Drugs Ostalon and Ostalon Calcium-D belong to the group of inhibitors of bone resorption in the occurrence of osteoporosis.
In addition to the treatment of bone diseases, the preparation Otalon Calcium D regulates the exchange of phosphorus and calcium, and also normalizes their level in bone tissue.
Table of contents
- Pharmacological action
- Pharmacokinetic profile of
- Composition and form of preparation
- Mechanism of action
- Indications for use
- Contraindications and limitations
- Drug use
- Overdose and side effects
- Special instructions
- Interaction with medicines
- Physicians opinion
- Patient feedback
- Purchase and storage of
Pharmacological action
The main active substance is wallpaperx preparations is alendronate - bisphosphonate, a synthetic analogue of pyrophosphate. It binds the hydroxyapatite of bone tissue.
Its action is aimed at eliminating bone resorption, as well as normalizing the balance of calcium and phosphorus in the body.
Pharmacokinetic profile of the drug
Preparation Ostalon( 35 or 70 mg) when taken on an empty stomach in the morning time of the day is absorbed at a value of 0.64% at least two hours before meals.
If the gap between eating and taking medication is reduced, the indicator is reduced to 0.39-0.46%.Efficiency does not fall. When taking tablets with coffee or orange juice, the bioavailability of the active substance is reduced by 60%.
At the time of distribution, the drug enters the soft tissue, and then penetrates into the bone tissue. With plasma proteins, it binds to 78%.
Chemical formula of colcalciferol
The metabolism of alendronate in the human body has not been confirmed. Excretion of the active substance occurs in the urine.
The preparation of Ostalon Calcium-D has the same pharmacokinetics due to the alendronate constituent. However, due to colcalciferol and calcium carbonate, there are individual features of the process of absorption and elimination of the drug.
Kolekaltsiferol is a bioavailable substance, despite the compound when taken with alendronic acid. When you take an oral calcium carbonate, one-third of the active substance is absorbed into the small intestine.
This process is due to the presence of vitamin D, and also depends on the level of pH, compliance with diet with the use of products containing calcium.
Calcium is absorbed better if the body expresses its lack, and also the person adheres to a food with its low content. When excreted, the substance is removed through the kidneys( 20%), and the remainder - through the intestine.
Composition and form of
Ostalon is available in the form of white tablets coated with a coating. On the surface of the tablet there is an engraving "M14".The preparation includes:
- alendronate sodium trihydrate 91.35 mg( 70 mg alendronic acid) - an active substance;
- microcrystalline cellulose;
- colloidal silicon dioxide;
- of croscarmellose sodium;
- magnesium stearate.
Ostalon Calcium-D is available in two types of tablets in one package. Tablets of alendronic acid do not differ from Ostalon in appearance and composition.
Kolekaltsiferol with calcium carbonate is presented in the form of oblong, brown-yellow, film-coated membranes.
The composition of tablets of colcalciferol and calcium carbonate includes the following substances:
- powder of colcalciferol 4 mg( 400 IU vitamin D3);
- calcium carbonate powder 1578 mg( 600 mg calcium);
- microcrystalline cellulose;
- Copovidone;
- crospovidone;
- magnesium stearate.
Mechanism of action
Alendronate due to the properties of a non-hormonal specific inhibitor of osteoclast activity contributes to the retardation and elimination of bone resorption.
Moreover, there is a positive effect of the drug in the restoration of bone tissue and the formation of new layers. Alendronovaya acid affects the increase in bone density due to saturation of their useful minerals.
When the preparation of Ostalon Calcium-D is applied to the body, a positive effect of calcium carbonate on muscle contraction, normalization of the process of nerve signal conduction, and also on the process of blood coagulability is noted.
Due to the presence of colcalciferol, the absorption of calcium and phosphate is enhanced. Also, there is a regulation of the excretion of the substance and monitoring of the concentration of calcium in the blood plasma.
Indications for use
Both drugs are used in diseases of the bone tissue of the body: 
- Women shows the drug during treatment of osteoporosis at the onset of the postmenopausal period. At this time, there is an increase in the incidence of vertebral fractures, as well as the head of the hip bone.
- For men, is prescribed during treatment with osteoporosis. The drug reduces the fragility of the vertebrae, pelvic and other bones.
- It is prescribed for the treatment of osteoporosis arising in during long-term use of glucocorticosteroid preparations .
Contraindications and limitations
Ostolon is contraindicated in certain diseases and body reactions: 
- is prohibited from taking in diseases of the esophagus , as well as other body reactions that make it difficult to walk through food;
- drug is contraindicated in detecting hypocalcemia and lack of vitamin D ;
- with severe chronic renal failure medication is prohibited;
- the drug is not assigned to if there is a mineral exchange violation , and also hypersensitivity to the constituents of the drug;
Ostalon Calcium-D is contraindicated for calcium carbonate and colcalciferol in the following conditions:
- , the taking of the drug with these active substances is prohibited by for hypercalcemia, hyperparathyreosis ( primary and secondary);
- is contraindicated in with a calcium level disorder in the body of as a result of hypercalciuria, calcium nephrolithiasis;
- when increasing the level of body saturation with vitamin D is prohibited to take the remedy;
- contraindication is the presence of sarcoidosis, osteoporosis as a result of immobilization, and tuberculosis in active form.
