancy and lactation
Nimulide is not allowed for use during pregnancy and during lactation. The drug can accumulate in the body and enter the breast milk or through the placenta. This in turn can harm the child.
From the practice of using
Reviews, comments and advice on how to take Nimulide as an ointment from ordinary people and doctors.
In autumn my joints are always aching, and I have to use drugs that relieve pain and inflammation. This problem worries me not for the first year and I have tried many means. After the unsuccessful treatment of Fastum-gel, I decided to try Nimulide.
After consulting with a doctor, I bought the drug. I was very pleased with the price, which turned out to be lower than that of similar means. I was a little embarrassed that the drug is non-steroid. Decided that I would not use it for more than 5 days, although the instructions indicated 10.
After 2 days of use, I noticed a significant reduction in pain and increased mobility of the joint( knee).The remedy turned out to be effective, but short-lived. After discontinuing use after about two weeks, the pain returned. Now I use his courses and do not remember problems with the knee.
Comment Elizabeth, accountant
I periodically get sore and inflamed joints on my legs, let me know about old injuries. My wife bought me Nemulid's gel and offered to try to heal them.
I liked the fact that it does not need to be rubbed, it dries quickly and leaves no residue on clothes. I apply it 3 times a day in small amounts to inflamed and painful areas. I have enough of one tuba for several courses.
The drug well relieves pain and reduces inflammation on the third day of use. When I found out the price, I was pleasantly surprised, because analogues of Nimulide gel cost at least twice as much! I recommend this tool now to all my friends.
Comment of Vasily, retired
I have been working as a rheumatologist for a long time, but I learned about Nimulide in the form of an ointment not so long ago. Me means has interested in the first place because of the low price. My patients are mostly people of retirement age and are asked to prescribe inexpensive drugs.
I began to get acquainted with the tool and learn about its qualities. I liked that in most cases, it literally after the first day of application relieves pain and reduces inflammation, it's very good, since not many are willing to wait for the result for weeks.
When I began recommending Nimulid, I heard a lot of positive reviews about him, and this was his best estimate. The drug refers to nonsteroidal drugs with anti-inflammatory and analgesic effect. The gel is most convenient because it does not need to be rubbed, and it is quickly absorbed. For me, this remedy has become one of the best in the treatment of joints.
Rheumatologist, Ivan Nikolaevich
Practical advice
The drug is not recommended to rub. It should also not be applied to mucous membranes and should be avoided in the eyes. If this happens, then it is necessary to wash the place of contact with clean, running water.
The gel can be used only on the skin without allergic reactions. If there are side effects, stop using the gel and consult a doctor immediately.
The drug is not recommended to be applied to the skin more than 4 times in 24 hours and use more than 10 days.
Purchase of the drug and its analogues
The price of the Nimulide gel varies from 197 to 240 rubles. The drug is stored at an air temperature of no more than 25 degrees Celsius for 2 years from the date of manufacture.
Gel is dispensed without a prescription.
Nimulide has analogues similar in composition and effect to the body. These include:
- Arthrosylen;
- Artrum;
- Bioran;
- Valusal;
- Diklogen;
- Indomethacin;
- Naklofen;
- Orthophene;
- Fastum gel.
