Active substances and a list of the absolute analogue
Metformin (metformin) is a hypoglycemic agent synthetic origin. Its action is aimed at reducing the level of glucose, which is indirectly involved in the process of losing weight. It does not activate the insulin production by the pancreas. A person without the presence of pre-diabetes, 1 or 2 type of diabetes does not reduce the amount of sugar in the body. That is, the substance is safe for healthy people.
Metformin helps moderate weight loss due to:
- improve processing of glucose by the body;
- reduce glucose production by the liver cells;
- delay glucose absorption in the gastrointestinal tract;
- activation of glycogen formation (important substance for the energy supply of tissues);
- improve lipid metabolism;
- supporting a stable amount of sugar in the body (the constant feeling of hunger disappears).
Means a substance release metformin tablets dispensed from the sheath 500 mg to 1000 mg. Medicines produced in Russia and abroad.
The list of one-component tools with metformin and a minimum price on 11/01/18 in rubles:
- Metformin - 9;
- Gliformin - 190;
- Glucophage - 117;
- Diaformin - 47;
- Metfogamma - 25;
- Siofor - 27;
- Sofamet - 100;
- Formetin - 46;
- Formin Pliva - 312;
- Other trade names of the substance m
Apply Metformin weight loss is necessary only with the proper correction of nutrition and physical activity. Before using it necessarily examined to rule out pathological causes of weight gain. If weight gain is caused by diseases of the endocrine, reproductive system or another, the tool will be effective in combination with medicines etiological treatment.
On a note! In pharmacies there are preparations in which metformin is combined with a substance vildagliptin, glibenclamide, gliclazide, glimepiride, rosiglitazone or sitagliptin. There are also funds with metformin prolonged action. Slimming, these drugs are ineffective.
Direct evidence of the drug
Metformin tablets used in the treatment of diabetes neinsulinozavisimogo with / without the presence of obesity. The medicine is also indicated for the prevention of this disease and prediabetic states. In his list of indications is not information that you need to lose weight to take Metformin. The medicament may recommend nutritionist as an auxiliary method of correcting obesity.
The annotation tablet Metformin and instructions of any single component of the drug substance with metformin clearly due to: apply in case of no effectiveness of the methods of diet therapy and exercise therapy. That is, first the patient adjust diet and exercise. If after 1-3 months it did not give the expected result (hypoglycemic effect, slimming), a person prescribed medication.
Lose weight by Metformin is impossible without compliance with a low-carb diet and intense 40-60 minute aerobic exercise. You may not use the drug for people who have food calorie content of less than 1000 kcal.
Features reception Medicine
Metformin (or its direct analogues) to lose weight consume immediately before / during / after meals. In this case, the therapeutic substance accumulates in the intestine and prevents glucose absorbed from digested food. The body to compensate for a deficiency, glycogen begins to develop at the expense of fat cells. If the pills to drink between meals, metformin blood is carried to the organs. This disrupts the body's response to the drug, causing weight loss does not occur.
Lose weight with metformin is possible for people who have immunity cells to insulin (insulin resistance). This show abnormalities in laboratory studies. Therefore, to avoid wasting "money down the drain", it is necessary to consult with the endocrinologist and / or nutritionist, and a blood test.
dosing Medicine
Metformin drink for weight loss to a minimum of 500 mg / 1 again. If you use less of the dose - effect does not occur. Do not take more than 3000 mg of metformin / day. The maximum dose of 3 g / 24 hours prescribed by the physician under strict medical indications, since in most cases the substance poorly tolerated.
The optimal dose of Metformin weight loss reset if necessary:
- 1-9 kg - 500 mg 3 times / day;
- 10-14 kg - 850 mg 3 times / day;
- 15 kg - 1000 mg 3 times / day.
To avoid significant side effects from the gastrointestinal tract, the first 5-7 days Metformin drink of 500-850 mg / day. Then, the number of stages is increased to the recommended dose for slimming.
Attention! A woman needs to adjust the dose of Metformin, if she takes oral contraceptives. This requirement also applies to losing weight people who are treated with corticosteroids, antipsychotics, beta-agonists, and a number of other medicines.
course duration
Diet drink drug Metformin are allowed healthy person 21-28 days. Repeat the course may be after 4-8 weeks. Reception of such a scheme does not require monitoring of renal function, if there was a history of urinary tract diseases.
For weight loss, many nutritionists recommend drinking Metformin 3 weeks if the digestive tract from the first day is well tolerated daily dose of 1500-2000 mg. During this period, the body gets used to metformin properties, and the body stops responding to the effects of the drug.
During Metformin reception and during the break between the courses you need to eat rationally, to observe low-calorie diet, exercise to perform with enhanced aerobic exercise. This condition is mandatory for weight loss process.
Features short reception
Application to lose weight in 1.5-2 weeks of checking the glucose level. Explore the concentration of lactate should definitely in the event of pain and / or cramps in the muscles. If necessary, the doctor changes the dosage of Metformin or instead appoints another drug.
