Omeprazole. Instructions for use, price, reviews, analogs, which treats like taking pills during pregnancy, before meals or after

Omeprazole (Omeprazole). Description, composition, the active ingredient

Due to the high efficiency, since the advent of omeprazole drug widely used in the treatment of diseases of the digestive tract. Most often, the medicine used to reduce gastric acidity and the treatment of the symptoms of stomach ulcers - heartburn, belching, bloating, nausea.

The main active ingredient - omeprazole. Additional components of the composition determined by the shape of the drug release.

As part of the capsule contains the following excipients:

• titanium dioxide;
• glycerol;
• propyl paraben;
• sodium dodecylsulfate;
• distilled water;
• gelatin.

Additional components of the composition in a tablet form of release:

• sodium dodecylsulfate;
• calcium carbonate;
• mannitol;
• sugar;
• talc;
• titanium dioxide.

issuance

Omeprazole is released in 3 forms:

• gelatin capsules contain 0.01 / 0.02 g of active substance in the form of granules.
• PowderBy which is prepared by intravenous injection. Supplied in packs of 5 vials. 1 vial contains 0.04 g of active ingredient.
• Pills (Pellets) dose: 0.01 g, 0.02 g or 0.04 g

pharmachologic effect

The drug reduces the production of stomach acid, but also exerts a bactericidal effect and antiulcer. Omeprazole regulates secretion by inhibiting the proton pump. Act begins in about an hour, it stops - a day later.

Pharmacodynamics and Pharmacokinetics

The active substance omeprazole acquires medical qualities only by reaction with the acid environment of the organism. Once in the stomach, the drug acts on the parietal cells by blocking the proton pump - specific proteins that regulate the exchange of hydrogen ions in the cells (inhibition).

Regulates the production of pepsin - the gastric juice. Omeprazole is also appointed with antibiotic therapy aimed at suppressing the bacteria Helicobacter pylori (Helicobacter pylori) - the main causes of peptic ulcer disease.

The drug is rapidly absorbed. Achieving maximum concentration takes from half an hour to an hour. After one receiving absorbed 30-40% of the formulation, at regular application (1 times a day) - 60.

Indications

According to the instructions for use, it is recommended to take Omeprazole:

• in the presence of H. pylori infection (in such cases the drug is taken with antibiotics);
• Zollinger-Ellison disease;
• multiple endocrine adenomatosis;
• ulcers caused due receiving NPC;
• heartburn;
• esophagitis;
• mastocytosis;
• GERD;
• gastritis with high acidity;
• necrosis of the gastrointestinal tract.

Special instructions and precautions

Do not take omeprazole if there are suspicions that malignancy may be present in the gastrointestinal tract. The action of the drug can interfere with accurate diagnosis, because it hides the symptoms of disease.

How to take: before meals or after?

• The capsules. The drug is taken or during a meal, or in front of it. Capsule need to drink water without chewing. If the patient can not swallow, or is necessary to give medicine to a child, you need to take some water, open the capsule and mix the content in a tablespoon of water. The mixed powder with the liquid also need to drink water. It is better to take medication in the morning, when the digestive process is only activated to the acidic environment has been lowered throughout the day. When combined therapy of omeprazole with other drugs time interval between drug administration should be at least 1 hr.

• Injections are administered intravenously. The powder is diluted in a special solution, then poured with a dropper for half an hour. The procedure is performed as a nurse in the office of the medical institution or at home.

How long can I take omeprazole?

According to the instructions for use, omeprazole is determined a diagnosis, stage of the disease and the characteristics of the patient:

• Patients with duodenal ulcer We must take medication for 2 weeks. If this is not enough, treatment is extended for the same period. After the well-being and improve ulcer zarubtsuyutsya need prevention to disease is not renewed. In prophylactic treatment taken 1 time a day at 0.01 g At the discretion of the dose can be raised up to 0.02 or 0.04 g
• When bad scarring ulcers KDP discharged 4-week course of the medication at a dosage of 0.04 g once daily.
• In gastric ulcer you need to take medicine for 4 weeks (0.02 grams daily). If the ulcer is not healed, it will take another similar course. Poorly healing ulcers treated 8-week-old taking the capsules at a dose of 0.04 g per day. After treatment you should drink daily dose of 20 mg.

