Dimexide. Instructions for use solution, poultice, gel, tablet. Price, analogues, reviews

Dimexidum (Dimethylsulfoxide, Dimexidum, DMSO) - refers to the drug and is part of many anti-inflammatory and analgesic agents orientation.

The drug is widely used for external use in treating trauma, systemic disease, to improve skin and hair conditions. A careful study of the instructions to the drug will help to avoid possible complications.

The composition and the active substance

The composition of the drug depends on the drug form - concentrate or gel. The active substance in both cases - it Dimexidum sulfoxide. Liquid form means comprises Dimexidum 99% and 1% water. The gel has a lower concentration of the substance. It contains Dimexidum 25 g per 100 g of means.

The remaining 75 g falls on auxiliary components:

• Nipagin and Nipasol 0.063 g - prolongatory action, preservatives, anti-oxidants, regulators of pH;
• carmellose sodium - 2 g - gelling agent;
• water - and solvent medium for the substance.

release Form

Dimexidum drug release in 2 dosage forms: concentrate and gel. Concentrate - is a clear liquid with a pungent odor resembling garlic. It is bottled in dark glass bottles of 50 and 100 g Each container with the drug is packaged in a cardboard box, which shows the basic information about it, and is provided with instructions for use.

Gel Dimexidum - means having a slightly yellow color and a faint characteristic odor. Its release in tubes of aluminum or plastic, cans with a lid, weighing from 20 to 500 g, each in an individual container carton.

pharmacological properties

Dimexide, instructions for use which describes in detail the mechanism of action - means reducing the symptoms of inflammation.

It operates through:

• improved local metabolism;
• deceleration of the excitation of the peripheral nervous system;
• inhibition of peroxidation in the lesion.

The drug relieves pain, facilitates the manifestations of inflammation, destroys microorganisms in inflammation. It shows the ability to dissolve fibrin Dimexidum education.

Pharmacokinetics

Dimexide, according to the instructions to the drug is readily absorbed and reaches the systemic circulationWhere it can be detected by laboratory methods already 10 minutes after application. Chemists have determined that the maximum content of the substance determined 2-5 hours after applying it, after 30 hours it completely exits the human body.

Dimexide does not accumulate in the body during treatment.

The drug is excreted in the urine, partly in unmodified form or in the oxidized to dimethyl sulfone and dimethyl sulfate. A quantity leaves the body with exhaled air, in the form of dimethyl sulfide. Dimexide easily penetrates into the joints, which allows wide use in the treatment of arthritis of various nature.

pharmacodynamics

Dimexide - a low-toxic substance. It has potent anti-inflammatory effect.

In addition, it provides the following types of action in the body:

• a local anesthetic;
• decontamination system;
• fibrinolytic system.

It should tell more, whereby a therapeutic effect is possible. The substance affects the formation of insoluble protein fibrin, which inhibits the formation of blood clots in the lesion. This effect is realized in trauma, systemic inflammatory reactions.

Also, the drug improves the local blood supply due to the fact that helps blood cells - phagocytes to "purify" the pathological focus from the dead blood cells, tissue fragments, bacteria and viruses. Dimexide reduces the adhesion of red blood cells, suppresses the direction of leukocytes to the site of injury. In addition to improving blood flow it is working to reduce the number of immune complexes in the blood.

The drug readily penetrates the membrane (skin, mucosal), improving the efficiency of drugs used in the complex therapy. He acts on the cell wall of microorganisms, reducing drug-resistant to antibiotics.

Indications

The drug is indicated for the treatment of pain and as an element in an integrated circuit with pathologies such as:

• deformirouyuschi osteoarthritis;
• radiculopathy;
• rheumatoid joint damage;
• reactive arthritis;
• erythema nodosum;
• limited forms of scleroderma;
• discoid form of systemic lupus erythematosus;
• ankylosing spondylitis;
• traumatic hematoma, infiltration;
• damage ligamentous apparatus;
• trigeminal neuralgia;
• thrombophlebitis and trophic ulcers;
• burns;
• Acne vulgaris, boils;
• eczema;
• erysipelas;
• baldness;
• burns and sores.

Plastic surgeons use the drug to save the skin of auto-, homografts.

How to compress breed Dimexidum

The medicament enters the pharmaceutical network as 99% concentrate. Localization of the hearth, the patient's age, type of disease define different degrees Dimexidum breeding. The solvent is cooled boiled water or water for injection.

