Anti-Müllerian hormone. The norm in women by age. Table 2, 3, 4, 5, 6 day cycle for IVF conception. What if downgraded, higher than normal

Hormones woman is an important component in the planning of pregnancy. Hormones perform a regulatory function of the whole body, helping it to work properly. They have to separate between them by type.

One is the Anti-Müllerian hormone (abbreviated AMG) - a biologically active substance (protein molecule), which is produced in the male and female body, but in men, its concentration much smaller. hormone norm depends on the age of the woman.

Named after the German scientist Johann Muller, isolated from male and female embryos common-channel tube - duct, from which developed the uterus, fallopian tubes and vagina in women, and the prostatic utricle and epididymis in men.

The concentration of the substance in the body refers to the ability to conceive, and abnormality may indicate a serious problem, for example, the presence of tumor in the cavity of the ovary.

The role of the hormone in a woman's body

Anti-Müllerian hormone (rate is calculated according to age and state of health) - a substance that produces ovarian cells, affecting the appearance of eggs in women. Anti-Müllerian hormone produced by the body is already on 32 week of the embryonic state, it is present in both male and female body, but in men, its concentration is much smaller.

The embryo begins to form a flow tube (Mueller). In males, it disappears in the 10th week, and uterine space is formed in the female out of it. An important role in the body of the girl hormone begins to play in the process of puberty.

After menopause, the hormone ceases to exist, this is due to the cancellation of the process of formation of eggs.

If during the sexual development of the concentration of the hormone does not reach the standards, it is considered the first sign of infertility.

Since 12 years gradually increased hormone concentration. From 20-30 years of hormones to be at the peak, and after 30 years, the concentration is on the decline, and the body gradually prepared for the onset of menopause. In menopausal hormone production stops.

Indications for depositing analysis

The cavity is formed of the ovarian follicles in which matures ready to fertilize the egg. Most of the follicles there are at rest, every month there is the maturation of one egg. The follicles that are buried in the ovarian cavity, secrete a hormone, and has matured no longer do so.

Blood sampling shows how many follicles remain dormant and ready to go in the stage of readiness. The concentration of AMH depends the ability to conceive and speed of onset of menopause.

There are several indications when necessary to analyze the concentration of AMH:

• set puberty girls step (earlier or later);
• find out the sex of the child, if there is androgyny;
• to evaluate the female (male) fertility;
• know what a reserve of eggs in the ovaries of women;
• fix the offensive early menopause;
• fix ovarian cancer and to monitor its development;
• record the increase or decrease of the ovaries;
• unsuccessful IVF;
• infertility.

  

If a woman has an acute problem with the conception of the child, medical experts recommend taking blood sampling for analysis antimyullerovogo concentration of the hormone in the next 30 days after the start of menstrual cycle.

The study should be carried out several times, and if there is risk of infertility, - it is necessary to hold Removing fruitful eggs to freeze them for subsequent artificial fertilization.

What will the hormone level

Results AMG analysis helps identify abnormalities that occur in a woman's body. With it you can learn in advance about the changes before menstruation cyclical change.

Also on hormone concentration can determine a decrease in fertility. With the right research can reveal the results of the period when the menopause, which allows, if desired, to conceive a child.

How to get tested

Anti-Müllerian hormone, which is the norm in women depends on the age, can testify to the pathology of the reproductive system. Typically, women with a normal delivery cycle prescribed analysis cyclic 3 day as co-produced blood sampling in other hormones.

On the 3rd day of the cycle shall also analyze the concentration of AMH for artificial insemination and cycle disorders. In other cases, blood sampling is required to carry out the fifth and fourth days of the cycle.

To obtain reliable results, it is necessary to observe a number of rules:

• morning before blood sampling does not eat or drink;
• four days to eliminate physical exercise and not be nervous;
• not to donate blood for AMG if the newly acute diseases have been transferred;
• before delivery (per hour) to exclude smoking;
• per day not to eat fried and fatty foods, and do not drink alcohol.

If available, any other rules that must be met prior to delivery of the analysis, the medical practitioner will warn and give recommendations. The results will be ready after 2-3 days, and in some cases laboratory tests can take up to a week. Diagnoses and decodes parameters only the treating physician.

Norma Antimyullerova hormone in women

Anti-Müllerian hormone, the rate of women has a wide range of demonstration, is not affected by the menstrual cycle. For each woman a different value as the stock fruitful eggs in all different. Normal values ​​hormone in girls to 8 - 9 years is in the range of 1.7 - 5.3 ng / ml.