• to cure helicobacter pylori infection, Using "triple therapy". Your doctor may prescribe different treatment regimen by varying the choice of antibiotics and dosage: take with omeprazole, clarithromycin, and metronidazole or tiniadazol. These drugs are taken for 7 days, regardless of the regimen. Each drug should be taken 2 times a day.
• When a bacterial infection managed to get rid of, continue to treat ulcers standard therapy. If the infection is left not eliminated, try to eliminate it, take a second course of antibiotic therapy.
• If the ulcer develops in the presence of NSAIDs, the medicine is drunk at a dose of 0.02 g for 4 weeks. If healing has not occurred, the duration of admission increased by another 4 weeks.
• In the treatment of reflux ezofakida recommended dosage of 0.02 g per day. The treatment lasts 4 weeks are the same and can be stretched up to 8 weeks if the sores are not healed in time. If the disease takes a severe form, the preparations immediately discharged for 8 weeks dosing of 0.04 g (one time per day).
• When it is in remission, the result is fixed and is supported by long-term therapy: received daily dose of 10 mg.
• When the disease Zollinger-Ellison duration of therapy may also vary. Starting dose - 0.06 g per single dose. Sometimes the doctor may increase the dose by 1.5-2 times, then it is divided into 2 doses.

treatment of gastritis

Doctors prescribe Omeprazole gastritis if hydrochloric acid is produced in a patient too rapidly. Due to the acidity of the stomach the gastric juice causes inflammation of the gastric walls. In that case be adjusted by means of acid secretion inhibitor drug. But if the secretion is low, the appointment of omeprazole bring harm to the patient.

The drug will cause the glands that work will be broken and thinned epithelium.

Standard deadline - 2 weeks. On the day should drink at 0.02 g capsule. The physician may increase the dose (two capsules a 2 administration) and to extend the treatment for a few weeks. If gastritis has developed due to the fact that the patient was infected by the bacterium Helicobacter, except Omeprazole have to go and antibiotic treatment: cure the disease without antibiotic therapy not out.

heartburn treatment

According to the instructions for use, omeprazole recommended for disposal from heartburn as a symptom of diseases of the digestive tract. On drug efficacy and duration ahead of antacids and alginates, which do not affect the production of hydrochloric acid, but only temporarily eliminate heartburn.

Duration of treatment is determined cause heartburn. The specialist may prescribe a course of therapy for a period from 2 weeks to 2 months. Upon receiving NSAIDs prevention lasts 2-3 weeks, with a dosage of 0.02 g capsules per day.

With heartburn, which arose not because of gastrointestinal diseases, the drug is recommended to drink no longer than 14 days. Patients with gastric or duodenal appointed reception in 1-3 months duration. If the cause of the symptom - poor diet, the patient may be discharged reception 0.01 g omeprazole for a few days as a preventive measure.

pancreatitis

Omeprazole is used to relieve symptoms of pancreatitis. People with this disease gland secreted enzymes are not released into the duodenum 12 and stay there for the same, leading to its destruction. Omeprazole helps to remove pancreatic enzymes, to remove its inflammation and swelling, as well as regulates the production of pancreatic juice and maintain an alkaline environment.

In acute pancreatitis, drug taking 1 per day - in the morning. Dosage - 0.02 g Duration of reception - 2 weeks. The course can be extended. In acute recurrent pancreatitis omeprazole taken 1 time in any time of day. The dose is increased to 0.04 g Better to take the medicine before meal. The duration of admission - about a month.

In chronic pancreatitis - 0.06 g once a day. In some cases your doctor may increase the dose to 0.12 g Exacerbation of chronic pancreatitis - 0.08 g once at any time. The standard course of treatment - 2 weeks. Together with a strict diet and additional drugs.

When renal impairment

There is no need to make adjustments in the dose of medication. Treatment is carried out under the supervision of a specialist.

In human liver

When liver problems should take no more than 0.01-0.02 g drug for 1 day. The drug is taken with care, under the supervision of a physician.

Use in the elderly

Omeprazole for elderly patients can be dangerous. Increased bone fragility.

