Approved by the Academic Council of State and TSNIKVI
Section №14 of the Scientific Council of the Russian Federation Ministry of Health
July 4, 2000.
definition
The disease is characterized by the appearance exophytic growths on the inner or outer genitals, perineum and prianalnoy area. Considered as a possible etiological factor of squamous carcinoma of the cervix, cancer of the vulva and vagina.
The spectrum required diagnostic and therapeutic measures
Diagnosis is carried out on the basis of clinical manifestations of disease, cytological biopsies or swabs, where the most appropriate criterion for evaluation is HPV detection koylotsitov.
Cytotoxic therapies
podophyllotoxin 0.5% solution was applied to warts in accordance with the instruction on use 2 times a day at 12 hour intervals. During the 3 consecutive days with a 4-day interval. Treatment continued until the disappearance of warts, but no more than 5 weeks.
Chemical destructive therapies
trichloroacetic acid - 80-90% solution is applied to the warts. To remove unreacted acid used talc or baking soda,
or
solkoderm applied to the surface warts or warts 1 time per week.
If necessary, the processing is repeated.
Destructive physical therapies
- Laser - removing formations using CO2 laser.
- Radiosurgery - removal of tumors via radionozha.
- Cryotherapy - removal of tumors using liquid nitrogen
- surgical excision.
Non-specific antiviral therapy
glycyrrhizic acid on the affected surface of the skin and mucosa of vulva applied 6 times a day for 5-7 days on vaginal mucosa - 3 times a day for 5 days.
Combination therapy method
Glycyrrhizic acid, and eubiotiki Immunocorrecting means in combination with destructive methods. With glitsirriziovuyu acid in combination with destructive methods are used for prevention of possible malignancy.
If no effect or frequent relapses recommended intralesional or systemic administration (s / c or i / m) of interferons α, β, γ in a dose of 1.5-3 million. ED 3 times a week during 4 weeks in combination with destructive methods.
treatment of pregnant women
physical methods are recommended for treatment of pregnant women - CO2 laser, radionozh, cryotherapy and local antiviral therapy.
the results of the treatment requirements
Achieving clinical cure, reducing the number of recurrences.
Follow-up
In order to monitor dysplastic precancerous conditions in women infected with human papilloma virus 16 and 18, must be 2 times a year to carry out cervical cytology or colposcopic examination.