What drugs for diabetes are better and more effective for treatment?

Everyone knows that diabetes is divided into 2 types. Insulin-dependent type 1 diabetes is characterized by impaired pancreatic function, which stops producing insulin or produces it in insufficient quantities. In this case, substitution therapy with insulin-like drugs is used. In type 2 diabetes, insulin is produced in sufficient quantities, but cell receptors are not capable of absorbing it. In this case, drugs from diabetes mellitus should normalize the level of sugar in the blood and promote the utilization of glucose.

Medications from non-insulin-dependent diabetes are prescribed taking into account the individual characteristics of the patient, his age of weight and the presence of concomitant diseases. It is clear that those drugs that are prescribed for the treatment of type 2 diabetes, absolutely do not fit diabetics, in the body of which insulin is not produced. Therefore, only a specialist can select the right tool and determine the necessary treatment regimen.

This will help slow the progression of the disease and avoid serious complications. What are the better and more effective drugs for diabetes? It is difficult to give an unambiguous answer to this question, since a medicine that is well suited to one patient is completely counter-indicative to another. Therefore, we will try to give an overview of the most popular means for diabetes and start with the drugs used to treat type 2 diabetes.

Type 2 diabetes mellitus

Patients with type 2 diabetes mellitus can for a long time dispense with sugar-lowering tablets, and maintain normal blood glucose values ​​only by observing a low-carb diet and sufficient physical activity. But the internal reserves of the body are not infinite and when they are exhausted, patients have to switch to taking medications.

Preparations for the treatment of type 2 diabetes are prescribed in the case when the diet does not give results and the sugar in the blood continues to increase for 3 months. But in some situations, even taking oral medications is ineffective. Then the patient will have to switch to insulin injections.

List of drugs for type 2 diabetes is very extensive, they can all be divided into several main groups:

Photo: preparations for type 2 diabetes

1. Secretologists are drugs that stimulate the secretion of insulin. In turn, they are divided into 2 subgroups: derivatives of sulfonylureas( Diabeton, Glenororm) and meglitinides( Novonorm).
2. Sensitizers are medicines that increase the sensitivity of tissues to the action of insulin. They are also divided into 2 subgroups: biguanides( Metformin, Siofor) and thiazolidinediones( Avandia, Actos).
3. Inhibitors of alpha-glucosidases. Preparations of this group are responsible for regulating the absorption of carbohydrates in the intestine and their excretion from the body( Acarbose).The drugs from type 2 diabetes of the new generation are incretins. These include Januvia, Exenatid, Liraglutid.

Let us dwell on each group of medicines:

Derived sulfonylureas

Photo: Derived sulfonylureas

Drugs of this group have been used in medical practice for more than 50 years and are well-deservedly popular. They have a hypoglycemic effect due to a direct effect on the beta cells that produce insulin in the pancreas.

Reactions occurring at the cellular level, ensure the release of insulin and its release into the bloodstream. Preparations of this group increase the sensitivity of cells to glucose, protect the kidney from damage and reduce the risk of vascular complications.

At the same time, sulfonylurea drugs gradually deplete pancreatic cells, cause allergic reactions, weight gain, stomach upsets, increase the risk of developing hypoglycemic conditions. They are not used in patients with pancreatic diabetes, children, pregnant and lactating women.

In the process of treatment with drugs, the patient should strictly adhere to a low-carbohydrate diet and bind the reception of tablets to the diet. Popular representatives of this group:

• Photo: Glikvidon

  Glikvidon - this drug is characterized by a minimum of contraindications, so it is prescribed to patients who do not receive the necessary result in diet therapy and to the elderly. Minor adverse reactions( skin itching, dizziness) are reversible. The drug can be prescribed even with renal failure, because the kidneys do not participate in its withdrawal from the body.

• Maninil - is considered the most powerful preparation for the pancreas in diabetes mellitus. Produced in the form of tablets with different concentrations of active ingredient( 1.75, 3.5 and 5 mg) and is used at all stages of the formation of type 2 diabetes. It is able to reduce the level of sugar for a long time( from 10 to 24 hours).
• Diabetic - is particularly effective in the first phase of insulin production. Additionally, it provides reliable protection of vessels from the damaging effects of glucose.
• Amaryl is the best drug for type 2 diabetes. Unlike other hypoglycemic drugs, it does not provoke weight gain and has minimal negative effects on the heart and blood vessels. The advantage of the drug is that it very slowly removes insulin in the bloodstream, which helps to avoid the development of hypoglycemia.

The average cost of sulfonylurea preparations is from 170 to 300 rubles.

Meglitinides

Photo: Starlix

The principle of action of this group of drugs is to stimulate the production of insulin by the pancreas. The effectiveness of medications directly depends on the level of glucose in the blood. The higher the sugar, the more insulin will be synthesized. Representatives meglitinidov - drugs Novonorm and Starlix. They refer to new generation drugs, characterized by short action. Tablets should be taken a few minutes before meals. Assign them more often as part of a comprehensive therapy for diabetes. Capable of causing such adverse events as abdominal pain, diarrhea, allergic and hypoglycemic reactions.