Properties of long reception
If a person suffers from obesity and diabetes mellitus - doctors prescribed him receiving prolonged courses of tablets for glucose lowering. Weight loss is an additional effect which can not occur.
People are constantly drink tablets required to periodically tests for determining kidney function and glucose. Lactate concentration in plasma is checked 2-3 times a year, as well as in case of muscle pain or cramps.
Further guidance on the application of
It is undesirable for weight loss or correction of hyperglycemia drink Metformin people engaged in heavy physical work, bodybuilders and other profile athletes who perform anaerobic exercise. These categories of higher risk of developing lactic acidosis. In patients older than 75 years may be impaired renal function who are asymptomatic.
When losing weight during the reception of Metformin can not:
- drink beverages containing alcohol (ethanol incompatible with metformin);
- eat fried food;
- eat sweets and sugar;
- enters in the diet foods rich in simple carbohydrates;
- diet with calories below 1000 kcal;
- starve;
- violate drinking and / or feeding regime.
For the correction of weight, it is desirable to use the recommendations of Pevsner doctor about nutrition and become familiar with the dietary table №8. The slimming period important fractional consume food, to observe a balanced diet, drinking the liquid from the calculation of 35-50 ml / 1 kg and abandon of some products. With each disease has a specific list of permitted / prohibited food.
Side effects Medicine
Often the first metformin in humans begin stomach problems: pain, vomiting, upset stool, bloating, and nausea. Dyspepsia in the background diet may point to side effects of the substance, and on the development of lactic acidosis or gastritis, enteritis. Rarely means for monthly course causes dysfunction of the liver, deterioration absorption of cyanocobalamin, and folic acid, hepatitis or lactic acidosis.
Contraindications Medicine
The substance metformin penetrates through the placenta or excreted in the milk. It is forbidden to them to adjust the weight of the child under 10 years of age or diet used in pregnant, lactating women. In the case of prescribing doctors must monitor the state of health of these groups of patients.
It is undesirable to try to lose weight with metformin people after 60 years. This group of agents increases the risk of lactic acidosis.
Other contraindications for use in the diet:
- intolerance to metformin;
- metabolic acidosis;
- hypoglycemic shock;
- diabetic ketoacidosis, coma, or precoma;
- renal / hepatic / cardiac insufficiency;
- dehydration;
- infectious diseases;
- infarction, respiratory failure, and other diseases, due to which the available cell hypoxia;
- alcoholism, alcohol intoxication;
If an operation or contrast radiography, the person should temporarily stop taking Metformin. Direct drug is contraindicated in / vennoe administering iodine preparations.
result of action
Healthy people lose weight by 1-4 kg of Metformin in the first month of its reception, Then weight loss is stopped or significantly decelerated. Experts believe that the first substance the body gives rise to the processing of fat cells, so the first 30 days is marked weight loss, and after 3-4 weeks the tissue stops responding metformin.
A minimum of 50% of people with diabetes or prediabetes weight loss does not occur. Doctors have noted the overwhelming majority of patients that their weight has ceased to grow and continues to stand on the performance since the beginning of the reception of this tool.
The feedback information of consumers found that to lose weight with metformin is obtained up to 10 kg / month. In most cases, such women results obtained in treatment of obesity, or metabolic syndrome premenopausal, gynecological, endocrine, digestive diseases. Pathology of these systems are a common cause of weight gain. The statement that a healthy person monthly "losing" a lot of weight without diet or exercise, doctors called quackery.
On a note
Effects from the substance have not stopped studying. At present, there are results that Metformin for diabetes prevention of osteoporosis, cardiovascular disease, thyroid dysfunction and treatment of metabolic syndrome. The substance reduces the risk of senile dementia and the formation of malignant tumors. It is often used without a doctor's prescription to lose weight, but it is dangerous to health.
According to doctors
From Metformin can lose weight up to 4 kg in 4 weeks, but drug use is always a complex with dieting and physical exercise. However, in healthy people without the medication, with proper nutrition and intense aerobic workouts also get to lose up to 4 kg per month.
Metformin may help gradually reduce the weight of people who have physical therapy methods of diet therapy and there is no effect. But weight loss usually occurs against parallel treatment of diseases, which are responsible for completeness.
At the drug severity of side effects on the gastrointestinal tract and many contraindications. Nutritionists have questioned the appropriateness of metformin use by healthy people to lose weight.
Attention! Dropping a month more than 4 kg can lead to sagging skin, kidney prolapse, hair loss, menstrual irregularities and / or metabolism, reversible infertility, depression, decreased operability. To preserve the health of the optimal rate of weight loss is considered to be 0.5-1 kg per week.
sources:
Vidal: https://www.vidal.ru/drugs/metformin-5
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = ac45cb5c-4394-42ca-8479-a60a7a67e0b0 & t =
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