For compresses applied 30-50% agent. His agitated, applied to cotton flap that closes the affected area. Top piece of cellophane is applied, the size of which is greater than 2 cm from each side, and warm cloth.

How to apply the solution

The drug is used only for external use. It is applied up to 2 times a day course up to 14 days. After treatment stages required to complete a break until 9-12 days, after which the procedure can be repeated. In infectious diseases of the skin is allowed to use up to 3 times a day, in violation trophism - up to 2 times a day, inflammation, pain syndrome - 1 times per day.

Necessary concentration indicated in the table below:

The concentration of the drug	disease
30-50%	erysipelas; ulcerative lesions; streptococcal infection of the skin; pyoderma; arthritis; arthritis; injuries of the joints, muscles and ligaments.
20-30%	3 degree burns, children's age
10-20%	Face, mucous membranes, plastic surgery

Gel Dimexidum: instructions for use

The drug gel is used in the form of applications. It sparingly applied to the skin. mucous and carefully triturated. Duration, frequency of application is different from that when using Dimexidum solution.

If it affects the veins of the lower extremities gel is used together with heparin ointment.

According to the statement, the gel is recommended for the treatment of transplant patients skin. The gel is applied to the flaps after operation and is used during the time required for engraftment.

How to plant a preparation for joint with gout?

Dimexide (instruction manual contains references to the appointment with synovitis) to combat gout is administered in the form of applications. The drug is recommended during the attack and resorption of the inflammatory infiltrate immediately relief after the main symptoms of the disease:

1. The preparation is diluted with water in ratio 1: 1. To enhance the effect added to a solution of 2% Novocain: 30 ml 20 ml Dimexidum take local analgesic.
2. Means impregnated gauze or cotton cloth and apply to the area of ​​the affected joint.
3. Applique insulated scarf, with the defeat of leg joints wear socks.

Duration finding bandage on the skin of from 40 to 60 minutes. The average treatment takes up to 2 weeks. The procedure is performed 1 time per day, at bedtime. If necessary, the course was increased to 60 days.

Application of the heel spur

Dimexidum at the plantar fascia is used in the form of a solution. To prevent the occurrence of burns, the concentrate is diluted with water in proportion 1: 2. If such treatment is well tolerated, the active substance content is increased to 50%.

The fabric impregnated with drug, is applied to the affected heel, harboring polyethylene graft slightly larger and insulated. Duration of treatment was 30 minutes.

To improve the treatment efficiency compress added antiinflammatory drugs - Diclofenac, Diprospan, Ketoprofen rate of 1 ampoule per 100 ml of final solution. Unused funds can be stored in the refrigerator for 2-3 days. The duration of treatment is 2 weeks, the procedure is carried out daily.

How do swabs Dimexidum?

The official instructions to the drug makes no mention of its use in gynecological practice. When such treatment is extremely difficult to control security solution for mucous genitals.

There is a hypothesis that the drug helps to improve blood circulation and increase the sensitivity of the microorganisms that cause chronic infections of female genitalia to antibiotics.

To prevent burn recommended to use a 10% solution in a short time - no more than 20 minutes. Drug-impregnated swabs of surgical gauze and plants into the vagina. Duration of the course determines the gynecologist individually.

Carry out the destruction of pathogenic flora in the vagina during pregnancy or breast-feeding in this way is strictly prohibited.

Some sources say the information on the application of turundae with Dimexidum for the treatment of sinusitis. Cotton swabs or gauze impregnated agent which is prepared from a solution of the drug, and hlorfilllipta antibiotic ampicillin. However, otorhinolaryngology categorically do not recommend this method of application Dimexidum due to the high risk of adverse manifestations.

Dimexide hair

Improved local blood flow helps to improve the nutrition of hair, and is the basis of the treatment or prevention of hair loss.

To this end, prepare a mask with Dimexidum, the procedure is performed on clean and dry hair:

1. For masks suitable drug solution: 1 part concentrate Dimexidum and 9 parts of water. Before use, it is heated in a water bath to a comfortable temperature.
2. Means, stirring constantly, gently applied to the scalp. To protect hands wearing thin medical gloves. Head harbor bathing cap, towel.
3. The duration of the first treatment is not more than 15 minutes, further it can be increased up to 1 hour. When the burning sensation should immediately wash off the mask.
4. The recommended frequency of application - 1 time per week, the duration of the course of -1.5 -2 months.

To achieve the best effect in the mask are added components such as burdock oil, oil or fat-soluble vitamins.

