Cortexin is produced by the Russian company GEROPHARM LLC.It is a nootropic product, available as a lyophilizate, white and slightly yellowish, from which a solution for intramuscular injection is made.
The active principle of the powder are polypeptides derived from the cerebral cortex of animals: pigs and cattle.
Glycine was added as a stabilizing agent in each vial of lyophilizate. There are two dosages of the drug 5 mg( children's release form) and 10 mg.
In addition to the nootropic effect of the drug, neuroprotective, antioxidant and tissue-specific effects can be expected.
Water-soluble powder polypeptides have a molecular weight of no more than 10 thousand daltons, so they can pass freely through a natural barrier that separates the blood and nervous system.
Contents of
- Mechanism of exposure
- Scope of application
- Prescription of medicament to specific patient categories
- Undesirable reactions and overdose cases
- Features of application of
- How and how to breed Cortexin to adults and children?
- Dosage and therapy regimen
- Complex of opinions
- Conditions of purchase and storage
Mechanism of exposure
The active substance of the drug normalizes the level of amino acids that regulate the processes of inhibition and excitation in the cerebral cortex.
In addition, it supports the balance of such mediators as dopamine and serotonin.
Simultaneously, it lowers the paroxysmal activity of the brain, prevents the appearance of free radicals.
Thanks to the nootropic effect, memory processes are normalized, concentration of attention is improved, the patient copes with stressful situations more easily. Against the background of treatment there is an increase in the resistance of brain tissue to various pathogenic factors.
Because of the antioxidant effect, the drug increases the survival rates of neurons during hypoxia.
The tissue-specific effect is manifested by an improvement in the neuronal metabolism of the central and peripheral nervous system, the activation of 
recovery processes in the central nervous system, the improvement of its activity and the increase in the tone of the nervous system.
After treatment, memory improves, headaches are passed, children become more calm, interest in the school program increases, babies develop progress, they have new skills in a short time( for example, they start to turn over themselves).
In children with cerebral palsy after injection, not only speech but motor function improves.
In elderly patients, also after the termination of therapy, there is memory improvement, there is a slowdown in the progression of senile dementia.
Since, when ingested, the amino acids and neuropeptides that make up Cortexin break down within 3 minutes, it is not possible to determine the pharmacokinetics of the drug.
Therefore, it is unknown whether the drug penetrates the placenta, is metabolized in the liver, how quickly and how it is excreted from the body, after what time the maximum concentration in the blood is observed.
Scope of application
What are the Cortexin injections for:
- for diseases of the nervous system caused by infectious agents( viruses or bacteria);
- violation of intracranial circulation;
- head trauma and their consequences;
- encephalopathy of various etiologies;
- cerebral autonomic dysfunction;
- epilepsy, acute and chronic CNS diseases of various nature( in combination with other medicines);
- learning difficulties, problems with memory and thinking;
- lag in psychomotor and speech development;
- asthenia;
- senile dementia;
- Cerebral Palsy for Children.
The only direct contraindication to treatment with the drug is individual intolerance.
Appointment of medication for special categories of patients
Because it is unknown whether the active substance has a negative effect on fetal development, pregnant women are not prescribed a drug.
No data, whether the active ingredient penetrates into breast milk, so it is advisable for babies who are on natural feeding for the time of therapy to be transferred to the mixture.
Elderly patients do not need to adjust the treatment regimen.
In pediatrics, the drug is administered individually, depending on the age and indications for use.
Patients with pathologies of the kidneys and liver drug prescribed by the standard scheme.
Undesirable reactions and cases of overdose
With individual intolerance, it is possible to develop allergies( eg, atopic dermatitis), which requires drug discontinuation and the appointment of antihistamines.
An allergic reaction may not be to Cortexin itself, but to a solvent in particular for novocaine. In this case, the course of treatment is continued, but the procaine is changed for saline or water for injections.
To date, no cases of overdose have been reported. Specific antidote is not developed, symptomatic therapy.