Name	Norm (ng / ml)	Promoted (ng / ml)	Lowered (ng / ml)
1. By age (s)
1.1. 20-24	1,88-7,29	≥7,30	≤1,87
1.2. 25-29	1,83-7,53	≥7,55	≤1,82
1.3. 30-34	0,95-6,70	≥6,71	≤0,94
1.4. 35-39	0,777-5,24	≥5,25	≤0,78
1.5. 40-44	0,097-2,96	≥3,00	≤0,095
1.6. 45-50	0,046-2,06	≥2,1	≤0,045

Decrypt the data analysis should only medical specialist. If the analysis gave up on the personal initiative of a woman, you should definitely see a doctor to obtain a valid response. Only, but can give to explain the changes in the female body.

Why hormone increased

There are a number of factors that can affect the level of the hormone in the blood:

• method by which the research was conducted;
• compliance with the rules of transportation and storage laboratory material;
• overweight, obesity, susceptibility to diabetes.
• race;
• indicators of vitamin D;
• bad habits (smoking, alcohol abuse);
• prolonged use of antibiotics or hormone preparations.

Anti-Müllerian hormone, which is the norm in women depends on the age, it is subject to change. Deviations in higher or lower may be indicative of different pathological processes in the body. Control of hormone changes should be conducted not only when the planned conception, but also for the detection of serious diseases.

AMG may rise as a result:

• polycystic ovary ( "lock" in the cavity of ovarian follicles);
• tumor formation in the ovaries;
• infertility;
• Late puberty;
• tuberculosis.

Based on blood tests results the doctor makes a diagnosis.

Why hormone downgraded

Anti-Müllerian hormone in women varies depending on age. To detect abnormalities, need to regularly give blood to balance hormonal levels. Women are often afraid of abnormalities in the smaller side, as this is primarily due to the inability to get pregnant.

Additionally, low level indicates AMG:

• to reduce the amount of productive follicle;
• to reduce the functionality of the ovaries due to their exhaustion;
• obesity;
• at the onset of menopause;
• genetic abnormalities in ovarian development;
• ovarian injury;
• malfunction of the pituitary gland.

These reasons indicate that women with low hormone levels, most likely, will not be able to conceive naturally. An attempt to conceive using IVF in this case be minimized.

The consequences of deviations from the norm

Not the normal state of AMH concentration in a woman's body testifies to its abnormal development or a pathological process occurring in the cavity of the ovaries. What is happening with hormone production can be understood after blood sampling for analysis.

The consequences of the abnormal hormone concentrations are directly proportional to the reasons that caused the imbalance. If the time does not take maintenance therapy at an elevated AMH concentration, it is likely that the woman can not get pregnant on their own.

In the advanced stages of a positive result from in vitro fertilization unlikely.

Features of treatment

If there is any deviation from the normal content of the hormone in a woman's body, then there is a number of features that should be taken during treatment:

• Increase the concentration of AMH medication methods is impossible, they are designed to prevent situations that result in a decrease of the hormone occurs. Preparations perform a catalytic function, ensuring the normal functioning of the ovaries.
• At elevated AMH can not take hormonal drugs, they may further aggravate the situation, to break the kidneys, nervous system and heart.
• During the treatment period the woman should continuously monitor the concentration of the hormone that the indicators are not passed limit of normal.

What if hormone increased?

Treat increased concentration of hormone needed, starting from the causes of the pathological condition.

As concomitant therapy aimed at lowering concentrations of the hormone, you need to:

• adjust body weight and build the correct mode meal;
• reduce or vice versa to increase physical activity on a doctor's recommendation;
• balance between work and hours of rest;
• normalize the overall hormonal levels.

In identifying the polycystic ovaries can resort to surgery, during which the artificially derived eggs and ovarian cavity free. Prerequisite is visiting the doctor (gynecologist, oncologist and endocrinologist). If no improvement is observed it is necessary to conduct more in-depth re-examination.

What if hormone downgraded

Today medical experts have been identified drugs that could increase the AMH concentration for a sufficient amount of a woman fruitful eggs.

Delay for time reduction AMG helps hormonal drugs that perform the function of the lock. During treatment stops the ovaries, which helps keep the ovarian reserve for future pregnancy.

If the hormone is reduced in adolescence, it is necessary to conduct a detailed investigation to determine the cause of deviations in time and prevent the development of serious diseases.

In some cases it is enough to relax and build a healthy lifestyle. If the hormone increase does not occur, then the woman to give birth, it is best to go to the clinic for artificial insemination.

AMG and IVF (in effect on the course of the procedure)

When planning a pregnancy, delivery of the analysis on the concentration of the hormone antimyullerova be mandatory. AMH and IVF inextricably linked. Before the procedure, an expert studying the general state of the hormonal status of the woman.