Before first use should be tested for the ability Dimexidum cause allergic reactions by applying the process solution on the forearm. Should take into account the characteristic odor of a substance, and not to use a mask when tendency to respiratory allergies and contraindications specified in the instructions to the drug.

Dimexide face

Dimexidum has potent anti-inflammatory action, dissolving elements rash on the face. The drug also kills bakterilnuyu flora and improves the local blood circulation.

These useful properties make it possible to use it to improve the skin. To combat rashes agent is diluted with water in a ratio of 1: 8-1: 10, is applied to cotton pads and applied to inflammatory elements 10-15 min. After the procedure on the affected skin is applied medications for acne.

As an alternative to using a solution of 25% gel dot. In some instructions found on board the need to cover oilcloth or cellophane affected areas. However, treatment of acne can cause a stronger Dimexidum contact with delicate facial skin and cause dermatitis, burns.

The use of anti-wrinkle drug based on the ability of a substance to improve the permeability of the skin to other means. Restricted is the fact that the application of the drug with a pungent smell have to do a large area of ​​the face.

Napkin with 10% solution Dimexidum applied for 10 minutes, then the skin is rinsed, applied cream or whey. Discuss the possibility of such treatment, its duration can be a beautician.

Dimexide cellulite

To get rid of "orange peel" are used 50% of the drug solution. It is applied to cloth napkins, which wraps the hips. As the next layer using a cellophane or plastic wrap, wear warm pants.

Duration of the course - 10 procedures. Care must be taken to stop treatment when a burning feeling, discomfort, symptoms of allergy to the drug. After each leg procedure rinsed with pure water and applied anti-cellulite agent.

Pregnancy and lactation

Dimexide prohibited the appointment of women during pregnancy or breastfeeding.

children

The drug is strictly banned for use in patients under 12 years old. Using Dimexidum to treat bronchitis, pneumonia (compresses the chest) is not recommended at children of all ages because of the high risk of undesirable effects: increased toxicity, allergy, bronchospasm.

When trauma, systemic disease of the joints and muscles use applications, compresses the drug in lesser concentrations - up to 10-30%. The duration of the course of therapy, the application of frequency determined by the attending physician.

In human liver

The drug is absolutely contraindicated in hepatic dysfunction.

When renal impairment

Dimexidum, instructions for use which contains all the information about the restrictions in the application can not be given to patients with kidney disease.

when glaucoma

This disease falls into the list of contraindications to Dimexidum treatment.

Contraindications

Doctors warn about the careful use of Dimexidum together with other drugs, explaining that co-administration therapy increases the toxicity of other components. This occurs by improving the permeability barrier of the organism, enhancing blood flow.

The medicament is not used as the mono- or combination therapy of the following diseases and conditions:

• idiosyncrasy active substance or auxiliary components in the composition means;
• gross pathology of the liver, kidney;
• acute (myocardial infarction) or chronic (angina pectoris) coronary circulatory insufficiency;
• severe atherosclerotic disease of large and small vessels;
• Patients younger than 12 years;
• gross violations of consciousness (coma);
• eye disease - glaucoma, cataracts;
• any period of pregnancy;
• lactation.

Side effects

Rheumatologists warn that the likelihood of undesirable effects in the treatment solution higher Dimexidum view of the large concentration of a substance, but they are the same for the gel and liquid forms.

These manifestations include:

• simple contact dermatitis;
• allergic rashes;
• feeling of dryness of the skin;
• burning at the site of application;
• the appearance of local skin pigmentation;
• nausea and vomiting (in response to a sharp odor substances);
• appearance garlic odors in the breath;
• spasm of the bronchial tubes.

If you have any undesirable manifestations should immediately consult a specialist.

Overdose

Dimexidum, instructions for use which contains all the known undesirable effects in response to the local application, and an overdose may cause. Against the background of her patients has increased, the intensity of side effects.

Upon detection of an overdose should be discontinued treatment gel or concentrate, immediately remove from the skin had not soak up the remnants of the drug. For this covers washed with abundant cool water.

Symptoms of overdose when using the drug inside - it's indigestion, lethargy, drowsiness, and headaches. In this case, you should immediately call the ambulance for gastric lavage.

special instructions

Before starting treatment, the patient or his relatives should ensure the safety of the substance. For this purpose a gel or a dilute solution to a working state Dimexidum concentrate is applied onto the inner side of the forearm near the elbow. The patient expects about 20 minutes and assesses their condition.

In the absence of cutaneous reaction respiratory manifestations drug licensed for use. If the background of the trial application or during the treatment of allergy symptoms occur, treatment should be stopped and prescribed antihistamines.