Take care with drugs in the presence of diseases of the gastrointestinal tract.
Use of
drug Ostalon and alendron component of Ostalon Calcium-D is taken once a week at a dosage of 70 mg per dose.
To ensure proper absorption of the drug, it is recommended to take it on an empty stomach at least 1.5-2 hours before meals.
The tablet is not allowed to chew, dissolve. It is recommended to drink the medicine with a glass of plain water. To properly dissolve the tablet after taking it is necessary to keep the vertical position for half an hour.
Tablets kolkaltsiferona and calcium carbonate take 1 time per day for 1 tablet. It is necessary to monitor the proper administration of the medication: it can not be consumed within three hours after taking alendronate.
Overdose and side effects of
In case of an overdose of the drug, there are signs of hypocalcemia, hypophosphatemia. If the drug is taken for a long time, then calcification of blood vessels and tissues may appear. The work of the digestive tract is disrupted.
If symptoms of an overdose appear, you should consult a doctor. In this case, there is no specific treatment. It is recommended to drink milk, take antacids.
Side effects are expressed in the form of violations:
- GI tract ( abdominal pain, indigestion, constipation, diarrhea, nausea, vomiting);
- of the musculoskeletal system ( ossalgia, arthralgia, myalgia);
- of the nervous system ( headache, irritability);
- skin conditions ( pruritus, rash);
- organs of vision ( uveitis, scleritis);
- also exhibits the manifestation of allergic reactions in the form of urticaria, Quincke's edema.
Special instructions
If the patient has symptoms of hypocalcemia, then before starting alendronic acid, it is worth restoring the mineral metabolism.
During the intake of bisphosphonates, it is necessary to normalize the level of calcium and vitamin D with food or medications.
Before receiving bisphosphonates, you need to undergo treatment with the dentist if the person is at risk( cancer, chemotherapy, radiation therapy, SCS reception).
It is also worthwhile to avoid surgical intervention in the oral cavity or at this time to refuse to take the drug.
Admission of both drugs is prohibited during pregnancy, lactation. Also, due to the lack of clinical data, the drug is banned in childhood.
Interaction with
Drugs The following reactions are observed when Ostalon is co-administered with other means:
- Calcium preparations , antacids reduce the absorption of alendronic acid.
- Ranitidine increases the bioavailability of the substance twofold.
- When combined with NSAID , there is an increase in gastrointestinal upset.
- Calcium excretion is difficult when taking with thiazide diuretics .Glucocorticosteroids interfere with calcium absorption. Therefore, an increase in the dose of colcalciferol and calcium carbonate may be required.
- It is forbidden to take colcalciferol and calcium carbonate together with tetracycline .
- If the patient is prescribed preparations with sodium fluoride content , then a break must be made between taking Ostalon Calcium-D and the drug for at least 3 hours.
- Calcium absorption decreases when reacted with oxalic acid .
Opinion of doctors
Reviews of doctors who practice Ostalon's appointment to their patients.
Ostalon Calcium-D reduces the so-called transparency of bones, which occurs with a lack of calcium and increased brittleness of bone tissue. Therefore, it is important to take it at the time of the violation in the bone system.
AARats, rheumatologist
Many patients note that Ostalon does not have a positive effect. This is due to improper administration of the drug. Strong side effects may occur with an overdose.
Yu. V.Ivanov, Trauma Physician
Patient Reviews
To obtain an effective result, you must follow the rules of taking the drug, without violating the dosage. Also it is worth taking the drug in the morning, keeping the vertical position after use.
Patients in their reviews note that the drug significantly reduces the risk of bone fractures, and Ostalon is convenient to take once a week.
Among the shortcomings is a high price of the drug, special rules for taking tablets, as well as the duration of treatment.
I take Ostelon, because I suffer from osteoporosis. A year has passed since the beginning of the reception. Has made repeated densitometry: bones of a backbone have strengthened on 12%, and hips - on 4%.
Anna Ivanovna, city of Stavropol
Mom and grandmother are suffering from bone problems. When taking the drug, they noted that not only the bones of the spine, thighs, strengthened, but also improved the condition of teeth and nails.
Pavel, Saratov
Purchase and storage of
Preparations are available in the form of tablets in blisters, which are in a cardboard bundle. The price for Ostalon and Otalon Calcium-D varies from 470 to 2,000 rubles. 
The products are stored at a temperature of no higher than 25 ° C.If the storage conditions are observed, the medicine can be taken within 2 years.
Drugs are dispensed with a prescription.
Ostalon has many analogues. Among them there is a Russian preparation - Alendronate.
You can also buy imported analogues: Ostererep( Poland), Tevanat( Israel), Forosa( Slovenia), Fosamax( Netherlands).