1. Novonorm - the doctor chooses the dosage of the drug individually. The tablet is taken 3-4 times a day, just before meals. Novonorm reduces glucose levels smoothly, so the risk of a sharp drop in blood sugar is minimal. The price of the drug is from 180 rubles.
2. Starlix - the maximum effect of the drug is noted 60 minutes after taking and remains for 6-8 hours. The medication is different in that it does not provoke an increase in weight, does not have a negative impact on the kidneys and liver. Dosage is selected individually.

Biguanides

Photo: Biguanides

These drugs from type 2 diabetes prevent the release of sugar from the liver and promote better absorption and movement of glucose in the cells and tissues of the body. Medicines of this group can not be used in type 2 diabetic patients suffering from cardiac or renal insufficiency.

Action biguanides lasts from 6 to 16 hours, they reduce the absorption of sugar and fats from the intestinal tract and do not provoke a sharp drop in blood glucose. Are capable to cause change of taste, a nausea, a diarrhoeia. The biguanide group includes the following medicines:

1. Siofor .The drug is often prescribed to patients with excessive body weight, as taking tablets helps to reduce weight. The highest daily dosage of tablets is 3 g, it is divided into several doses. The optimal dose of medicine is chosen by the doctor.
2. Metformin .The drug slows the absorption of glucose in the intestine and stimulates its utilization in peripheral tissues. Tablets are well tolerated by patients, can be administered in combination with insulin with concomitant obesity. The doctor selects the dosage individually. Contraindication to the use of Metformin is the propensity to ketoacidosis, serious pathology of the kidneys, rehabilitation period after surgical intervention.

The average price of drugs ranges from 110 to 260 rubles.

Thiazolidinediones

Photo: Thiazolidinediones

Drugs from diabetes mellitus of this group, as well as biguanides improve the absorption of glucose by body tissues and reduce the release of sugar from the liver. But unlike the previous group have a higher price with an impressive list of side effects. This weight gain, brittle bones, eczema, swelling, a negative impact on the function of the heart and liver.

1. Actos - this agent can be used as a mono drug in the treatment of type 2 diabetes. The action of the tablets is aimed at increasing the susceptibility of tissues to insulin, slowing down the synthesis of sugars in the liver, reducing the risk of vascular damage. Of the deficiencies of the drug noted increase in body weight during admission. The cost of the medication is from 3000 rubles.
2. Avandia - is a powerful hypoglycemic agent whose action is aimed at improving metabolic processes, lowering blood glucose levels and increasing the sensitivity of tissues to insulin. Tablets can be used in type 2 diabetes as a monotherapy or in combination with other hypoglycemic agents. Medication can not be prescribed for kidney disease, during pregnancy, childhood, and hypersensitivity to the active substance. Among the adverse reactions noted the appearance of edema and dysfunction of the cardiovascular and digestive system. The average price of a medicine is from 600 rubles.

Inhibitors of alpha-glucosidases

Photo: Glyukobay

Similar preparations from diabetes block the production of a special enzyme of the intestine that dissolves complex carbohydrates. Due to this, the rate of absorption of polysaccharides is significantly slowed down. These are modern hypoglycemic medications that are practical, have no side effects, do not cause digestive system disorders and abdominal pain.

Tablets should be taken with the first gulp of food, they well reduce the level of sugar and do not affect pancreatic cells. Drugs of this series can be used in combination with other hypoglycemic agents and insulin, but the risk of hypoglycemic manifestations increases. Bright representatives of this group are Glukobay and Miglitol.

• Glucobay( Acarbose) - is recommended to be taken if the sugar level rises sharply right after eating. The medicine is well tolerated, does not cause weight gain. Tablets are prescribed as an auxiliary therapy, supplementing a low-carbohydrate diet. Dosage is selected individually, as much as a day can take 300 mg of the drug, dividing this dose into 3 divided doses.
• Miglitol - is given to patients with an average grade of type 2 diabetes if the diet and exercise do not work. Tablets should be taken on an empty stomach. Contraindication to the treatment of Miglitol is pregnancy, child age, chronic intestinal pathology, the presence of large hernias. In some cases, a hypoglycemic agent provokes allergic reactions. The cost of drugs in this group varies between 300 and 400 rubles.

incretins

Photo: Galvus

In recent years, new generation drugs have appeared, so-called dipeptidyl peptidase inhibitors, whose action is aimed at increasing insulin production, based on glucose concentration. In a healthy organism, more than 70% of insulin is produced precisely under the influence of incretin hormones.

These substances trigger processes such as the release of sugar from the liver and the production of insulin by beta cells. New drugs are used as stand-alone drugs or included in complex therapy. They smoothly reduce the level of glucose and release the stocks of incretin to combat increased sugar.

Take the pill during or after a meal. They are well tolerated and do not contribute to weight gain. This group of funds include Januvia, Galvus, Saksagliptin.