The more active follicles found in the woman, the more likely a successful artificial insemination. If the concentration antimyullerova hormone is at high level, then IVF can be performed using its own active eggs.

If the concentration of the hormone is approximated to zero, then stimulate the egg available does not make sense, since they can not produce offspring. In such situations resort to donor specimens and produce artificial insemination.

If the Anti-Müllerian hormone ponizhet, then artificial insemination is possible, provided that the follicle index is within normal limits. Under these conditions, in vitro fertilization is carried out in two stages, during which the applied stimulation increased ova hormones.

1. Long protocol (stimulation oocytes occurs over 30 days, 2-4 follicles formed as a result);
2. Short protocol (stimulation takes place 14 days, 10 active follicles formed as a result).

All appointments carried out only after a full examination of the female body, as after intensive stimulation artificial hormones can happen even greater reduction in the concentration of AMH in connection with what form the new problems health.

The entire period after successful fertilization, a woman is under the strict supervision of medical specialists. Medical specialist prescribes supportive hormonal therapy to avoid rejection occurred ovum.

Quality and reliability of the laboratory blood tests on AMH concentration may depend on the following factors:

• how well the chosen laboratory;
• which method was chosen for analysis;
• how well and correctly it was produced blood sampling;
• storage and transportation taken analysis;
• properly calibrated;
• the patient's age (women);
• Genetic changes in the body;
• disease diabetes mellitus;
• autoimmune diseases;
• weight category of the patient;
• application previously hormonal medicines;
• intake of vitamin D in a woman's body.

AMG and pregnancy

To determine the probability of getting pregnant for deviations in the index of AMG, medical experts consider the possibility that ovarian stimulation would yield positive results.

If pregnancy is planned for the period of early menopause, the stimulation and the possibility of conception should be discussed with the endocrinologist. Specialist will help you choose simulating drugs to delay menopause and revitalize the follicles.

Pregnancy options with low rate of AMG:

• pregnancy possible if hormone concentration reached critical levels, specialist selected correction parameters using hormone replacement therapy;
• if downgraded AMH, FSH but ranges from 10 to 15 IU, then become pregnant and bear a healthy child likely;
• if AMH concentration is low, while FSH is critical for high level, the low chances for pregnancy.

AMG high performance point to reproductive disorders associated with genetic problems, tumors and polycystic. Conception at inflated rates is postponed until the cause. Should not delay treatment because of this life may depend.

It is worth noting that the low AMH during pregnancy can affect the sex of the child, namely the right to education of male and female genitalia. This occurs in the first trimester. In some cases, doctors prescribe supportive therapy, which contains a small amount of hormones that regulate the state of pregnancy to a successful birth.

How to improve the AMG folk remedies

Folk remedies, in the opinion of women and medical professionals to help restore normal hormonal levels.

These include royal jelly, honey and vitamin D.

• Vitamin D can be obtained by walking on the street on a sunny day or turn to pharmaceutical drugs.
• At the pharmacy you can buy supplements «DHEA» or vitamin D3. Vitamin effective in AMH concentrations of less than 0.5. Taking the drug must be in consultation with a medical specialist. It is necessary to study the instruction sheets that came with the drug. For some people, there are an allergic reaction to vitamin D. In such cases, will have to obtain its full-scale way from sunlight.
• Even in ordinary life, doctors recommend guzzle a course of vitamin D during the winter season, as this is the time solar activity is minimized, and the body needs to use it.
• Royal jelly and honey, according to supporters of traditional medicine, also contribute to the hormone. To conduct this type of treatment is effective in conjunction with a special power supply mode. It is proved that bee products has a favorable effect on the human body, strengthening it from within. The daily dose is calculated from the weight category women, it can vary in the range of 100-500 mg. Before application it is necessary to find out whether a woman's reactions to bee products, because they are allergenic foods. Royal Jelly is rich in carbohydrates, amino acids, proteins, minerals and vitamins.

Royal Jelly can help:

• improve the immune system;
• strengthen the heart;
• improve lymphatic flow;
• relax uterine muscles;
• bring to normal pressure;
• improve the performance of the thyroid gland;
• improve hormone balance.

For pregnant women it means also shows it helps to get rid of insomnia, mood swings and any miscarriage. Reception period varies from 1 to 3 months. The dose of royal jelly to be taken for 1 hour before a meal. It is proved that a fortified body is able to partially heal itself, as well as to restore to normal the entire hormonal levels in women.

Registration of the article: Mila Friedan

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