For normal childbearing needs 17-OH progesterone, the pregnancy rate at which prevents the development of dangerous diseases. Intermediate result kortizolnogo synthesis formed in the crust of paired endocrine glands. In pregnant women increases the amount of the steroid as a result of an imbalance of hormones.
Norm
To determine the correct value of the steroid must take into account the woman sex, age.
In the 1st trimester
17 It is measured in pregnancy week by week:
- 5-6 - 18.57 OH;
- 7-8 - 32.98 OH;
- 11-12 - 42.80 OH.
The norm of 17-OH does not fluctuate, it increases with respect to gestational age. A low number of steroid leads to miscarriage. hormone excess causes abnormalities in the fetus.
In the 2nd trimester
In the 2nd trimester rate of endogenous steroid is 71,6-303,2 nmol / l. Pregnancy is every woman differently. However, the threat of losing a child may be from 13 to 24 a week, that is. To. OH progesterone level rises. To save the child patient is being treated. Number of 17-OH into 24 week equals 2.0-5.0 ng / ml.
17-OH - a chemical compound produced by placental tissue during metabolic processes. Investigation of synthesis of intermediate kortizolnogo performed by ELISA using reagents procedure.
With the loss of a child reduces the amount of endogenous steroids. If the tests show a reduction in the amount of the hormone can cause miscarriage.
In trimester 3
Before birth in the 33-34 week 17 it amounted to 112.45, then it rises to 219.58 units. Progestogen hormone during pregnancy relaxes the muscles of the uterus. The patient with threatened miscarriage, tests for 17-OH allow you to adjust therapy.
Drugs used from 14 to 24 week at a deviation from the norm of endogenous steroid, can not be taken in 3 trimester.
Use of influencing the amount of sex hormone may cause premature labor.
In 3 trimester abnormality dangerous; particularly poor steroid excess.
Causes, symptoms and treatment of abnormalities
17-OH progesterone during pregnancy sometimes rises. Woman hands over the analysis on HCG to confirm fertilization. Fluctuations 17-OH occurs at different times of day, the deviation can be in tumors, adrenal disease, severe stress.
Pregnant woman's body is suffering, experiencing negative symptoms:
- memory impairment;
- violation of the emotional state;
- reduction in the body's defenses;
- prolonged infection;
- increase blood pressure and strain on the heart and blood vessels.
For the treatment of the following drugs are used:
- Duphaston;
- utrozhestan;
- Progesterone;
- ingest;
- Crinone.
The physician in order to increase the progesterone synthesis selects the drug and its dose individually.
increased rate
Pregnant women are often 17-OH progesterone is increased. The doctor prescribes therapy metipred for 1 ½ tablet once a day. The quantity of the hormone may reach 120.8 ng / ml (1 trimester normal value - 4,73-50,74).
During the period of gestation at increased performance of developing complications:
- swelling;
- preeclampsia;
- diabetes;
- cholestasis.
Progesterone in a large amount lowers the concentration of glucose and increases it after meals. Immune maternal tissues glucose is also provided progesterone. 17 It stimulates gluconeogenesis and inhibits insulin action in the parent bodies, stimulates the formation of gestational diabetes.
Reduced rate
Sometimes a woman can not get pregnant because she had been a violation of adrenal function. 17-OH deficiency affects the preparation of other compounds: testosterone, cortisol. A woman complains of chest pain, chronic diseases of the reproductive organs, infertility associated with hormonal deficiency.