1. Photo: Yanuvia

   Januvia - the preparation is released in the form of tablets coated with enteric coating, with active substance concentration of 25, 50 and 100 mg. The medicine should be taken only once a day. Yanuvia does not cause weight gain, well supports glycemia both on an empty stomach and when eating. The use of the drug slows the progression of diabetes and reduces the risk of possible complications.

2. Galvus - active substance of the drug - vildagliptin, stimulates the functions of the pancreas. After its administration, the secretion of polypeptides and the sensitivity of beta cells increase, insulin production is activated. The drug is used as a monotherapy supplementing the diet and physical activity. Or appoint in combination with other hypoglycemic agents.

The average cost of Yanuvia is 1500 rubles, Galvus - 800 rubles.

Many patients with type 2 diabetes are afraid to switch to insulin. Nevertheless, if therapy with other hypoglycemic drugs does not work and the sugar level increases steadily to 9 mmol / l after meals, you will have to think about the use of insulin therapy.

With such indicators, no other hypoglycemic drugs can stabilize the condition. Ignoring medical recommendations can lead to dangerous complications, because with a consistently high sugar, the risk of developing kidney failure, gangrene of the limbs, loss of vision and other conditions leading to disability is significantly increased.

Alternative drugs for diabetes

Photo: Alternative drug for diabetes mellitus - Diabentho

One of the alternative drugs is the drug from Diabetic Diabetes. This is an innovative two-phase agent based on safe plant components. The drug was developed by German pharmacists and only recently appeared on the Russian market.

Capsules Diabenthot effectively stimulate the work of beta cells of the pancreas, normalize metabolic processes, purify blood and lymph, reduce sugar levels, prevent the development of complications and maintain immunity.

The preparation will promote the production of insulin, the prevention of glycemia and the restoration of liver and pancreas. The drug has virtually no contraindications and side effects. Take capsules twice a day( morning and evening).The drug is available only on the official website of the manufacturer. More details with instructions for use and reviews of Diabenot capsules can be found here.

Drugs for the treatment of type 1 diabetes

Medications used for the treatment of type 1 diabetes can be divided into 2 groups: it is a vital insulin and other drugs that are prescribed for the elimination of concomitant diseases.

Insulin is classified according to the validity period for several types:

• Photo: Insulin

  Short insulin - it has a minimal duration and has a therapeutic effect 15 minutes after ingestion.

• Average insulin - is activated approximately 2 hours after the administration.
• Long insulin - starts working 4-6 hours after the injection.

The choice of the optimal drug, the choice of dosage and treatment regimen is made by an endocrinologist. Insulin treatment is carried out by injecting or sewing insulin pump, which will regularly give the body a dose of a vital drug.

The second group of drugs that are used in the treatment of type 1 diabetes include:

• Photo: ACE inhibitors

  ACE inhibitors - their action is aimed at normalizing blood pressure and preventing the negative impact of other medications on the kidneys.

• Medicines, whose action is aimed at combating diseases of the digestive tract, associated with type 1 diabetes. The choice of the drug depends on the nature of the problem and the clinical symptoms of the pathology. Prescribes medicines to the attending physician.
• With predisposition to cardiovascular diseases, prescribe drugs that stop the symptoms of the disease and support the work of the heart and blood vessels.
• Diabetes is often accompanied by symptoms of atherosclerosis. To combat these manifestations, drugs are selected that reduce the level of cholesterol in the blood.
• When symptoms of peripheral nephropathy are used drugs with analgesic effect.

Complex therapy for type 1 diabetes is aimed at improving the general condition of the patient and preventing possible complications. Diabetes mellitus is currently considered an incurable disease, and taking glucosamine medications or receiving insulin therapy will have throughout life.

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See video: How to make insulin shot yourself

Feedback on treatment

Testimonial No. 1

Last year, I had an elevated blood sugar level. The doctor prescribed a strict diet and increased physical activity. But my character of work is such that it is not always possible to eat in time. In addition, there is almost no time for classes in the gym.

But I still tried to adhere to medical recommendations and regularly controlled the level of sugar in the blood. For some time it was possible to keep it in norm, but recently the level of glucose is constantly high and it can not be knocked down.

Therefore, the doctor additionally prescribed a hypoglycemic drug Miglitol. Now I take tablets daily, and the sugar level has decreased, and the condition has improved noticeably.

Дина, Санкт - Петербург

Review №2

I am a diabetic with experience, I sit on insulin. Sometimes there are difficulties with the purchase of the drug, and as a whole you can live. I have type 2 diabetes, first prescribed hypoglycemic drugs, diets, exercise therapy. Such treatment produced a result, but in the end this scheme ceased to function and had to switch to insulin injections.

Every year I go through the examination, check my eyesight, because there is a risk of injury to the retina, and I also go through other preventive measures.

Arkady, Orenburg

Review №3

I have type 2 diabetes. Now I accept Acarbose. Tablets should be drunk while eating. They are well tolerated, side effects do not appeal, and most importantly, unlike other hypoglycemic drugs, do not contribute to a set of extra kilograms.

While this remedy helps, of course, in combination with a low-calorie diet and restricting the use of simple carbohydrates.

Olga, Moscow