Diffuse changes in the liver parenchyma and pancreatic cancer. What it is, treatment

diffuse changes can affect many organs of the person, most often they are identified during the examination of the digestive system. The parenchyma of the liver and pancreas suffering in most cases, since it is this part of the gastrointestinal tract performs important functions.

Reasons for changes in diffuse liver parenchymal tissue and pancreas

The parenchyma of the liver and pancreas is composed mainly of connective tissue that lines the inside and outside organs. Diffuse changes constitute a disease state in which this tissue is damaged, but not in a separate compartment, and the entire area.

Today, experts have determined that this condition does not develop as an independent disease, and acts as a complication of other diseases.

The main causes of diffuse lesions are as follows:

• smoking for many years, provoking regular food poisoning organism nicotine disintegration;
• Drinking large amounts of alcohol on a regular basis, provoking organ dysfunction;
• unhealthy diet with a predominance of fatty, salty, fried, smoked and spicy food;
• occasional meals, drinking on an empty stomach strong tea and coffee;
• long-term use of potent medicines from the group of antibiotics, and nonsteroidal antiinflammatory drugs, the passage of chemotherapy;
• drug addiction;
• professional activities related to the frequent contact with hazardous substances, poisons;
• a genetic predisposition to disease of pancreas and liver;
• autoimmune disease affecting the whole body (systemic lupus erythematosus, rheumatism);
• diabetes, provoking malabsorption of protein and carbohydrates, which leads to the appearance of lesions in the liver and pancreas functioning disturbance;
• serious illnesses bodies: hepatitis viral nature, cirrhotic changes, pancreatitis.

Diffuse changes in the liver parenchyma and pancreatic cancer may be the result of multiple causes.

Clinical manifestations of disease

Symptomatology of the disease is not immediately. Doctors attribute this to the lack of sensory receptors in the liver parenchyma. Body can not hurt, so patients do not go to a specialist. Only for advanced stages there are signs of violation.

The first symptom is heaviness in the right upper quadrant, aggravated after eating. It is worth noting that there is discomfort due to increased body and rubbing it on the edge of the costal arches. In addition, the production is disturbed and the flow of bile, as necessarily affected by gallbladder with lesions of the liver.

A clear sign of pancreatic involvement process will be nausea, vomiting, seizures, loose stools, constipation are periodically alternated. This suggests violation of the developing body enzymes necessary for proper digestion.

human appetite in most cases deteriorates receiving any fried foods provoke weight and belching. Sometimes there is heartburn, but the symptom is not typical for this condition. If the cause was diffuse changes cirrhosis or hepatitis, skin and mucous membranes acquire a yellow tinge.

With long-term course of the disease the patient's condition deteriorates, the skin becomes dry and rough on touch, there are areas of peeling, irritation as well as spider veins in places where the veil thin. The patient loses weight, becomes weak, apathetic.

Interconnection liver and pancreas

Diffuse changes in the liver parenchyma rarely affects only one body as the pancreas in most cases involved in the process. For several decades, the experts could not identify the relationship, until there was no exact information about the anatomy of the digestive tract.

However, after a careful study of the structure and the structure of the bodies revealed that the pancreas coupled with liver and gallbladder using common ducts which open into the duodenum intestine. That is why one organ failure necessarily leads to the violation of other functions. In addition, if the involved gland and liver, disrupted the stomach, small intestine and colon in the process.

DIP children

Diffuse changes can be detected even in young children and school age children. Sometimes the symptoms are present in the newborn, which is a consequence of inflammatory processes in the body of the mother during pregnancy or genetic diseases affecting the liver parenchyma.

In older children, symptoms of diffuse changes may occur after a viral hepatitis, or a course of treatment with potent medicines.

It should be noted that the clinical manifestations in most cases are mild or nonexistent, making it difficult to diagnose in the early stages. The only way to detect the disease is considered a periodic diagnostic examination of the child.

structural transformation

Diffuse changes may be minor, moderate and severe. First hardly occur, are diagnosed only by means of hardware. The latter appear more often, but the symptoms are smoothed out, and do not cause serious concern.

When expressed changes in symptoms is bright, the liver is often enlarged, the patient's condition serious. In addition, the condition can manifest as steatosis, ie vascular pattern pronounced by ultrasound, there are pockets of lipid accumulation.

When gepatoze changes are accompanied by the formation of fatty deposits, they gradually replace all the connective tissue cells. Running forms are characterized by degeneration of body fat that leads to disruption of its operation. There are also other types of DIP.