How to treat burns from Dimexidum?

Prolonged compress finding use with the drug or a concentrated solution may cause chemical burns on contact with the drug.

If the patient is found redness, exfoliation with blistering, soreness, should be discontinued immediately contact the affected area with Dimexidum. and wash the lesion with water.

Next, in the burn applied:

• prednisolone ointment while maintaining the integrity of the skin - for reducing inflammatory manifestations;
• Panthenol spray, Solcoseryl gel - to promote healing.

drug interactions

Due to the positive effects Dimexidum blood flow, increased permeability of the barrier body, the drug enhances the efficacy of such antifungal and antibacterial agents, such as:

• aminoglycosides;
• rifampin;
• penicillins;
• cephalosporins;
• carbapenems;
• griseofulvin.

The same action improves the performance of NSAIDs and heparin in the joint appointment, increases the sensitivity of the patient to the drugs used for general anesthesia. If necessary, surgical intervention should inform your doctor about using Dimexidum.

Furthermore, a drug enhances the effect of ethyl alcohol and the hormone insulin.

Where can I buy

Preparation implement through pharmacies in the department of OTC.

The cost of packaging is as follows:

• Dimexidum concentrate 99% - 100 ml 50 rub .;
• Dimexidum 25% gel in 30 g tube - from 164 rubles.

Storage conditions

To maintain the properties of the drug stored in a dark place protected from children at a temperature of from 3 to 24 0 C in a package with the name, expiration dates. Dimexide licensed for use for 2 years from date of manufacture.

analogs

Analogues preparation containing the same active substance, not present, however, there are drugs having similar effect on inflammatory lesions.

The name of the drug, the release form	The active substance in the composition of	Features of the application	Efficiency and price
Fastum gel	Ketoprofen (non-steroidal anti-inflammatory agent)	The drug helps in the affected joints, muscle pain. It has a pronounced anti-inflammatory and analgesic action. Contraindicated to 12 years in the treatment of women in the 3 trimester of pregnancy and during lactation. Should not be applied to the open wound surface. Interactions with other drugs have been reported. When applied to the skin bioavailability of less than 5%. The gel is rubbed with gentle movements in the affected area, cover compress prohibited.	The drug is effective in injuries of joints, treatment deforming osteoarthritis. Patients note a pleasant smell means high efficiency with injuries, lower in spinal osteochondrosis. Preparation tubes sold in weights from 30 to 100 g, costs - 260 rubles. per pack.
ihtiolovaya ointment	Ihtammol - stlantsev distillate bitumen, the preparation with antiseptic and disinfectant action	Means prescribed for inflammatory diseases of the skin (erysipelas, furuncle, carbuncle), destruction of muscle and ligaments, joint capsules, arthritis. The drug relieves pain, disinfects the lesion, restoring local blood circulation, has anti-inflammatory effects. Ointment is contraindicated in the development of individual intolerance.	Patients note the high efficiency of the drug in the first place for skin infectious lesions. The drug is produced in tubes and glass jars weighing 25 grams, priced from 123 rubles.
Bishofit, solution, gel	Natural mineral, the bulk of which is a compound of magnesium chloride	Inflammatory diseases of the nasopharynx, joints and muscles. It has anti-inflammatory, analgesic, improves tissue regeneration. The drug is prohibited to be applied to areas of skin with impaired integrity, pregnancy, allergic reactions. Interactions with other drugs have been reported.	Patients evaluated the drug to be sufficiently effective in arthrosis. radiculitis. gout. The cost of the gel tube 75 g of RUB 100, the means for baths of 500 ml -. 99 rubles.
Hlorfillipt alcohol solution	Extract of leaves of eucalyptus. Agent has anti-inflammatory action, destroys bacteria, fungus, viruses, enhances tissue repair	The drug is prescribed as a part of comprehensive treatment of various inflammatory processes: the defeat of the respiratory tract, burns, dermatitis, trophic ulcers, neuritis, radiculitis, degenerative-dystrophic lesions spine. It means prohibited for allergic manifestations in history	Patients reported rapid healing of venous ulcers, postoperative wounds when applied Hlorfillipta. Cost 100 ml of the product is about 170 rubles.

Dimexide available in most pharmacies in the free market. For its acquisition does not require the prescription of the extract, the low cost makes it suitable not only for the treatment of systemic diseases, but also to eliminate cosmetic problems. A careful study of the instructions for the use of funds will prevent the development of complications during therapy.

Registration of the article: Mila Friedan

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