Pharmacological compatibility and specific instructions
Features of the application
The drug is administered intramuscularly slowly, since rapid administration is very painful. Children up to 6 months, not to damage the sciatic nerve prick do in the front of the thigh.
How and how to grow Cortexin for adults and children?
Before the injection, the drug should be diluted either in 1-2 ml of a 0.5% solution of novocaine, or in water for injection, or 0.9% solution of sodium chloride.
The medication is allowed to children from birth, including newborns that appeared before the term, but they can not be diluted with Novocain. Since procaine is a powerful allergen and can provoke cramps.
Before you enter the drug, a solvent is drawn into the syringe, then pierce the bottle cap. In order not to form a foam, the needle should preferably be directed to the wall of the vial.
After this, the syringe itself is removed, the needle must be inside the vial and shaken well, so that the powder will dissolve. Then, the syringe is reattached and the required amount of medicament is collected.
Dosage and therapy regimen of
Cortexin is able to induce psychomotor agitation, so it is advisable to administer it before lunch.
Adults prescribe at a dosage of 10 mg 1 time per day. The course of treatment is 10 days. 
In case of extensive ischemic stroke in the acute phase, the daily dosage should be 20 mg, then the drug is administered in this case in the morning and before bedtime for 10 days. After 10 days break, the course is recommended to be repeated.
Children with body weight less than 20 kilograms, the drug is prescribed in a dosage of 0.5 mg / kg / day.
If the child's weight exceeds 20 kilograms, then the daily dosage is 10 mg. The course of therapy is 10 days.
Cortexin does not adversely affect the ability to drive.
Complex of opinions
Reviews of a doctor and patients who have been treated with Cortexin.
Son was 5 months old, because of the tone in the legs, we were prescribed a course of Cortexin. After treatment, the child crawled after 1 week. Of the minuses the high price.
Aida
The child went to the 2 nd grade. School program was given to him with difficulty: the multiplication table does not remember, can not concentrate, reads badly, poems can not learn. The neurologist prescribed Cortexin.
I, after reading that the injection was very painful, spread it with novocaine. My son started a terrible allergy. It turns out that novocaine is generally contraindicated in persons under the age of 18.If the drug is administered very slowly, it is less painful. The effect of treatment was noticed by everyone and the teacher and I.
Even the child said that it became easier for him to learn. Now he easily remembers verses, retells the texts, became more balanced.
Marina
The drug has virtually no contraindications, rarely causes allergic reactions, is well tolerated by patients. The therapeutic effect of injections is particularly noticeable in patients younger than one year. But in children before school age, shifts from treatment are visible. This medicine among mothers was called "golovranchiki", since even sometimes one course is enough for the child to start talking.
Before starting therapy, you need to undergo tests to detect epilepsy.
Often, Cortexin is prescribed with drugs that have excitatory actions, such as Lucetam, in which case the polypeptides smooth out unwanted effects from them.
If you administer the drug quickly, it does not matter how the powder is dissolved with novocaine or water for injection, since in both cases the prick will be equally painful.
Unfortunately, the drug is not available in oral form.
Lyudmila Aleksandrovna neurologist seniority 15 years
Terms of purchase and storage
You can buy the medicine strictly on prescription form. The drug belongs to list B, store the drug at t 2-20 degrees, protected from light and moisture, and also inaccessible to children.
Shelf life 3 years from the date of manufacture, after expiration of which the medicine is subject to destruction. Do not store diluted powder. The average price of Cortexin in pharmacies in a dosage of 10 mg No. 10 is about 1200 rubles, 5 mg of No. 10 is about 750 rubles.
There is no complete analogue of the drug Cortexin on sale.
There are only medicines similar in mechanism of action:
- Glycine;
- Omaron;
- Nootropil;
- Cinnarizine;
- Trental;
- Cavinton.
Only the attending physician should select the analogue, as each drug has its own characteristics, appointments, negative phenomena, the dosing regimen.