Diffuse inhomogeneous

Diffuse change liver parenchyma can flow through inhomogeneous type. This is manifested in a decrease or increase in the individual sections of the body. On examination the expert noted the heterogeneity of liver structure, the appearance of her bumps and fat islands.

The condition more often becomes the result of metabolic disorders in diabetes, obesity, viral infection organ, as well as obstruction of hepatic veins in other diseases.

Diffuse-dystrophic

Changing the parenchyma of this type is characterized by a decrease in the body due to the destruction of some of its cells and of dysfunction. In most cases, the state is caused by viral infections, common intoxication, receiving potent antibiotics, sedatives and diuretics. Sometimes DIP shown after transferring the patient several serious operations requiring the use of general anesthesia.

Diffuse transformation of prostate channels

The liver is made up of lobes, between which the venous vessels and bile channels. When changes parenchyma marked channel distortion, which affects the body and the gallbladder. Patients who abuse spicy, fatty, fried foods, alcohol, diets on a regular basis, often suffer from this form of the disease.

Regular and improper fasting can also cause.

Diffuse lesion in the background cholecystitis

Cholecystitis represents gallbladder disease characterized by inflammation of the inner shells and its functional impairment. The majority of patients with this disease marked change in the liver parenchyma. Usually disorders are mild, but if left untreated, the condition is exacerbated cholecystitis.

Increase in body and DIP

Diffuse changes against the backdrop of increasing the body appear quite often. Liver parenchyma in this case expands. State of medicine is known as hepatomegaly. It also acts as an independent disease, but occurs in response to any precipitating factors.

Patient discomfort appears when exercising. Palpation (palpation) enhanced liver pain.

on reactive type of defeat

Reactive parenchymal always accompanied by disorders of the pancreas. Result from acute diseases of the gastrointestinal tract. The patient's condition is deteriorating rapidly at the same time, the symptoms appear almost immediately, making it easier to diagnose.

patchy conversion

When the diagnosis of diffuse lesions can be seen that the whole body is involved in the process. But focal changes in the lesions alternating with healthy tissue. When ultrasound physician can accurately distinguish the number of lesions and their approximate resolution.

Diagnostics

For full examination of the liver and pancreas, various methods complement each other:

Method	Description
Overall patient examination	At the first visit expert examines the skin and mucous membranes of the patient, assess their condition, degree of hydration, elasticity, color
Palpation liver boundaries	Is carried out after a thorough inspection, it helps determine whether the liver if the discomfort on palpation there is increased
Clinical and biochemical blood	The first analysis helps to assess the overall condition of the patient, noted deviations, the second is considered most important for the diagnosis of liver and pancreas. The main parameter to be liver function tests, that is, the level of direct and indirect bilirubin. Normally a straight line in the analysis is not determined
Ultrasound of the liver and pancreas	The most important stage of diagnosis, helps to see the changes in the liver parenchyma pancreas. Depending on the development mechanism of diffuse changes in the doctor device screen will see a variety of abnormalities in as fat lesions on connective tissue, changes in the structure, reducing or increasing the body, its swelling
MRI	Magnetic resonance imaging is carried out not always, just in case, when ultrasound showed no abnormalities, but symptoms of the disease are present. The method makes it possible to detect even small pockets

After receiving the results of the survey the doctor establishes the definitive diagnosis and following treatment.

Treatment of diffuse liver changes

Diffuse changes in the liver parenchyma requires proper and timely treatment, because it can lead to unpleasant consequences. Today, experts use medicines, folk remedies, prescribed diet. In severe cases require an organ transplant.

Diet and helper methods

The first step to recovery will be dieting №5 by Pevsner. It involves exclusion from the diet of all the products, which could adversely affect the condition and function of the liver and pancreas. Dietary food completely eliminates the use of alcohol, carbonated drinks, coffee.

Should avoid salty, spicy, fried, sour, smoked, canned food. Should not be included in the diet of cakes and pastries, mushrooms in any form, nourishing broths and poultry fat, such as goose and duck.

The daily menu should consist of a soup with chicken broth, low-fat, cereal porridges, a small amount boiled potatoes, galetnogo cookies, berries and fruits, steamed vegetables, boiled liver, fish, low-fat meat. It is not necessary to cook in a pan, it is better to give preference to a double boiler. Portions should be small, frequent meals.

