Hepatitis C - viral liver disease proceeding with diffuse liver inflammation.
It contains the RNA genome.
A method for transmitting
- intravenously, intramuscularly (by blood transfusion and its products, hemodialysis, injections, surgical and dental treatment);
- sexual contact with a person infected with S.
Manifestations of Hepatitis C
The incubation period - 20-90 days.
The majority of patients with chronic hepatitis C disease is asymptomatic. If there are complaints, it is often
- weakness,
- dull pain in the right upper quadrant,
- nausea,
- loss of appetite,
- itchy skin,
- pain in the muscles and joints.
For HCV characteristically wavy current; transition probability for chronic icteric - 50%, in other acute forms - approximately 85%.
Diagnostics
- Blood chemistry;
- General blood analysis;
- PHK-HCV (PCR). RNA virus detected in the serum after 1-2 weeks. after challenge;
- Anti-HCV (linked immunosorbent assay, Western blot); Antibodies to viral proteins; in test systems determine IgM (activity markers) and IgG.
Treatment of Hepatitis C
The vaccine against hepatitis C has not yet been set up due to the high variability of the virus.
interferon preparations
The basic formulation is effective in the treatment of hepatitis C is proved, it is interferon alpha (intron A) Scheme .Optimalnaya treatment of chronic hepatitis C in the present time - is a combination of Intron A and Ribavirin.
Recommended: 3 million IU INTRON-A s / c or i / m 3 p / week.. or a day in combination with rebetolom 1000-1200 mg / day. for 6 months, and then explore the RNA of hepatitis C virus (HCV) in serum (twofold). If a positive result of continued treatment according to this scheme is not very promising. In the absence of HCV RNA treatment should be continued until 12 months.
Using PegIntron in a dose of 1.5 mg / kg 1 time / week. instead of the usual interferon alpha allows if necessary to reduce the ribavirin dose to 800 mg / day.
With good tolerability of both drugs is optimum combination of PegIntron at a dose of 1.5 mg / kg 1 time / week. and ribavirin in a daily dose of 13 mg / kg 2 mg / kg daily. Such a protocol can achieve a stable response in more than 60%, including 88% of patients infected with HCV genotype 2 or 3.
Lamivudine is taken once daily at a dose of 100 mg orally is due to the meal. The combination of lamivudine with intron increases the effectiveness of treatment.
Diet for hepatitis C.
Table 5 № on Pevzneru.
Eating 5 times per day in powdered form.
- vegetarian, fruit, milk soups, cereals soups vegetable broth,
- boiled meat, poultry, low-fat varieties, boiled lean fish,
- milk, fresh buttermilk, yogurt, acidophilus milk, cottage cheese and 200 grams per day,
- cereals and flour dishes (except for baking), white bread, stale black,
- ripe fruit, berries (except acidic species) in cheese, baked, cooked,
- vegetables and herbs in cooked and raw (especially carrots, beets)
- jam, honey, sugar (70 g daily)
- vegetable, fruit juice in a significant amount,
- rather weak tea with milk.
limit
- fat (cream, butter and 10 g, 20-30 g of vegetable oil)
- egg (one per day).
excluded are:
- alcoholic beverages,
- liver, brains, bacon,
- beans, mushrooms, spinach, sorrel, onions,
- baking,
- fatty meats, fish,
- fried, spicy, smoked products,
- extractives of meat, fish,
- spices, vinegar, canned,
- ice cream, cocoa, soft drinks, chocolates, creams).
