Late embryo implantation and 100 mIU hCG / l in the blood is considered normal when the artificial conception. Egg need some time to adapt to the further development of the female body.
What is late embryo implantation during IVF
Normally, introduction of a fertilized egg in the uterine endometrial layer was observed after 40-48 hours after replanting. In some cases, it falls into the thickness of tissues later. This phenomenon is considered to be a natural, it does not lead to the formation of intrauterine fetal anomalies, and not provoke the emergence of a pathological process.
Later, the introduction of the female reproductive cells in the endometrium because the artificial conception, the egg is fertilized in a special container. It is carried out for further growing the embryo transplantation. Due to the fact that fertilization occurs outside the human body, the embryo takes time to adapt to the new conditions and further cell division.
On what day after the transfer takes place the embryo implantation
On what day of the female reproductive gamete is ready for implantation it depends on the degree of its development. Embriologists recommended to transfer three- and five-day embryos. In the first case, the embryo is at the stage of development called morula. Cells divide rapidly, so ready for transplanting an embryo in the uterus. In this implementation a morula mother layer may take about 2-4 days.
After 5 days after fusion with the sperm enters the egg blastocyst stage, however it can implanting. It is easier embedded in the endometrium, so that the process takes about 24-48 hours. The main advantage of five days before the three-day embryos - a higher viability, so they are often used for transplant.
In some cases, within the IVF technique used krioperenosa. The procedure is the freezing healthy embryos using liquid nitrogen, which, after removal from cryobank transplanted into the uterus. Krioperenos may be performed upon receipt of hormones that stimulate ovulation.
After thawing the embryos do not die and retain activity, so self-introduced into the mother liquor layer.
In order to avoid the negative consequences of the embryologist selects the most viable samples.
The main advantages of krioperenosa:
- Pregnancy can be postponed until the most convenient time;
- Preservation will delay the embryonic development of the required phase;
- Frozen samples can be used for multiple protocols IVF.
Late embryo implantation and hCG IVF using frozen embryos are not pathology.
dynamics of hCG
HCG for late implantation in the blood and urine of women is determined to confirm conception. Growth hormone is noted at 12-14 hours after the introduction of ovum in endometrial layer.
At later embryonic fixation point following changes in the dynamics of hCG:
- After 14 days after replanting gonadotrophin concentration rises to 100 mIU / l. This indicates pregnancy.
- If the index of hCG ranges from 25 to 100 mIU / L, there is a risk of disease. In 95% of cases, this is a symptom of the death of the embryo or its attachment outside the uterus.
- If for 12-15 hours plasma concentration below 25 mIU hCG / l, pregnancy has not occurred. The embryo has left the body with mucous secretions.
When the level of human gonadotropin reach 1,000 mIU / L, it is possible to control the formation of the fetus by ultrasound. Most such hormone concentration is observed at 19 days after replanting.
Comparison of hCG is given in the table below:
| The day after the introduction of a fertilized egg in the uterine cavity (DPP) | Whey indicator hCG mIU / l | |||
| The fruit of the morula, 3 days | The five-day embryos | the lowest index | average values | The maximum possible |
| 11 | 9 | 30 | 110 | 170 |
| 15 | 13 | 220 | 650 | 840 |
| 18 | 16 | 750 | 1960 | 3200 |
| 21 | 19 | 1830 | 4650 | 7800 |
| 24 | 22 | 5400 | 10200 | 19500 |
| 27 | 25 | 10500 | 16500 | 40000 |
| 30 | 28 | 14000 | 27200 | 70000 |
| 39 | 37 | 28000 | 65000 | 128100 |
The five-day fruit ahead of three days of maturation for 48 hours. Due to this difference it survives in the female body 2 times faster, however, in most cases up to 100 mIU hCG / l by the 9 day. 10 hours a woman can check if she is pregnant, with the help of special tests, respond to the hormone in the urine. Positive three-day fetal implantation is determined 11-12 hours.