Instructions for use for children

According to the instructions for use, omeprazole may be taken of children between the ages of 1 year and weighing 10 kg, with reflux esophagitis and gastroesophageal reflux disease. Dosage in this case is 0.01 grams per day. The contents of the capsule to mix with 50 mL of water, then give the child a half volume of the solution. The dosage for children aged 2 years and weighing 20 kg is 0.02 g per day.

Assigned 4-week course, which may be extended if necessary.

The drug is indicated for children aged 4 years with duodenal ulcer caused by H. pylori infection. Depending on body weight, are assigned different dosages of omeprazole and antibiotics. All drugs in all treatment regimens are drunk for a week (twice a day). omeprazole therapy in children should take place under the close supervision of a physician.

Application of pregnancy and lactation period

In rare cases, the drug is issued to pregnant women. Such a decision is made if there are no alternatives and the doctor believes that the positive effect of the treatment justifies the potential risk. During the period of lactation is recommended to refrain from taking the drug, since it is excreted in the milk during lactation.

Interaction with other drugs

It does not interact with antacids. Because of omeprazole is slowly absorbed:

• ampicillin;
• ketoconazole;
• iron supplements;
• iitrakonazol.

Interaction with omeprazole slower output and strong action:

• warfarin;
• diazepam;
• phenytoin.

Combining the drug with digoxin increases the bioavailability (ability to penetrate into the systemic circulation) of 10%, which in some cases leads to intoxication. Parallel receiving clarithromycin and omeprazole leads to the fact that the drugs enhance the effects of each other.

Increases haematotoxicity the following means:

• lithium preparations;
• chloramphenicol;
• methimazole.

It reduces the effectiveness of clopidogrel.

Omeprazole and alcohol

Instructions for use contains no prohibition on combining the drug and alcohol. Alcohol does not interfere with the effect of the drug, however, bring direct harm to the stomach and is contraindicated in patients with any disease of the digestive tract.

Contraindications

Do not take medicine in the following cases:

• in the presence of allergy to the components;
• osteoporosis patient (receiving the drug enhances leaching of calcium from the bones);
• patients with salmonella;
• with lactose intolerance, lactase deficiency and malabsorption glucose-galactose.

Side effects

The following effects may occur after receiving omeprazole:

• dry mouth, stomatitis, nausea, abdominal pain, disorders of the chair;
• depression, insomnia, severe drowsiness, dizziness, headache, if there were serious liver disease - encephalopathy;
• pain, muscle weakness;
• pruritus, rash, alopecia;

• urticaria, bronchospastic syndrome, nephritis, acute allergic reactions;
• visual disturbances, edema, increased sweating, gynecomastia.

Overdose

Symptoms of overdose:

• blurred vision;
• drowsiness;
• irregular heartbeat;
• headache;
• nausea.

In the study, 13 receiving omeprazole capsules in 1 day did not induce severe intoxication. There is no antidote.

analogs of omeprazole

• omez - closest analog with the same active substance and a higher cost.
• Omeprazole-Teva - the same drug, but producing the Israeli pharmaceutical company. It is much more expensive.
• Nolpaza. This medication is usually given for longer courses than omeprazole. Instructions on the use of analogue prohibits patients younger than 18 years, but it is more commonly prescribe to women during pregnancy. Nolpaza different main active substance - pantoprazole also performs the function of the inhibitor, but having other characteristics. Analogue is slower than omeprazole, and has a much higher cost.

• Ranitidine. The duration of action is much lower: about 12 hours versus 24 hours for omeprazole. The disadvantage is that after stopping gastric acidity is greatly increased. Additionally, Ranitidine requires a gradual increase in the amount of the drug. The body gets used to the standard dose and effect is reduced.
• famotidine - a modern equivalent of Ranitidine mentioned above. Omeprazole is more effective because it acts directly on the proton pump. Famotidine is only sold in the form of tablets and therefore is slower.
• Emanera - another analog. It is characterized by a slight advantage in the treatment of GERD, but it is much more expensive than omeprazole.

Conditions of supply of pharmacies

Available on medical prescription.

Shelf life

The storage place should be dry, dark and inaccessible to children. The preparation is fit for 2 years.

Price

Price ranges from 40 to 150 rubles. Omeprazole value is determined by the manufacturer and the form. For patients who received a doctor's instructions that involve prolonged use of the drug, more profitable and more convenient to purchase the package with a lot of capsules.

Author: AP Morozov (flykt)

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