Among the auxiliary methods experts allocate use of tea from herbs and other natural products. It is useful to prepare a drink based chamomile flowers, hypericum, rosehips and viburnum with honey (300 ml of boiling water required 1 h. l of one of the ingredients). In addition, you should regularly consume low-fat dairy products.

medicines

Drug treatment brings good effect in a timely fashion, it starts.

The most effective drugs to date are as follows:

• Essential phospholipids (Leventsiale, Essentiale) to help restore the body structure and prevents further disease progression, improve the metabolism throughout the body, stimulate recovery. Drugs only prescribed by the doctor, the course lasts from 2 weeks to 3 months depending on the extent of disrepair.
• Hepatoprotectors (Phosphogliv, Geptral) appointed to prevent the spread of lesions on all the healthy areas of the organ. They help restore liver cells, improve the functioning of the body, normalize the indicators of bilirubin in the blood. The minimum duration for - 14 days. If necessary, the physician extends the course.
• Of vegetable origin (CARS Legalon, Silimar, Gepabene) appointed when the patient will have a long course. Preparations have gentle composition containing natural components, allowing the structure to restore liver gently.
• Bile medicines, for example, allow Allohol stimulate the formation and outflow of bile, prevents it from stagnating, improve the composition to normalize digestion. Showing the appearance of pronounced symptoms involving violation of the process of digestion.
• Immunostimulatory agents (Ergoferon, Tsiklovir) possess antiviral properties further, so help stimulate the recovery, prevent the development of complications, significantly improve the condition patient. Always used in the case where diffuse changes are the result of viral hepatitis.

If necessary, the doctor prescribes vitamin complexes (Complivit, Vitrum) after passing the main course of the patient, which allows you to restore the balance of nutrients in the body. Any of the drugs may be administered in the form of tablets or capsules, as well as injections. Self-administration without prior examination is strictly prohibited.

Folk remedies

Recipes Alternative Medicine suggest receiving infusions and other products based on natural ingredients. This helps to improve the general condition and minimize the negative effects of drug treatment.

The most effective means are the following:

• Oat broth is extremely useful for the liver and pancreas beverage. It is possible to prepare 1 liter of boiling water and 150 g oat flakes. The product should boil water for 5 minutes, leave for 2 hours for infusion, filter. The resulting broth to make small meals throughout the day. Repeat at least 21 consecutive days.
• Flask based tansy has excellent medicinal properties. In 300 ml of boiling water will need 3 g of ground herb infusion time - 30 minutes, taken daily for one month.
• Tea with sage can be used for 2 weeks. To prepare the required 500 ml of boiling water and 5 g of grass, the infusion time - 20 min. The resulting tea is taken in small portions throughout the day.
• Honey and royal jelly has an extremely positive effect on the liver. Daily necessary to use a mixture of 15 g of honey and 10 g of royal jelly. Duration of treatment - 3 weeks. The effectiveness of the method is scientifically proven specialists.
• Corn silk possess choleretic and hepatoprotective properties. Infusion of the herb is prepared by pouring 1 tbsp. l. feedstock 500 ml of boiling water. After infusion over 30 minutes infusion filtered and taking 20 ml 3 times per day. Duration of the course - at least 2 weeks.

Any of the recipes used only after the permission of the expert. Each of them has contraindications and side effects if used improperly can harm the organism.

Transplantation

In the absence of any effect of the treatments and the rapid deterioration of patient's condition and specialist decides the operation of organ transplantation. In addition, the indication for surgery is the development of acute liver failure, the critical indicators of increased bilirubin in the blood, congenital anomalies of the body.

Donor liver should approach the patient, the operation is very complex, there is a significant risk of death. When the success of the patient has a chance to recover.

Prognosis and complications

In identifying the disease at the initial stage of a favorable prognosis. Timely initiation of treatment helps to eliminate the possibility of complications. The most unfavorable forecast will be in the event of detection of disease at an advanced stage. Then even an operation to transplant a donor organ does not help the patient.

The most common complication is considered to be chronic hepatitis. Often patients develop steatosis. The worst prognosis is revealed in the development of cirrhosis, as the disease leads to liver failure and death of the patient. The maximum duration of life of these patients is 5 years.

Diffuse changes may affect different organs and provoke unpleasant symptoms. The parenchyma of the liver and pancreas is the most vulnerable, so often involved in the process. To avoid complications it is important to timely detect the disease and begin treatment.

Video of diffuse changes in the liver parenchyma

Diffuse Liver Disease: